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http://dx.doi.org/10.3344/kjp.2009.22.1.39

The Effect of a Target Controlled Infusion of Low-Concentration Ketamine on the Heart Rate Variability of Normal Volunteers  

Jung, Jai Yun (Department of Anesthesiology and Pain Medicine, Sanbon Hospital, College of Medicine, Wonkwang University)
Lee, Jun Ho (Department of Anesthesiology and Pain Medicine, Bucheon Hospital, Soonchunhyang University College of Medicine)
Lee, Jeong Seok (Department of Anesthesiology and Pain Medicine, Bucheon Hospital, Soonchunhyang University College of Medicine)
Kim, Yong Ik (Department of Anesthesiology and Pain Medicine, Bucheon Hospital, Soonchunhyang University College of Medicine)
Publication Information
The Korean Journal of Pain / v.22, no.1, 2009 , pp. 39-46 More about this Journal
Abstract
Background: Ketamine has an indirect sympathetic stimulation effect. We investigated heart rate variability (HRV) as a marker of cardiac autonomic function after a target controlled infusion (TCI) of ketamine with a plasma concentration of 30 or 60 ng/ml. Methods: In 20 adult volunteers, the mean of the R wave to the adjacent R wave interval (RRI), the range of RRI, the root mean square successive difference of intervals (RMSSD), the total power, the low frequency (LF, 0.04-0.15 Hz) power, the high frequency (HF, 0.15-0.4 Hz) power, the normal unit HF (nuHF), the normal unit LF (nuLF), the LF/HF ratio and the SD1 and the SD2 in the Poincare plot were measured before and after a TCI of ketamine. We observed for any psychedelic symptoms or sedation. Results: There were no differences in the mean and range of the RRI, RMSSD, total power, LF power, HF power, nuHF, nuLF, LF/HF ratio, SD1 and SD2 between before and after ketamine administration. The OAA/S score was higher and there were more psychedelic symptoms with a 60 ng/ml plasma concentration than with a 30 ng/ml plasma concentration. Conclusions: This study did not show any effect of a low plasma concentration of ketamine on the autonomic nervous system.
Keywords
autonomic nervous system; ketamine; target controlled infusion;
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