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Single Oral Dose Toxicity Study of WK-38 in Rats  

Chang, Bo-Yoon (College of Pharmcy, Wonkwang University)
Kim, Yoon-Chul (College of Pharmcy, Wonkwang University)
Lee, An-Sook (Korea Professional Graduate School of Oriental Medicine, Research Institute(MeRRI), Wonkwang University)
Kang, Dae-Gill (Korea Professional Graduate School of Oriental Medicine, Research Institute(MeRRI), Wonkwang University)
Lee, Ho-Sub (Korea Professional Graduate School of Oriental Medicine, Research Institute(MeRRI), Wonkwang University)
Kim, Sung-Yeon (College of Pharmcy, Wonkwang University)
Publication Information
Journal of Food Hygiene and Safety / v.22, no.2, 2007 , pp. 93-98 More about this Journal
Abstract
Acute toxicity of WK-38, a herbal preparation for the atherosclerosis, was examined using male and female Sprague-Dawley rats. WK-38 is composed of Rhei Rhizoma, Magonoliae Cortx, Moutan Cortex Radicis. Rats were treated with the WK-38 intragastrically at 0 mg/kg, 5 mg/kg, 50 mg/kg, 500 mg/kg or 2,000 mg/kg and observed for two weeks. No mortality was observed at the doses used. Abnormal clinical signs such as eye bleeding, nasal bleeding and hyperemia had been shown temporary after administration. All rats were appeared to be healthy and normal during the 2 week observation. Also there was no difference in net body weight gain, gross pathological findings, and urine analysis among the groups rats treated with different doses of the WK-38.
Keywords
WK-38; Acute oral toxicity; Rats; Atherosclerosis;
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