• Sleep Medicine and Psychophysiology
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• v.14 no.2
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• pp.86-91
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• 2007

Background: Actigraphy is a reliable and valid method for assessing sleep in normal, healthy populations, but it may be less reliable and valid for detecting disturbed sleep in patients. In this study, we attempted to assess the utility of actigraphy in the estimation of sleep quality in patients with obstructive sleep apnea syndrome (OSAS), a major sleep disorder. Method: We analyzed the data of patients who underwent polysomnography (PSG) and actigraphy simultaneously for one night at the Center for Sleep and Chronobiology, Seoul National University Hospital from November 2004 to March 2006. Eighty-nine subjects with OSAS alone and 21 subjects with OSAS and periodic limb movement disorder (PLMD) were included for final data analyses between groups. Polysomnographic and actigraphic data were also compared. Results: In subjects with mild OSAS (RDI<15), modretae ($15{\leq}RDI$<30), and OSAS with PLMD, PSG and actigraphy did not show significant difference in total sleep time and sleep efficiency. However in severe ($30{\leq}RDI$) OSAS subjects, PSG and actigraphy showed significant difference in total sleep time and sleep efficiency. In all patients, no correlations were found between sleep parameters from PSG and from those using actigraphy. Conclusions: We suggest that in severe OSAS patients, PSG is the diagnostic tool. In mild and moderate cases, actigraphy might be used as a screening tool.

• Journal of Oral Medicine and Pain
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• v.23 no.1
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• pp.75-84
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• 1998

The Purpose of this Study was to examine the anatomic differences in the upper airway according to severity of respiratory disturbance index of habitual snorers. Forty-three male habitual snorers, aged 28-68, were examined by polysomnography and divided into 4 groups according to severity determined by polysomnography. Anatomic differences in the upper airway were assessed by lateral cephalograms in upright position, and epidemiological surveys were done by using questionnaires. The obtained results were as follows : 1. All subjects were habitual snorers and 35 patients (81.4%) complained the loudness of snoring as severe as be heard outside of the room. 2. According to the results of polysomnography, the number of the primary snoring patients was 7(16.3%), mild obtrusive sleep apnea 7(16.3%), moderate 7(16.3%), and severe 22(51.2%). 3. The respiratory disturbance index (RDI) of subjects was 39.5$\pm$24.4 and the body mass index(BMI) was 26.2$\pm$2. 4. More inferiorly positioned hyoid bone according to the degree of respiratory disturbace index (RDI) was observed. (p<0.001) 5. The width of superior oropharyngeal airway space was according to the degree of RDI. (p<0.001)

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.27 no.2
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• pp.157-161
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• 2001

The purpose of this study cephalometrically evaluated changes in the posterior airway space for patients with obstructive sleep apnea syndrome(OSAS) before and after surgical advancement of the maxilla and mandible. The change in calculated airway resistance was correlated with the respiratory disturbance index(RDI). Twenty cephalometric radiographs were traced before and after surgery to determine the posterior airway area and calculate resistance. Polysomnograms of each patient were obtained before and after surgery. All patients had a decrease in calculated airflow resistance in the airway. The mean amount of resistance was 865.15 before surgery, decreasing to 192.65 after surgery (p<0.01). Eighty-five percent of the patients experienced improvement in their RDI. Reduction in the RDI appears to be due to an increase in the posterior airway space and decrease in flow resistance.

• Korean Journal of Microbiology
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• v.22 no.4
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• pp.265-269
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• 1984

For the utilization as donor cells of conjugation, DAP-Auxotrophs were isolated from C. coli cells, carrying plasmid $p^{RD1}$ with(a) drug resistance makers from Pseudononas $(Km^r, \;Carb^r, \;Tc^r)$ and (b) the nif-gene group from Klebsiela. E. coli $p^{RD1}$ cells were treated with nitrosoguanidine for the mutagenesis and cephalexin for the isolation of DAP-Auxotrophs. The nature of auxotrophs was verified by suitable biochemical test and checking with 6-cyanopurine as a color indicator for the presence of nif-gene.

• Journal of Korea Water Resources Association
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• v.52 no.6
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• pp.381-395
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• 2019

The purpose of this study is to predict agricultural reservoir storage rate (RSR) in a month. This algorithm was developed by multiple linear regression model (MLRM) which included the past 3 months RSRs data and the future climate change scenarios. In order to improve use of predicted RSR, this study need the severe criteria in terms of drought. So, the predicted RSR was indexed as the 3 months reservoir drought index (RDI3) and then it was disaggregated into drought duration, severity, and intensity. For the future RSR estimation by climate change scenarios, the 6 RCP 8.5 scenarios of HadGEM2-ES, CESM1-BGC, MPI-ESM-MR, INM-CM4, FGOALS-s2, and HadGEM3-RA were used in three future evaluation periods (S1: 2011~2040, S2: 2041~2070, S3: 2071~2099). The future S3 period of HadGEM2-ES scenario which has the biggest increase in precipitation and temperature showed the largest decrease to 60.2% among the 6 scenarios compared to the historical RSR (1976~2005) 77.3%. In contrast, INM-CM4 scenario which has smallest changes in precipitation and temperature in S3 period showed the smallest decrease to 72.8%. For the CESM1-BGC and MPI-ESM-MR, FGOALS-s2, and HadGEM3-RA, the S3 period RSR showed 72.6%, 72.6%, 67.4%, and 64.5% decrease respectively. The future severe drought condition of RDI3 below -0.25 showed the increase trend for the number and severity up to -2.0 during S3 period.

• Sleep Medicine and Psychophysiology
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• v.24 no.2
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• pp.86-96
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• 2017

Objectives: This study aimed to analyze causality among sleep apnea, depression and cognitive function in patients with obstructive sleep apnea. Methods: We reviewed the medical records of 105 patients with sleep apnea and snoring who underwent overnight polysomnography (PSG). We analyzed various biological data, sleep variables (sleep duration and percentage) and respiratory variables [arousal index (AI), periodic leg movement index (PLM index), snoring Index (SI), mean SpO2, minimum SpO2, apnea-hypopnea index (AHI), and respiratory disturbance index (RDI)]. We also analyzed various data by sleep, cognition, and mood related scales: Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), snoring index by scale (SIS), Montreal Cognitive Assessment-Korean (Moca-K), Mini-mental State Examination-Korean (MMSE-K), clinical dementia rating (CDR), and Beck Depression Inventory (BDI). We analyzed causation among sleep, and respiratory, mood, and cognition related scales in obstructive sleep apnea patients. We analyzed the mediating effects of depression on sleep apnea patient cognition. Results: As Duration N1 increased and Total sleep time (TST) decreased, MOCA-K showed negative causality (p < 0.01). As BDI and supine RDI increased, causality was negatively related to MOCA-K (p < 0.01). As PSQI (p < 0.001) and SIS (p < 0.01) increased and as MMSE-K (p < 0.01) decreased, causality was positively related to BDI. BDI was found to mediate the effect of age on MOCA-K in patients with obstructive sleep apnea. Conclusion: Duration N1, total sleep time, BDI, and supine RDI were associated with cognitive function in obstructive sleep apnea patients. Depression measured by BDI partially mediated cognitive decline in obstructive sleep apnea patients.

• Tuberculosis and Respiratory Diseases
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• v.48 no.6
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• pp.956-963
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• 2000

Backgrounds : Obstructive sleep apnea syndrome(OSA) can divided into two groups, positional(PP) and non-positional(NPP) obstructive sleep apnea syndrome, according to the body position while sleeping. In this study, we evaluated the differences of anthropometric data and polysomnographic recordings between the two types of sleep apnea syndrome. Materials : Fifty patients with OSA were divided two groups by Cartwright's criteria. The supine respiratory disturbance index (RDI) was at least two times higher than the lateral RDI in the PP group, and the supine RDI was less than twice the lateral RDI in the NPP group. This patients underwent standardized polysomnographic recordings. The anthropometric data and polysomnographic data were analyzed, statistically. Results : Of all 50 patients, 30% were found to be positional OSA. BMI was significantly higher in the PP group(p<0.05). Total sleep time was significantly longer in the PP group (350.6$\pm$28.2min, 333.3$\pm$46.0min, (p<0.05). Sleep efficiency was high in the PP group(89.6$\pm$6.4%, 85.6$\pm$9.9%, p<0.05). Deep sleep was significantly higher and light sleep was lower in the PP group than in the NPP group but no difference was observed in REM sleep between the two groups. Apnea index(AI) and RDI were significantly lower( 17.0$\pm$10.6, 28.5$\pm$13.3, p<0.05) and mean arterial oxygen saturation was higher in the PP group(92.7$\pm$1.8%. p<0.05) than in the NPP group. Conclusion : Body position during sleep has a profound effect on the frequency and severity of breathing abnormalities in OSA patients. A polysomnographic evaluation for suspected OSA patients must include monitoring of the body position. Breathing function in OSA patients can be improved by controlling their obesity and through postural therapy.

• Journal of the Korean Association of Geographic Information Studies
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• v.21 no.3
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• pp.19-34
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• 2018

The purpose of this study is to estimate monthly agricultural reservoir storage with multiple linear regression model(MLRM) based on reservoir storage and meteorological data. The regression model was developed using 15 years(2002 to 2016) of 3,067 reservoirs by KRC(Korea Rural Community) and 63 meteorological stations by KMA (Korean Meteorological Administration), and the MLRM showed the determination coefficient($R^2$) of 0.51~0.95. The MLRM was applied to 9 selected reservoirs among the whole reservoirs and validated with $R^2$ of 0.44~0.81. The ROC(Receiver Operating Characteristics) analysis of Reservoir Drought Index(RDI) classified by comparing the present reservoir storage with normal year(1976~2005 average) reservoir storage showed average value of 0.64 for 2 years(2015~2016) with the highest value of 0.70 for winter period, lowest value of 0.58 for summer period. If 1 to 3 months weather forecasting data such as Glosea5 produced by KMA are applied, the predicted monthly reservoir storage from the MLRM can be a useful information for agricultural drought pre-preparation.

• Journal of Oral Medicine and Pain
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• v.26 no.4
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• pp.369-376
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• 2001

Objectives : The purposes of the study was to evaluate cephalometric characteristics in snorers and patients with obstructive sleep apnea (OSA) and to see any relationships between the cephalometric measurements and respiratory disturbance indices (RDI). Materials and Methods : Twelve snoring patients, 11 patients with OSA, and 10 normal subjects were included for the study. After taking a screening sleep study for a night to obtain RDI, $SaO_2$, and snoring index, a detailed cephalometric analysis was conducted to obtain SNA, SNB, SN-MP, IAS, MAS, SPAS, SAAS, Mn-H, and PNS-P. All the data were compared between groups. For a group including 12 snoring patients and 11 OSA patients, correlation coefficients were calculated between respiratory disturbance index and each item of cephalometric measurements. Results : The mandible and the maxilla are retropositioned. The oropharyngeal and hypopharyngeal airway is reduced in area and is a factor that could produce or enhance OSA symptoms. The hyoid bone is displaced inferiorly. The soft palate is significantly elongated. Conclusions : These data suggest that cephalometric evaluation could be useful to evaluate snoring and OSA patients, and to assist with the planning treatment for improvement of upper airway patency.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.180-180
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• 2017

최근 기후변화에 따른 기상이변으로 전 세계적으로 가뭄피해가 증가하고 있다. 기존의 가뭄지수들은 자연현상만을 분석하여 가뭄의 심화정도를 나타내고 있다. 하지만 도시개발에 따른 도시화가 진행됨에 따라 인문 사회적 요소들이 서로 얽혀서 결합되어 단순히 자연현상만으로는 가뭄재해를 표현하기 어려워지고 있다. 본 연구에서는 복원력개념을 고려한 사회경제적 가뭄지수를 개발하고자 하였다. 복원력개념을 도입하기 위해서 가뭄위험지수, 가뭄대응능력 지수, 가뭄취약성 지수를 산정하였다. 가뭄위험지수로는 SDI(Streamflow Drought Index)를 사용하였으며, 사회 경제적 가뭄을 판단하기 위해서 적합 가뭄지속기간을 고려하였다. 대응능력 지표로는 인문, 사회적 요소와 생활, 농업, 공업용수 공급량, 지하수 함양량을 고려하였다. 취약성 지표로는 인문 사회적 요소와 생활, 농업용수 부족량, 기상요소를 고려하였다. 각 요소의 가중치는 AHP분석을 통해 산정하였다. 산정된 SDI(Streamflow Drought Index), 가뭄대응능력지수, 가뭄취약성지수를 표준화하여 잠재가뭄피해지수 PDDI(Potential Drought Damage Index)를 산정하였으며, 실제 가뭄 기간을 참고하여 등급화를 실시하였다. 그 후, 단순강우를 고려한 SPI(Standardized Precipitation Index)와 강우와 증발산량을을 고려한 RDI(Recommaissamce Drought Index)와의 비교를 통하여 복원력 개념을 고려한 잠재가뭄피해지수의 필요성을 확인하였다.