• Clinical and Experimental Pediatrics
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• 제48권8호
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• pp.806-812
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• 2005

Repair mechanisms in the postnatal and mature central nervous system(CNS) have long been thought to be very limited. However recent works have shown that the mature CSN contains neural progenitors, precursors, and stem cells that are capable of generating new neurons, astrocytes, and oligodendrocytes especially in germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus. These findings raise the possibilities for the development of novel neural repair strategies via mobilization and replacement for dying neurons of neural stem cells in situ. Indeed recent reports have provided evidences that endogenous stem cells are activated in response to various injuries, and in some injury models, limited neuronal replacement occurs in the CNS. Here, current understandings for endogenous neurogenesis and induction neurogeneis in postnatal CNS including neonatal brain are summarized and discussed.

• Computers and Concrete
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• 제8권5호
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• pp.541-561
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• 2011

The Finite Element Method (FEM) was employed to demonstrate that accurate simulations of seismically repaired and retrofitted reinforced concrete shear walls can be achieved provided a good analysis program with comprehensive models for material and structural behaviour is used. Furthermore, the analysis tool should have the capability to retain residual damage experienced by the original structure and carry it forward in the repaired and retrofitted structure. The focus herein is to provide quick, simple, but reliable modelling procedures for repair and retrofitting strategies such as concrete replacement, addition of diagonal reinforcing bars, bolting of external steel plates, and bonding of external steel plates and fibre reinforced polymer sheets, thus illustrating versatility in the modelling. Slender, squat, and slender-squat shear walls were investigated. The modelling utilized simple rectangular membrane elements for the concrete, truss bar elements for the steel and FRP retrofitting materials, and bond-link elements for the bonding interface between steel or FRP to concrete. The analyses satisfactorily simulated seismic behaviour, including lateral load capacity, displacement capacity, energy dissipation, hysteretic response, and failure mode.

• 한국IT서비스학회지
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• 제13권3호
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• pp.275-298
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• 2014

The purpose of this study is to verify the difference between the importance level and the satisfaction level of each purchase decision factor of smart phone. Through review of literatures about purchase decision factors, we have derived about attributes of 6 factors. T-test, importance performance analysis (IPA), and regression analysis were conducted to identify priorities among the details of the importance and satisfaction and to analyze the effect relationship between satisfaction of each factor and overall satisfaction. Looking at a few high-priority order, battery capacity, memory capacity, fast and accurate repair, the adequacy of the repair cost, and processor in the top five factors were shown to be an important factor when purchasing smart phones. The results of this study can provide the marketing strategies for smart phone suppliers. In addition, these results imply what factors of smart phones should be more considered before launching into chinese smart phone market.

• Clinics in Shoulder and Elbow
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• 제26권3호
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• pp.323-329
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• 2023

Rotator cuff tear is a common shoulder injury that compromises both function and quality of life. Despite the prevalence of the injury and advancements in repair techniques, a significant percentage of these repairs fail. This review aims to explore the multifactorial reasons behind this failure, including the degenerative nature of the rotator cuff tendon, inherent and extrinsic factors, and the role of hypoxia in tissue degeneration. Additionally, it elucidates potential strategies for improving healing outcomes.

• 한국경영과학회지
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• 제22권1호
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• pp.87-99
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• 1997

This paper considers warranty servicing for repairable products when product lifetimes are phase-type(PH) distributions. Two replace-repair strategies are analyzed based on renwal processes. The quantities of interest can be expressed in terms of the renewal function which, in general, is very difficult to evaluate. By exploiting properties of PH distributions we obtain simplification to evaluate these performance measures. Numerical examples for four different PH distributions with typical functions are presented and the results are discussed.

• KIEAE Journal
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• 제8권5호
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• pp.17-22
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• 2008

Dosan Seowon, one of the earliest and most prestigious private Confucian academies in Korea, is an example of a heritage property citizens wish to sustain for the benefit of future generations. It is recognized of its contribution to the Korean society and as an architectural and historical interest. This study conducts architectural and cultural research about Dosan Seowon by scrutinizing its evidential, historical, aesthetic and spatial values. By doing so, it is possible to recognize how appreciated qualities are vulnerable to harm through only understanding their heritage values without practical management solutions. That understanding should then provide the basis for developing and implementing management strategies (including maintenance, cyclical renewal and repair) that will best sustain the heritage values in a physical aspect. The conclusion suggests that communication about Dosan Seowon among those who are concerened is significant.

• BMB Reports
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• 제48권12호
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• pp.655-667
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• 2015

Lineage tracing is a widely used method for understanding cellular dynamics in multicellular organisms during processes such as development, adult tissue maintenance, injury repair and tumorigenesis. Advances in tracing or tracking methods, from light microscopy-based live cell tracking to fluorescent label-tracing with two-photon microscopy, together with emerging tissue clearing strategies and intravital imaging approaches have enabled scientists to decipher adult stem and progenitor cell properties in various tissues and in a wide variety of biological processes. Although technical advances have enabled time-controlled genetic labeling and simultaneous live imaging, a number of obstacles still need to be overcome. In this review, we aim to provide an in-depth description of the traditional use of lineage tracing as well as current strategies and upcoming new methods of labeling and imaging.

• BMB Reports
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• 제52권1호
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• pp.35-41
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• 2019

Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally evolved to limit the proliferation of old or damaged cells. However, it has been recently shown that cellular senescence is a physiological and pathological program contributing to embryogenesis, immune response, and wound repair, as well as aging and age-related diseases. Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. Thus, cellular senescence has also been considered suppressive mechanism of tumorigenesis. Current studies have revealed that therapy-induced senescence (TIS), a type of senescence caused by traditional cancer therapy, could play a critical role in cancer treatment. In this review, we outline the key features and the molecular pathways of cellular senescence. Better understanding of cellular senescence will provide insights into the development of powerful strategies to control cellular senescence for therapeutic benefit. Lastly, we discuss existing strategies for the induction of cancer cell senescence to improve efficacy of anticancer therapy.

• Molecular & Cellular Toxicology
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• 제3권3호
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• pp.151-158
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• 2007

The failure of injured axons to regenerate in the mature central nervous system (CNS) has devastating consequences for victims of spinal cord injury (SCI). Traditional strategies to treat spinal cord injured people by using drug therapy and assisting devices that can not help them to recover fully various vital functions of the spinal cord. Many researches have been focused on accomplishing re-growth and reconnection of the severed axons in the injured region. Using cell transplantation to promote neural survival or growth has had modest success in allowing injured neurons to re-grow through the area of the lesion. Strategies for successful regeneration will require tissue engineering approach. In order to persuade sufficient axons to regenerate across the lesion to bring back substantial neurological function, it is necessary to construct an efficient biocompatible bridge (cell-free or implanted with different cell lines as hybrid implant) through the injured area over which axons can grow. Therefore, in this paper, spinal cord and its injury, different strategies to help regeneration of an injured spinal cord are reviewed. In addition, different aspects of designing a biocompatible bridge and its applications and challenges surrounding these issues are also addressed. This knowledge is very important for the development and optimalization of therapies to repair the injured spinal cord.

• Animal Bioscience
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• 제34권3_spc호
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• pp.338-344
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• 2021

In the modern pig production, pigs are weaned at early age with immature intestine. Dietary and environmental factors challenge the intestine, specifically the jejunum, causing inflammation and oxidative stress followed by destruction of epithelial barrier and villus structures in the jejunum. Crypt cell proliferation increases to repair damages in the jejunum. Challenges to maintain the intestinal health have been shown to be related to changes in the profile of mucosa-associated microbiota in the jejunum of nursery pigs. All these processes can be quantified as biomarkers to determine status of intestinal health related to growth potential of nursery pigs. Nursery pigs with impaired intestinal health show reduced ability of nutrient digestion and thus reduced growth. A tremendous amount of research effort has been made to determine nutritional strategies to maintain or improve intestinal health and microbiota in nursery pigs. A large number of feed additives have been evaluated for their effectiveness on improving intestinal health and balancing intestinal microbiota in nursery pigs. Selected prebiotics, probiotics, postbiotics, and other bioactive compounds can be used in feeds to handle issues with intestinal health. Selection of these feed additives should aim modulating biomarkers indicating intestinal health. This review aims to define intestinal health and introduce examples of nutritional approaches to handle intestinal health in nursery pigs.