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http://dx.doi.org/10.5483/BMBRep.2019.52.4.051

Biological roles and an evolutionary sketch of the GRF-GIF transcriptional complex in plants  

Kim, Jeong Hoe (Department of Biology, School of Biological Sciences, Kyungpook National University)
Publication Information
BMB Reports / v.52, no.4, 2019 , pp. 227-238 More about this Journal
Abstract
GROWTH-REGULATING FACTORs (GRFs) are sequence-specific DNA-binding transcription factors that regulate various aspects of plant growth and development. GRF proteins interact with a transcription cofactor, GRF-INTERACTING FACTOR (GIF), to form a functional transcriptional complex. For its activities, the GRF-GIF duo requires the SWITCH2/SUCROSE NONFERMENTING2 chromatin remodeling complex. One of the most conspicuous roles of the duo is conferring the meristematic potential on the proliferative and formative cells during organogenesis. GRF expression is post-transcriptionally down-regulated by microRNA396 (miR396), thus constructing the GRF-GIF-miR396 module and fine-tuning the duo's action. Since the last comprehensive review articles were published over three years ago, many studies have added further insight into its action and elucidated new biological roles. The current review highlights recent advances in our understanding of how the GRF-GIF-miR396 module regulates plant growth and development. In addition, I revise the previous view on the evolutionary origin of the GRF gene family.
Keywords
Evolution; GIF; GRF; miR396; Organ growth;
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