• Journal of Life Science
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• v.27 no.7
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• pp.834-839
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• 2017

Propolis is a natural product collected from plants by honey bees product used extensively in traditional medicine for its antioxidant, anti-inflammatory, immunomodulatory and anti-cancer effects. Propolis exhibits a broad spectrum of biological activities because it is a complex mixture of natural substances. Ovarian cancer is the second most common newly diagnosed cancer from all cancers among women in Korea and the leading cause of death from gynecological malignancies. While most ovarian cancer patients initially respond to surgical debulking and chemotherapy, patients later succumb to the disease. Thus, there is an urgent need to test novel therapeutic agents to counteract the high mortality rate associated with ovarian cancer. In this study, we investigated the anti-cancer properties and the active mechanism of Australian propolis in human epithelial ovarian cancer A2780 cells. Our data revealed that propolis showed a cytotoxic activity in a dose-dependent manner. Flow cytometric analysis for cell cycle arrest and apoptosis using propidium iodide staning and annexin V-FITC indicated that propolis could induce cycle arrest in the G0/G1 phase and apoptosis in a dose-dependent manner on human epithelial ovarian cancer cells. These results suggest that the Australian propolis is potential alternative agent on ovarian cancer prevention and treatment.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.7
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• pp.1068-1074
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• 2014

This study investigated the quality characteristics of baked rice cake added with maltitol syrup. The hardness, adhesiveness, cohesiveness, gumminess, and chewiness of baked rice cake significantly decreased (P<0.05) according to the level of added maltitol syrup. Hunter's color values of baked rice cake did not differ significantly according to the level of added maltitol syrup. Sensory evaluation indicated that appearance, moistness, chewiness, hardness, and overall acceptance of baked rice cake prepared with added maltitol syrup were improved compared to those of baked control rice cake. Hunter's color values and texture properties of baked rice cake added with 10% maltitol syrup were compared with those of baked control rice cake during storage at room temperature for 3 days. Hunter's color L values of baked rice cake decreased during storage, whereas a and b values increased. The rate of hardness increase in baked rice cake with maltitol syrup was lower than that in baked control rice cake during storage. The Avrami exponents (n) of baked control rice cake and baked rice cake added with 10% maltitol were 2.418 and 2.098, respectively. The time constants (1/k) of the former and latter were 43.860 and 60.976, respectively. Overall, addition of 10% maltitol syrup improved the texture, sensory properties, and retarding retrogradation of baked rice cake.

• Korean Chemical Engineering Research
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• v.52 no.1
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• pp.119-125
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• 2014

This study evaluated the environmental impacts of a soil washing (SW) process, especially, we compared the on-site and off-site remediation of TPH-contaminated soil using green and sustainable remediation (GSR) tool. To assess relative contribution of each stage on environmental footprints in the entire soil washing process, we classified the process into four major stages: site foundation (stage I), excavation (stage II), separation & washing (stage III), and wastewater treatment (stage IV). In on-site SW process, the relative contribution of $CO_2$ emissions and energy consumption were 87.1% and 80.4%, respectively in stage I, and in off-site SW process, the relative contribution of $CO_2$ emissions and energy consumption were 82.7% and 80.5%, respectively in stage II. In conclusion, the major factor contributing environmental impact in the SW process were consumable materials including steel and stainless steel for washing equipment in on-site treatment and fuel consumption for transportation of soil in off-site treatment.

• Korean Chemical Engineering Research
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• v.55 no.1
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• pp.34-39
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• 2017

In this study, intermolecular crosslinked carboxymethyl cellulose sodium salt (CMC) and porcine Cartilage Acellular Matrix (PCAM) blended hydrogel films for anti-adhesive barriers were prepared by gamma-ray radiation. The effects of the CMC/PCAM concentration and blending ratio on the morphology, gel fraction, gel strength, and degree of swelling were determined. The results indicated that crosslinked CMC/PCAM films show significantly lower the gel-fraction than CMC films. The degree of attachment and proliferation of human vascular endothelial cells on CMC/PCAM films was lower than the CMC films. We show the capacity of the CMC and PCAM to be hydrogel films, and the ability to reduce cell adhesion and proliferation on these films by modification with cell anti-adhesion molecules of PCAM. In conclusion, this study suggests that radiation cross-linked CMC/PCAM hydrogel films endowed with anti-adhesion ligands may allow for improved regulation of cell anti-adhesion behavior for prevent peritoneal adhesions.

• The Journal of the Korea Contents Association
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• v.20 no.3
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• pp.309-323
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• 2020

The purpose of this study is to examine the structural relationship between psychological exhaustion, turnover intention, and social support of the dedicated workforce in order to investigate the effects of social support on psychological exhaustion, turnover intention of PAS assistant. Based on the results of the study, this study attempted to make the basic data for devising method to alleviate the intention to turnover of disabled PAS assistant. It was intended to help improve the quality of the activity support service. For this purpose, a questionnaire consisting of psychological exhaustion, turnover intention, and social support measures was conducted to 274 PAS Assistants of 11 service agencies in Seoul to verify the mediating effect of social support. In this study, the psychological exhaustion of PAS Assistants's showed a positive correlation, and the social support of the dedicated personnel perceived by the PAS Assistants's showed a negative correlation with the psychological exhaustion. Also, the social support of the dedicated workforce partially mediated the causal relationship between psychological exhaustion and turnover intention. The results of this study suggests that the social support of the dedicated personnel dedicated to support activities is high in reducing the psychological burnout and turnover intention of the PAS Assistant, it means that the social support of a dedicated workforce is an important resource in reducing the turnover intention.

• Journal of Life Science
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• v.17 no.7 s.87
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• pp.956-963
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• 2007

The purpose of the present study was to examine the effects of iron shot practice volume based on golf skill level on the indices of muscle damage and fatigue in blood. Twenty four golf players were studied under conditions of different golf skill level (beginners, intermediate, expert) and practice volume (100, 200, 300balls). In this study blood CK and LDH were determined to show the level of muscle damage, and blood phosphorus, lactate, and ammonia were measured to see the level of fatigue. Blood creatinine, and IGF- I generally used to see the rate of protein synthesis were also measured. In summary, these results are interpreted to mean that 1) blood fatigue factors, muscle damages, and creatinine levels increased due to a rise in the practice volume of iron shot, 2) those levels decreased due to rise in the golf skill level, 3) blood fators and creatinine recovered quickly after exercise, however muscle damages did not recover even after 24hr, Therefore, both golf skill lev-el and practice volume should be considered to prevent muscle damage and fatigue during practice iron shot.

• Journal of Life Science
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• v.22 no.11
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• pp.1545-1551
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• 2012

Authors report the glycoside hydrolase (GH) family 16 ${\beta}$-agarase from the strain of Agarivorans sp. JA-1, which authors previously stated as recombinant expression and characterization of GH-50 and GH-118 ${\beta}$-agarase. It comprised an open reading frame of 1,362 base pairs, which encodes a protein of 49,830 daltons consisting of 453 amino acid residues. Valuation of the total sequence showed that the enzyme has 98% nucleotide and 99% amino acid sequence similarities to those of GH-16 ${\beta}$-agarase from Pseudoalteromonas sp. CY24. The gene corresponding to a mature protein of 429 amino acids was recombinantly expressed in Escherichia coli, and the enzyme was purified to homogeneity by affinity chromatography. It showed maximal activity at $40^{\circ}C$ and pH 5.0, representing 67.6 units/mg. Thin layer chromatography revealed that mainly neoagarohexaose and neoagarotetraose were produced from agarose. The enzyme would be valuable for the industrial production of functional neoagarooligosaccharides.

• Imaging Science in Dentistry
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• v.40 no.2
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• pp.69-74
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• 2010

Purpose : The research was performed to predict the three dimensional relationship between the impacted mesiodens and the maxillary central incisors and the proximity with the anatomic structures by comparing their panoramic images with the CT images. Materials and Methods : Among the patients visiting Seoul National University Dental Hospital from April 2003 to July 2007, those with mesiodens were selected (154 mesiodens of 120 patients). The numbers, shapes, orientation and positional relationship of mesiodens with maxillary central incisors were investigated in the panoramic images. The proximity with the anatomical structures and complications were investigated in the CT images as well. Results : The sex ratio (M : F) was 2.28 : 1 and the mean number of mesiodens per one patient was 1.28. Conical shape was 84.4% and inverted orientation was 51.9%. There were more cases of anatomical structures encroachment, especially on the nasal floor and nasopalatine duct, when the mesiodens was not superimposed with the central incisor. There were, however, many cases of the nasopalatine duct encroachment when the mesiodens was superimpoised with the apical 1/3 of central incisor (52.6%). Delayed eruption (55.6%), crown rotation (66.7%) and crown resorption (100%) were observed when the mesiodens was superimposed with the crown of the central incisor. Conclusion : It is possible to predict three dimensional relationship between the impacted mesiodens and the maxillary central incisors in the panoramic images, but more details should be confirmed by the CT images when necessary.

• Journal of Korean Society of Forest Science
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• v.104 no.1
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• pp.90-97
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• 2015

The objective of this study was to find optimal amount of fertilization of container seedling production for Zelkova serrata, Ulmus parvifolia, Betula costata and Tilia amurensis. To reach our goal, we measured root collar diameter (RCD), height, biomass and seedling quality index (SQI) of container seedlings of four deciduous hardwood species grown at three different fertilization treatments ($0.5g{\cdot}L^{-1}$, $1.0g{\cdot}L^{-1}$ and $2.0g{\cdot}L^{-1}$). Z. serrata seedlings grown at $2.0g{\cdot}L^{-1}$ fertilization and B. costata seedlings grown at $0.5g{\cdot}L^{-1}$ fertilization showed the highest RCD, height, biomass and SQI. The RCD and height of U. parvifolia and T. amurensis seedlings showed no significant differences by fertilization treatments. Seedlings of two species at $0.5g{\cdot}L^{-1}$ fertilization showed the lowest SQI, however, SQI at 1.0 and $2.0g{\cdot}L^{-1}$ fertilization treatments were not significantly different. Based on these results, it is appeared that container seedlings of Z. serrata at minimum $2.0g{\cdot}L^{-1}$ fertilization, U. parvifolia and T. amurensis at $1.0g{\cdot}L^{-1}$ fertilization and B. costata at maximum $0.5g{\cdot}L^{-1}$ fertilization were optimal nutrient conditions. Practice of optimal fertilization rate will make us get better quality seedlings and reduction of production costs in the container nursery system as well as good field performances with higher survival rate after planting.

• Journal of the Korean Chemical Society
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• v.55 no.2
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• pp.189-198
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• 2011

In the present paper two new thiosemicarbazones i.e., 4[N-(4'-ethylbenzalidene)amino]antipyrine thiosemicarbazone (EBAAPTS) and 4[N-(2',4'-dimethylbenzalidene)amino]antipyrine thiosemicarbazone (DMBAAPTS) have been synthesized and characterized. The complexing abilities of these thiosemicarbazones i.e. EBAAPTS and DMBAAPTS towards cobalt(II) and nickel(II) salts have been explored. The reactions of the hot ethanolic solutions of cobalt(II) and nickel(II) salts with EBAAPTS and DMBAAPTS led to the formation of the novel complexes of general composition [$MX_2(L)H_2O$] (M=$Co^{2+}$ or $Ni^{2+}$; X=$Cl^-$, $Br^-$, $NO_3^-$, $NCS^-$ or $CH_3COO^-$; L=EBAAPTS or DMBAAPTS). The newly synthesized complexes have been characterized by elemental analyses, molar mass, molar conductance, magnetic susceptibility, infrared and electronic spectral studies. The molar conductance measurements of the complexes in nitrobenzene correspond to their non-electrolytic nature. All the complexes are of high-spin type. On the basis of spectral studies an octahedral geometry has been assigned for Co(II) and Ni(II) complexes of the type [$MX_2(L)H_2O$]. These complexes were screened for their antibacterial and antifungal activities on different species of pathogens, fungi and bacteria and their biopotency has been discussed.