• International Journal of Automotive Technology
• /
• v.6 no.5
• /
• pp.537-544
• /
• 2005

This paper presents the efficiency measurement and energy analysis for a parallel HEY. Using the HEV test rig, the efficiency of each powertrain component is measured for a given driving cycle including the regenerative braking system. Accompanied by the efficiency measurements, a detailed energy analysis is performed. Based on the efficiency measurement and energy analysis, a HEV performance simulator is developed. Using the simulator, the HEV performance is evaluated for a mild hybrid system. It is expected that the HEV simulator developed can be used to obtain further optimization potentials.

• Animal Systematics, Evolution and Diversity
• /
• v.35 no.2
• /
• pp.57-62
• /
• 2019

Eutima japonica Uchida, 1925, a bivalve-inhabiting hydrozoan was collected for the first time in Korea, associating with Mytilus galloprovincialis. The morphology of male medusae of this hydrozoan is clarified by culture and described as well as other developmental stages. As the present material from Korea is in good accord with that of the northern Japanese form of E. japonica, so the geographical distribution of the northern form of this species is widened, Japan, China and Korea. Green fluorescent protein distribution pattern of this medusa is also described and compared with that of the most related species Eutima sapinhoa Narchi and Hebling, 1975.

• Journal of ILASS-Korea
• /
• v.29 no.1
• /
• pp.1-6
• /
• 2024

This paper is a numerical analysis study for evaluating the energy efficiency of electric vehicles. Currently, the methods for testing and evaluating the energy consumption efficiency of electric vehicles have limitations such as resources and time. Therefore, there is a need for research on developing models to predict the energy consumption efficiency of electric vehicles. In this study, a numerical analysis research is conducted to predict the energy efficiency of electric vehicles using a vehicle dynamics numerical analysis model. To validate the accuracy of the simulation model, it is compared the results of dynamometer tests with the simulation results and used the Unified Diagnostic Services (UDS) protocol to acquire internal data from the electric vehicle. It is ensured the reliability of the simulation model by comparing data such as motor speed, battery voltage, current, state of charge (SOC), regenerative braking power generation, and total driving distance of the test vehicle with dynamometer test data and simulation model results.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.63 no.11
• /
• pp.1615-1621
• /
• 2014

A wireless tram which runs without catenary and instead uses batteries installed in the tram has been recently researched actively. This paper presents a new method maximizing absorption of regenerative energy of a wireless tram and extending life cycle of the energy storage device in the wireless tram by applying line-optimized charging and discharging scenario. Energy efficiency and life cycle of energy storage system (ESS) are highly dependent on the characteristic of operating conditions. For example, frequent charge and discharge with high power cause the problems that decrease the battery life cycles. Hybrid energy storage system (HESS) is combination of two ESSs which have complementary characteristics to each other. HESS can provide even better functionality and performance than the battery only ESS due to the synergy effect of two ESSs. This paper also provides a power distribution strategy and driving scenarios which increase the life cycle and energy efficiency of the HESS consisting of a battery and an ultra-capacitor. The developed strategy was tested and verified by a hardware-in-the-loop-simulation (HILS) system which emulates the a wireless tram.

• Journal of Periodontal and Implant Science
• /
• v.32 no.4
• /
• pp.811-825
• /
• 2002

Recently, many natural medicines, whose advantages are less side effects and possibility of long-term use, have been studied for their capacity, their anti-bacterial and anti-inflammatory effects and regenerative potential of periodontal tissues. Cervi Parvum Comu(CPC) have been traditionally study as an hale, growth. hematogenous, anti-aging, hack pain in Eastern medicine. The purpose of present study was to investigate the effects of CPC extract on cell cycle progression and its molecular mechanism in human fetal osteoblasts. CPC extracts (10 ${\mu}g/ml$) increased cell proliferation in the human fetal osteoblasts compared to non-supplemented control. There was no significant change in the G1 and S phase, hut a increase in the G2/M phase in 10 ${\mu}g/ml$ and 100 ${\mu}g/ml$ of CPC extracts group as compared to non-supplemented control. The protein expression of cyclin E, cdk 2, cycln D, cdk 4, and cdk 6 was higher than that of control group. The level of p21 was lower than that of control. But that of pRb and pl6 was not distinguished from control. These results indicate that the increase of cell proliferation by CPC extracts may be due t o the increased expression of cyclin E, cdk 2, cyclin D, cdk 4 and cdk 6, and the decreased expression of p21 in human fetal osteoblasts.

• BMB Reports
• /
• v.55 no.12
• /
• pp.633-638
• /
• 2022

Liver regeneration is a well-known systemic homeostatic phenomenon. The N⁶-methyladenosine (m⁶A) modification pathway has been associated with liver regeneration and hepatocellular carcinoma. m⁶A methyltransferases, such as methyltransferase 3 (METTL3) and methyltransferase 14 (METTL14), are involved in the hepatocyte-specific-regenerative pathway. To illustrate the role of METTL14, secreted from non-parenchymal liver cells, in the initiation phase of liver regeneration, we performed 70% partial hepatectomy (PH) in Mettl14 heterozygous (HET) and wild-type (WT) mice. Next, we analyzed the ratio of liver weight to body weight and the expression of mitogenic stimulators derived from non-parenchymal liver cells. Furthermore, we evaluated the expression of cell cycle-related genes and the hepatocyte proliferation rate via MKI67-immunostaining. During regeneration after PH, the weight ratio was lower in Mettl14 HET mice compared to WT mice. The expressions of hepatocyte growth factor (HGF) and tumor necrosis factor (TNF)-α, mitogens derived from non-parenchymal liver cells that stimulate the cell cycle, as well as the expressions of cyclin B1 and D1, which regulate the cell cycle, and the number of MKI67-positive cells, which indicate proliferative hepatocyte in the late G1-M phase, were significantly reduced in Mettl14 HET mice 72 h after PH. Our findings demonstrate that global Mettl14 mutation may interrupt the homeostasis of liver regeneration after an acute injury like PH by restraining certain mitogens, such as HGF and TNF-α, derived from sinusoidal endothelial cells, stellate cells, and Kupffer cells. These results provide new insights into the role of METTL14 in the clinical treatment strategies of liver disease.

• Journal of Microbiology and Biotechnology
• /
• v.30 no.2
• /
• pp.279-286
• /
• 2020

A novel compound named 'kanakugiol' was recently isolated from Lindera erythrocarpa and showed free radical-scavenging and antifungal activities. However, the details of the anti-cancer effect of kanakugiol on breast cancer cells remain unclear. We investigated the effect of kanakugiol on the growth of MCF-7 human breast cancer cells. Kanakugiol affected cell cycle progression, and decreased cell viability in MCF-7 cells in a dose-dependent manner. It also enhanced PARP cleavage (50 kDa), whereas DNA laddering was not induced. FACS analysis with annexin V-FITC/PI staining showed necrosis induction in kanakugiol-treated cells. Caspase-9 cleavage was also induced. Expression of death receptors was not altered. However, Bcl-2 expression was suppressed, and mitochondrial membrane potential collapsed, indicating limited apoptosis induction by kanakugiol. Immunofluorescence analysis using α-tubulin staining revealed mitotic exit without cytokinesis (4N cells with two nuclei) due to kanakugiol treatment, suggesting that mitotic catastrophe may have been induced via microtubule destabilization. Furthermore, cell cycle analysis results also indicated mitotic catastrophe after cell cycle arrest in MCF-7 cells due to kanakugiol treatment. These findings suggest that kanakugiol inhibits cell proliferation and promotes cell death by inducing mitotic catastrophe after cell cycle arrest. Thus, kanakugiol shows potential for use as a drug in the treatment of human breast cancer.

• Transactions of the Korean hydrogen and new energy society
• /
• v.25 no.6
• /
• pp.648-655
• /
• 2014

This paper describes the continuing effort to develope a single acting free-piston Stirling engine/alternator combination for use of the household cogeneration. Free piston Stirling engines(FPSE) use variations of working gas pressure to drive mechanically unconstrained reciprocating elements. Stirling cycle free-piston engines are driven by the Stirling thermodynamic cycle which is characterized by an externally heated device containing working gas that is continuously re-used in a regenerative, reversible cycle. The ideal cycle is described by two isothermal process connected by two constant volume processes. Heat removed during the constant volume cooling process is internally transferred to the constant volume heating process by mutual use of a thermal storage medium called the regenerator. Since the ideal cycle is reversible, the ideal efficiency is that of Carnot. Free-piston Stirling engine is have no crank and rotating parts to generate lateral forces and require lubrication. The FPSE is typically comprised of two oscillating pistons contained in a common cylinder. The temperature difference across the displacer maintains the oscillations, and the FPSE operate at natural frequency of the mass-spring system. The power is generated from a linear alternator. The purpose of this paper is to describe the design process of the single acting free-piston Stirling engine/alternator. Electrical output of the single acting free-piston Stirling engine/alternator is about 0.95 kW.

• Reproductive and Developmental Biology
• /
• v.36 no.4
• /
• pp.249-254
• /
• 2012

This study aimed at investigating whether a porcine follicular fluid (pFF) supplementation positively affects the characteristics of donor cells and the developmental competence of porcine cloned embryos. Ear fibroblast cells (donor cell) from an Massachusetts General Hospital miniature pig were cultured in different culture methods: (1) Dulbecco's modified Eagle's medium (DMEM)+10% FBS (Control); (2) DMEM+0.5% FBS (SS); and (3) DMEM+10% FBS+10% pFF (pFF) for 72 h. In each conditioned medium, the concentrations of 4 amino acids (Thr, Glu, Pro, and Val) in the pFF group were significantly different from those in the control group (p<0.05 or p<0.01). The proliferation of the cells cultured in the SS group was significantly lower than that of the other treatment groups (p<0.01). The population of apoptotic and necrotic cells in the SS group was significantly higher than that of either the control or the pFF group (p<0.01). The number of embryos that cleaved (p<0.05) and developed into blastocysts (p<0.01) in the SS group was significantly lower than that of either the control or the pFF group. Compared to other groups, the blastocysts produced from the donor cells in the pFF group had higher total cells and lower apoptotic cells (p<0.05). It can be concluded that pFF supplementation in the donor cell culture medium positively affects cell death, cell cycle and quality of the cloned blastocyst.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.14 no.1
• /
• pp.56-64
• /
• 2010

A system design has been conducted of the liquid rocket engine for Korean launch vehicle (KSLV-II, Korea Space Launch Vehicle II). The present turbopump-fed liquid rocket engine of vacuum thrust 76 ton and vacuum specific impulse 297 sec adopts gas generator cycle. The combustion pressure of the regeneratively cooled combustor is 60 bar. The propellant is LOx/kerosene. The engine is started by pyrostarter and the combustor is ignited by TEA (TriEthylAluminium). The engine system performance and the subsystems performance requirements are given through energy balance analysis. The combustion pressure, specific impulse and the engine mass are analyzed to be reasonable comparing with the published data. The startup analysis method which will be used in the future has been validated against the turbopump-gas generator coupled test. The tuning method for performance variation of the engine which is not actively controled has been prepared by mode analysis and performance deviation analysis.