• Journal of International Academy of Physical Therapy Research
• /
• v.5 no.2
• /
• pp.752-756
• /
• 2014

This study investigated the effects of changes to the pulsation factor of pulsed direct currents on wound healing. Patients with a pressure ulcer at a care hospital for the elderly were randomly divided into three groups: Group 1 involved the application of $100{\mu}s$ in pulse duration, 10 ms in pulse period, 100 pps in a pulsation factor, 15 mA in pulse amplitude, and polarity red+ by using pulsed direct currents; Group 2 involved a change of pulse period to 8 ms; and Group 3 received general wound management. Although there were no statistically significant differences in the changing stages of pressure ulcers among the groups, all the groups dropped in numerical stages. In the two groups to which pulsed direct currents were applied, there was a statistically significant reduction in the stages of pressure ulcers from the initial assessment to the 12-week assessment (p<.05). Even though there were no statistically significant differences in changes to the area of pressure ulcers among the groups, a statistically significant decrease was found in pulsed direct current group 2 whose pulse period was shortened (p<.05). There was no difference in the healing rate of pressure ulcers among the groups, but it made a numerical increase in pulsed direct current group 1 and group 2 and a numerical decrease in group 3. There were no significant differences in the characteristics of those who had a full recovery among the groups. Those findings indicate that pulsed direct currents have positive effects on the wound healing of patients with a pressure ulcer and that a treatment with pulsed direct currents whose pulsation factor is raised by reducing the pulse duration is especially effective.

• Journal of applied mathematics & informatics
• /
• v.41 no.1
• /
• pp.51-70
• /
• 2023

The flow of an incompressible Ellis fluid in an inclined asymmetric channel, driven by peristaltic waves was studied under low Reynolds number and long wavelength assumptions. The wave on each side of the channel are assumed to be an infinite train of sinusoidal waves, both having the same constant wave speed and wavelength however, they vary in wave amplitude, channel half width and phase angle. We derived expressions for the axial and transverse velocities, volume flow rate, pressure rise per unit wavelength and streamlines. The effects of varying the wave amplitudes, the phase angle, the channel width, the angle of inclination of the channel as well as the fluid parameters on the flow were analyzed. Trapping conditions were determined and the presence of reflux highlighted using the streamlines for the necessary channel and fluid conditions. By varying the fluid parameters, changes in the fluid that deviated from the Newtonian case resulted in a reduction in the axial velocity in the neighborhood of the center of the channel and a simultaneous increase in the velocity at the periphery of the channel. A nonlinear relation was observed with the pressure rise and the volume flow rate. This nonlinear relation is more pronounced with an increase in the absolute value of the volume flow rate. For Newtonian fluids a linear relation exists between these two variables. The fluid parameters had little effects on the streamlines. However, variations of the wave amplitudes, volume flow, channel width and phase angle had greater effects on the streamlines and hence the trapped region.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
• /
• 1998.11a
• /
• pp.143-147
• /
• 1998

Autonomic and EEG responses of 38 college students were studied during 60-sec long presentation of International Affective Picture System (IAPS )slides evoking, according to subjective reports, negative (disgust, sadness, surprise) and positive (happiness, exciting) emotional. states. Observed were significant heart rate (HR) deceleration, large skin conductance responses (SCR), moderate respiration frequency slowing, reduction of frontal (F 3, F 4 ) and occipital (O 1, O 2 ) fast alpha, and increases of theta, delta and beta relative spectral power values during the first 30 sec of exposure of IAPS pictures. Analysis carried out to differentiate emotion categories according to autonomic responses indicated that observed HR deceleration was larger in magnitude in surprise and sadness than in disgust, SCR amplitude higher in sadness than in disgust. EEC showed significant differences in theta (F 3, F 4 ) and delta (O 1) power increase in disgust vs. happiness, fast alpha (F 3, F 4 ) power was lower in surprise than in happiness, and slow beta power higher. in happiness than in disgust (0 1). Despite some differences. observed within discrete emotion conditions, overall responses pattern of monitored parameters exhibited similar profiles with few variations, most. obvious. in disgust state, which suggests that affective visual stimulation elicits stereotypical responses in a given passive viewing paradigm. However, the magnitude of physiological responses may vary to certain extent across discrete emotional states making it possible to differentiate among particular experimentally-induced emotional states, e.g., disgust vs. sadness by ANS responses or disgust vs. happiness by EEG measures.

• The Korean Journal of Physiology and Pharmacology
• /
• v.26 no.1
• /
• pp.25-36
• /
• 2022

To identify the effect and mechanism of carbon monoxide (CO) on delayed rectifier K⁺ currents (I_K) of human cardiac fibroblasts (HCFs), we used the wholecell mode patch-clamp technique. Application of CO delivered by carbon monoxidereleasing molecule-3 (CORM3) increased the amplitude of outward K⁺ currents, and diphenyl phosphine oxide-1 (a specific I_K blocker) inhibited the currents. CORM3-induced augmentation was blocked by pretreatment with nitric oxide synthase blockers (L-NG-monomethyl arginine citrate and L-NG-nitro arginine methyl ester). Pretreatment with KT5823 (a protein kinas G blocker), 1H-[1,-2,-4] oxadiazolo-[4,-3-a] quinoxalin-1-on (ODQ, a soluble guanylate cyclase blocker), KT5720 (a protein kinase A blocker), and SQ22536 (an adenylate cyclase blocker) blocked the CORM3 stimulating effect on I_K. In addition, pretreatment with SB239063 (a p38 mitogen-activated protein kinase [MAPK] blocker) and PD98059 (a p44/42 MAPK blocker) also blocked the CORM3's effect on the currents. When testing the involvement of S-nitrosylation, pretreatment of N-ethylmaleimide (a thiol-alkylating reagent) blocked CO-induced I_K activation and DL-dithiothreitol (a reducing agent) reversed this effect. Pretreatment with 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)-21H,23H porphyrin manganese (III) pentachloride and manganese (III) tetrakis (4-benzoic acid) porphyrin chloride (superoxide dismutase mimetics), diphenyleneiodonium chloride (an NADPH oxidase blocker), or allopurinol (a xanthine oxidase blocker) also inhibited CO-induced I_K activation. These results suggest that CO enhances I_K in HCFs through the nitric oxide, phosphorylation by protein kinase G, protein kinase A, and MAPK, S-nitrosylation and reduction/oxidation (redox) signaling pathways.

• Korean Journal of Oriental Medicine
• /
• v.9 no.2
• /
• pp.121-130
• /
• 2003

The goal of this study is construction and efficacy evaluation of MPC-25 (Magnetic Pain Control-25), a medical device using magnetic stimulation. MPC-25 consists of a main body containing power supply and control module and a bed containing magnetic core and coil. In distinction from electric pain control medical devices, magnetic pain control system is non-contact, so the patients need not take off their clothes to be treated. High amplitude current pulses are applied to a magnetic coil and induce time varying magnetic field generating eddy current in a conductor like human body. Clinical efficacy test was performed in patients suffering from musculoskeletal pain of lumbar, shoulder and joint. Degree of pain before and after treatment for 30 minutes was compared using Visual Analogous Scale. As a result, 14 cases out of 20 showed decreased pain perception, so the rate of efficacy is 70%. Reduction of pain perception was statistically significant (P=0.001 by Wilcoxon Signed Rank Test).

• Proceedings of the Korean Institute of Surface Engineering Conference
• /
• 2016.11a
• /
• pp.152-152
• /
• 2016

Anodizing is a technology to generate thicker and high-quality films than natural oxide films by treating metals via electrochemical methods. It is a technique to develop metals for various uses, and extensive research on the commercial use has been performed for a long time. Aluminum anodic oxide (AAO) is generate oxide films, whose sizes and characteristics depending on the types of electrolytes, voltages, temperatures and time. Electrochemical manufacturing method of nano structure is an efficient technology in terms of cost reduction, high productivity and complicated shapes, which receives the spotlight in diverse areas. The sulfuric acid was used as an anodizing electrolyte, controlling its temperature to $10^{\circ}C$. The anode was 5083 Al alloy with dimension of $5(t){\times}20{\times}20mm$ while the cathode was the platinum. The distance between the anode and the cathode was maintained at 3 cm. Agitation was introduced by magnetic stirrer at 300 rpm to prevent localized temperature rise that hinders stable growth of oxide layer. In order to observe surface characteristics with applied current density, the electrolyte temperature, concentration was maintained at constant condition for $10^{\circ}C$, 10 vol.%, respectively. To prevent hindrance of stable growth of oxide layer due to local temperature increase during the experiment, stirring was maintained at constant rate. In addition, using galvanostatic method, it was maintained at current density of $10{\sim}30mA/cm^2$ for 40 minutes. The cavitation experiment was carried out with an ultrasonic vibratory apparatus using piezo-electric effect with modified ASTM-G32. The peak-to-peak amplitude was $30{\mu}m$ and the distance between the horn tip and specimen was 1 mm. The specimen after the experiment was cleaned in an ultrasonic, dried in a vacuum oven for more than 24 hours, and weighed with an electric balance. The surface damage morphology was observed with 3D analysis microscope. As a result of the investigation, differences were observed surface hardness and anti-cavitation characteristics depending on the development of oxide film with applied current density.

• Nuclear Engineering and Technology
• /
• v.55 no.3
• /
• pp.968-980
• /
• 2023

The dynamic structural responses are sensitive to the time-frequency content of seismic waves, and seismic input motions in time-history analysis are usually required to be compatible with design response spectra according to nuclear codes. In order to generate spectra-compatible input motions while maintaining the intrinsic non-stationarity of seismic waves, an improved time-domain approach is proposed in this paper. To maintain the nonstationary characteristics of the given seismic waves, a new time-frequency envelope function is constructed using the Hilbert amplitude spectrum. Based on the intrinsic mode functions (IMFs) obtained from given seismic waves through variational mode decomposition, a new corrective time history is constructed to locally modify the given seismic waves. The proposed corrective time history and time-frequency envelope function are unique for each earthquake records as they are extracted from the given seismic waves. In addition, a dimension reduction iterative technique is presented herein to simultaneously superimpose corrective time histories of all the damping ratios at a specific frequency in the time domain according to optimal weights, which are found by the genetic algorithm (GA). Examples are presented to show the capability of the proposed approach in generating spectra-compatible time histories, especially in maintaining the nonstationary characteristics of seismic records. And numerical results reveal that the modified time histories generated by the proposed method can obtain similar dynamic behaviors of AP1000 nuclear power plant with the natural seismic records. Thus, the proposed method can be efficiently used in the design practices.

• The Journal of Engineering Geology
• /
• v.14 no.2
• /
• pp.147-168
• /
• 2004

Purpose of this study is to quantitatively characterize the fracture roughness which was measured with a confocal laser scanning microscope. The roughness discrete data measured by confocal laser microscope were analyzed by spectral analysis and fast Fourier transform (FFT).The roughness data by used noise reduction filter were applied for fractal analysis to describe roughness features quantitatively. Artificial fractures created by Brazilian test on granites were used to measure fracture roughness under the confocal laser scanning microscope. Measurements were performed along three scan lines on each fracture surface. 36 scan lines were determined on 12 specimens in total. Features of roughness showed that coarse and medium grained granites tend to more rough features than those of fine grained granites. Continuous analog data of roughness is possible to described as discrete data of measure roughness with a fixed interval under the confocal laser microscope. Results of FFT with the measured data showed the highest values on the second harmonics. Distribution of average amplitude of second harmonics was observed 0.9853 in coarse grained granite, 1.0792 in medium grained granite and 0.6794 in fine grained granite. This indicates that the larger roughness has the higher energy of harmonics as the result of fractal analysis in low frequency zone.

• Journal of the Korean Society of Radiology
• /
• v.12 no.4
• /
• pp.491-496
• /
• 2018

The purpose of this study is to analyze the noise spectra in DWI (diffusion-weighted imaging) pulse sequences of 1.5 Tesla and 3.0 Tesla MRI, The ACR (American College of Radiology) phantom and noise spectrum were analyzed by FFT (fast Fourier transform) and TFFT (temporal frequency analysis) using WavePad sound editor version 8.13 (NCH software, Greenwood Village, CO, USA). Noise spectra, FFT and TFFT were analyzed for laboratory 1.5Tesla and 3.0Tesla DWI MR pulse sequences. The noise threshold of the frequency amplitude in the FFT and TFFT at 3.0Tesla compared to 1.5Tesla was between 1.5Tesla and -6 dB, and between 3.0Tesla and 0 dB, the DWI pulse sequence for the patient's noise reduction was appropriately MR examination needs to be applied.

• Wind and Structures
• /
• v.25 no.2
• /
• pp.101-129
• /
• 2017

Local transient extreme wind loads caused by group tower-related interference are among the major reasons that lead to wind-induced damage of super-large cooling towers. Four-tower arrangements are the most commonly seen patterns for super-large cooling towers. We considered five typical four-tower arrangements in engineering practice, namely, single row, rectangular, rhombic, L-shaped, and oblique L-shaped. Wind tunnel tests for rigid body were performed to determine the influence of different arrangements on static and dynamic wind loads and extreme interference effect. The most unfavorable working conditions (i.e., the largest overall wind loads) were determined based on the overall aerodynamic coefficient under different four-tower arrangements. Then we calculated the one-, two- and three-dimensional aerodynamic loads under different four-tower arrangements. Statistical analyses were performed on the wind pressure signals in the amplitude and time domains under the most unfavorable working conditions. On this basis, the non-Gaussian distribution characteristics of aerodynamic loads on the surface of the cooling towers under different four-tower arrangements were analyzed. We applied the Sadek-Simiu procedure to the calculation of two- and three-dimensional aerodynamic loads in the cooling towers under the four-tower arrangements, and the extreme wind load distribution patterns under the most unfavorable working conditions in each arrangement were compared. Finally, we proposed a uniform equation for fitting the extreme wind loads under the four-tower arrangements; the accuracy and reliability of the equation were verified. Our research findings will contribute to the optimization of the four-tower arrangements and the determination of extreme wind loads of super-large cooling towers.