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Novel CRF1-receptor Antagonists from Pulsatilla koreana Root  

Li, Wei (school of Biotechnology, Yeungnam University)
Noh, Hyojin (Department of Biomedical Technology, College of Engineering, Sangmyung University)
Lee, Sunghou (Department of Biomedical Technology, College of Engineering, Sangmyung University)
Lee, Min Ho (OBM Lab.)
Lee, Eun Young (Department of Applied Bioscience, CHA University)
Kang, Sangjin (Department of Applied Bioscience, CHA University)
Kim, Young Ho (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.20, no.4, 2014 , pp. 281-284 More about this Journal
Abstract
In this study, twenty-one oleanane-type triterpenoid saponins were isolated from a methanol extract of the roots of Pulsatilla koreana. Antagonistic activities were measured in these compounds by the aequorin based cellular functional assay system for the corticotropin releasing factor receptor (CRF1). Of them, compounds 7 - 10 showed the highest degree of CRF1 inhibition further at the concentration of $10{\mu}M$. Moreover, by the analysis based on the structure-activity relationship of isolated saponins, a sugar chain at C-3 and a carboxyl group at C-28, as well as a methyl group at C-23 seems to be key functional elements. To our knowledge, this is the first report on CRF1 inhibition of saponins from P. koreana.
Keywords
Pulsatilla koreana; Ranuculaceae; Corticotropin releasing factor receptor; Saponin;
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