• 한국수산과학회지
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• 제46권2호
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• pp.147-153
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• 2013

To prevent paralytic shellfish poisoning (PSP) due to the consumption of shellfish contaminated with PSP toxins, the quantitative analysis of these toxins is very crucial. The AOAC International mouse bioassay (MBA) has been used widely for the routine monitoring of PSP toxins for more than 50 years. However, this method has low sensitivity and high limit of quantification (LOQ) and interferences from other components in the extract, and it cannot determine toxic profiles. Ethical problems also exist with the continued use of this live mouse assay. To establish an alternative method to the MBA used for PSP toxins analysis, we attempted to optimize the analysis conditions of a precolumn high-performance liquid chromatography (HPLC) oxidation method and succeeded in validating its accuracy and precision in quantifying PSP toxins. A clear peak and the isolation of PSP toxins were obtained by injecting the working standards of Certified Reference Materials using HPLC. The LOQ of the precolumn HPLC oxidation method for PSP toxins was about $0.1002{\mu}g/g$, which represented an approximately fourfold improvement in detection capability versus the AOAC MBA. The intra-accuracy and precision for PSP toxins in oysters were 77.0-103.3% and 2.0-5.7%, respectively, while the respective inter-accuracy and precision were 77.3-100.7% and 2.4-6.0%. The mean recoveries of PSP toxins from oysters were 75.2-112.1%. The results of a comparison study showed good correlation between the results of the precolumn HPLC oxidation method and those of MBA, with a correlation factor of 0.9291 for mussels. The precolumn HPLC oxidation method may be used as an alternative to, or supplementary method with, MBA to monitor the occurrence of PSP toxins and to analyze the profiles of these toxins in shellfish.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.539-545
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• 2013

Background: The National Breast Cancer Audit Database of the Society of Breast Surgeons of Australia and New Zealand is used by surgeons to monitor treatment quality and for research. About 60% of early invasive female breast cancers in Australia are recorded. The objectives of this study are: (1) to investigate associations of socio-demographic, health-system and clinical characteristics with treatment of invasive female breast cancer by mastectomy compared with breast conserving surgery; and (2) to consider service delivery implications. Materials and Methods: Bi-variable and multivariable analyses of associations of characteristics with surgery type for cancers diagnosed in 1998-2010. Results: Of 30,299 invasive cases analysed, 11,729 (39%) were treated by mastectomy as opposed to breast conserving surgery. This proportion did not vary by diagnostic year (p>0.200). With major city residence as the reference category, the relative rate (95% confidence limits) of mastectomy was 1.03 (0.99, 1.07) for women from inner regional areas and 1.05 (1.01, 1.10) for those from more remote areas. Low annual surgeon case load (${\leq}10$) was predictive of mastectomy, with a relative rate of 1.08 (1.03, 1.14) when compared with higher case loads. Tumour size was also predictive, with a relative rate of 1.05 (1.01, 1.10) for large cancers (40+ mm) compared with smaller cancers (<30 mm). These associations were confirmed in multiple logistic regression analysis. Conclusions: Results confirm previous studies showing higher mastectomy rates for residents of more remote areas, those treated by surgeons with low case loads, and those with large cancers. Reasons require further study, including possible effects of surgeon and woman's choice and access to radiotherapy services.

• 한국인터넷방송통신학회논문지
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• 제10권5호
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• pp.31-37
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• 2010

본 논문은 홈 케어를 위해 생체 센서 시스템으로 홈 네트워크 시스템을 구성하여 생체 신호가 전달되도록 생체 신호 알고리즘을 구현하였다. 알고리즘의 구성 조건은 입력함수, 주파수 변화 함수, 변위 점 산출 발생 함수, 위치 변동 축 발생 함수, 축 변화 흔들림 변위(Sway Displacement)의 함수에서 변위치의 최대 값과 최소 값을 기준에 조정할 수 있는 단계로 주파수 변동이 0.01 단위로 변화가 있도록 조정하였다. 산출되는 항목은 맥박(Heart Rate), 체온(Temperature), 체중(Weight) 로 구성되고, 파형으로 신체적 균형정도를 확인하고 건강의 상태를 확인하도록 의미를 부여하였다. 본연구의 결과로 홈 네트워크를 통해 헬스 센터 및 건강관리 중앙 시스템에 단말기를 통해 전송된 알고리즘으로 홈 내 건강 관리시스템이 진행되는 결과를 얻을 수 있고, 다양한 신체적 파라메타를 통한 모니터링 기능을 갖춘 시스템관리가 형성 될 것으로 예상된다.

• 한국지능시스템학회논문지
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• 제22권1호
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• pp.87-93
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• 2012

본 논문에서는 TCP/COF의 불량패턴 검출 알고리즘을 제안하고 실시간 검사 시스템을 구현하였다. TCP/COF는 마이크로미터 단위의 패턴 굵기를 갖는 관계로 검사를 위해서는 작업자가 고성능 현미경을 보며 전수 검사 해야 하는 어려움이 있다. 이에 본 연구에서는 작업자로 하여금 모니터를 보면서 검사시스템이 검출해내는 불량에 대해서 검사할 수 있는 시스템을 제안하였다. 검사 알고리즘은 기준 영상과 검사 영상간의 패턴 비교 방법에 의해 수행된다. TCP/COF의 특성에 맞는 고성능 카메라 및 조명시스템을 구현하기 위하여 카메라의 종류와 조명의 형태 및 광원에 따른 다양한 실험을 수행하였다. 실험결과 구현된 검사 시스템은 TCP/COF 필름의 불량 위치를 작업자에게 정확하게 알려줌을 확인할 수 있었다.

• 한국임상약학회지
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• 제17권1호
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• pp.19-32
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• 2007

Objectives : It is necessary to monitor consumption of drugs in order to enhance promote appropriate use of drugs. Defined Daily Dose(DDD) of World Health Organization(WHO) has been used for evaluating the amount of medicine use. However, DDD of some drugs must be determined for drugs in Korea which are not listed by WHO. Our formulary follows ourself classification and DDD of some drugs must be determined since they exist only in Korea. This study was aimed to determine DDD value using RAND Appropriateness Methods and evaluate the amount of antibiotics use using DDD value. Methods : J01 antibiotics of WHO anatomical therapeutic chemical(ATC) classification were extracted from drug formulary. Antibiotics list without DDD was identified to determine their DDD with comprehensive review of references and recommendation of experts. defined. Review of reference was executed. of Expert panels were comprised of clinical pharmacist and clinical doctors. Modified Delphi Method was applied by survey and consensus meeting. Amount of antibiotic use was calculated by DDD/1000 inhabitants/day in the national level using health insurance claim data. Results : The result of 1 round, DDD values of 28 ingredients were determined from the first round of consensus meeting. With 2nd round meeting, 3 ingredients were deleted and DDD of 17 ingredients were decided. Analysis of antibiotic use in health insurance claim data showed 22.97 DDD/1000 inhabitants/day in 2003 year. Conclusion : This study can contribute to the establishment of DDD assignment and thus quantifying drug uses.

• 한국컴퓨터정보학회논문지
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• 제16권1호
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• pp.117-124
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• 2011

본 논문은 생체 센서 시스템(bio-physical sensor system)을 이용하여 홈 네트워크 시스템을 구성하고, 생체 신호가 전달되도록 생체 신호 원격용 네트워크를 구현하였다. 측정 시스템의 구성조건은 시각(Vision), 체성감각(Somatosensory), 전정기관(Vestibular), 중추신경계통(CNS)의 변위점에서 평가하고, 맥박(Heart Rate), 체온(Temperature), 체중(Weight)을 기본 측정항목에 사용하였다. 주파수 변동에 따른 0.01 단위로 측정하여 평균값을 가지고 기준치에 비교하여 설정환경을 구성하고 측정값을 결정하였다. 생체 신호는 신체의 균형조절기능인 신경생리학적 감각처리 및 운동 출력기전으로 시각, 체성감각, 전정기관, 중추신경계통, 체질량지수(BMI)의 신체적 감각 기관의 수용체들 간의 운동에 대한 균형과 자세를 통한 기준으로 정상적인 균형 조절 상태와 균형의 크기 형태로 구분하고, 건강의 상태를 확인하도록 의미를 부여하였다. 본 연구의 결과로 제안한 홈 네트워크를 통해 헬스 센터 및 건강관리 중앙 시스템에 단말기를 통하여 전송됨으로 전문가을 통한 건강 관리시스템이 진행되는 결과를 얻을 수 있고, 다양한 신체적 파라메타를 통한 원격네트워크 모니터링 기능의 관리시스템이 형성 될 것으로 추론 할 수 있다.

• 한국환경복원기술학회지
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• 제16권1호
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• pp.207-225
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• 2013

Current ecological stream restoration is focusing on recovery of physical characteristic and ecological functions of individual stream. For effective stream restoration, the relationship between stream environment and riparian flora should be investigated. The purpose of this study is to analyze the relationship between disturbance of hydromorphological structures and naturalized plants ratio in small to mid-sized streams. For the study sites, Gwanpyeong stream, Dongdal stream, and Yongchoo streams were chosen as 'reference stream' while, Gunnam stream, Anchang stream, and Hwa stream were chosen as 'damaged stream'. The hydromorphological structures of streams were evaluated with LAWA and flora of the streams were completely enumerated to calculate naturalized plants ratio. The result showed that there was a significant correlation between the outcome of LAWA and naturalized plants ratio(r=0.675, p<0.01). The result of factor analysis of LAWA identified three factors, 'River front and land use', 'River bed materials and structures', and 'Crossing structure and bar'. Among the factors of hydromorphological structures given by the result of factor analysis, 'river front and land use' and 'bed materials and structures' have statistically significant relationship with naturalized plants ratio($R^2$=0.470, p<0.01). Given this results, quantitative analysis on the relationship between disturbance of hydromorphological structures of streams and naturalized plants ratio could provide some essential information for stream restoration. Also, as this study figured out major factors of hydromorphological structures that affect naturalized plants ratio, it might help monitor ecological states and current problems of small and mid-sized streams.

• Journal of Radiation Protection and Research
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• 제25권4호
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• pp.197-205
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• 2000

실리콘 PIN 다이오드 검출기를 이용하여 전자선량계(PED)를 설계 및 제작하고, 전자신호회로의 성능과 방사선 검출 반응특성을 평가하였다. 전자회로의 성능검사에서는 방사선에 의한 검출기의 신호가 신호처리회로에서 양호하게 출력되었으며, $^{137}Cs$ 감마 방사선을 이용한 방사선조사 시험결과 선량계의 반응도 및 분산계수는 각각 1.85 cps/$Gy{\cdot}h^{-1}$ 및 19.3%로 측정되어 전자선량제의 성능기준을 만족하는 것으로 나타났다. 본 전자선량계의 시작품은 향후 전자회로의 성능향상과 작동 프로그램을 보완 및 개선함으로써 개인 방사선 모니터링에 활용될 것으로 기대된다.

• Asian-Australasian Journal of Animal Sciences
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• 제19권1호
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• pp.26-30
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• 2006

The study was undertaken to investigate the validity of milk urea concentration as an index of the reproductive performances in crossbred Karan-Fries (Holstein Friesian${\times}$Tharparkar) cows under farm condition. Milk urea was analysed in noon milk samples (1200 to 1300 h) to interrelate with the interval from parturition to first service, number of insemination per conception, first service conception rate and service period. Milk progesterone (P4) was analysed in noon milk samples on the day 1, 10, 20 and 30 post insemination to study the effect of milk urea concentration on early embryonic mortality. The interval from parturition to first service was found significantly (p<0.01) higher ($77.2{\pm}5.5$ days) when milk urea concentration was ${\geq}63.4mg/dl$. The average milk urea concentrations (mg/dl) were found $42.1{\pm}2.5$, $47.9{\pm}1.5$ and $50.3{\pm}3.1$, respectively in cows that conceived at $1^{st}$, $2^{nd}$ and $3^{rd}$ insemination. However, the variation was not statistically significant. The first insemination conception rate was found significantly (p<0.05) higher (68.8%) when milk urea level was ${\leq}32.4mg/dl$. The service period was found significantly (p<0.05) higher ($125.4{\pm}8.8$ days) when milk urea concentration was ${\geq}45.1mg/dl$. The milk P4 level indicated that the cows, those were detected as non-pregnant on day 60 post insemination were initially pregnant but the pregnancy was terminated sometime during the day 30 to 60 post insemination. The study indicates that the milk urea values may be used as an index of reproductive performances in dairy herd when individual animals are not being monitored for nutritional status. The altered milk urea values may be utilised by the farmers as ready reference to rectify the protein and energy nutrition in cows to achieve the better reproductive performances in herd.

• 한국학교수학회논문집
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• 제2권1호
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• pp.55-66
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• 1999

In mathematics education, teaching-learning activity can be divided largely into the understanding the mathematical concepts, derivation of principles and laws acquirement of the mathematical abilities. We utilize various media, teaching tools, audio-visual materials, manufacturing materials for understanding mathematical concepts. But sometimes we cannot define or explain correctly the concepts as well as the derivation of principles and laws by these materials. In order to solve the problem we can use the computer. In this paper, ′the process of the length of curve being equal to the sum of the vectors when intervals get smaller′ and ′the process of calculating volume of spinning curve by using definite integral.′ Using the computers is more visible than other educational instruments like blackboards, O.H.Ps., etc. Also it can help students with solving mathematical problems intuitively. Consequently more effective teaching-learning activity can be done. Usage of computers is the best method for improving the mathematical abilities because computers have functions of the immediate reaction, operation, reference and deduction. One of the important characters of mathematics is accuracy, so we use computers for improving mathematical abilities. This paper is about the program focused on the part of "the application of definite integral", which exists in mathematical curriculum the second and third grade of high school. When this study is used for students as assisting materials, it is expected the following educational effect. 1. Students will have precise concepts because they can understand what they learn intuitively. 2. Students will have positive thought by arousing interests of learning because this program is composed of pictures, animations with effectiveness of sound. 3. It is possible to change the teacher-centered instruction into the student-centered instruction. 4. Students will understand the relation between velocity and distance correctly because they can see the process of getting the length of curve by vector through the monitor. For the purpose of increasing the efficiencies and qualities of mathematics education, we have to seek the various learning-teaching methods. But considering that no computer can replace the teacher′s role, teachers have to use the CIA program carefully.