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An early transcription checkpoint ; A dual role of capping enzyme in RNA polymerase II transcription

  • Cho Eun-Jung
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 2005.04a
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    • pp.5-14
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    • 2005
  • Recently, data from several groups have raised the concept of 'checkpoint' in transcription. As capping of nascent RNA transcript is tightly coupled to RNA polymerase II transcription, we seek to obtain direct evidence that transcripiton checkpoint via capping enzyme functions in this early regulatory step. One of temperature sensitive (ts) alleles of ceg1, a guanylyltransferase subunit of the Saccharomyces cerevisiaecapping enzyme, showed 6-azauracil (6AU) sensitivity at the permissive growth temperature, which is a phenotype that is correlated with a transcription elongational defect. This ts allele, ceg1-63 also has an impaired ability to induce PUR5 in response to a 6AU treatment. However, this cellular and molecular defect is not due to the preferential degradation of the transcript attributed from a lack of guanylyltransferase activity. On the contrary, the data suggests that the guanylyltransferase subunit of the capping enzyme plays a role in transcription elongation. First, in addition to the 6AU sensitivity, ceg1-63is synthetically lethal with elongation defective mutations of the largest subunit of RNA polymerase II. Secondly, it exhibited a lower GAL1 mRNA turn-over after glucoseshut off. Third, it decreased the transcription read through a tandem array of promoter proximal pause sites in an orientation dependent manner. Interestingly, this mutant also showed lower pass through a pause site located further downstream of the promoter. Taken together, these results suggest that the capping enzyme plays the role of an early transcription checkpoint possibly in the step of the reversion of repression by stimulating polymerase to escape from the promoter proximal arrest once RNA becomes appropriately capped.

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Epitaxial Overlayers vs Alloy Formation at Aluminum-Transition Metal Interfaces

  • Smith, R.J.
    • Proceedings of the Korean Vacuum Society Conference
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    • 1999.07a
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    • pp.29-29
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    • 1999
  • The synthesis of layered structures on the nanometer scale has become essential for continued improvements in the operation of various electronic and magnetic devices. Abrupt metal-metal interfaces are desired for applications ranging from metallization in semiconductor devices to fabrication of magnetoresistive tunnel junctions for read heads on magnetic disk drives. In particular, characterizing the interface structure between various transition metals (TM) and aluminum is desirable. We have used the techniques of MeV ion backscattering and channeling (HEIS), x-ray photoemission (ZPS), x-ray photoelectron diffraction(XPD), low-energy ion scattering (LEIS), and low-energy electron diffraction(LEED), together with computer simulations using embedded atom potentials, to study solid-solid interface structure for thin films of Ni, Fe, Co, Pd, Ti, and Ag on Al(001), Al(110) and Al(111) surfaces. Considerations of lattice matching, surface energies, or compound formation energies alone do not adequately predict our result, We find that those metals with metallic radii smaller than Al(e.g. Ni, Fe, Co, Pd) tend to form alloys at the TM-Al interface, while those atoms with larger atomic radii(e.g. Ti, Ag) form epitaxial overlayers. Thus we are led to consider models in which the strain energy associated with alloy formation becomes a kinetic barrier to alloying. Furthermore, we observe the formation of metastable fcc Ti up to a critical thickness of 5 monolayers on Al(001) and Al(110). For Ag films we observe arbitrarily thick epitaxial growth exceeding 30 monolayers with some Al alloying at the interface, possible driven by interface strain relief. Typical examples of these interface structures will be discussed.

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A Simplified Two-Step Majority-Logic Decoder for Cyclic Product Codes (순환 곱 코드의 간단한 두 단계 다수결 논리 디코더)

  • 정연호;강창언
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.10 no.3
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    • pp.115-122
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    • 1985
  • In this paper, A decoder for the product of the (7, 4) cyclic code and the (3, 1) cyclic code was designed with less majority gates than other ordinary two-step majority-logic decoder using the same codes, then it was constucted in simple sturucture as a result of the use of a ROM as a mojority gate. It took 42 clock pulses to correct a received word(or 21bits) entirely. And so the decoding time in this decoding was multiplied by a factor of about 0.7 relative to the decoding time in the previous decoding in which two decoders and two-demensional word arrays were used together.

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Detection of Fire Location And Reliability Improvement of the Conventional Fire Detector and P-type Receiver (재래식 화재감지기와 P형 수신기에 대한 화재위치검출 및 신뢰성 개선)

  • Jee, Seung-Wook;Kim, Shi-Kuk;Yang, Seung-Hyun;Lee, Jae-Jin;Kim, Pil-Young;Lee, Chun-Ha
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.25 no.5
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    • pp.39-44
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    • 2011
  • Automatic fire alarm system is set up to automatically detect fire on buildings. Because of economic reasons, P-type receiver and a conventional type fire detector is normally used for automatic fire alarm system in Korea. Because early detection of fire is regarded as important, the need of finding technique of fire location increases. This paper is studied a method to improve a reliability and add a function of fire location detection on a conventional type fire detector and P-type receiver. Fire location is detected by a method that controller attached on the receiver and the detector is read with a time lag. A reliability of fire detection alarm system is improved with a method that false fire alarm is able to decrease using two different principle detector together. This paper is studied for basic data of improvement of low-cost addressable automatic fire alarm system.

The Psychiatrist and the Revolutionary: Frantz Fanon's Critique of Colonial Discourse

  • Rasmussen, Kim Su;Sorensen, Eli Park
    • Cross-Cultural Studies
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    • v.24
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    • pp.5-18
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    • 2011
  • This article offers a reflection on Frantz Fanon's diagnosis and analysis of French colonialism in Algeria. We will attempt to demonstrate that there is a concrete and clear connection between Fanon as the psychiatrist diagnosing the devastating effects of the French colonial system, and his subsequent political involvement in the Algerian revolution. This is not to say that each part does not contain valuable insights in their own rights, but rather to stress that without being read together, as a whole, one would miss a significant element in the understanding of the importance Fanon's thought subsequently came to play in the emancipation struggles of the colonized worldwide. Furthermore, we argue that it is crucial to understand the intimate connection between Fanon's psychiatric work, his diagnosis of colonial mental disorders, as well as diagnosis of the colonial system as such, and then his political engagement, in order to understand the particular context in which he favourably discusses the use of violence in the name of fighting against the oppressive system of colonialism. Above all, we argue that Fanon's critique of colonialism continues to spark controversy because it still represents the most powerful and incisive analysis of, as well as answer to, the troubled relationship between the blessed and the wretched of the earth.

Before Serindia: The Achaemenid Empire Along and Astride the Silk Roads

  • Marco, FERRARIO
    • Acta Via Serica
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    • v.7 no.2
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    • pp.133-152
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    • 2022
  • Both in popular perception and specialized literature, the Achaemenid Empire, for over two centuries the most important player from the Aegean to the Indus, is rarely evoked in correlation with the complex of socio-cultural dynamics which shaped the spaces of what has become known as the Silk Road(s). Building on the case study of the Pazyryk carpet on the one hand (King 2021, 353-361, Linduff and Rubinson 2021, 88-97), and of the spread of an artistic motive such as the quatrefoil on the other (Kim 2021), this paper explores the rich and complex nature of the commercial networks that flourished across Central Asia under the aegis of Achaemenid Great Kings. Both archaeological and literary evidence shall be discussed (especially the Aramaic Documents from Ancient Bactria: Naveh and Shaked 2012, and now King 2021, 315-320). If taken together and read against the grain, such material is significant for the following reasons. First, it suggests the existence - and the scale - of commercial activities directly fostered or indirectly promoted by the imperial administration in Central Asia, an area of crucial importance within the Achaemenid domains, but for which our evidence is rather scanty and difficult to assess. Second, it shows how the Achaemenid "Imperial Paradigm" (Henkelman 2017) affected the social and economic landscape of Central Asia even after the demise of the Empire itself, thus considerably shaping the world of the Silk Road(s) a century before the Ancient Sogdian Letters (de la Vaissière 2005, 43-70) or Zhāng Quiān's famous report.

Analyzing Characters and Designing Actions to Feature - Sarafanov of Written by A. B. Vampilov (형상화를 위한 인물분석과 행동설계 - A. B. 밤필로프 작 <장남>의 사라파노프)

  • Cheon, Hyo-Bum
    • The Journal of the Korea Contents Association
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    • v.14 no.11
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    • pp.79-88
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    • 2014
  • Vampilov, who is not well known as a playwright in domestic, is acknowledged comparable to Anton Chekhov in Russia. This paper was planed in order to promote a unsatisfied study until now in domestic for works by Vampilov and studied a part of composing play to put on the stage for , a drama written by Vampilov. This paper, originated from a viewpoint that actor have to complete the final text of the play for audiences to read depending on the drama and based on work features and characters of Vampilov, established an analysis scheme according to segments of unit actions for actions of Sarafanov, the character of the play, in order to achieve a purpose under suggested situation at the drama and focused on completing purposes per units individually. We have analyzed Sarafanov and his actions referring patterns and probabilities of the characters in the other works by Vampiov and regarded it as the important item together with logical basis of actions. Lyric and humanism emphasizing works by Vampilov, affected by Anton Chekhov and Nikolai Vasilevich Gogol, are acknowledged as realistic descriptions using contingency and a play within a play outstandingly and emphasized an importance of human relation. We have selected as a primary way to compose action text that audiences would read on the stage and used it as the method to design action of the characters in order to activate natural good of Sarafanov and general absurdities that human, does creative works, never give up purposes of ideal life.

A Qualitative Study on Classroom Culture in a Toddler Class of 2 year olds (만 2세 영아반의 교실문화에 관한 질적연구)

  • Hong, Sung Hee;Cho, Eun-Lae
    • Korean Journal of Childcare and Education
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    • v.9 no.6
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    • pp.171-196
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    • 2013
  • The purpose of this study was to examine the characteristics of classroom culture in a toddler class of 2 year olds. Data was collected through 16 sessions of non-participatory observations and teacher interviews of toddlers in H daycare center. Collected data was carefully read and categorized accordingly to fit the theme of this qualitative study. Data analysis yielded four conclusions regarding the toddlers' classroom culture: behavior to advance together as a group, communicating through body language, complete reliance and responses towards the instructor, and a dichotomy between disintegration and integration. The result of this study suggests a need for instructor's proper guidance and establishing an appropriate childcare environment, as well as a reconsideration regarding toddlers as a host of the classroom culture, to increase the understanding of toddler's interactions in classrooms and social trends.

A Study on Evaluation Development of PBL in a Mongolian University (몽골 대학에서의 PBL 수업 평가 개발 연구)

  • Bayarmaa, Natsagdorj;Lee, Keunsoo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.8
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    • pp.322-328
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    • 2018
  • The purpose of this study is to examine the performance of Problem-Based Learning (PBL) based on Google Classroom(GC). GC is an easy and free online learning that plays an important role in education and training recently. Students become increasingly independent in self-directed learning while sharing ideas and resources, transferring knowledge actively across domains and researching for solutions to the given problem in PBL. Students can check the submission date on the task page and start the task with a single click, and teachers can quickly check if the task is complete, and score it directly from GC. Designed The Evaluation of Problem -Based Learning based on GC in this study. The students read the given materials and identify the purpose of the subjects and selected the learning issues, investigated them. After then they discuss the subjects and make the reports. The students work to study them with research papers, books and internet materials. The research findings showed that PBL based on GC was effective in learning together. Students had positive attitude in their PBL learning environment. This study suggests it is possible that the development of PBL Evaluation on the GC.

An Integrated Design of Middleware and EPCIS for RFID and Sensor Data (RFID와 센서 데이터 처리를 위한 미들웨어와 EPCIS 통합 설계)

  • Hyun, Seung-Ryul;Lee, Sang-Jeong
    • Journal of the Korea Society of Computer and Information
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    • v.17 no.1
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    • pp.193-202
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    • 2012
  • RFID tag awareness information and sensor data continuously change, and are categorized with the position. They are able to similar data in the side, called massive data to change in time. If two data are managed together, a convergence process of object awareness along change of environment is possible. If RFID middleware and EPCIS repository realized the integrated system, it is usable with the functions of middleware and repository at the same time. The real-time awareness information retrieval is possible without process, getting information from another middleware. In this paper, it is able to continuously read information from RFID reader and sensor equipment and store to database in order to make general object awareness and an object retrieval dependent on an environmental information change possible by real time. ALE-compliant middleware and EPCIS repository proposing for standards at EPCglobal is designed and implemented to be able to deal with RFID and sensor data to bases on the collected data.