• Korean Journal of Digital Imaging in Medicine
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• v.7 no.1
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• pp.7-13
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• 2005

Purpose : Image plate (IP) is substituted for film in computed radiography. This study is to investigate into a variation of contrast and detail by the number used of image plate in computed radiography. Materials and Methods : A Contrast-Detail(CD)-RAD 2.0 phantom(Nijmegen hospital, The Netherlands) was used for this study. The computed radiography(CR) CD-RAD phantom images were acquired at 40 kVp, 160 mA, 1.6 mAs, and small focus with the Shimadzu general radiography UD-150B-10 system and Fuji FCR 5000 image process system with speed of 200. The IP used including once, 5000 times, and 10000 times also was used. The numerical value of image quality figures (IQF) was produced by CD-RAD analyser(the program is installed in the directory), and then contrast-detail curve was drawn. Results : In this study, the value of IQF was 3.53 in IP used once, 3.40 in 5000 times, and 3.22 in 10000 times. Conclusions : There was a variation of contrast-detail curve by the number used of IP with contrast-detail phantom in computed radiography. Therefore, it is necessary that the IP with lower IQF and a shift of contrast-detail curve to the lower left part is used.

• Journal of the Korean Society of Safety
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• v.33 no.4
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• pp.46-53
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• 2018

This study examined the maximum resistant moment and nonlinear rotational stiffness of wedge joint between the vertical and horizontal members of system supports. To examine the maximum resistant moment and propose the nonlinear rotation stiffness of wedge joint, 6 specimens were tested and additional 3 specimens, where the horizontal member was welded to the vertical member, were tested to compare the moment capacity of wedge joints. The average maximum moment in the tested wedge joint was 1.183 kNm which represented about 70 % of the maximum moment developed in the welded specimens. And, as simulating nonlinear rotational stiffness of the wedge joint, a tri-linear model was suggested. The rotational stiffness was estimated as 23.095 kNm/rad in first stage, 7.945 kNm/rad in second stage, and 3.073 kNm/rad in third stage. For the failure mode, the specimen with the wedge joint showed the failure of joint between vertical and horizontal members. However, the specimen with welded joint represented the yielding of horizontal members.

• Applied Biological Chemistry
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• v.10
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• pp.63-68
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• 1968

The effects of $^{60}Co-{\gamma}$ radiation on the change of composition and susceptibility to soft rot during the storage of sweetpototoes and the radioresistance of spores of the soft rot fungus were investigated and the following results were obtained. 1) Gamma-irradiation of sweetpotatoes caused the increase in water-soluble sugar content and the decrease in ascorbic acid content during the storage. 2) The rate of oxygen uptake in sweetpotato slices becomes higher as the dose increases. But the oxygen uptake in slices irradiated with higher doses decreases along with the color change as the time passes. 3) Irradiation with high doses (above $2.5{\times}10^5$ rad) brought about the increased susceptibility to soft rot decay as the chilling injury did in the storage of sweetpotatoes. 4) Average lethal dose for the spores of Rhizopus nigricans was $3.0{\times}10^5$ rad and the complete death required the level of $1.25{\times}10^6$ rad.

• Polymer(Korea)
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• v.31 no.6
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• pp.532-537
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• 2007

The rheological properties of the solutions of atactic poly(vinyl alcohol)(PVA) in dimethyl sulfoxide (DMSO) were investigated in terms of molecular weight distribution (MWD) of the polymer. The dynamic viscosity (${\eta}#$) and loss modulus (G") for the PVA/DMSO solutions with broader MWD were lower than those with narrower MWD at the similar $M_w$. It could be explained by the fact that the free volume for the solution with broader MWD at the similar $M_w$ was increased. The storage modulus(G#) of 14 wt% PVA/DMSO solutions with broader MWD was higher than that with narrower MWD at a lower frequency than 1.3 rad/sec, but lower than that with narrower MWD at a higher frequency (>1.3 rad/sec). The slopes of modified Cole-Cole plots of the 14 wt% solutions showed that as the MWD was broadened, the phase transition with frequency was more noticeable.

• Journal of Animal Reproduction and Biotechnology
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• v.38 no.3
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• pp.99-108
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• 2023

Background: Efficient gene editing technology is needed for successful knock-in. Homologous recombination (HR) is a major double-strand break repair pathway that can be utilized for accurately inserting foreign genes into the genome. HR occurs during the S/G2 phase, and the DNA mismatch repair (MMR) pathway is inextricably linked to HR to maintain HR fidelity. This study was conducted to investigate the effect of inhibiting MMR-related genes using CdCl₂, an MMR-related gene inhibitor, on HR efficiency in HC11 cells. Methods: The mRNA and protein expression levels of MMR-related genes (Msh2, Msh3, Msh6, Mlh1, Pms2), the HR-related gene Rad51, and the NHEJ-related gene DNA Ligase IV were assessed in HC11 cells treated with 10 μM of CdCl₂ for 48 hours. In addition, HC11 cells were transfected with a CRISPR/sgRNA expression vector and a knock-in vector targeting Exon3 of the mouse-beta casein locus, and treated with 10 μM cadmium for 48 hours. The knock-in efficiency was monitored through PCR. Results: The treatment of HC11 cells with a high-dose of CdCl₂ decreased the mRNA expression of the HR-related gene Rad51 in HC11 cells. In addition, the inhibition of MMR-related genes through CdCl₂ treatment did not lead to an increase in knock-in efficiency. Conclusions: The inhibition of MMR-related gene expression through high-dose CdCl₂ treatment reduces the expression of the HR-related gene Rad51, which is active during recombination. Therefore, it was determined that CdCl₂ is an inappropriate compound for improving HR efficiency.

• Korean Journal of Remote Sensing
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• v.27 no.2
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• pp.171-180
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• 2011

MAI (multiple aperture SAR interferometry) method has been recently developed to improve the measurement accuracy of along-track surface deformation. By means of split-beam SAR processing, this novel technique produces forward- and backward-looking interferograms, which are combined to generate an MAI interferogram. The along-track surface deformation can then be derived from the MAI interferogram. The achieved accuracy of the along-track surface deformation is approximately 8 cm for interferograms with a coherence of 0.6. It is commonly recognized that the topographic phase on an MAI interferogram can be ignored. However, in this paper, we have generated an MAI interferogram from an ALOS P ALSAR interferometric pair spanning the 2010 Haiti earthquake, and shown that the topographic phase distortion on the MAI interferogram can reach to about $3.45{\times}10^{-4}$ rad./m. This distortion corresponds to an along-track surface deformation of about 98 cm. We have proposed an efficient method to remove the topographic phase distortion. After correcting the distortion, the topographic phase distortion on the MAI interferogram is reduced to about $7.82{\times}10^{-6}$ rad./m. This means that the proposed method can effectively remove the topographic distortion on the MAI interferogram to improve along-track surface deformation measurement.

• Korean Journal of Food Science and Technology
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• v.1 no.1
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• pp.51-61
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• 1969

In order to eliminate the considerable loss of rice by insects, to protect the human body from toxin excreted by some microbes, and to promote the storage efficiency of rice by employing the irradiation, the following experiments were carried out. Two varieties of rice, Paldal and Nongkwang polished and unpolished by the conventional methods and were packaged in polyethylene bags. After irradiating to the doses of 6-400 Krad of gamma-radiation from a $Co-^{60}$ source the samples were stored at the room temperature $20^{\circ}C$ for 8 months. The effects of radiation in terms of the removal of insects and microbes and the changes of chemical components (such as moisture, amylose, free sugar, and rancidity) were determined monthly from march to October during the storage. 1) Infestation of insects was greatly influeneed by the packaging materials used. There was no infestation in rice being packaged in a polyethylene bag, while as the rice packaged in a straw sack was infested in two months of the storage. 2) Some yeast and molds survived 400 K rad of radiation. Sterilizing dose to inhibit reproduction and growth of microbes was presumed to be higher than 400 K rad. Yeast mainly were found on the surface of rice, but mold were embeded into rice kernels by mycelium. 3) Changes of moisture contents during storage was not affected by radiation but was by humidity of the storage room. 4) Amylose content in starch increased with increasing dose of radiation and with the length of storage time, indicating possible depolymerization of starch molecules. 5) Free reducing sugar content was not affected by radiation and decreased with storage time. 6) Rancidity also increased with does and storage time.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.12 no.2
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• pp.83-91
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• 1987

In this paper, the extended inverse Chebyshev function have been derived from Chebyshev function. We presented normalized biquads coefficients of n=5, 6 for passband attenuation Ap(dB)=0.1, 0.2, 0.5, 1.0, 2.0, 3.0 and stopband frequency Ws(rad/s)=1.2, 1.3, 1.4, 1.5, 1.6. A designed low-pass filter from extended inverse Chebyshev transfer function produces the magnitude haracteristic which is maximally flat in the passband and equalripple in the stopband as shown in fig. 3(c), (d). Finally, it showed the magnitude and loss characteristics through realistic circuit simulation, and presented element values.

• Radiation Oncology Journal
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• v.5 no.1
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• pp.13-21
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• 1987

The effect of local hyperthermia of 41 to $43^{\circ}C$ for 30 minutes on radiosensitivity of normal tissue was studied utilizing jejunal crypt microcolony assay. Hyperthermia of this range enhanced the radiation effect and the effect was mainly additive without significant effect on the slopes of cell survival curves. At the isoeffect level of 20 microcolony formation, the thermal enhancement ratio was 1.02, 1.10 and 1.39 for $41^{\circ},\;42^{\circ}\;and\;43^{\circ}C$, respectively. The distribution of microcolony formation along the circumference of jejunum was not uniform, having more colonies around the mesenteric border, and this suggests the effect of uneven cooling by blood circulation.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3403-3409
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• 2013

Breast cancer is the most common cancer among women affecting up to one third of tehm during their lifespans. Increased expression of some genes due to polymorphisms increases the risk of breast cancer incidence. Since mutations that are recognized to increase breast cancer risk within families are quite rare, identification of these SNPs is very important. The most important loci which include mutations are; BRCA1, BRCA2, PTEN, ATM, TP53, CHEK2, PPM1D, CDH1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, BRIP1, RAD50, RAD51C, STK11 and BARD1. Presence of SNPs in these genes increases the risk of breast cancer and associated diagnostic markers are among the most reliable for assessing prognosis of breast cancer. In this article we reviewed the hereditary genes of breast cancer and SNPs associated with increasing the risk of breast cancer that were recently were reported from candidate gene, meta-analysis and GWAS studies. SNPs of genes associated with breast cancer can be used as a potential tool for improving cancer diagnosis and treatment planning.