• Journal of the Korean Institute of Telematics and Electronics D
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• v.35D no.3
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• pp.46-55
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• 1998

This stud demonstrates the profiles of heavy ions (As, Sb) in silicon by high energy (1~10 MeV) implantation. Implanted profiles were measured by SIMS (Cameca 4f) and compared with simulation results (TRIM) program and analytical description method using Pearson function). The experimental results have a little bit deviation with simulation data in the case of As high energy implatation. But in the case of Sb, the experimental results are in good agreement with TRIM data. SIMS profiles are perfectly fitted with a analytical description method only using one pearson function in Sb implantation. but in the case of As, fitted profilesshow with a little bit deviations by channeling effects of SIMS profiles. Thermal annealing for electrical activation of implanted ions was carried out by furnace annealing and RTA(Rapid Thermal Annealing). Concentration-depth profile after heat treatement were measured by SR(Spreading Resistance) method.

• Structural Engineering and Mechanics
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• v.43 no.1
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• pp.71-87
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• 2012

This paper extends a single equation, semi-analytical approach for three-span bridges to multi-span ones for the rapid and precise determination of natural frequencies and natural mode shapes of an orthotropic, multi-span plate. This method can be used to study the dynamic interaction between bridges and vehicles. It is based on the modal superposition method taking into account intermodal coupling to determine natural frequencies and mode shapes of a bridge deck. In this paper, a four- and a five-span orthotropic roadway bridge deck are compared in the first 10 modes with a finite element method analysis using ANSYS software. This simplified implementation matches numerical modeling within 2% in all cases. This paper verifies that applicability of a single formula approach as a simpler alternative to finite element modeling.

• Journal of the Korea Institute of Military Science and Technology
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• v.2 no.2
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• pp.70-82
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• 1999

During the aircraft conceptual design stage, rapid aerodynamic analyses over various configurations are required. Hence, empirical and analytical methods play important roles in predicting the aero-dynamic characteristics. In this study, total drag estimation method based on empirical and analytical approaches is developed. By comparing with the results of the wind tunnel experiment and existing prediction methods, it is demonstrated that the developed method is accurate and useful in predicting total drag for the whole Mach number range.

• Analytical Science and Technology
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• v.8 no.4
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• pp.829-834
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• 1995

Whole column coldtrapping(WCC) on a fused silica capillary (FSCC)combined with GC/MS analysis was evaluated for use in the investigation of volatile organic compounds(VOCs) in indoor air. Research had indicated that a temperature of $-80^{\circ}C$ is optimal for WCC. Samples were analyzed on a $50m{\times}0.2mm$ cross-linked 5% phenylmethylsilicone fused silica column. Liquid nitrogen was used as the coolant for the peak resolution significantly. The analysis can be performed quickly and conveniently. More than 112 of VOCs were determined in the samples from three typical indoor environment including: (1) a room which had just been decorated involving building materials and paints; (2)a kitchen used for Chinese cooking, and (3) a room had tobacco smoke. The method is could be readily applied to rapid sample screening for VOCs contamination surveys or initial investigations with its valid and simple sampling and analytical technique.

• Steel and Composite Structures
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• v.52 no.3
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• pp.343-356
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• 2024

This paper presents an analytical solution for correctly predicting the Lateral-Torsional Buckling critical moment of simply supported castellated beams, the solution covers uniformly distributed loads combined with compressive loads. For this purpose, the castellated beam section with hexagonal-type perforation is treated as an arrangement of double "T" sections, composed of an upper T section and a lower T section. The castellated beam with regular openings is considered as a periodic repeating structure of unit cells. According to the kinematic model, the energy principle is applied in the context of geometric nonlinearity and the linear elastic behavior of materials. The differential equilibrium equations are established using Galerkin's method and the tangential stiffness matrix is calculated to determine the critical lateral torsional buckling loads. A Finite Element simulation using ABAQUS software is performed to verify the accuracy of the suggested analytical solution, each castellated beam is modelled with appropriate sizes meshes by thin shell elements S8R, the chosen element has 8 nodes and six degrees of freedom per node, including five integration points through the thickness, the Lanczos eigen-solver of ABAQUS was used to conduct elastic buckling analysis. It has been demonstrated that the proposed analytical solution results are in good agreement with those of the finite element method. A parametric study involving geometric and mechanical parameters is carried out, the intensity of the compressive load is also included. In comparison with the linear solution, it has been found that the linear stability underestimates the lateral buckling resistance. It has been confirmed that when high axial loads are applied, an impressive reduction in critical loads has been observed. It can be concluded that the obtained analytical solution is efficient and simple, and offers a rapid and direct method for estimating the lateral torsional buckling critical moment of simply supported castellated beams.

• Proceedings of the Korean Society of Toxicology Conference
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• 2006.11a
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• pp.65-74
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• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.

• Structural Engineering and Mechanics
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• v.8 no.6
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• pp.547-560
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• 1999

In this paper an asymptotic iteration method is adopted to analyze non-linear free vibration of reticulated circular plates composed of beam members placed in two orthogonal directions. For the resulting linear ordinary differential equations in the process of iteration, the power series with rapid convergence has been applied to obtain an analytical solution for non-linear characteristic relation between the amplitude and frequency of the structure. Numerical examples are given, and the phenomena indicating hardening of such structures have been presented for the (immovable or movable) simply-supported and clamped circular plates.

• Bulletin of the Korean Chemical Society
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• v.19 no.11
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• pp.1189-1193
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• 1998

The determination of total paraffin, naphthene, and aromatic (PNA) contents in naphtha samples, which were directly obtained from actual refining process, has been studied using near-infrared (NIR) spectroscopy. Each of the total PNA concentrations in naphtha has been successfully analyzed using NIR spectroscopy. Partial least squares (PLS) regression method has been utilized to quantify the total PNA contents in naphtha from the NIR spectral bands. The NIR calibration results showed an excellent correlation with those of conventional gas chromatography (GC). Due to its rapidity and accuracy, NIR spectroscopy is appeared as a new analytical technique which can be substituted for the conventional GC method for the quantitative analysis of petrochemical products including naphtha.

• Analytical Science and Technology
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• v.33 no.4
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• pp.186-196
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• 2020

A simple and rapid preconcentration method of actinide from seawater using Actinide resin was developed and tested with the seawater spiked with a known U and Th. The developed method of Actinide resin based on column chromatography is less time-consuming and requires less labor compared with a typical co-precipitation technique for preconcentration of actinides. U and Th, which are relatively weak-bonded with Actinide resin among actinides, were used to determine the optimum flow rate of seawater sample and evaluate the capacity of Actinide resin to concentrate actinides from seawater. A flow rate of 50 mL min^-1 was available with Actinide resin 2 mL (BV, bed volume). When 5 or 10 L of seawater containing U were loaded on Actinide resin (2 mL, BV) at 50 mL min^-1, the recovery of U was 93 % and 86 %, respectively. For extraction of actinides bound with Actinide resin, we compared three methods: solvent extraction, ashing-acid digestion, and ashing-microwave digestion. Ashing-microwave digestion method shows the best performance of which is the recovery of 100 % for U and 81 % for Th. For the preconcentration of actinides in 200 L of seawater, a typical coprecipitation method requires 2-3 days, but the developed method in this study is achieved the high recovery of actinides within 12 h.

• Analytical Science and Technology
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• v.15 no.5
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• pp.410-416
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• 2002

In this study, a new quantitative analytical method has been developed for the rapid determination of vancomycin in human plasma and urine using liquid chromatography/tandem mass spectrometry (LC - MS/MS). Chromatography was carried out on a $C_{18}$ XTerra MS column ($2.1{\times}30mm$) with a particle size of $3.5{\mu}m$. The mobile phase was 0.25% formic acid in 10% acetonitrile and the flow rate was $250{\mu}L/min$. Vancomycin and caffeine (internal standard) were detected by MS/MS using multiple reaction monitoring (MRM). Vancomycin gives a predominant doubly protonated precursor molecule ($[M+2H]^{2+}$) at m/z 725.0 and a corresponding product ion of m/z 100.0. Detection of vancomycin was good, accurate and precise, with a limit of detection of 1 nM in plasma. The calibration curves for vancomycin in human plasma was linear in a concentration range of $0.01{\mu}M$ - $100{\mu}M$ for plasma. This method has been successfully applied to determine the concentration of vancomycin in human plasma and urine from pharmacokinetic study and relative studies.