• Journal of the Institute of Electronics Engineers of Korea SC
• /
• v.49 no.4
• /
• pp.45-54
• /
• 2012

Location-based services with GPS positioning technology as a key technology, but recognizing the current location through satellite communication is not possible in an indoor location-aware technology, low-power short-range communication is primarily made of the study. Especially, as Chirp Spread Spectrum(CSS) based location-aware approach for low-power physical layer IEEE802.15.4a is selected as a standard, Ranging distance estimation techniques and data transfer speed enhancements have been more developed. It is known that the distance measured by CSS ranging has quite a lot of noise as well as its bias. However, the noise problem can be adjusted by modeling the non-zero mean noise value by a scaling factor which corresponds to the change of magnitude of a measured distance vector. In this paper, we propose a localization system using the CSS signal to measure distance for a mobile node taken a measurement of the exact coordinates. By applying the extended kalman filter and least mean squares method, the localization system is faster, more stable. Finally, we evaluate the reliability and accuracy of the proposed algorithm's performance by the experiment for the realization of localization system.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.45 no.3
• /
• pp.60-68
• /
• 2008

This work describes a re-configurable 10MS/s to 100MS/s, low-power 10b two-step pipeline ADC operating at a power supply from 0.5V to 1.2V. MOS transistors with a low-threshold voltage are employed partially in the input sampling switches and differential pair of the SHA and MDAC for a proper signal swing margin at a 0.5V supply. The integrated adjustable current reference optimizes the static and dynamic performance of amplifiers at 10b accuracy with a wide range of supply voltages. A signal-isolated layout improves the capacitor mismatch of the MDAC while a switched-bias power-reduction technique reduces the power dissipation of comparators in the flash ADCs. The prototype ADC in a 0.13um CMOS process demonstrates the measured DNL and INL within 0.35LSB and 0.49LSB. The ADC with an active die area of $0.98mm^2$ shows a maximum SNDR and SFDR of 56.0dB and 69.6dB, respectively, and a power consumption of 19.2mW at a nominal condition of 0.8V and 60MS/s.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• v.45 no.12
• /
• pp.105-113
• /
• 2008

In Ubiquitous Society, accurate Location Calculation of user's device is required to achieve the need of users. As the location calculation is processed by ranging between transceivers, if some obstacles exist between transceivers, NLoS(Non-line-of-Sight) components of received signal increase along with the reduction of LoS(Line-of-Sight) components. Therefore the location calculation error will increase due to the NLoS effect. The conventional location calculation algorithm has the original ranging error because there is no transformation of ranging information which degrades the ranging accuracy. The Iterative Calculation method which minimizes the location calculation error relys on accurately identifying NLoS or LoS condition of the tested channel. We employ Kurtosis, Mean Excess Delay and RMS Delay spread of the received signal to identify whether the tested channel is LoS or NLoS firstly. Thereafter, to minimize location calculation error, the proposed Iterative Calculation method iteratively select random range and finds the averaged target location which has high probability. The simulation results confirm the enhancement of the proposed method.

• Journal of IKEEE
• /
• v.20 no.1
• /
• pp.61-67
• /
• 2016

In this paper, a hardware design method is proposed for high speed high precision neutron radiation measurements. Our system is fabricated to use a high performance A/D Converter for digital data conversion of high precision and high speed analog signals. Using a neutron sensor, incident neutron radiation particles are detected; a precision microcurrent measurement module is also included: this module allows for more precise and rapid neutron radiation measurement design. The high speed high precision neutron measurement hardware system is composed of the neutron sensor, variable high voltage generator, microcurrent precision measurement component, embedded system, and display screen. The neutron sensor detects neutron radiation using high density polyethylene. The variable high voltage generator functions as a 0 ~ 2KV variable high voltage generator that is robust against heat and noise; this generator allows the neutron sensor to perform normally. The microcurrent precision measurement component employs a high performance A/D Converter to precisely and swiftly measure the high precision high speed microcurrent signal from the neutron sensor and to convert this analog signal into a digital one. The embedded system component performs multiple functions including neutron radiation measurement for high speed high precision neutron measurements, variable high voltage generator control, wired and wireless communications control, and data recording. Experiments using the proposed high speed high precision neutron measurement hardware shows that the hardware exhibits superior performance compared to that of conventional equipment with regard to measurement uncertainty, neutron measurement rate, accuracy, and neutron measurement range.

• Publications of The Korean Astronomical Society
• /
• v.27 no.3
• /
• pp.49-59
• /
• 2012

KASI (Korea Astronomy and Space Science Institute) has developed an SLR (Satellite Laser Ranging) system since 2008. The name of the development program is ARGO (Accurate Ranging system for Geodetic Observation). ARGO has a wide range of applications in the satellite precise orbit determination and space geodesy research using SLR with mm-level accuracy. ARGO-M (Mobile, bistatic 10 cm transmitting/40 cm receiving telescopes) and ARGO-F (Fixed stationary, about 1 m transmitting/receiving integrated telescope) SLR systems development will be completed by 2014. In 2011, ARGO-M system integration was completed. At present ARGO-M is in the course of system calibration, functionality, and performance tests. It consists of six subsystems, OPS (Optics System), TMS (Tracking Mount System), OES (Opto-Electronic System), CDS (Container-Dome System), LAS (Laser System) and AOS (ARGO Operation System). In this paper, ARGO-M system structure and integration status are introduced and described.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.34 no.1
• /
• pp.57-62
• /
• 2008

No matter how small amount of heavy metals it may be cause skin allergies through percutaneous adsorption when existing in cosmetic products as impurities. In order to develop a highly sensitive method for simultaneous determination of $Pb^{2+},\;Fe^{2+},\;Cu^{2+},\;Ni^{2+},\;Zn^{2+},\;Co^{2+},\;Cd^{2+},\;and\;Mn^{2+}$ in coloring agents and cosmetic products with rapidity and accuracy, we carried out the determination on ion chromatography. All of these metals are well separated through a bifunctional ion-exchange column(IonPac CS5A) and detected by post-column reaction and spectrophotometric detection. The calibration graphs are linear($r^2>0.999$) in the range $0.1{\sim}1000{\mu}g/mL$. Detection limits for 200 ${\mu}L$ of sample solution are at the level of ${\mu}g/L$, which is sufficient for judging whether the product is safe or not. The relative standard deviations(RSDs) of the retention time and the peak area are less than 0.21 and 1.24%, respectively. The recovery rates are $97{\sim}104%$. The new method was applied to analyze the amount of heavy metals which were contained in 22 cosmetic products and 11 coloring agents.

• Geophysics and Geophysical Exploration
• /
• v.5 no.4
• /
• pp.299-308
• /
• 2002

We have derived an analytical expression for the sensitivity of the frequency domain small-loop electromagnetic (EM) surveys over a two-layer earth in order to estimate the depth of investigation with an instrument having the source-receiver separation of about 2 m. We analyzed the sensitivities to the lower layer normalized by those to the upper half-space and estimated the depth of investigation from the sensitivity analyses and the mutual impedance ratio. The computational results showed that the in-phase components of the sensitivity to the lower layer dominates those to the upper layer when the thickness of the upper layer is less than 20 m, while the quadrature components are not sensitive to the lower layer over the entire frequency range. Hence we confirmed that the accurate measurement of the in-phase component is essential to increase the depth of investigation in the multi-frequency small-loop EM survey. When conductive basement of 10 ohm-m underlies the upper layer of 100 ohm-m, an accurate measurement of the in-phase components ensures the depth of the investigation more than 10 m even accounting a noise effect, from which we conclude that the small-loop EM survey is quite effective in imaging the conductive plume down to a considerable depth. On the other hand, in the presence of the resistive basement of 1,000 ohm-m, the depth of investigation may not exceed 5 m considering the instrumental accuracy, which implies that the application of the small-loop EM survey is not recommended over the resistive environment other than detecting the buried conductor.

• YAKHAK HOEJI
• /
• v.54 no.5
• /
• pp.348-353
• /
• 2010

The dissolution test method and an analytical procedure by HPLC were developed and validated for viquidil hydrochloride capsules and alibendol tablets. These drugs were not yet characterized by the dissolution specifications in Korean Pharmaceutical Codex. So, with each reference and test drugs, we did the preliminary and standard experiments based on the Korean Pharmacopeia Guideline of dissolution testing for solid oral dosage forms. The dissolution test for viquidil hydrochloride capsules was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 50 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 30 min in this method. Also the dissolution test for alibendol tablets was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 100 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 45 min in this method. The dissolution samples were analyzed with a precise and accurate HPLC method. The developed dissolution test showed specificity, linearity, precision and accuracy within the acceptable range. The dissolution testing method described above was adequate for the purpose and may be proposed as a pharmacopeial standard to assess the performance of viquidil hydrochloride capsules and alibendol tablets.

• YAKHAK HOEJI
• /
• v.51 no.2
• /
• pp.96-102
• /
• 2007

Measurement of globotriaosylceramide (Gb3, ceramide trihexoside) in urine has clinical importance for monitoring after enzyme replacement therapy in Fabry disease patients. The disease is an X-linked lipid storage disorder that results from a deficiency of the enzyme ${\alpha}$-galactosidase A (${\alpha}$-Gal A). The lack of ${\alpha}$-Gal A causes an intracellular accumulation of glycosphingolipids, mainly Gb3. A simple, rapid, and highly sensitive analytical method for Gb3 in urine was developed without labor-extensive pre-treatment by electrospray ionization MS/MS (ESI-MS/MS). Only simple 5-fold dilution of urine is necessary for the extraction and isolation of Gb3 in urine. Gb3 in diluted urine was dissolved in dioxane containing C17:0 Gb3 as an internal standard. After centrifugation it was directly injected and analyzed through guard column by in combination with multiple reaction monitoring mode of ESI-MS/MS. Eight isoforms of Gb3 were completely resolved from urine matrix. C24:0 Gb3 occupied 50% of total Gb3 as a major component in urine. Linear relationship for Gb3 isoforms was found in the range of 0.005${\sim}$5.0 ${\mu}$g/ml. The limit of detection (S/N=5) was 0.005 ${\mu}$g/ml and limit of quantification was 0.05 ${\mu}$g/ml for C24:0 Gb3 with acceptable precision and accuracy. Correlation coefficient of calibration curves for 8 Gb3 isoforms ranged from 0.9598 to 0.9975. This method could be useful for rapid and sensitive 1st line Fabry disease screening, monitoring and/or diagnostic tool for Fabry disease.

• YAKHAK HOEJI
• /
• v.51 no.2
• /
• pp.133-139
• /
• 2007

A simple and sensitive HPLC-MS method for quantitation of 10${\alpha}$-methoxy-9,10-dihydrolysergol (MDL), the main metabolite of nicergoline, in human plasma was developed and the bioavailability parameters of MDL was assessed in Korean healthy male volunteers. Clomipramine was used as an internal standard. MDL and internal standard in plasma sample were extracted using ethyl acetate. A centrifuged upper layer was then evaporated and reconstituted with mobile phase of 10 mM ammonium acetate-acetonitrile (10 : 90, v/v). The reconstituted samples were injected into a Zorbax SB-C8 column (2.1${\times}$150 mm,5 ${\mu}$m) at a flow-rate of 0.3 ml/min. Using MS with selected ion monitoring (SIM) mode, MDL and clomipramine were detected without severe interference from human plasma matrix. MDL produced a protonated molecular ion ([M+H]$^+$) at m/z 287. Internal standard produced a protonated molecular ion ([M+H]$^+$) at m/z 315. A linear relationship for MDL was found in the range of 2.5${\sim}$100 ng/ml. The lower limit of quantitation (LLOQ) was 2.5 ng/ml with acceptable precision and accuracy. The intra- and inter-day validation for all coefficients of variation (R.S.D.%) were found less than 15%. Main pharmacokinetic parameters of 30 mg of nicergoline were revealed as follows: AUC$_t$ 321.1${\pm}$64.5 ng${\cdot}$hr/ml, C$_{max}$, 51.2${\pm}$25.3 ng/ml, T$_{max}$ 3.6${\pm}$1.5 hr, K$_{el}$ 0.12${\pm}$0.07 hr$^{-1}$ and t$_{1/2}$ 7.6${\pm}$3.4 hr. Inter subject variations and race differences were shown in comparison with the published data in the literature.