• Korean Journal of Pharmacognosy
• /
• v.38 no.1
• /
• pp.71-75
• /
• 2007

Acute toxicity of BDR-29, a combined preparation of Cassia Semen, Prunellae Spica, Tribuli Fructus, and Uncariae Rhamulus et Uncus was examined using male and female Sprague-Dawley rats. Rats were treated with the BDR-29 intra-gastrically at 0 mg/kg, 5 mg/kg, 50 mg/kg, 500 mg/kg or 2,000 mg/kg and observed for two weeks. At the doses used no mortality or abnormal clinical signs in animals were shown during at the observation period. Also there was no difference in net body weight gain, gross pathological findings, and urine analysis at the terminal sacrifice among the groups rats treated with different doses of the test substance. The results suggested that acute oral toxicity of BDR-29 in rats is very low at the conditions employed in this study.

• Proceedings of the Korean Society of Agricultural Engineers Conference
• /
• 2005.10a
• /
• pp.232-240
• /
• 2005

There are positive evaluation as well as negative evaluation for Rural Industrial Park Project which was implemented since 1984 to boom up the regional economy in Korea. By conducting a survey for Rural Industrial Park enterprises located in Miryang-si, this study intends to examine the management condition of enterprises in Rural Industrial Parks and so derive the policy suggestion. According to the secondary data and the survey results, Rural Industrial Parks play an important role in the regional economy. The result of the survey shows that the enterprises are dissatisfied with excessively high distributing costs and they want improvement of roads and transportation condition. They recruit their employees mainly through advertisement and loan money from banks. One of serious problems is giving up the business due to shortage of fund or failing to find the markets. To prevent quitting business, a preliminary analysis of the feasibility of running business should be conducted. Technology and management guidance and marketing support are necessary not only for new enterprises, but for existing enterprises. Alternatives for connecting local resources and Rural Industrial Park and forming a network between local universities, institutes, and firms should be considered.

• Proceedings of the PSK Conference
• /
• 2005.11a
• /
• pp.136-136
• /
• 2005

• Proceedings of the KIEE Conference
• /
• 2008.07a
• /
• pp.2001-2004
• /
• 2008

모든 심전도 압축에서는 압축율과 신호왜곡간의 관계를 다루며 이는 매우 중요하다. 특별히 임상적인 의미를 가진다고 평가되는 5%의 Percent Root mean square Difference(PRD)값을 만족 시키면서 높은 압축율을 얻기 위한 연구는 필수적이다. 본 논문에서는 DCT를 사용하여 심전도 압축을 수행하였을 때, 심전도의 주요한 파라미터인 파형과 RRI(R-R Interval)가 압축율에 따라 어떻게 변화하는지를 평가하고 심전도의 두 가지 주요 파라미터를 진단정보의 왜곡 없이 압축할 수 있는 DCT계수 및 압축율을 도출해 내었다. 실험에는 MIT-BIH ECG Compression Test Database를 사용하였으며 DCT압축을 수행하였을 때 5 % 이하의 PRD를 확보하기 위해서는 81개 샘플에 대하여 평균 4.496 : 1, 최하 3.422 : 1 의 CR을 가지는 것을 확인할 수 있었으며, QRS를 올바르게 검출하는 범위에서의 78개의 샘플에 대하여 평균 CR은 17.3 : 1 최저 CR은 4.6512 : 1 로 나타났다. QRS 검출 한계에서의 RRI 시간왜곡은 평균 3.7149 $\pm$ 4.3147 ms로 나타났으며, 최대 시간왜곡은 13.0256 $\pm$ 14.2035 ms 로 조사되었다.

• Annual Conference of KIPS
• /
• 2015.10a
• /
• pp.1381-1383
• /
• 2015

스마트폰에 내장된 카메라를 이용해 손가락 끝에서 맥박 신호를 획득한 후, peak detection 알고리즘에 적용하여 실시간 R-R interval(RRI)를 구한다. 각 RRI의 값을 바탕으로 스마트폰 위에 애니메이션 이미지를 보여준다. 이와 같은 스마트폰기반 심장박동 홀로그램은 투명한 OHP 필름을 스마트폰 스크린위에 설치하여 실제 심장의 움직임을 모니터링 할 수 있게 한다.

• Journal of Electrical Engineering and Technology
• /
• v.12 no.1
• /
• pp.346-355
• /
• 2017

Atrial fibrillation (AF) and Congestive heart failure (CHF) are increasingly widespread, costly, deadly diseases and are associated with significant morbidity and mortality. In this study, we analyzed three statistical methods for automatic detection of AF and CHF based on the randomness, variability and complexity of the heart beat interval, which is RRI time series. Specifically, we used short RRI time series with 16 beats and employed the normalized root mean square of successive RR differences (RMSSD), the sample entropy and the Shannon entropy. The detection performance was analyzed using four large well documented databases, namely the MIT-BIH Atrial fibrillation (n=23), the MIT-BIH Normal Sinus Rhythm (n=18), the BIDMC Congestive Heart Failure (n=13) and the Congestive Heart Failure RRI databases (n=25). Using thresholds by Receiver Operating Characteristic (ROC) curves, we found that the normalized RMSSD provided the highest accuracy. The overall sensitivity, specificity and accuracy for AF and CHF were 0.8649, 0.9331 and 0.9104, respectively. Regarding CHF detection, the detection rate of CHF (NYHA III-IV) was 0.9113 while CHF (NYHA I-II) was 0.7312, which shows that the detection rate of CHF with higher severity is higher than that of CHF with lower severity. For the clinical 24 hour data (n=42), the overall sensitivity, specificity and accuracy for AF and CHF were 0.8809, 0.9406 and 0.9108, respectively, using normalized RMSSD.

• The Korean Journal of Pain
• /
• v.22 no.1
• /
• pp.39-46
• /
• 2009

Background: Ketamine has an indirect sympathetic stimulation effect. We investigated heart rate variability (HRV) as a marker of cardiac autonomic function after a target controlled infusion (TCI) of ketamine with a plasma concentration of 30 or 60 ng/ml. Methods: In 20 adult volunteers, the mean of the R wave to the adjacent R wave interval (RRI), the range of RRI, the root mean square successive difference of intervals (RMSSD), the total power, the low frequency (LF, 0.04-0.15 Hz) power, the high frequency (HF, 0.15-0.4 Hz) power, the normal unit HF (nuHF), the normal unit LF (nuLF), the LF/HF ratio and the SD1 and the SD2 in the Poincare plot were measured before and after a TCI of ketamine. We observed for any psychedelic symptoms or sedation. Results: There were no differences in the mean and range of the RRI, RMSSD, total power, LF power, HF power, nuHF, nuLF, LF/HF ratio, SD1 and SD2 between before and after ketamine administration. The OAA/S score was higher and there were more psychedelic symptoms with a 60 ng/ml plasma concentration than with a 30 ng/ml plasma concentration. Conclusions: This study did not show any effect of a low plasma concentration of ketamine on the autonomic nervous system.

• Journal of Food Hygiene and Safety
• /
• v.22 no.2
• /
• pp.93-98
• /
• 2007

Acute toxicity of WK-38, a herbal preparation for the atherosclerosis, was examined using male and female Sprague-Dawley rats. WK-38 is composed of Rhei Rhizoma, Magonoliae Cortx, Moutan Cortex Radicis. Rats were treated with the WK-38 intragastrically at 0 mg/kg, 5 mg/kg, 50 mg/kg, 500 mg/kg or 2,000 mg/kg and observed for two weeks. No mortality was observed at the doses used. Abnormal clinical signs such as eye bleeding, nasal bleeding and hyperemia had been shown temporary after administration. All rats were appeared to be healthy and normal during the 2 week observation. Also there was no difference in net body weight gain, gross pathological findings, and urine analysis among the groups rats treated with different doses of the WK-38.

• Kosin Medical Journal
• /
• v.33 no.3
• /
• pp.369-379
• /
• 2018

Objectives: Analysis of heart rate variability (HRV) has been used as a measure of cardiac autonomic function. According to the pNN50 statistic, the percentage of differences between successive normal RR intervals (RRI) that exceed 50 ms, has been known to reflect cardiac vagal modulation. Relatively little is known about the validity of pNN50 during general anesthesia (GA). Therefore, we evaluated the correlation of pNN50 with other variables such as HF, RMSSD, SD1 of HRV reflecting the vagal tone, and examined the validity of pNN50 in anesthetized patients. Methods: We assessed changes in RRI, pNN50, root mean square of successive differences of RRI (RMSSD), high frequency (HF) and standard deviation 1 (SD1) of $Poincar{\acute{e}}$ plots after GA using sevoflurane anesthesia. We also calculated the probability distributions for the family of pNNx statistics (x: 2-50 ms). Results: All HRV variables were significantly decreased during GA. HF power was not correlated with pNN50 during GA (r = 0.096, P = 0.392). Less than pNN47 was shown to have a correlation with other variables. Conclusions: These data suggest that pNN50 can not reflect the level of vagal tone during GA.

• Korean Journal of Agricultural Science
• /
• v.48 no.3
• /
• pp.433-446
• /
• 2021

In this study, the future flood inundation changes under a climate change were simulated in the Tonle Sap basin in Cambodia, one of the countries with high vulnerability to climate change. For the flood inundation simulation using the rainfall-runoff-inundation (RRI) model, globally available geological data (digital elevation model [DEM]; hydrological data and maps based on Shuttle elevation derivatives [HydroSHED]; land cover: Global land cover facility-moderate resolution imaging spectroradiometer [GLCF-MODIS]), rainfall data (Asian precipitation-highly-resolved observational data integration towards evaluation [APHRODITE]), climate change scenario (HadGEM3-RA), and observational water level (Kratie, Koh Khel, Neak Luong st.) were constructed. The future runoff from the Kratie station, the upper boundary condition of the RRI model, was constructed to be predicted using the long short-term memory (LSTM) model. Based on the results predicted by the LSTM model, a total of 4 cases were selected (representative concentration pathway [RCP] 4.5: 2035, 2075; RCP 8.5: 2051, 2072) with the largest annual average runoff by period and scenario. The results of the analysis of the future flood inundation in the Tonle Sap basin were compared with the results of previous studies. Unlike in the past, when the change in the depth of inundation changed to a range of about 1 to 10 meters during the 1997 - 2005 period, it occurred in a range of about 5 to 9 meters during the future period. The results show that in the future RCP 4.5 and 8.5 scenarios, the variability of discharge is reduced compared to the past and that climate change could change the runoff patterns of the Tonle Sap basin.