• The Korean Journal of Physiology and Pharmacology
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• v.11 no.1
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• pp.1-7
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• 2007

Altered environmental gravity, including both hypo- and hypergravity, may result in space adaptation syndrome. To explore the characteristics of this adaptive plasticity, the expression of immediate early gene c-fos mRNA in the vestibular related tissues following an exposure to hypergravity stimulus was determined in rats. The animals were subjected to a force of 2 g (twice earth's gravity) for 1, 3, or 12 h, and were examined poststimulus at 0, 2, 6, 12, and 24 h. RT-PCR (reverse transcription polymerase chain reaction) and real-time quantitative RT-PCR were adopted to analyze temporal changes in the expression of c-fos mRNA. The hypergravity stimulus increased the expression of c-fos mRNA in the vestibular ganglion, medial vestibular nucleus, inferior vestibular nucleus, hippocampus, cerebellum, and cortex. The peak expression occurred at 0 h poststimulation in animals stimulated with hypergravity for 1 h, and at 6 h poststimulus in those stimulated for 3 h. In contrast, those stimulated for 12 h exhibited dual peaks at 0 and 12 h poststimulus. Bilateral labyrinthectomy markedly attenuated the degree of c-fos mRNA expression. Glutamate receptor antagonist also dramatically attenuated the degree of c-fos mRNA expression. These results indicate that expression of c-fos mRNA in response to hypergravity occurs in the vestibular related tissues of the central nervous system, in which peripheral vestibular receptors and glutamate receptors play an important role. The temporal pattern of c-fos mRNA expression depended on the duration of the hypergravity stimulus.

• Journal of Korean Society of Steel Construction
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• v.23 no.4
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• pp.429-438
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• 2011

In this study, the explicit numerical algorithm was proposed to simulate the stress erection process and ultimate-load analysis of the strarch (stressed arch) system. The strarch system is a unique and innovative structural system and member prestress comprising prefabricated plane truss frames erected through a post-tensioning stress erection procedure. The flexible bottom chord, which has sleeve and gap details, is closed by the reaction force of the prestressing tendon. The prestress imposed on the tendon will enable the strarch system to be erected. This post-tensioning process is called "stress erection process." During this process, plastic rigid-body rotation occurs to the flexible top chord due to the excessive amount of plastic strain, and the structural characteristic is unstable. In this study, the dynamic relaxation method (DRM) was adopted to calculate the nonlinear equilibrium equation of the system, and a displacement-based finite-element-formulated filament beam element was used to simulate the nonlinear behavior of the top chord sections of the strarch system. The section of the filament beam element was composed by the amount of filaments, which can be modeled by various material models. The Ramberg-Osgood and bilinear kinematic elastic plastic material models were formulated for the nonlinear material behaviors of the filaments. The numerical results that were obtained in the present study were compared with the experiment results of the stress erection and with the results of the ultimate-load analysis of the strarch unit frame. The results of the present studies are in good agreement with the previous experiment results, and the explicit DRM enabled the analysis of the post-buckling behaviors of the strarch unit frame.

• Journal of dental hygiene science
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• v.9 no.2
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• pp.249-255
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• 2009

This study was carried out for the purpose of comparing bacterial culture method, single PCR, and multiplex PCR for identification of F. nucleatum and A. actinomycetemcomitans in subgingival plaque of adult periodontitis. Targeting 20 patients with adult periodontitis, the subgingival plaque was collected in teeth, respectively, for #16, #36, #44. A bacillus was cultivated by painting it over the solid selective media of F. nucleatum and A. actinomycetemcomitans. Bacterial species were detected in 0 tooth with 12 pieces, respectively. Through single PCR and multiplex PCR, the positive reaction was indicated in 43 teeth with 45 pieces, respectively, as for F. nucleatum, and in 1 tooth with 4 pieces, respectively, as for A. actinomycetemcomitans. In the comparative analysis between bacterial identification methods. F. nucleatum showed the more statistically significant difference(p=0.0(0) in comparison between single PCR and multiplex PCR. Even A. actinomycetemcomitans was indicated significantly(p=0.067) in a case that is based on 0.1 in significant level in the comparison between single PCR and multiplex PCR. In conclusion, as a result of comparing the bacterial identification methods, the detection frequency was indicated to be higher in PCR than in bacterial culture method. Single PCR and multiplex PCR showed the mutually similar detection frequency. Accordingly, given thinking of economic efficiency, quickness, and reduction in labor force, it is thought to be more efficient method to use single PCR as the bacterial identification method.

• Journal of Korean Philosophical Society
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• v.144
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• pp.339-369
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• 2017

Mengzi's biological analogies of man's moral tendency need to be analyzed in order to understand his ethical perspective because he uses lots of analogies to advocate his own moral naturalism. The biological analogies he uses are composed of human body, plant's seeds and sprouts. First, Mengzi thinks that human beings have inborn moral nature as if our bodies are given and plants can be grown from their seeds. His ethical approach to define morality in terms of natural properties such as the Four Sprouts(四端) causes a philosophical debate with Gaozi who thinks that morality cannot be described by natural property. Second, we have a moral preference as if we have a physical desire. This kind of moral sentimentalism emphasizing the preference is continued to Jeong Yakyong's ethical theory that nature is a preference(性嗜好說). Third, if we examine our preference and desire, then we can find that the moral preference is more valuable than the physical desire. Fourth, the biological analogies accepts monism that mind and body are composed of material force(氣). For this reason, the innate moral tendency is manifested on body such as a facial expression, a visceral reaction, and affect. Finally, Mengzi's theory of Four Sprouts causes two different interpretation. One is Zhuxi's interpretation that Duan端 is the visible end(緖) of a thread out of pack, the other is Jeong Yakyong's interpretation that Duan端 is a starting point(始) to cultivate virtues. While Zhuxi considers the Four Sprouts as a clue to find virtues in one's mind, Jeong Yakyong believes that we can cultivate our virtues by preserving the Four Sprouts.

• The Korean Society of Law and Medicine
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• v.21 no.3
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• pp.77-116
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• 2020

The use of drugs that reflect the experiences and achievements of modern science has given human being the benefits of treating diseases and improving health conditions. However, in addition to the benefits of those, medicines have inherently inevitable adverse reactions. Many countries are taking measures such as market entry regulations or post-marketing surveillance to minimize damage caused by drug side effects, but the occurrence of side effects cannot be eliminated. Although the damage is force majeure, in some cases, the doctor who prescribed the drug or the pharmacist who administered the drug may have to compensate for the damage. The liability depends on whether the side effects were known in advance, the type of medicine, etc. On the other hand, in some cases, drug manufacturer may have to take liability for the side effect itself. As it is not easy for victims to be compensated for damages in those cases, many countries, including Korea, are setting to protect victims through the Product Liability Act. Drugs are also one of the product, so liability set by the Product Liability Act may apply. Even before the enactment and enforcement of the Product Liability Act, damage caused by drug has occurred. To resolve them, precedents have developed case law, which have many similarities with the Product Liability Act, but also have differences. Damage caused by drug manufactured prior to the enforcement of the Product Liability Act may occur in the future. In this context, the legal principles of the case laws will remain valid and be applied. This is an important reason to review the case law of precedents.

• Korean Journal of Child Education & Care
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• v.18 no.4
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• pp.65-89
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• 2018

Objective: The purpose of this study is to analyze the science concepts and teaching and learning methods presented in the science education-related activities of the Nuri Curriculum teacher guidebooks for ages 3-5. Methods: The research data included 772 activities related to science education in the teachers' guidebook. The analysis of science concepts was based on physical science (force and motion, physical structure, electricity and magnetism, light and shadow, sound properties), chemistry (material properties, material reaction), life science (organizational structure, growth and change, heredity and evolution, animal plant and human relationships), earth science (earth system interaction, earth system structure, and universe), engineering (designed world, engineering design, engineering, technology and society) and ecology (environment preservation). Teaching and learning methods were analyzed according to the types of small and large group activities and of free play activities. Results: Science concepts were mainly presented in the fields of engineering, chemistry, and life science commonly among children aged 3-5, whereas the concepts of physical science were lowly presented in all ages. Science concepts appeared mainly in the daily subjects of 'animal plant and nature', 'life tools', 'environment and life', and 'spring, summer, autumn and winter'. As the teaching and learning method, free paly activities (science area, free outdoor selection activity, math and manipulative activity) were mostly used for the ages of 3 and 4, and small and large group activities (cooking, story sharing, music activity) were for the age of 5. Conclusion/Implications: It is necessary to select the level of science area and concept that can be taught according to the age of children and the timing of the teaching.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.31 no.2
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• pp.73-87
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• 2019

Ocean waves are the driving force for the sediment transport and the beach process. However, wave actions are nonlinear and non-stationary, and the response of the beach is inconsistent in terms of reaction rate and magnitude. Therefore, the beach process is difficult to predict accurately. The purpose of this study is to identify the correlations between the shoreline change and ocean waves observed in the east coast of Korea. The relation of the beach width obtained from video monitoring at five sandy beaches and the wave data obtained from nearby wave monitoring at three points was analyzed. Although the correlations estimated over the whole data sets was not significant, the correlations estimated based on the seasonal period or wave conditions provided more noteworthy information. When the non-exceedance probability of the wave height was greater than 0.99, the wave period and beach width showed strong negative correlations. In case the non-exceedance probability of the wave period was greater than 0.99, the wave height and beach width showed strong negative correlations as well. Furthermore, the erosion rate of the beach width increased when the primary wave direction was close to normal to the coastline. Little significant seasonal or monthly change was found between the beach width and the wave, but it was greatly affected by intensive events such as typhoons. Thus, it is necessary to analyze in detail the wave height or period level explaining the change of beach width for more relevant and practical information.

• Journal of the Korean GEO-environmental Society
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• v.22 no.3
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• pp.45-51
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• 2021

The evaluation of the degree of compaction of the embankment area, which accounts for most of highway earthworks, is generally performed by a flat plate loading test. The plate loading test is a traditional test method and has high reliability in the field. However, as reaction force equipment must be carried out and it takes about 40 minutes per site during the test, there may be limitations in managing the entire expanse of earthworks. Meanwhile, in order to overcome this, the Ministry of Land, Infrastructure and Transport proposed a simple method of evaluating the level of compactness in the provisional guidelines for compaction management of the packaging infrastructure in 2010. However, it has not been utilized at the highway construction site until now, 10 years later. Therefore, this study attempted to verify the utility of the compaction evaluation method using LFWD (Light Falling Weight Deflectometer) of the impact loading method among the test methods suggested in the provisional guideline. To this end, the correlation was derived by conducting a plate loading test and an LFWD test for each site property and compaction degree. As a result of the test, there was no consistency of test data in the ground with a relative compaction of 80% or less. However, it was confirmed that the correlation has a tendency to increase beyond that. If the test method or test equipment is improved to ensure the consistency of the test values of the impact loading method in the future, it will play a big role in solving the blind spot for compaction management in the earthworks.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.1
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• pp.43-50
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• 2021

A Leg Mating Unit (LMU) is a device utilized during the float-over installation of offshore structures that include hyperelastic pads and mating part. The hyperelastic pads absorb the loads, whereas the mating part works as guidance between topside and supporting structures during the mating sequence of float-over installation. In this study, the design optimization of an LMU for the float-over installation of floating-type offshore structures is conducted to enhance the performance and to satisfy the requirements defined by classification society regulations. The initial dimensions of the LMU are referred to the dimensions of those used in fixed-type float-over installation because only the location and the number of LMUs are known. The two-parameter Mooney-Rivlin model is adopted to describe the hyperelastic pads under given material parameters. Geometric variables, such as the thickness, height, and width of members, as well as configuration variables, such as the angle and number of members, are defined as design variables and are parameterized. A sampling-based design sensitivity analysis based on latin hypercube sampling method is performed to filter the important design variables. The design optimization problem is formulated to minimize the total mass of the LMU under maximum von Mises stress and reaction force constraints.

• Journal of the Korean Orthopaedic Association
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• v.56 no.4
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• pp.283-293
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• 2021

Degenerative disc disease has traditionally been thought of as low back pain caused by changes in the nucleus pulposus and annulus fibrous, in recent studies, however, changes in the upper and lower endplates cause degeneration of the disc, resulting in mechanical pressure, inflammatory reactions and low back pain. Recently, the bone marrow of the vertebral body-endplate-nucleus pulposus and annulus fibrous were considered as a single unit, and the relationship was explained. Once the endplate is damaged, it eventually aggravates the degeneration of the bone marrow, nucleus pulposus, and annulus fibrosus. In this process, the compression force of the annulus fibrosus increases, and an inflammatory reaction occurs due to inflammatory mediators. Hence, the sinuvertebral nerves and the basivertebral nerves are stimulated to cause back pain. If these changes become chronic, degenerative changes such as Modic changes occur in the bone marrow in the vertebrae. Finally, in the case of degenerative intervertebral disc disease, the bone marrow of the vertebral body-endplate-nucleus pulposus and annulus fibrous need to be considered as a single unit. Therefore, when treating patients with chronic low back pain, it is necessary to consider the changes in the nucleus pulposus and annulus fibrosus and a lesion of the endplate.