Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
권호 표지

Sensitization of Radiation-Induced Cell Death by Genistein

제니스틴에 의한 방사선유발 세포사멸 민감도증가

  • Kim, Tae Rim (Department of Radiation Biology, Environment Radiation Research Group, Korea Atomic Energy Research Institute) ;
  • Kim, In Gyu (Department of Radiation Biology, Environment Radiation Research Group, Korea Atomic Energy Research Institute)
  • 김태림 (한국원자력연구원 원자력환경안전연구부 방사선생물학연구실) ;
  • 김인규 (한국원자력연구원 원자력환경안전연구부 방사선생물학연구실)
  • Received : 2010.03.04
  • Accepted : 2010.03.12
  • Published : 2010.03.30

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Abstract

A number of epidemiological studies as well as biological experiments, showed that genistein, one of the isoflavone, prevents prostate cancer occurrence. In this study, we showed that genistein inhibited the cell proliferation of human promyeoltic leukemia HL-60 cells and induced G2/M phase arrest. In addition, combination of genistein treatment and ${\gamma}$-irradiation displayed synergistic effect in apoptotic cell death of HL-60 cells. This means that the repair of genistein-induced DNA damage was hindered by ${\gamma}$-radiation and thus cell death was increased. In conclusion, genistein is one of the important chemicals that sensitize radiation-induced cell death.

Keywords

Acknowledgement

Supported by : 교육과학기술부