• 비파괴검사학회지
• /
• 제32권5호
• /
• pp.502-508
• /
• 2012

현재 골다공증 진단을 위하여 임상에서 이용되고 있는 정량적 초음파 기술은 종골(발뒤꿈치뼈)에서 음속(speed of sound; SOS) 및 광대역 초음파 감쇠(normalized broadband ultrasound attenuation; nBUA)와 같은 초음파 변수를 측정한다. 본 연구에서는 소 대퇴골로부터 제작된 20개의 해면질골 샘플을 이용하여 골절 위험도가 높은 대퇴골에서 SOS 및 nBUA의 골밀도에 대한 의존성을 살펴보았다. 대퇴골 해면질골 샘플의 SOS 및 nBUA는 1.0 MHz의 중심주파수를 갖는 한 쌍의 초음파 트랜스듀서와 함께 투과법을 이용하여 측정 하였다. 20개의 해면질골 샘플에서 측정된 SOS 및 nBUA는 골밀도와 각각 r = 0.83 및 0.72라는 높은 Pearson 상관계수 (r)를 갖는 것으로 나타났다. 또한 SOS 및 nBUA를 독립변수로 하고, 골밀도를 종속변수로 하는 다중선형회귀분석으로부터 다중선형회귀모델의 상관계수는 r = 0.85로서 SOS 또는 nBUA 중 하나만을 독립변수로 하는 단순선형회귀모델의 상관계수보다 높게 나타났다. 이와 같이 초음파 변수와 골밀도 사이의 높은 선형적인 상관관계는 대퇴골에서 측정된 초음파 변수가 대퇴골의 골밀도를 예측하기에 충분한 지표라는 것을 의미한다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권16호
• /
• pp.6505-6510
• /
• 2014

Objective: This study was conducted to identify whether polymorphic variants of set domain-containing protein 8 (SET8) and tumor protein p53 (TP53) codon 72, either independently or jointly, might be associated with increased risk for cervical cancer. Methods: We genotyped SET8 and TP53 codon 72 polymorphisms of peripheral blood DNA from 114 cervical cancer patients and 200 controls using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct DNA sequencing. Results: The frequency of SET8 CC (odds ratios (OR) = 2.717, 95% CI=1.436-5.141) or TP53 GG (OR=2.168, 95% CI=1.149-4.089) genotype was associated with an increased risk of cervical cancer on comparison with the SET8 TT or TP53 CC genotypes, respectively. In additional, interaction between the SET8 and TP53 polymorphisms increased the risk of cervical cancer in a synergistic manner, with the OR being 9.913 (95% CI=2.028-48.459) for subjects carrying both SET8 CC and TP53 GG genotypes. Conclusion: These data suggest that there are significant associations between the miR-502-binding site SNP in the 3'-UTR of SET8 and the TP53 codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction.

• Plant Biotechnology Reports
• /
• 제4권1호
• /
• pp.23-27
• /
• 2010

Quantitative trait loci (QTLs) controlling ability of somatic embryogenesis were identified in soybean. A frame map with 204-point markers was developed using an RI population consisting of 117 $F_{11}$ lines derived from a cross between cultivar 'Keburi' and a weedy soybean 'Masshokutou Kou 502'. The parents differed greatly in their abilities of somatic embryogenesis using immature cotyledons as explants. The ability of somatic embryogenesis was evaluated in five different experiments: the $F_{11}$ (evaluated in 1998) and $F_{15}$ (2002) generations cultured on basal media supplemented with $40\;mg\;l^{-1}$ 2,4-D (2,4-D1998 and 2,4-D2002), $F_{14}$ (2001) generation on medium with $40\;mg\;l^{-1}$ 2,4-D and high sucrose concentration [2,4-D2001 ($30\;g\;l^{-1}$ sucrose)], and the $F_{11}$ (1998) and $F_{12}$ (1999) generations on medium with $10\;mg\;l^{-1}$ NAA (NAA1998 and NAA1999). The RILs showed wide and continuous variations in each of the five experiments. In the composite interval mapping analysis, 2 QTLs were found in group 8 (D1b + W, LOD = 5.42, $r^2$ = 37.5) in the experiment of 2,4-D1998 and in group 6 (C2, LOD = 6.03, $r^2$ = 26.0) in the experiment of 2,4-D2001 (high concentration sucrose). In both QTLs, alleles of 'Masshokutou Kou 502' with high ability of somatic embryogenesis contributed to the QTLs. For the other three experiments, no QTL was detected in the criteria of LOD >3.0, suggesting the presence of minor genes.

• Journal of Ginseng Research
• /
• 제41권4호
• /
• pp.496-502
• /
• 2017

Background: Ginsenosides are the major components of Panax ginseng Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and immunomodulatory properties. In this study, we investigated the antiviral effects of 15 ginsenosides and compound K on gammaherpesvirus. Methods: The antiviral activity of ginsenosides was examined using the plaque-forming assay and by analyzing the expression of the lytic gene. Results: 20(R)-Ginsenoside Rh2 inhibited the replication and proliferation of murine gammaherpesvirus 68 (MHV-68), and its half-maximal inhibitory concentration ($IC_{50} $) against MHV-68 was estimated to be $2.77{\mu}M$. In addition, 20(R)-ginsenoside Rh2 inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpesvirus in the Kaposi's sarcoma-associated herpesvirus (KSHV)-positive cell line BC3. Conclusion: Our results indicate that 20(R)-ginsenoside Rh2 can inhibit the replication of mouse and human gammaherpesviruses, and thus, has the potential to treat gammaherpesvirus infection.

• Journal of Advanced Marine Engineering and Technology
• /
• 제27권4호
• /
• pp.494-502
• /
• 2003

The near-tip field of mode-I dynamic cracks steadily propagating in a strain softening material is investigated under plane strain conditions. The material is assumed to be incompressible and its deformation obeys the $J_2$ flow theory of plasticity. A power-law stress-strain relation with strain softening is adopted to account for the damage behavior of materials near the dynamic crack tip. By assuming that the stresses and strain have the same singularity at the crack tip. this paper obtains a fully continuous dynamic crack-tip field in the damage region. Results show that the stress and strain components the same logarithmic singularity of (In(R/r))$\delta$, and the angular variations of filed quantities are identical to those corresponding to the dynamic cracks in the elastic-perfectly plastic material.

• Asia pacific journal of information systems
• /
• 제29권3호
• /
• pp.489-502
• /
• 2019

The WeChat mini program is an application embedded in WeChat that users can use without downloading and installing. After it was officially released in 2017, many travel enterprises have launched their own mini programs on the WeChat platform. This study applies affordance theory to investigate the WeChat mini program's role in tourism activities through social network analysis using the R programming language. The authors searched the topic of "how do you perceive the travel-related WeChat mini program" and then crawled the 200 comments found; 180 comments were analyzed after data cleansing. The results show that travel-related WeChat mini programs play a very important role in Chinese social network tourism activities. This paper found that WeChat played a more active role in various tourism-related interactions with Chinese social networks. Moreover, the results show how affordance theory is applied to the use of WeChat mini programs.

• 한국심리학회지:여성
• /
• 제16권1호
• /
• pp.97-113
• /
• 2011

본 연구는 남녀 대학생들의 자기애 성향이 우울이나 정신병질 성향에 어떠한 관계가 있는지 알아보고자 실시되었다. 자기애, 우울, 정신병질의 각 변인들을 남녀 별로 비교하고, 부적응적 자기애 수준에 따라서 우울, 정신병질과 외현적 자기애 성향이 달라지는지 살펴봄으로써 부적응적 자기애가 다양한 변인들과 가지는 관계를 알아보았다. 자기애와 정신병질 측정을 위한 다양한 척도를 사용하여, 동일변인을 측정하는 두 척도들 간에 차이가 있는지 살펴 보았다. 이를 위해 경기도 지역의 대학생 여자 502명과 남자 501명(총 1003명)을 대상으로 자기애 성격 척도인 NPI와 NPDS, 우울척도인 BDI과 정신병질 척도인 PPI-R과 SRPS를 실시하였다. 연구결과, 척도별 평균비교에서 대학생들은 외현적 자기애(NPI), 우울(BDI)과 정신병질 척도인 PPI-R에서 남녀에 따라 유의하게 차이나는 양상을 보였다. 그리고 부적응적 자기애 수준이 높은 집단이 낮은 집단에 비해 우울, 정신병질 성향과 외현적 자기애 성향이 높게 나타났다. 이러한 결과들을 성차와 자기애 수준과 연관 지어 논의하고 추후 연구 방향에 대해 제언하였다.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 1995년도 봄 학술발표회 논문집
• /
• pp.136-141
• /
• 1995

The early evaluation on strength of concrete is useful to achieve on quality control and improvement of properties of concrete. Especially, we could say that the confidence of construction is increased by the increase durability and safety building, due to early evaluation. In this study, was proposed to ultra-sonic pulse method as a early evaluation method for strength of concrete with main parameter, sush as W/C ratio and S/A ratio. The experiment results are summarized to follow as : $\circled1$ The ultra-sonic pulse was decreased as the increase of W/C ratio. $\circled2$ The maximum value for the ultra-sonic pulse velocity and compressive strength was presented in the case of 40% S/A ratio and these value was decreased as the change of S/A ratio over 40% $\circled1$ The relationship of the ultra-sonic pulse velocity and compressive strength on 28days according to the change of W/C and S/A ratio is to be: $F_{28} = -209193R^2 + 384417R - 1763441$(W/C Ratio) $F_{28} = 1726R^2 - 774R - 502 (S/A Ratio)

• 대한한방내과학회지
• /
• 제28권3호
• /
• pp.502-509
• /
• 2007

Objectives : Folium perillae (FP) can relieve superficial pathogenic factors to dissipate cold and promote the circulation of qi and regulate the function of the stomach and is often used for interior qi-stagnation. We hypothesized that FP could rescue cerebral ischemia in rats. Methods : The present study was carried out to investigate the effects of FP on cerebral ischemia in terms of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. Finally, lactate dehydrogenase (LDH) release was investigated, too. Results : In this study, treatment with FP elevated rCBF and MABP levels in dose-dependent manner. Pre-treatment with indomethacin, an inhibitor of cyclooxygenase, inhibited rCBF increase induced by FP effectively. However, FP did not affect stability during cerebral reperfusion. Finally, FP significantly inhibited LD H activity in vitro Conclusions : These results suggest that FP is useful to treat patient with diseases related to cerebral ischemia, because FP can increase rCBF and MABP.

• 한국응용과학기술학회지
• /
• 제37권4호
• /
• pp.688-698
• /
• 2020

본 연구는 병원간호사의 간호조직문화, 조직커뮤니케이션만족, 직무착근도의 관계를 확인하고, 직무착근도에 미치는 영향요인을 파악하기 위함이다. C시 소재한 대학병원에 근무하고 있는 간호사 238명을 대상으로 2017년 8월 1일~8월 10일까지 자료수집 하였다. 자료는 SPSS WIN 22.0 통계 프로그램을 이용하여, 기술통계, t-test, ANOVA, Pearson's correlation coefficient, Stepwise Multiple Linear Regression으로 확인하였다. 본 연구결과 간호조직문화는 5점 만점에 평균 3.32±0.33점 이었고, 조직커뮤니케이션만족은 5점 만점에 평균 3.19±0.37점 이었으며, 직무착근도는 5점 만점에 평균 3.19±0.44점이었다. 일반적 특성에 따른 직무착근도의 차이는 연령(F=9.00, p<.001), 학력(F=13.24, p<.001), 직위(t=-5.42, p<.001), 결혼(t=-3.11, p=.002), 근무경력(F=10.55, p<.001), 근무형태(F=10.99, p<.001)에서 유의한 차이가 있었다. 직무착근도와 간호조직문화(r=.502, p<.001), 조직커뮤니케이션만족(r=.673, p<.001)은 양의 상관관계가 있었다. 직무착근도에 영향을 미치는 요인으로 조직커뮤니케이션만족(β=.575 p=.000), 근무경력 '10년 이상'(β=.342 p=.000), 간호조직문화(β=.203 p=.000), 근무경력 '5년 이상~10년 미만'(β=.121 p=.000)의 순이었고, 모형의 설명력은 57.4%이었다. 이상의 결과에 따라 병원간호사의 간호직무에 착근도를 높이기 위하여 조직커뮤니케이션만족도를 수시로 파악하고, 근무경력, 간호조직문화 등을 고려한 간호실무 및 교육중재 프로그램 개발이 필요하다.