• Title/Summary/Keyword: Radiation effect

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Is it possible to treat COVID-19 pneumonia by low-dose radiation?

  • Jae Min Jeong
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.7 no.1
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    • pp.50-55
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    • 2021
  • Low-dose radiotherapy has been known to have anti-inflammatory activity and been used for treatment of pneumonia together with anti-serum and sulfanilamide. However, it rapidly discontinued after the development of various antibiotics showing outstanding effect. Recently, it was re-considered to treat COVID-19 which has very limited treatment such as remdesivir and dexamethasone. So, several studies of COVID-19 therapy using low-dose radiation were reported very recently. They showed that low-dose radiation of 0.5~1.5 Gy were useful for decreasing the oxygen consumption and hospitalization period of COVID-19 patients without adverse reaction. Radiopharmaceuticals such as [99mTc]Tc-macroaggregated albumin (MAA) also might be used for low-dose radiotherapy. Administration of vitamin D having anti-inflammatory effect would also be helpful for therapy with synergistic effect.

The Variation of UV Radiation by Cloud Scattering at King Sejong Station in West Antarctica (남극 세종기지에서의 구름 산란에 의한 자외선 변화)

  • Lee, Kyu-Tae;Lee, Bang-Yong;Won, Young-In;Kim, Youn-Joung;Lee, Won-Hak;Jee, Joon-Bum
    • Ocean and Polar Research
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    • v.26 no.2
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    • pp.133-143
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    • 2004
  • For the purpose of understanding the cloud scattering effect of UV radiation at King Sejong station In West Antarctica, we analyzed the data measured by UV-Biometer at surface and compared its result with solar radiation model. The parameterization of UV radiation by cloud ice crystal was applied to solar radiation model and the sensitivity of this model for the variation of ice crystal was tested. The cloud optical thickness was calculated by using this solar radiation model. It was compared the result from calculation with CERES satellite data. In solar radiation model, the UV radiation was less scattered with increase of ice crystal size in cloud and this scattering effect was more important to UV-A radiation than Erythemal UV-B radiation. But scattering effects by altitude of cloud was not serious. The calculated cloud optical thicknesses in Erythemal UV-B and UV-A region were compared with CERES satellite data and the result by UV-A was more accurate than Erythemal UV-B region.

Effect of Gamma Irradiation on Microbial Populations in the Dried Raw Materials and Saengsik Powder (감마선 조사에 따른 원료분말 및 생식의 미생물 제어 효과)

  • Choi, Soo-Jeong;Park, Jae-Nam;Song, Beom-Seok;Yoon, Young-Min;Han, In-Jun;Park, Jong-Heum;Kim, Jae-Kyung;Byun, Eui-Baek;Lee, Ju-Woon;Hong, Seong-Gil;Yook, Hong-Sun;Kim, Jae-Hun
    • Journal of Radiation Industry
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    • v.7 no.2_3
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    • pp.177-182
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    • 2013
  • This study was conducted to evaluate the effect of gamma irradiation on the microbial populations of dried raw materials (9 products) and Saengsik powder. The samples were gammairradiated at doses of 2, 4, 6 and 8 kGy and the microbiological populations were evaluated. The total numbers of bacteria and Bacillus cereus in non-irradiated dried-raw materials for Saengsik powder was 1.3~3.4 and $1.7{\sim}2.4log\;CFU\;g^{-1}$. However, gamma irradiation reduced the microbiological populations in all samples, and Saengsik powder were sterilized at more than 6 kGy. Moreover, Clostridium perfringens were not observed in all samples within detection limit (<$1log\;CFU\;g^{-1}$). Therefore, the results of this study suggest that gamma irradiation at 6 kGy is sufficient to sterilize Saengsik powder, and thus, irradiated Saengsik powder at 6 kGy fulfills the microbiological requirements for sterilized food.

The Effect of Gamma Irradiation on the Survival of Lactic Acid Isolated from Commercial Daily Product (시판 유제품 중에서 분리된 젖산균의 감마선 조사에 의한 생존 효과)

  • Lee, Ji-hye;Kim, Jae-Kyung;Jo, Eu-Ri;Sung, Nak-Yun;Choi, Jong-Il;Kim, Jae-Hun;Song, Beom-Seok;Park, Jong-Heum;Yook, Hong-Sun;Lee, Ju-Woon
    • Journal of Radiation Industry
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    • v.5 no.2
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    • pp.175-178
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    • 2011
  • This study was conducted with effect of lactic acid bacteria by gamma irradiation. Lactic acid bacteria were exposed to irradiation with a single absorbed dose of 1, 2, 3, 4, 5, 6, 8, and 10 kGy. Possible lactic acid bacteria, including Lactobacillus paracasei KCTC 13169, Lactobacillus casei KCTC 3109, Lactobacillus acidophilus KCTC 3140, Lactobacillus plantarum subsp plantarum KCTC 3103, Lactobacillus debruekii subsp bulgaricus KCTC 3635, Streptococcus thermophilus KCTC 3658 were selected. The radiation sesitivities of lactic acid bacteria were expressed as $D_{10}$ values. The $D_{10}$ values of Lactobacillus paracasei, Lactobacillus casei, Streptococcus thermophilus, Lactobacillus acidophilus, Lactobacillus plantarum, and Lactobacillus debruekii were calculated as 0.42, 0.51, 0.47, 0.90, 0.44, and 0.61 kGy, respectively. Results suggest that L. acidiphilus has the highly resistant to gamma irradiation.

Analysis of a gas-particle direct-contact heat exchanger with two-phase radiation effect (복사효과를 고려한 기체-입자 직접접촉식 열교환기 해석)

  • Park, Jae-Hyeon;Baek, Seung-Uk;Gwan, Se-Jin
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.22 no.4
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    • pp.542-550
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    • 1998
  • A direct contact heat exchanger using particle-suspended gas as a heat transfer medium is analyzed with an extended emphasis on the radiation, i. e., considering the radiation by both gas and particles. While the Runge-Kutta method is used for a numerical analysis of the momentum and energy equations, the finite volume method is utilized to solve the radiative transfer equation. Present study shows a notable effect by the gas radiation in addition to the particle radiation, especially when changing the chamber length as well as the gas and particle mass flow rate. When the gas and particle mass flow rate is raised, the gas temperature in the particle heater still increases as the gas absorption coefficient increases, which is different from the results for the small scale heat exchanger.

RADIATION HEAT TRANSFER IN HORIZONTAL CYLINDRICAL ANNULUS (수평원관 사이 환상유로에서의 복사열전달 연구)

  • Han, C.Y.;Park, E.S.;Jeon, H.Y.;Yu, M.J.
    • 한국전산유체공학회:학술대회논문집
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    • 2011.05a
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    • pp.75-77
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    • 2011
  • Thermofluid flow analysis is major subject in most computational fluid dynamics applications. Accompanying convective and conductive heat transport phenomena, radiation plays an important role in high temperature operating systems. Cares in which the radiation dominates are found in such systems as boilers, furnaces, rocket engines, etc. In this paper the finite-volume method (FVM) are employed to simulate two-dimensional radiation problems in concentric and eccentric horizontal cylindrical annuli with general body-fitted coordinates. In that case the simplest and intuitive remedies are proposed for mitigation of ray effect.

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A novel p53-activating radioresponse regulator

  • Jung, Hyun-Ju;Kim, Eun-Hee;Lee, Yun-Sil;Bae, Sang-Woo
    • Proceedings of the Korean Nuclear Society Conference
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    • 2005.05a
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    • pp.1008-1009
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    • 2005
  • In order to screen ionizing radiation induced early-response genes, we employed subtractive hybridization method and isolated a metabolism associated gene. The gene expression was very sensitive to ionizing radiation as revealed by a rapid induction of its messenger RNA. We characterized the function of this gene in radiation response. This gene activated p53 and enhanced cell killing effect of ionizing radiation. This effect was attributable to p53 phosphorylation and transcriptional activation.

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Analysis of Learning Effect of Online Learning Application for Radiation Therapy Major (방사선치료학 전공의 온라인 학습 애플리케이션 학습효과 분석)

  • Dae-Gun, Kim;Sungchul, Kim
    • Journal of radiological science and technology
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    • v.45 no.6
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    • pp.515-522
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    • 2022
  • The aim of the study was analyzed effect of the interaction with contents (IC), learning satisfaction (LS) and learning achievement (LA) through evaluation of the self-directed learning ability (SDLA) and immersion in learning (IL) for online learning application in the radiation therapy. A total of fifty university students who completed the radiation therapy course were be surveyed. There was significant positive correlation with the IC and the intention to continue using (ICU) in SDLA, and IC, LS, LA, and ICU in LC. The online learning application could be increase the satisfaction and achievement of radiation therapy learning.

Sensitization of Radiation-Induced Cell Death by Genistein (제니스틴에 의한 방사선유발 세포사멸 민감도증가)

  • Kim, Tae Rim;Kim, In Gyu
    • Journal of Radiation Industry
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    • v.4 no.1
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    • pp.91-94
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    • 2010
  • A number of epidemiological studies as well as biological experiments, showed that genistein, one of the isoflavone, prevents prostate cancer occurrence. In this study, we showed that genistein inhibited the cell proliferation of human promyeoltic leukemia HL-60 cells and induced G2/M phase arrest. In addition, combination of genistein treatment and ${\gamma}$-irradiation displayed synergistic effect in apoptotic cell death of HL-60 cells. This means that the repair of genistein-induced DNA damage was hindered by ${\gamma}$-radiation and thus cell death was increased. In conclusion, genistein is one of the important chemicals that sensitize radiation-induced cell death.