• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.531-535
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• 2015

본 연구에서는 한반도 관측 공백지역인 북한지역에 대하여 레이더와 위성 원격탐사자료를 활용하여 강수량과 토양수분 등 수문기상정보를 생산 및 검증하고 효율적인 수문 모니터링 및 수문 기상 재해 감시와 평가 방안을 수립하고자 한다. 또한, 북한지역의 수문 기상 정보 수집 및 통합 DB를 마련하고 북한 수문기상 포털시스템을 구축함으로써 부처 간 자료를 공유할 수 있는 매개체를 마련하여 일관된 정책 수립과 효율적인 물관리를 도모하고자 한다. WPMM(Window Probability Matching Method)방법을 기반으로 구성된 RAD-RAR(Rain rate system) 산정 알고리즘(Rosenfeld et al., 1993)을 활용하여 산출된 합성 강우장 데이터의 정확성을 비교 분석하기 위해 접경지역 AWS 강수량과 세계기상통신망(GTS)기반 강수량을 산출하여 각각 레이더 강수량과 검증분석을 실시하였다. 연구기간은 2012년과 2013년 여름철 기간 중 5개의 기간을 선별하였다. 연구 기간 동안의 RAR 합성 강우장 데이터를 이용하여, 기간 중 1시간 동안 누적된 강수량을 산출하고 접경지역 AWS 강수량과 비교하였고 12시간 누적 강수량을 산출하여 GTS 강수량과 비교 분석을 실시하였다. 전반적으로 레이더 강수량에 비해 AWS 강수량이 더 높게 나타났으며 마찬가지로 레이더 강수량과 GTS 강수량의 비를 통해 레이더 자료가 상대적으로 과소추정되고 있음을 확인 할 수 있었다. 미항공우주국(NASA)과 일본항공우주국(JAXA)을 중심으로 진행된 GPM(Global Precipitation Measurement)미션은 한 개의 핵심위성과 마이크로파 복사계를 탑재한 10여개의 보조위성으로 구성되어 있으며, 매 3시간 간격의 전구 강수량 자료 생산에 목적이 있다. 이는 홈페이지를 통해 Level 1, 2, 3의 GPM 데이터를 배포하고 있다. 특히 Level 2 데이터는 언급된 3시간 간격의 전구 강수량 데이터를 제공한다. 이 경우 복사량을 강수량으로 변환하는 번거로움을 덜 수 있으며 NASA가 제공하는 Panoply라는 프로그램을 이용하여 한반도 강수 자료 가시화가 가능하다.

• Nuclear Engineering and Technology
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• v.53 no.9
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• pp.3026-3034
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• 2021

Multi-target X-ray tube is a new type X-ray source, and can be applied in many fields such as sensitive X-ray fluorescence analysis and medical imaging. In this work, we report an electric field modulation multi-target X-ray tube, which contains four targets (Cr, Ni, Au, Mo) coated on a Beryllium (Be) window. A four-valve electric field deflector was developed to deflect the electron beam to bombard the corresponding targets. Particle dynamics analysis software was employed to simulate the particle tracking of electron beam. The results show that the 30 keV electron beam could get a 6.7 mm displacement on the target plane by 10⁵ V/m electric field. The focus areas are about 2 mm × 5 mm and 4 mm × 2.5 mm after deflection in two directions. Thermal behavior calculated by ANSYS shows that the designed target assembly could withstand a 10 W continuous power. The optimum target thicknesses and emission spectra were obtained by Geant4 when the thickness of Be window was 300 mm and the electron beam incident angle was 0.141 rad. The results indicate that this multi-target X-ray tube could provide different X-ray sources effectively.

• Journal of Pharmacopuncture
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• v.22 no.1
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• pp.35-40
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• 2019

Objective: Adriamycin (ADR) is an important anti-cancer drug which can cause renal toxicity. Given the known anti-inflammatory and antioxidant effects of Plantago major (P. major), the aim of this study was to determine the effects of hydroalcoholic extract of P. major on ADR- induced nephropathy in rats. Methods: Fifty male Wistar albino rats were randomly divided into 5 groups including: control, ADR (5 mg/kg), ADR + P. major (600 and 1200 mg/kg) and P. major (1200 mg/kg). The animals were treated with P. major extract for 5 consecutive weeks and ADR was intravenously injected on the 7th day of the study. Urine and serum samples were collected on days 0, 14, 21, 28, and 35 for the measurement of serum cholesterol and albumin levels and urine protein excretion rate. At the end of the study, the left kidneys were removed for apoptosis assessment. Results: Administration of ADR significantly decreased serum albumin level and increased serum cholesterol and urine protein excretion rate as well as, apoptotic cell numbers compared to the control group (P < 0.001) while had no effect on glomerular filtration rate (P > 0.05). Treatment with P. major, in both 600 and 1200 mg/kg doses, increased serum albumin level and decreased serum cholesterol concentration, urine protein excretion rate and as well as the number of apoptotic cell compared to the ADR group (P < 0.001). Conclusion: Our results showed that the P. major extract effectively protects against ADR- induced nephropathy by reducing kidney apoptosis and improving renal functioning in rats.

• Journal of Pharmacopuncture
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• v.21 no.4
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• pp.249-257
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• 2018

Objectives: The hepatotoxicity induced by Acetaminophen (AAP) mostly mediated by effect on oxidative stress parameters. The Zataria multiflora (Z.M) is an herbal medicine with well-known antioxidant effect. The aim of this study is investigation of preventive effects of Z.M and Carvacrol (CAR) on AAP-induced hepatotoxicity in rats. Methods: Rats were randomly divided into four groups including: 1) Control, 2) Acetaminophen (AAP), 3) and 4) CAR. The saline, Z.M (200 mg/kg) and CAR (20 mg/kg) were administrated orally for 6 days, after that AAP (600 mg/kg) was administrated in the $7^{th}$ day. Blood sampling was performed on the first and last days. Also, the liver tissue was removed for evaluation of Malondyaldehide (MDA), Thiol content, Superoxide dismutase (SOD) and Catalase (CAT). Total Protein (tPro), Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT) and Alkaline Phosphatase (ALP) in liver tissue were evaluated. The changes (${\Delta}$) of enzymes activities were presented. Results: The ${\Delta}GOT$, ${\Delta}GPT$ and ${\Delta}ALP$ in CAR group significantly decreased compared to AAP group (P < 0.01 to P < 0.001) and ${\Delta}GPT$ in Z.M group was significantly reduced in comparison with AAP group (P < 0.05). Also, MDA, Thiol, SOD and CAT levels in treated groups were attenuated compared to AAP group (P < 0.05 to P < 0.001). Conclusion: Z.M and CAR have a powerful hepatoprotective effect. CAR is more effective than Z.M. Based on the results. Z.M and CAR could be potent supplementary agents against hepatotoxicity of AAP in patients.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.2
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• pp.167-175
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• 2019

Objectives: The purpose of this study was to evaluate airborne radon and thoron levels and estimate the effective doses of workers who made household goods and mattresses using monazite. Methods: Airborne radon and thoron concentrations were measured using continuous monitors (Rad7, Durridge Company Inc., USA). Radon and thoron concentrations in the air were converted to radon doses using the dose conversion factor recommended by the Nuclear Safety and Security Commission in Korea. External exposure to gamma rays was measured at the chest height of a worker from the source using real-time radiation instruments, a survey meter (RadiagemTM 2000, Canberra Industries, Inc., USA), and an ion chamber (OD-01 Hx, STEP Co., Germany). Results: When using monazite, the average concentration range of radon was $13.1-97.8Bq/m^3$ and thoron was $210.1-841.4Bq/m^3$. When monazite was not used, the average concentration range of radon was $2.6-10.8Bq/m^3$ and the maximum was $1.7-66.2Bq/m^3$. Since monazite has a higher content of thorium than uranium, the effects of thoron should be considered. The effective doses of radon and thoron as calculated by the dose conversion factor based on ICRP 115 were 0.26 mSv/yr and 0.76 mSv/yr, respectively, at their maximum values. The external radiation dose rate was $6.7{\mu}Sv/hr$ at chest height and the effective dose was 4.3 mSv/yr at the maximum. Conclusions: Regardless of the use of monazite, the total annual effective doses due to internal and external exposure were 0.03-4.42 mSv/yr. Exposures to levels higher than this value are indicated if dose conversion factors based on the recently published ICRP 137 are applied.

• Korean Journal of Applied Biomechanics
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• v.29 no.2
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• pp.53-60
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• 2019

Objective: The purpose of this study was to investigate the differences of smoothness and coordination of the fingers and upper extremities between skilled and non-skilled players during receiving the basketball. Method: Ten male recreational basketball players (age: $23.2{\pm}2.7yrs.$, career: $8.6{\pm}1.6yrs.$, height: $177.3{\pm}6.0$, weight: $72.9{\pm}8.5kg$) careering over five years and ten non-skilled males (age: $27.3{\pm}1.5yrs.$, height: $173.7{\pm}5.6$, weight: $73.2{\pm}12.6kg$) were participated in this study. Then, participants were asked to perform basketball receiving movement for ten times. The receiving movements were recorded by eight infrared cameras (Oqus 300, Qualisys, Sweden). The collected rad data were calculated to duration of basketball receiving, Jerk-Cost, CRP and CRP variability. Results: The CRP of MCP-Wr, Wr-El in skilled group were greater than non-skilled group (p<.05). The CRP variability of El-Sh in non-skilled group was greater than skilled group (p<.05). Conclusion: These results suggest that skilled players perform more effective movement for impact absorption from the basketball. Moreover, the skilled players have consistent movement patterns during basketball performance. Lastly, it is important to train finger sensation and cognitive ability of thrown basketball from the passer.

• Journal of Pharmacopuncture
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• v.22 no.2
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• pp.95-101
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• 2019

Objectives: Angiotensin II (AngII), a major product of renin-angiotensin system (RAS) has important role in induction of hypertension and antihypertensive effect of several medicinal plant was mediated by effect on this agent. Therefore, this study examined the possible effect of hydroalcoholic extract of Crocus sativus (C. sativus) on hypertension induced by AngII. Methods: Six groups (n = 6) of rats were used as follow: 1) Control, 2) AngII (300 ng/kg), 3) Losartan (Los, 10 mg/kg) + AngII and 4-6) C. sativus extract (10, 20 & 40 mg/kg,) + AngII. The femoral artery and vein were cannulated for recording cardiovascular parameters and drugs administration, respectively. All drugs were injected intravenously (i.v). Los and all doses of C. sativus injected 10 min before AngII. Systolic blood pressure (SBP), mean arterial blood pressure (MAP) and heart rate (HR) were recorded throughout the experiment and those peak changes (${\Delta}$) were calculated and compared to control and AngII. Results: AngII significantly increased ${\Delta}MAP$, ${\Delta}SBP$ and ${\Delta}HR$ than control (P < 0. 01 to P < 0.001) and these increments were significantly attenuated by Los. All doses of C. sativus significantly reduced peak ${\Delta}MAP$, ${\Delta}SBP$, and ${\Delta}HR$ than AngII group (P < 0. 05 to P < 0.001). In addition, peak ${\Delta}MAP$, ${\Delta}SBP$ in doses 10 and 20 were significant than Los + AngII group (P<0.05 to P< 0.01) but in dose 40 only MAP was significant (P<0.05). Peak ${\Delta}HR$ in all doses of C sativus was not significant than Los+ AngII. Conclusion: Regarding the improving effect of the C. sativus extract on AngII induced hypertension, it seems that this ameliorating effect partly mediated through inhibition of RAS.

• BMB Reports
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• v.52 no.3
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• pp.208-213
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• 2019

Chemoresistance is the primary obstacle in the treatment of locally advanced and metastatic nasopharyngeal carcinoma (NPC). Recent evidence suggests that the transcription factor forkhead box M1 (FoxM1) is involved in chemoresistance. Our group previously confirmed that FoxM1 is overexpressed in NPC. In this study, we investigated the role of FoxM1 in cisplatin resistance of the cell lines 5-8F and HONE-1 and explored its possible mechanism. Our results showed that FoxM1 and NBS1 were both overexpressed in NPC tissues based on data from the GSE cohort (GSE12452). Then, we measured FoxM1 levels in NPC cells and found FoxM1 was overexpressed in NPC cell lines and could be stimulated by cisplatin. MTT and clonogenic assays, flow cytometry, ${\gamma}H2AX$ immunofluorescence, qRT-PCR, and western blotting revealed that downregulation of FoxM1 sensitized NPC cells to cisplatin and reduced the repair of cisplatin-induced DNA double-strand breaks via inhibition of the MRN (MRE11-RAD50-NBS1)-ATM axis, which might be related to the ability of FoxM1 to regulate NBS1. Subsequently, we demonstrated that enhanced sensitivity of FoxM1 knockdown cells could be reduced by overexpression of NBS1. Taken together, our data demonstrate that downregulation of FoxM1 could improve the sensitivity of NPC cells to cisplatin through inhibition of MRN-ATM-mediated DNA repair, which could be related to FoxM1-dependent regulation of NBS1.

• Journal of the Architectural Institute of Korea Structure & Construction
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• v.35 no.4
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• pp.135-146
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• 2019

Deep beam has high section modules compared with shallow beam of the same weight. However, deep beam has low rotational capacity and high possibility of brittle failure so it is not possible to apply deep beams with a long span to intermediate moment frames, which should exhibit a ductility of 0.02rad of a story drift angle of steel moment frames. Accordingly, KBC and AISC limit the beam depth for intermediate and special moment frame to 750mm and 920mm respectively. The purpose of this paper is to improve the seismic performance of intermediate moment frame with 1200mm depth beam. In order to enhance vulnerability of plastic deformation capacity of deeper beam, Multi-Reduced Taper Beam(MRTB) shape that thickness of beam flange is reinforced and at the same time some part of the beam flange width is weakened are proposed. Based on concept of multiple plastic hinge, MRTB is intended to satisfy the rotation requirement for intermediate moment frame by dividing total story drift into each hinge and to prevent the collapse of the main members by inducing local buckling and fracture at the plastic hinge location far away from connection. The seismic performance of MRTB is evaluated by cyclic load test with conventional connections type WUF-W, RBS and Haunch. Some of the proposed MRTB connection satisfies connection requirements for intermediate moment frame and shows improved the seismic performance compared to conventional connections.

• International journal of steel structures
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• v.18 no.5
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• pp.1639-1653
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• 2018

Bolted connections are suitable due to high quality prefabrication in the factory and erection in the workplace. Prefabrication and modularization cause high speed of erection and fabrication, high quality and quick return of investment. Their technical hitches transportation can be removed by prefabrication of joints and small fabrication of components. Box-columns are suitable members for bolted structures such as welded steel structures with moment frames in two directions etc., but their continual fabrication in multi-story buildings and performing the internal continuity plate in them will cause some practical dilemmas. The details of the proposal technique introduced here, is to remove such problems from the box columns. Besides, some other advantages include new prefabricated bolted beam-to-column connections referred to BBCC. This connection is a set of plates joined to columns, beams, support, and bolts. For a better understanding of its fabrication and erection techniques, two connection and one structural maquettes are made. The present work aims to study the cyclic behavior of connection numerically. To verify the accuracy of model, a similar tested connection was modelled. Its verification was then made through comparison with test results. The behavior of connection was evaluated for an exterior connection using three different support shapes. The effects of support shapes on rigidity, ductility, rotation capacity, maximum strength, four rad rotation strength were compared to those of the AISC seismic provision requirements. It was found that single beams support has all the AISC seismic provision requirements for special moment frames with and without a continuity plate, and box with continuity plate is the best support in the BBCC connection.