• 한국정보시스템학회지:정보시스템연구
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• 제31권4호
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• pp.161-187
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• 2022

Purpose This study analyzed the topic of game review contents and how the characteristics of game reviews affect the reviews helpfulness. In addition, this study explore the content of game reviews according to the game's sales strategy such as early access strategy and releasing without early access. Design/methodology/approach We collected a list of 3,572 action genre games released in 2020. 58,336 online reviews were collected by random sampling 50 reviews in each games, and topic modeling was performed on those reviews. We dynamized the results of topic modeling and analyzed the effect on review helpfulness with multiple regression analysis. Findings The results of analysis indicate that the longer the review is or the shorter the time it is written, the more helpful the review is. In addition the topic with positive and negative review has a significant effect on the review helpfulness. As a result of exploratory analysis, games from early access had relatively fewer reviews of story-related topics than games that were released without early access. These findings can present direct guidelines for collecting specific opinions from customers in the game industry when releasing games.

• 한국경영과학회지
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• 제39권4호
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• pp.1-17
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• 2014

The functions of stocking and releasing in logistics center consist of three major procedure such as receiving, shipping and stock managements. Each process includes various sub-processes which are complicatedly connected with each other. Furthermore, lots of operators execute various tasks in the different sub-processes, simultaneously. It makes difficult to standardize, monitor, and analyze the processes. This paper proposed the quantitative methodology using process mining approach to discover and analyze receiving and shipping processes. For this purpose, the PDA operation log data is analyzed to build a realistic process model. The deduced model has been compared with official process model. In addition, task assignment and social networks analysises are carried out by utilizing process mining tools. Also, it has been proposed how to improve the processes with the analytical simulation model based on the results of process mining.

• 통합자연과학논문집
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• 제8권3호
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• pp.176-183
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• 2015

Corticotropin-releasing actor receptors (CRFRs) activates the hypothalamic pituitary adrenal axis, one of the 2 parts of the fight or flight response to stress. Increased CRH production has is associated with Alzheimer's disease and major depression and hypoglycemia. In this study, we report the important structural and chemical parameters for CRFR inhibitors using the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolines. A 3D QSAR study, Comparative molecular field analysis (CoMFA) was performed. The best predictions were obtained for the best CoMFA model with a $q^2$ of 0.607 with 6 components and $r^2$ of 0.991. The statistical parameters from the generated CoMFA models indicated that the data are well fitted and have high predictive ability. The contour map resulted from the CoMFA models might be helpful in the future designing of novel and more potent CRFR derivatives.

• Natural Product Sciences
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• 제20권4호
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• pp.281-284
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• 2014

In this study, twenty-one oleanane-type triterpenoid saponins were isolated from a methanol extract of the roots of Pulsatilla koreana. Antagonistic activities were measured in these compounds by the aequorin based cellular functional assay system for the corticotropin releasing factor receptor (CRF1). Of them, compounds 7 - 10 showed the highest degree of CRF1 inhibition further at the concentration of $10{\mu}M$. Moreover, by the analysis based on the structure-activity relationship of isolated saponins, a sugar chain at C-3 and a carboxyl group at C-28, as well as a methyl group at C-23 seems to be key functional elements. To our knowledge, this is the first report on CRF1 inhibition of saponins from P. koreana.

• 대한기계학회논문집B
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• 제27권7호
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• pp.867-876
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• 2003

The Lagrangian dispersion of fluid particles in inhomogeneous turbulence is investigated by a direct numerical simulation of turbulent channel flow. Four points Hermite interpolation in the homogeneous direction and Chebyshev polynomials in the inhomogeneous direction is adopted to simulate the fluid particle dispersion. An inhomogeneity of Lagrangian statistics in turbulent boundary layer is investigated by releasing many particles at several different wall-normal locations and tracking those particles. The fluid particle dispersions and Lagrangian structure functions of velocity are scaled by the Kolmogorov similarity. The auto-correlations of velocity and acceleration are shown at the different releasing locations. Effect of initial particle location on the dispersion is analyzed by the probability density function at the several downstreams and time instants.

• 소성∙가공
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• 제21권4호
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• pp.246-251
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• 2012

The mechanism for mechano-luminescence(ML) in SAO phosphor was investigated quantitatively by measuring the emission intensity under three different tensile conditions. It was found that the ML of SAO was strongly dependent on the dynamic loading rate rather than by the applied load itself. The mechano-luminescent emission in SAO was evaluated based on the trap-releasing process. It was found that the shape of the ML curve in the transient regime obtained from the rate equation has good agreement with the experimental data.

• 한국발생생물학회지:발생과생식
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• 제2권2호
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• pp.189-196
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• 1998

Growth Hormone Releasing Hormone (GHRH)은 척추동물의 시상하부로부터 합성, 분비되어 시상하부-뇌하수체간의 문맥계를 통해 뇌하수체 전엽에 작용하여 Growth Hormone (GH)의 분비를 촉진한다. 시상하부에서 발현되는 일부 Releasing Hormone 들이 여러 시상하부외 조직에서도 검출되고 조직특이적인 기능을 수행한다는 사실이 여러 연구자들에 의해 밝혀졌다. 이러한 사실들을 배경으로 본 연구자는 GHRH가 흰쥐의 뇌하수체 전엽과 뇌하수체로부터 유래된 종양세포주들에서 발현될 가능성을 조사하였다. GHRH 펩타이드와 mRNA의 존재와 구조를 규명하기 위하여 뇌하수체와 배양 세포를 사용하여 GHRH immunocytochemistry, 방사면역측정법, GHRH PCR과 RNase protection assay를 시행하였다. Immunocytochemistry의 결과 gonadotrope (대형)와 somat-olactotrope (중간형)로 추정되는 세포들에서 GHRH 염색이 나타났고, Somatolactotrope성 종양세포인 GH3 cell 추출물에서 immunoreactive GHRH가 방사면역측정법으로 검출되었다. 3'rapid amplification of cDNA end (3'-RACE)를 시행한 결과, 흰쥐 뇌하수체에 GHRH transcript가 존재하고, 그 3'end 부분이 다른 조직내의 GHRH와 동일함을 확인하였다. GHRH RT-PCR에서도 뇌하수체와 종양세포주들인 $\alpha$T3 cell (gonadotrope성)과 GH3 cell에서 예상 산물들이 증폭되었다. RNase protection assay를 시행한 결과 난소절제에 의해 뇌하수체내 GHRH 유전자 발현이 증가됨을 확인하였다. 이상의 결과는 GHRH가 뇌하수체 전엽의 gonadotrope와 somatotrope에서 발현되고, paracrine 또는 autocrine조절물질로 작용하여 GH 분비 외에도 뇌하수체 전엽 세포들의 분화와 분열등에 관여함을 시사한다.

• 대한한의학방제학회지
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• 제26권4호
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• pp.363-380
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• 2018

Objectives : We analyzed the principle of compatibility of socheongnyong-tang and expanded the range of application in clinical practice. Methods : Socheongnyong-tang was analyzed by the compatibility principle through the system of chief, deputy, assistant, and envoy, but the basic formulas of "Discussion of Cold Damage" and "Synopsis of the Golden Chamber" was used. Results : Socheongnyong-tang treats exterior wind-cold and interior water accumulation. Exterior wind-cold is treated mainly by exterior-releasing herbs constituting mahwang-tang and gyeji-tang in "Discussion of Cold Damage", and interior water accumulation is treated mainly by retained fluid-resolving herbs constituting yeonggamomigangsinha-tang, yeonggamomigagangsinbanhahaengin-tang and yeonggamomigagangsinbanhaengdaehwang-tang in "Synopsis of the Golden Chamber". Depending on the weight of exterior wind-cold and interior water accumulation, the disease condition is classified as a case where exterior wind-cold is heavier than interior water accumulation, a case where exterior wind-cold is lighter than interior water accumulation, and a case where it is equivalent. When exterior wind-cold is heavier than interior water accumulation, chief herbs are Ephedrae Herba and Cinnamomi Ramulus of exterior-releasing herbs series and deputy herbs are Zingiberis Rhizoma and Asari Radix et Rhizoma of retained fluid-resolving herbs series. When exterior wind-cold is equal to the disease condition of interior water accumulation, chief herbs are Ephedrae Herba of exterior-releasing herbs series and Zingiberis Rhizoma of retained fluid-resolving herbs series, and deputy herbs are Cinnamomi Ramulus of the exterior-releasing herbs series and Asari Radix et Rhizoma of retained fluid-resolving herbs series. When exterior wind-cold is lighter than interior water accumulation, chief herbs are Zingiberis Rhizoma and Asari Radix et Rhizoma of retained fluid-resolving herbs series and deputy herbs are Ephedrae Herba and Cinnamomi Ramulus of exterior-releasing herbs series. In any case, assistant herbs are Pinelliae Rhizoma, Paeoniae Radix alba, and Schisandrae Fructus, and envoy herb is Glycyrrhizae Radix preparata. Conclusions : In conclusion, socheongnyong-tang must differently formulate the system of chief, deputy, assistant, and envoy according to the grade of exterior wind-cold and interior water accumulation. These results suggest that socheongnyong-tang can be applied flexibly when applied in clinical practice to enhance the therapeutic effect.

• 한국비블리아학회지
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• 제29권2호
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• pp.35-56
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• 2018

본 연구는 공공데이터 포털을 통해 개방된 도서관 관련 데이터의 현황을 다각도로 살펴보며, 공개된 데이터의 수준과 공개 주체에 따라 데이터의 활용 정도에 어떠한 차이가 나타나는지 분석하였다. 또한 데이터의 공개주체를 지방자치단체와 국가 및 공공기관으로 구분하여 데이터에 부여된 키워드를 활용해 PathFinder Network 분석을 수행함으로써 양 주체가 공개한 데이터의 주제 군집과 중심성에 어떠한 차이를 보이는지 분석하였다. 그 결과 국가 및 공공기관이 공개한 데이터로부터는 연구자료 등을 중심으로 4개의 주제군집이, 지방자치단체가 공개한 데이터로부터는 소장자료, 평생교육프로그램 등을 중심으로 8개의 주제 군집이 형성되었으며, 국가 및 공공기관이 공개한 데이터가 학교 및 공공도서관의 단순 현황을 주로 공개하고 있는 지방자치단체 공개 데이터보다 높은 활용도를 나타냈다.

• 대한화학회지
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• 제29권2호
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• pp.129-136
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• 1985

공기-아세틸렌 불꽃 원자 흡수분광법으로 칼슘분석을 하는 경우 비교적 방해가 큰 것은 지르코늄, 주석, 알루미늄, 안티몬 등 양이온과 황산이온, 바나듐산이온, 규산이온 등 음이온이다. 여기에 해방제로서 세륨을 사용하면 이들 방해 효과를 제거할 수 있음을 알게 되었다. 칼슘과 같은 농도($3.0 {\times} 10^{-4}$M)의 이 방해이온들에 의한 방해는 방해이온 농도의 2배의 세륨에 의하여 완전히 해방됨을 보았고 방해 양이온혼합물(지르코늄, 주석, 알루미늄, 안티몬), 방해음이온 혼합물(황산이온, 바나듐산이온, 규산이온)또는 방해양이온 음이온 혼합물의 방해는 각각의 양이온 혹은 음이온에 의한 방해보다 더 큰 방해를 주는데 세륨($1.5 {\times} 10^{-2}$M)에 의한 해방효과는 방해양이온, 음이온 혼합물의 농도가 각각 $3.0 {\times} 10^{-3}$M까지 증가하여도 거의 변하지 않고 좋았다.