• Journal of the Korean Society of Radiology
• /
• v.13 no.1
• /
• pp.133-140
• /
• 2019

Triglycerides (TG) are one of the triggers of chronic inflammatory lesions in the blood vessels. In the key factors in the development of inflammatory diseases, Pro-inflammatory cytokines such as tumor necrosis factor-alpha $(TNF-){\alpha}$ and interleukin-1 beta ($IL-1{\beta}$) contribute to the development of inflammatory lesions by recruiting other immune cells in the inflamed area or causing cell necrotic death. In this study, I investigated the effect of Jurkat T lymphocytes and U937 monocytes involved in vascular inflammation development on the expression of $TNF-{\alpha}$ and $IL-1{\beta}$ on exposure to TGs. In Jurkat cells, mRNA expression of $TNF-{\alpha}$ is increased by exposure to TGs. However, the expression levels of $TNF-{\alpha}$ and $IL-1{\beta}$ were increased by TGs in U937 cells. To investigate whether inducible nitric oxide synthase (iNOS) is involved in the increase of expression of $TNF-{\alpha}$ and $IL-1{\beta}$ by TGs, treatment of W1400 (an iNOS inhibitor) resulted in recovery of expression level both $TNF-{\alpha}$ and $IL-1{\beta}$. Based on the present study, it was confirmed that the expression of $TNF-{\alpha}$ and $IL-1{\beta}$ in monocytes and T lymphocytes. This increased cytokines contribute to development of vascular inflammatory lesions. In addition, iNOS is involved in the increase of $TNF-{\alpha}$ and $IL-1{\beta}$ expression by TGs.

• Journal of the Korean Society of Radiology
• /
• v.15 no.2
• /
• pp.257-263
• /
• 2021

This study derives the relative cross-section for the natW(p,xn)176Re nuclear reaction by measuring the gamma rays generated from the nuclear reaction with natural tungsten using a 100 MeV linear accelerator of the Korea Multi-purpose Accelerator Complex in the Korea Atomic Energy Research Institute. In general, research on isotopes with a short half-life always shows a tendency that the intensity of radioactivity decreases rapidly within a short period of time, making it very difficult to measure itself. In particular, 176Re is one of the relatively short radionuclides with a half-life of 5.3 minutes. In this study, 109.08 keV gamma rays generated from the 176Re isotope having such a short half-life were measured using a high-purity Ge detector(HPGe detector). The obtained relative measurements were the results in the 8 to 14 MeV proton energy domain published by Richard G. in 1967, and the TENDL-2019 value, which was the result of A. J. Koning in 2019, which evaluated the nuclear reaction cross-section by calculation based on this comparative analysis was performed. The results of this study are expected to be usefully applied to the design of nuclear fusion reactor which is known as future energy sources, elements ratio for the nuclear synthesis of astrophysics.

• Journal of the Korean Society of Radiology
• /
• v.14 no.7
• /
• pp.981-989
• /
• 2020

In this study, a self-made customized phantom was used to quantitatively measure the change in CT number and noise according to the change of pitch. In order to acquire an image using the phantom, the inside of the phantom was filled with sterile distilled water. Inside the glass tube, a solution obtained by diluting the ratio of normal saline and contrast medium to 100%(NS), 400:1, 200:1, 100:1, 50:1, respectively, was placed and imaged. At this time, the pitch was divided into steps of 0, 0.35, 0.7, 1.05, and 1.4 for each dilution ratio of the solution and imaged, respectively. One-way ANOVA analysis were performed to verify whether the mean of the CT number and noise values measured in all ROIs by dilution ratio showed a significant difference according to the change in pitch. As a result of the experiment, there was no statistically significant difference in the change of the CT number according to the change in the pitch for each dilution ratio, but the noise value tended to increase with the increase of the pitch, and showed a statistically significant difference. In the spiral image acquisition of CT, noise can be changed to a significant level depending on the pitch. Therefore, it will be necessary to set the quality evaluation items and criteria for CT images using the spiral image acquisition method.

• Journal of the Korean Society of Radiology
• /
• v.14 no.7
• /
• pp.1003-1011
• /
• 2020

This study aims to compare and evaluate the image differences between single and dual sources in applying a technique to reduce metal artifacts using dual energy CT. Discovery CT 256 (GE, USA) as a single source device and Somatom Definition Flash (Siemens Health Care, Forchheim, Germany) as a dual source device. The self-made phantom (pigs with medical titanium screws inserted) was quantitative and qualitatively evaluated under the same conditions by varying the dose under the same conditions using a dual energy CT. The evaluation method was compared by measuring SNR for metal artifacts (scattering, stripe) generated by metal inserts, divided around bones and around tissues. There was a difference in images in the method of reducing metal artifacts between single-source and dual-source devices. In a single source device, the linearized prosthesis by metal implantation showed a greater decrease than the image obtained from a double source device, and the surrounding tissue was well observed without interference from the artifact. In dual-source devices, scattering and stripe artifacts caused by metal inserts decreased more than on a single source device, and signals from adjacent tissues surrounding the metal implant were well observed without diminishing. If the examination is conducted separately between single source and dual source devices depending on whether the area to which the patient is intended to be viewed during the examination is adjacent to the metal insert or the total tissue surrounding the metal insert, it is believed that diagnostic helpful images can be obtained.

• Journal of the Korean Society of Radiology
• /
• v.14 no.7
• /
• pp.871-879
• /
• 2020

The purpose of this study was to analysis the correlation between kidneys function indicators and these size in ultrasonography. A total of 170 (male:86, female:84) patients of sex and age groups were examined by abdominal ultrasonography. The patients classified as those in their 20's, 30's, 40's, and over 50's. We measured the length, width, and cross-sectional height of the kidneys twice. At this time, the length of these were measured from the maximum upper to the maximum lower pole and the widest width in the same ultrasonography was measured to obtain the cross-sectional area. Other relevant indicators included body surface area, serum creatinine, glomerular filtration rate (GFR), MDRD (Modification of diet in renal disease) and C-G (Cockcroft-Gault). Significant comparisons of differences between relevant factors by age groups and sex were conducted with a one-way distribution analysis. Correlation analysis was also performed between relevant factors by using Pearson and Spearman correlation coefficient. It was defined as meaningful when the p-value was less than 0.05. As a result, the length, the width, and the cross-sectional area of kidneys were correlated with GFR, C-G, MDRD. Therefore, it is expected that the accuracy of diagnosis of kidneys disease will be increased if the relevant indicators are evaluated together rather than measuring only length of these in ultrasonography.

• Journal of the Korean Society of Radiology
• /
• v.14 no.7
• /
• pp.915-922
• /
• 2020

This study analyzed the content of use Tendency and addiction according to smartphone use of targeting radiological Technologist working in Gyeongnam area. The tool used as the data for the study is a survey. From April 21 to May 31, 2019, a total of 330 questionnaires were distributed to radiological Technologist working at medical institutions in Gyeongnam, and 300 copies suitable for the study were SPSS/PC Ver 18.0 program for Analysis was performed using. The factors of the study subject's tendency to use smartphone were communication, information, leisure, and convenience. As for the addiction factors, a total of 37 questions were analyzed, including daily living disorder, virtual world orientation, tolerance, and withdrawal. Smartphone-related characteristics were set as monthly average fee, usage time, and SNS usage time, and technical statistics, t-test, ANOVA, correlation and regression analysis were performed. The radiological Technologist tendency to use smartphones was 3.10±.55 points, which was average, and smartphone addiction was 2.34±.62 points, which was lower than the average. It was found that there was a significant correlation between the radiological Technologist Tendency to use smartphone and addiction. The effect of radiological Technologist tendency to use smartphone on addiction it was found to account for 10.8%. Through this study, it can be said that it is important to analyze the addiction factors according to the tendency use smartphone of radiological Technologist and to prepare a desirable plan for smartphone use.

• Journal of the Korean Society of Radiology
• /
• v.15 no.4
• /
• pp.473-479
• /
• 2021

The diagnostic criteria for diffuse thyroid disease are ambiguous and there are many errors due to the subjective diagnosis of experts. Also, studies on ultrasound imaging of thyroid nodules have been actively conducted, but studies on diffuse thyroid disease are insufficient. In this study, features were extracted by applying the GLCM algorithm to ultrasound images of normal and diffuse thyroid disease, and quantitative analysis was performed using the extracted feature values. Using the GLCM algorithm for thyroid ultrasound images of patients diagnosed at W hospital, 199 normal cases, 132 mild cases, and 99 moderate cases, a region of interest (50×50 pixel) was set for a total of 430 images, and Autocorrelation, Sum of squares, sum average, sum variance, cluster prominence, and energy were analyzed using six parameters. As a result, in autocorrelation, sum of squares, sum average, and sum variance four parameters, Normal, Mild, and Moderate were distinguished with a high recognition rate of over 90%. This study is valuable as a criterion for classifying the severity of diffuse thyroid disease in ultrasound images using the GLCM algorithm. By applying these parameters, it is expected that errors due to visual reading can be reduced in the diagnosis of thyroid disease and can be utilized as a secondary means of diagnosing diffuse thyroid disease.

• Journal of the Korean Society of Radiology
• /
• v.15 no.4
• /
• pp.409-414
• /
• 2021

In order to acquire an image from a gamma camera, linearity correction must be performed. To this end, digital coordinates are acquired by using a linearity map to accurately specify the location where the scintillator and gamma rays interact. In this study, a method for acquiring undistorted images and digital coordinates was developed using a lookup table and maximum likelihood position estimation without using a linearity map. The proposed method was verified by configuring a small gamma camera through DETECT2000 simulation. A gamma camera was constructed using a GAGG scintillator and a SiPM optical sensor, and a gamma-ray interaction was generated at the center of the scintillator, and a lookup table was prepared using the ratio of the signals obtained from the SiPM. Through the prepared lookup table and the maximum likelihood position estimation, the position of the signal obtained by the gamma-ray interaction was acquired as digital coordinates to compose an image. As a result, the linearity was maintained compared to the generally acquired image, the accuracy of the location where the gamma-ray interaction was generated was excellent, and the distance between the locations was uniform. Since the lookup table obtained through simulation is created using the ratio of the signal, it can be directly used in the experiment, and the position of the signal can be conveniently obtained with digital coordinates with corrected linearity without creating a linearity map.

• Journal of the Korean Society of Radiology
• /
• v.16 no.2
• /
• pp.157-162
• /
• 2022

Since preclinical positron emission tomography imaging is performed on small animals that are very small compared to the human body, a detector with excellent spatial resolution is required. For this purpose, a system was constructed using a detector using small scintillation pixels. Since the size of the currently developed and used photosensors is limited, excellent spatial resolution can be obtained when the minimum scintillation pixel and maximum array are used. In this study, the size of the photosensor is fixed and various scintillation pixel arrays are configured to match the size of the scintillation pixels, so that no overlap occurs in the flood image and the maximum scintillation pixel array in which all scintillation pixels are distinguished. For this purpose, DETECT2000, which can simulate a detector module composed of a scintillator and an photosensor, was used. A photosensor consisting of a 4 × 4 array of 3 mm × 3 mm pixels was used, and the scintillation pixel array was configured from 8 × 8 to 13 × 13, and simulations were performed. A flood image was constructed using the data obtained from the photosensor pixel, and the maximum scintillation pixel array that does not overlap the image was found through the flood image and the profile. As a result, the size of the scintillation pixel array in which all scintillation pixels are imaged without overlapping each other in the flood image was 11 × 11.

• Journal of the Korean Society of Radiology
• /
• v.16 no.3
• /
• pp.273-279
• /
• 2022

In order to reduce the absorbed dose given to the patient during dental radiography, a sensor that inserts a shield into the intraoralsensor was designed. Using the designed sensor, the change in absorbed dose depending on whether or not a shield was used was evaluated. The system used to evaluate the absorbed dose is VEX-S300C from Vatech, and the energy spectrum of X-rays was obtained through SPEKTR simulation based on the irradiation conditions of 65 kV, 3 mA, and 0.15 sec, and the number of photons for each energy was derived. After designing the system through Genat4 Application for Tomographic Emission(GATE) simulation, the energy spectrum obtained was used as a radiation source to calculate the absorbed dose. Lead was used for the shield, and simulations were performed at 0.1 mm thickness intervals from 0.1 mm to 0.5 mm was evaluated. In the case of using an X-ray field with a diameter of 60 mm, the decrease in absorbed dose according to the presence or absence of a shield decreased exponentially as the thickness of the shield increased. In addition, when a 20 mm × 30 mm field was used, the absorbed dose was significantly reduced even when no shield was used, and it was confirmed that the absorbed dose was further reduced when a shield was used.