• Journal of Periodontal and Implant Science
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• v.33 no.4
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• pp.573-584
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• 2003

Bone remodeling results from the combined process of bone resorption and new bone formation which is regulated in part by some of Dexamethasone related proliferation & mineralization of cultured bone cell and polypeptide growth factors such as platelet derived growth factor(PDGF), which has been known to be an important local regulator of bone cell activity and participate in normal bone remodeling. To evaluate the effects of Dex and PDGF on bony healing of calvarial defect in rats, 10 ng/ml PDGF were applied on P group and 10 ng/ml PDGF and $10^7$ M Dex were applied PD group. 4 rats in each group were sacrificed at 7, 14. 21 days after operation respectively, and the tissue blocks were prepared for light microscope with H-E for evaluation of overall healing, with TRAP(tartrate resistant acid phosphatase) for evaluation of osteoclastic activity and with immunohistochemical staining for macrophages. The results were as follows : 1. In all group, healing aspects were progressed from 7 days to 21 days in soft and bony tissue, but complete repair were not observed in bony defect 2. PDGF and control group were showed similar bony healing aspect , but bony healing in combination of PDGF-BB and Dex were observed slower aspect compared to PDGF and control group from early healing times. 3. There were no significant difference on activities of osteoclast and macrophages in bony healing between control and experimental group In conclusion, PDGF were not influenced on bony healing of defect and combination of PDGF-BB and Dex were showed slower healing through early healing times. it was considered that Dex compared to PDGF did influenced on early hone formation factors in healing period

• Journal of Chest Surgery
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• v.56 no.5
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• pp.295-303
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• 2023

Background: The use of Adriamycin (ADR), also known as doxorubicin, as a chemotherapy agent is limited by its detrimental adverse effects, especially cardiotoxicity. Recent studies have emphasized the crucial role of angiotensin II (Ang-II) in the development of ADR-induced cardiomyopathy. This study aimed to explore the potential cardioprotective effects of losartan in a rat model of ADR-induced cardiomyopathy. Methods: Male Sprague-Dawley rats were randomly divided into 3 groups: a control group (group C), an ADR-treated group (ADR 5 mg/kg/wk for 3 weeks via intraperitoneal injections; group A), and co-treatment of ADR with losartan group (same dose of ADR and losartan; 10 mg/kg/day per oral for 3 weeks; group L). Western blot analysis was conducted to demonstrate changes in brain natriuretic peptide, collagen 1, tumor necrosis factor (TNF)-α, interleukin-6, matrix metalloproteinase (MMP)-2, B-cell leukemia/lymphoma (Bcl)-2, Bcl-2-associated X (Bax), and caspase-3 protein expression levels in left ventricular (LV) tissues from each group. Results: Losartan administration reduced LV hypertrophy, collagen content, and the expression of pro-inflammatory factors TNF-α and MMP-2 in LV tissue. In addition, losartan led to a decrease in the expression of the pro-apoptotic proteins Bax and caspase-3 and an increase in the expression of the anti-apoptotic protein Bcl-2. Moreover, losartan treatment induced a reduction in the apoptotic area compared to group A. Conclusion: In an ADR-induced cardiomyopathy rat model, co-administration of ADR with losartan presented cardioprotective effects by attenuating LV hypertrophy, pro-inflammatory factors, and apoptosis in LV tissue.

• Journal of the Korean Society of Safety
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• v.38 no.1
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• pp.9-17
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• 2023

In this study, we aimed to identify the important hazard factors and determine their criticality in causing serious accidents in vehicle-mounted mobile elevated work platforms (MEWPs). Fuzzy failure modes and effects analysis (FMEA)was performed using accident data and a survey of experts. To determine the hazard factors, the accident data for the last 10 years were used and a questionnaire survey was designed. The questionnaire survey was sent to four experts in the field of occupational safety to determine the severity, occurrence, and detectability of serious accidents in MEWPs. Furthermore, objective RPN scores and risk priority were obtained using fuzzy FMEA. Finally, the criticality of hazard factors in descending order was found to be overloading, non-installation or defective installation of outriggers, breakage due to wire rope aging, and illegal remodeling of vehicle structures. The results were verified by comparing the occurrence data of serious disasters.

• Korean Journal of Construction Engineering and Management
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• v.10 no.2
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• pp.65-74
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• 2009

It is expected that the number of apartment complexes in Korea that are over 20 years old will rapidly increase to more than 3,500,000. Consequently, the remodeling of these buildings is being revitalized throughout the country. Among the requirements for such remodeling, the expansion of parking lots has considerable weight. When enlarging a parking lot, the access route from an underground floor to the main building (i.e., the means of entry into the main building) determines the possibility of vertical enlargement for elevators, the size of the parking lot, the construction period, and construction expenses, etc. When enlarging an underground parking lot of an apartment complex, the access between the main building and the parking lot, as well as the inhabitants' requirements for entering the main building, are generally determined based on the designer's experience, rather than on the exact estimation of the peculiarity of the complex. In order to resolve such a problem, when enlarging an underground parking lot, a systematic and rational method is needed for selecting the means of entry into the main building. In this study, a selection model is derived for the method of selecting an access route into the main building when constructing an underground parking lot, in order to provide a reasonable decision-making process. A research method was investigated for determining the access route into the main building when enlarging a parking lot. On the basis of research carried out through in-depth interviews with experts, the characteristics for each means of entry into the main building were analyzed and the factors affecting the selection of the access route were deduced. The affecting factors selected were construction efficiency, convenience efficiency and economic efficiency. Weight values were then estimated for the selected affecting factors by applying the AHP method. Results showed that convenience efficiency, which gained the highest value, is the most important factor in selecting the means of entry into the main building. The most suitable means of entry into the main building was also suggested after estimating the applicability of the site by selecting complexes with remodeling possibility. This study will be applied as a reference for selecting the means of entry into the main building when constructing an underground parking lot particularly for older apartment complexes.

• BMB Reports
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• v.52 no.4
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• pp.227-238
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• 2019

GROWTH-REGULATING FACTORs (GRFs) are sequence-specific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requires the SWITCH2/SUCROSE NONFERMENTING2 chromatin remodeling complex. One of the most conspicuous roles of the duo is conferring the meristematic potential on the proliferative and formative cells during organogenesis. GRF expression is post-transcriptionally down-regulated by microRNA396 (miR396), thus constructing the GRF-GIF-miR396 module and fine-tuning the duo's action. Since the last comprehensive review articles were published over three years ago, many studies have added further insight into its action and elucidated new biological roles. The current review highlights recent advances in our understanding of how the GRF-GIF-miR396 module regulates plant growth and development. In addition, I revise the previous view on the evolutionary origin of the GRF gene family.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2007.11a
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• pp.995-998
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• 2007

The number of households old over as much as 20 years is expected to get increased rapidly more than 1,000,000(1 million). As a measure to this fact remodeling is being revitalized over the country. parking lots expansion actually takes up a great deal of weight among the requirement for remodeling. When constructing a parking lot for enlargement, the way of going into the main building determines such construction features as selection of Retaining Wall Method, installation of an elevator, parking measure of capacity, etc. This study derived the affecting factors for selecting the way of going into the main building when constructing an underground parking lot. In a research way, we examined the features on each method of going into the main building in an apartment complex through an in-depth interview with some experts after investigating the method of enlarging an underground parking lot and going into the main building. After that, we derived the affecting factors for selecting the way of going into the main building. The affecting factors include constructability, convenience, economic efficiency as a high level as well as existence and nonexistence of basement and removal, safety of current building, parking measure of capacity, amenity, inhabitant traffic line, construction expenses and construction duration as a low one. This study will be applied as a reference for selecting the way of going into the main building when constructing an underground parking lot especially targetted on an old apartment house.

• The Journal of Dong Guk Oriental Medicine
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• v.9
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• pp.1-23
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• 2000

Osteoporosis is a common disorder characterized by reduced bone mineral density, deterioration of the microarchitecture of bone tissue and increased risk of fracture. The aim of treatment of osteoporosis is to maintain and, ideally, to restore bone strength safely. In recent years the role of polypeptide growth factors in bone metabolism has begun to appear. It has been proposed that alterations in the expression or production of growth factor can modulate the proliferation and activity of bone forming cells. Thus, the role of structurally diverse peptides for the management and diagnosis of osteoporosis has attracted the attention of many investigators. This paper reviews numerous findings concerning the use of polypeptides, hormones, and growth factors, for the management of osteoporosis. Many of the compounds mentioned here are experimental prototypes of new therapeutic classes. Though it is unlikely that some of the compounds may ever be used clinically, development of safe and efficacious agents in each class will define the future course of therapy for osteoporosis.

• Journal of the Korean housing association
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• v.26 no.6
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• pp.115-126
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• 2015

Using the 2013 Korea Housing Survey, this research analyzed factors influencing residential satisfaction of low-income households concerning the economic condition, satisfaction about interior and exterior environments in dwelling, recognition of housing welfare policy. The economic condition showed that if there are less living expenses and more ordinary income, it brought about more positive effects in the ownership of a detached house, row and multi-family house. Most variables about satisfaction with the interior environment in dwelling have a significant influence on a detached house, apartment, row and multi-family house. The following factors played a significant role: accessibility to commercial facilities, neighborhood relationship and natural environment in the satisfaction with the exterior environment in dwelling about most types. Specifically, from an institutional perspective of housing welfare policy, the effect of the housing expenses support and the intention about remodeling were factors influencing residential satisfaction in cheonsei and monthly rent, free of a detached house and free of an apartment. These results will utilize preliminary data to establish housing welfare policy for low-income households.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.5
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• pp.405-411
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• 2016

Given the importance of ensuring continued residency and maintenance of the 1st Planned New Town, which is the first of more than 20 such projects, this study aims to identify the factors determining the residents' living intention. The results show that age, gender, length of stay, and occupancy type are significant factors influencing their living intention. Among the environmental factors, the educational environment and shopping environment are crucial. This means that in order to achieve the "Ageing in Place" concept, it is necessary to improve the educational environment, provide a variety of commercial facilities and expand the living facilities. While it has no direct influence on the pros and cons of building remodeling, the results showed that when the living intention is used as a parameter, the transportation, educational, and shopping environment have an indirect influence on the pros and cons of building remodeling.

• Journal of Korean Society of Rural Planning
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• v.18 no.3
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• pp.67-76
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• 2012

The purpose of this study is to analyze the landscape preference and landscape images of the Agricultural Aqueduct Bridges(AAB) by several different criteria. Semantic Differential Scale(SD scale) with landscape adjectives and landscape preference are used to estimate the alternatives of the AAB. The statistic methods such as descriptive analysis, t-test, factor analysis and regression, cluster analysis, are operated. The landscape preference of the alternatives is generally positive, 3.977 out of 7.000. The gate type is the most preferred, but the road-along type is the worst, by the location types. The simple repair type is the worst preferred, but total remodeling is the most, by the repair types. The characteristics of the AAB are analyzed and 4 factors of visual landscape are contracted; interest, orderliness, naturality and spatiality. Cumulative factor loading of these factors is about 65%, which is quite high. The higher and bigger AAB's are preferred, and the advanced finishing materials are also preferred, such as aluminum or wood panels. The long span is also preferred and the high repair cost would be preferred. But in this study, the cost-benefit analysis is not included, so it is recommended to research further, considering the cost variable with the visual factors.