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http://dx.doi.org/10.9713/kcer.2017.55.1.34

Radiation-Crosslinked Carboxymethyl Cellulose/Porcine Cartilage Acellular Matrix Hydrogel Films to Prevent Peritoneal Adhesions with physical properties and anti-adhesivity  

Jeong, Sung In (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Park, Jong-Seok (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Gwon, Hui-Jeong (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
An, Sung-Jun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Song, Bo Ram (Cell Therapy Center, Ajou University Medical Center)
Kim, Young Jick (Cell Therapy Center, Ajou University Medical Center)
Min, Byoung Hyun (Cell Therapy Center, Ajou University Medical Center)
Kim, Moon Suk (Department of Molecular Science and Technology, Ajou University)
Lim, Youn-Mook (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
Publication Information
Korean Chemical Engineering Research / v.55, no.1, 2017 , pp. 34-39 More about this Journal
Abstract
In this study, intermolecular crosslinked carboxymethyl cellulose sodium salt (CMC) and porcine Cartilage Acellular Matrix (PCAM) blended hydrogel films for anti-adhesive barriers were prepared by gamma-ray radiation. The effects of the CMC/PCAM concentration and blending ratio on the morphology, gel fraction, gel strength, and degree of swelling were determined. The results indicated that crosslinked CMC/PCAM films show significantly lower the gel-fraction than CMC films. The degree of attachment and proliferation of human vascular endothelial cells on CMC/PCAM films was lower than the CMC films. We show the capacity of the CMC and PCAM to be hydrogel films, and the ability to reduce cell adhesion and proliferation on these films by modification with cell anti-adhesion molecules of PCAM. In conclusion, this study suggests that radiation cross-linked CMC/PCAM hydrogel films endowed with anti-adhesion ligands may allow for improved regulation of cell anti-adhesion behavior for prevent peritoneal adhesions.
Keywords
Carboxymethyl cellulose sodium salt; Porcine cartilage acellular matrix; Hydrogel; Gamma-ray radiation; Crosslinking; Anti-adhesive barriers;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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