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http://dx.doi.org/10.5012/jkcs.2011.55.2.189

Synthesis, Antibacterial and Antifungal Activities of Some Cobalt(II) and Nickel(II) Complexes of Thiosemicarbazones  

Prasad, Surendra (Division of Chemical Sciences, Faculty of Science, Technology and Environment, The University of the South Pacific)
Agarwal, Ram K. (Department of Chemistry, Lajpat Rai Postgraduate College)
Publication Information
Journal of the Korean Chemical Society / v.55, no.2, 2011 , pp. 189-198 More about this Journal
Abstract
In the present paper two new thiosemicarbazones i.e., 4[N-(4'-ethylbenzalidene)amino]antipyrine thiosemicarbazone (EBAAPTS) and 4[N-(2',4'-dimethylbenzalidene)amino]antipyrine thiosemicarbazone (DMBAAPTS) have been synthesized and characterized. The complexing abilities of these thiosemicarbazones i.e. EBAAPTS and DMBAAPTS towards cobalt(II) and nickel(II) salts have been explored. The reactions of the hot ethanolic solutions of cobalt(II) and nickel(II) salts with EBAAPTS and DMBAAPTS led to the formation of the novel complexes of general composition [$MX_2(L)H_2O$] (M=$Co^{2+}$ or $Ni^{2+}$; X=$Cl^-$, $Br^-$, $NO_3^-$, $NCS^-$ or $CH_3COO^-$; L=EBAAPTS or DMBAAPTS). The newly synthesized complexes have been characterized by elemental analyses, molar mass, molar conductance, magnetic susceptibility, infrared and electronic spectral studies. The molar conductance measurements of the complexes in nitrobenzene correspond to their non-electrolytic nature. All the complexes are of high-spin type. On the basis of spectral studies an octahedral geometry has been assigned for Co(II) and Ni(II) complexes of the type [$MX_2(L)H_2O$]. These complexes were screened for their antibacterial and antifungal activities on different species of pathogens, fungi and bacteria and their biopotency has been discussed.
Keywords
Cobalt(II); Nickel(II); Thiosemicarbazones; Cobalt(II) thiosemicarbazones complexes; Nickel(II) thiosemicarbazones complexes; Biological properties;
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