• 한국게임학회 논문지
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• 제12권4호
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• pp.53-64
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• 2012

본 논문은 2006년 이후 수년째 산업 기반마저 위태로울 정도로 침체된 국내 아케이드게임에 대해 새로운 규제 패러다임의 필요성에 대한 연구이다. 아케이드 플랫폼은 일체형 특성과 PC기반으로 전환은 아케이드게임에서 사행성 문제가 더 심각할 수 있는 기술적 환경을 제공한다. 아케이드게임 초기부터 문제되는 사행 도구화의 문제를 해결하기 위해서도 기존의 게임물과 사행성에 초점을 맞춘 규제 패러다임은 전환의 필요성이 제기된다. 국내와 유사한 경험을 갖고 새롭게 아케이드게임시장을 선도하고 있는 중국의 사례를 통해, 게임장과 사행행위를 핵심으로 하는 규제 패러다임의 전환에 대한 검토가 필요할 때이다.

• 전기학회논문지
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• 제65권6호
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• pp.979-986
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• 2016

At present, electric power industry around the world are being gradually changed to a new paradigm, such as electrical energy storage system, the wireless power transmission. Demand for ESS, the core technology of the new paradigm, has been growing worldwide. However, it is essential to estimate the optimal capacity of ESS facilities for frequency regulation because the benefit would be saturated in accordance with the investment moment and the increase of total invested capacity of ESS facilities. Hence, in this paper, the annual optimal mathematical investment model is proposed to estimate the optimal capacity and to establish investment plan of ESS facility for frequency regulation. The optimal mathematical investment model is newly established for each season, because the construction period is short and the operation effect for the load by seasons is different unlike previous the mathematical investment model. Additionally, the marginal operating cost is found by new mathematical operation model considering no-load cost and start-up cost as step functions improving the previous mathematical operation model. ESS optimal capacity is established by use value in use iterative methods. In this case, ESS facilities cost is used in terms of the value of the beginning of the year.

• Nuclear Engineering and Technology
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• 제37권3호
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• pp.221-230
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• 2005

This paper reviews the pivotal phases of the evolution of the current technology-dependent nuclear power safety regulation in the United States. Understanding of this evolution is essential to the development of any future regulatory paradigm, including the technology-neutral regulatory approach that the U.S. Nuclear Regulatory Commission (NRC) has recently embarked on to develop. The paper proposes and examines the implications of a predominately rationalist and best-estimate probabilistic regulatory framework called safety goals-driven performance-based regulation. This framework relies on continuous assessment of performance of a set of time-dependent safety-critical systems, structures and components that assure attainment of a broad set of technology-neutral protective, mitigative, and preventive goals. Finally, the paper discusses the steps needed to develop a corresponding technology-neutral regulatory system from the proposed framework.

• 한국산학기술학회논문지
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• 제16권10호
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• pp.6905-6916
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• 2015

본 연구는 20세기 이후 급속한 과학기술의 발달로 산업의 공업화 및 인구의 도시화 등으로 인류의 생활터전인 환경이 위협받는 현 시점에, 이슈가 되고 있는 환경문제의 해결방안인 환경규제를 복잡계적 사고로 해석을 한 것이다. 산업혁명이후 출현한 산업의 고도화 과정에서 발생하고 있는 다양한 문제점들을 해결하기 위하여 오래전부터 많은 노력들이 시도되었다. 하지만 이러한 현상을 이해하기 위해서는 단순한 무역수준이나 경제 기술적 수준에서 해석할 수 없는 문제가 제기 되고 있다. 이러한 이슈들에 대해 복잡계적 사고를 통해 기술의 진화에 대한 우발성이 아니라 그들이 만들어낸 차이를 인식하고 혼돈의 가장자리에서 새로운 질서를 창발하는 현상에서 복잡계 시스템을 이해하고 선제적 대응 및 관리에 대한 기술적 혁신을 예측할 수 있는 기반을 제공하고자 한다. 복잡계적 사고로 분석해보면 지구가 처한 환경문제는 혼돈의 가장자리에 자리잡고 있다. 이러한 부분은 공공적인 부분에서 주도를 하고 있지만 이들만의 노력만으로는 해결이 되지 않는 다양한 구성요소들 간의 상호작용을 통한 인과관계를 형성하고 있다. 본 연구는 이러한 상호작용으로 환경규제에 대한 새로운 질서의 창발현상을 설명하고 있으며 환경규제를 공공적인 부분만의 질서가 아니라 민간 혹은 기업에서의 의지와 행동이 임계점에 도달하여 새로운 질서를 창발하는 노력이 필요함을 제시하고자 한다. 따라서 불확실성에 대한 환경규제의 새로운 질서를 이해하려는 기반을 제공하고자 한다.

• International Journal of Computer Science & Network Security
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• 제21권9호
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• pp.118-124
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• 2021

The article examines the formation of a competitive paradigm of economic security of industrial enterprises in the formation of a circular economy. The basic laws of industrial enterprises are formed, which determined the characteristics of competitive positions and threats. The basic competitive concepts and their application at maintenance of economic safety of the industrial enterprises in the conditions of formation of circular economy are described. Thus, the technological approach to the formation of a competitive paradigm is based on production technologies, opportunities for technological modernization and development of infrastructure and intellectual competencies. The institutional concept reveals the regulatory mechanisms for ensuring competitiveness through the protectionism of national industrial enterprises, standardization and regulation of market imbalances. The innovation-investment approach within the competitive paradigm is also manifested in the creation of competitive advantages due to the presence of active innovative developments and their commercialization, knowledge and competencies of staff, capitalization of intelligence and communications, constant updating of infrastructure and technologies. Collectively, innovation and investment effects on the level of economic security allow industrial enterprises to ensure resilience to increasing competition, the emergence of new market challenges in the formation of a circular economy. A strategic approach to the application of a competitive paradigm to ensure the economic security of industrial enterprises allows you to justify the prospects for development and design behavioral models to predict and assess potential threats. The concept of system management is based on the complexity of threat analysis, the integrity of the economic security system, system-forming functions and patterns of implementation of industrial development tasks in the formation of a circular economy. The application of the described concepts is formalized by the authors through the definition of the basic patterns, directions and characteristics of their impact on the elements of the security system of industrial enterprises in the formation of a circular economy.

• Genomics & Informatics
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• 제5권3호
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• pp.107-112
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• 2007

MicroRNAs (miRNAs) are known to negatively control protein-coding genes by binding to messenger RNA (mRNA) in the cytoplasm. In innate immunity, the role of miRNA gene silencing is largely unknown. In this study, we performed microarray-based experiments using lipopolysaccharide (LPS)-stimulated macrophages derived from wild-type, MyD88 knockout (KO), TRIF KO, and MyD88/TRIF double KO mice. We employed a statistical approach to determine the importance of the commonality and specificity of miRNA binding sites among groups of temporally co-regulated genes. We demonstrate that both commonality and specificity are irrelevant to define a priori groups of co-down regulated genes. In addition, analyzing the various experimental conditions, we suggest that miRNA regulation may not only be a late-phase process (after transcription) but can also occur even early (1h) after stimulation in knockout conditions. This further indicates the existence of dynamic interactions between miRNA and signaling molecules/transcription factor regulation; this is another proof for the need of shifting from a 'hard-wired' paradigm of gene regulation to a dynamical one in which the gene co-regulation is established on a case-by-case basis.

• 한국IT서비스학회지
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• 제18권4호
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• pp.39-53
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• 2019

This article analyzes the effects of regulation that restrict the conglomerate firms to participate in the public procurement of software. The regulation was implemented in 2013, and this article analyzes five years of firm performance before and after 2013 through DID (difference-in-difference method). In particular, this article analyzes how restrictions on conglomerate firms' participation in public software procurement affect middle and small firms performance. As a result, small-size firms achieve relatively positive results in private sector revenues compared to mid-size firms. However, there was no significant difference between the mid-size and small-size firms in profit margin. This study implies that the new policy is needed to improve the small and medium-size firms revenues on the private market by leveraging the public procurement market which restricted the conglomerate firms to participate. This can be done by complementing the regulation in line with servitization paradigm.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제22권2호
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• pp.25-33
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• 2016

Purpose : The information of mental health facilities in Korean law is so unclear that people hardly enable to understand what sort of proper mental health service is prepared for them. Futhermore, there is not enough regulation and standard to classify each type of facilities in the law. Therefore the purpose of this study is to provide data on the basis for classification and facility standards by analysing Korean law and policies. Methods : This study was conducted by a research on law and regulation of mental health facility. Results : The result of this study can be summarized into three points. The first one, current law and policy do not reflect a change in community mental health services paradigm. The second one, the classified facility should be designed to fit the community mental health services. The third one, overall, it requires more detailed guidelines to enhance the quality of mental health services. Besides, the treatment as well as the function of the prevention and rehabilitation are necessary criteria that can also be enhanced. Implications : This study looked at the classification and facility standard of mental health facility by the change in community mental health services paradigm. Forward according to these changes, there is a need for specific guidelines for mental health facility.

• International Journal of Computer Science & Network Security
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• 제22권1호
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• pp.39-48
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• 2022

Today the regulation of socio-economic development has been the subject of active scientific debate. The modern paradigm of regulatory policy in foreign countries involves a change in the role and strategy of the state, which determines the relevance of this topic. The aim of the article is to study the current state of regulatory policy research. The article is based on a bibliographic analysis of the study of regulatory policy. The study is based on the data search functions of the Scopus platform. It uses a set of VOSviewer program, online visualization of keywords in the titles of scientific journals and citations of publications. The study led to the conclusion that the number of publications that directly study the nature and features of regulatory policy is insignificant, but constantly growing. In our opinion, further research should determine the essence of regulatory policy as a separate category, a description of its features and factors of formation. It is also necessary to develop a common concept that governments should be actively involved in ensuring the quality of regulation, rather than responding to the shortcomings of regulation, which is evolving into regulatory governance.

• Journal of Yeungnam Medical Science
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• 제38권3호
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• pp.183-193
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• 2021

Since its discovery in 1780, lactate has long been misunderstood as a waste by-product of anaerobic glycolysis with multiple deleterious effects. Owing to the lactate shuttle concept introduced in the early 1980s, a paradigm shift began to occur. Increasing evidence indicates that lactate is a coordinator of whole-body metabolism. Lactate is not only a readily accessible fuel that is shuttled throughout the body but also a metabolic buffer that bridges glycolysis and oxidative phosphorylation between cells and intracellular compartments. Lactate also acts as a multifunctional signaling molecule through receptors expressed in various cells and tissues, resulting in diverse biological consequences including decreased lipolysis, immune regulation, anti-inflammation, wound healing, and enhanced exercise performance in association with the gut microbiome. Furthermore, lactate contributes to epigenetic gene regulation by lactylating lysine residues of histones, accounting for its key role in immune modulation and maintenance of homeostasis.