• Korean Chemical Engineering Research
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• 제60권1호
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• pp.100-115
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• 2022

교대로 운전되는 광촉매반응기 공정 및 바이오필터 공정[전통적 바이오필터(L 반응기)와 두 개의 유닛(R_up 및 R_dn)을 가지는 개선된 바이오필터(R 반응기)]으로 구성된 통합 하이브리드시스템(통합처리시스템)에서 에탄올과 황화수소를 동시 함유한 폐가스 처리를 성공적으로 수행하였다. 통합처리시스템의 운전 단계로서 HA1, HA2 및 폐가스의 공급 방향이 뒤바뀐 HA3T stage의 광촉매 공정에서 각각 55, 50 및 45%의 에탄올 제거효율과 각각 70, 60 및 37%의 황화수소 제거효율을 보였다. 특히, HA3T stage에서 통합처리시스템으로 공급되는 폐가스(feed)의 황화수소 농도가 10 ppmv에서 20 ppmv로 급증함에 따른 황화수소 부하량의 증가로 인하여 특히 황화수소 제거효율의 급격한 감소를 관찰하였다. 통합처리시스템의 HA1, HB1, HA2 및 HB2 stage 및 HA3T stage의 초반에, 개선된 바이오필터(R 반응기)의 각 유닛에 설치한 sampling 구들의 에탄올의 파과 순서 및 에탄올 처리효율의 크기 순서는, HA3T stage 후반과 HB3T stage의 경우에서 각각 거꾸로 바뀌었다. 한편 개선된 바이오필터(R 반응기)에서 황화수소의 경우는 파과 정도가 에탄올의 경우만큼 두드러지지는 않았으나 비슷한 추세가 관찰되었다.

• Molecules and Cells
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• 제40권3호
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• pp.222-229
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• 2017

Adipose-derived stem cells (ADSCs) were previously considered to have an anti-inflammatory effect, and Interleukin-$1{\beta}$ ($IL-1{\beta}$) was found to be a pro-inflammatory factor in chondrocytes, but the mechanism underlying ADSCs and $IL-1{\beta}$ is unclear. In this study, we investigate whether P2X7 receptor (P2X7R) signalling, regulated by microRNA 373 (miR-373), was involved in the ADSCs and $IL-1{\beta}$ mediated inflammation in osteoarthritis (OA). Chondrocytes were collected from 20 OA patients and 20 control participants, and ADSCs were collected from patients who had undergone abdominal surgery. The typical surface molecules of ASDCs were detected by flow cytometry. The level of nitric oxide (NO) was determined by Griess reagent. Concentrations of prostaglandin E2 (PGE2), interleukin 6 (IL-6), matrix metallopeptidase 3 (MMP-3) were detected by enzyme-linked immunosorbent assay (ELISA). The expressions of IL-6, MMP-3, miR-373 and P2X7R were determined by real-time polymerase chain reaction (PCR), and Western blot was used to detect the protein expression of P2X7R. The typical potential characters of ADSCs were verified. In chondrocytes or OA tissues, the miR-373 expression level was decreased, but the P2X7R expression was increased. $IL-1{\beta}$ stimulation increased the level of inflammatory factors in OA chondrocytes, and ADSCs co-cultured with $IL-1{\beta}$-stimulated chondrocytes decreased the inflammation. OA chondrocytes transfected with the miR-373 inhibitor increased the inflammation level. The miR-373 mimic suppressed the inflammation by targeting P2X7R and regulated its expression, while its effect was reversed by overexpression of P2X7R. $IL-1{\beta}$ induced inflammation in OA chondrocytes, while ADSCs seemed to inhibit the expression of P2X7R that was regulated by miR-373 and involved in the anti-inflammatory process in OA.

• 기술혁신학회지
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• 제2권2호
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• pp.201-218
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• 1999

The article contains an introduction of possibility of applying Multi-Attribute Utility Theory(MAUT) for priority setting of R&D projects. MAUT is compared with AHP, which is widely used recently. These two techuiques are applied to set priorities of R&D projects In a Government-funded Research Institute. Six criteria are chosen from consultation with decision makers. They are composed of 1) validity as representative projects, 2) possibility of resource mobilization, 3) spillover effect of developed technologies, 4) possibility of success, 5) scope of participation and 6) clarity of research goal. To set priorities of R&D projects, SMART(Simple MultiAttribute Rating Technique) and DVM(Difference Value Measurement) out of many MAUT methods are used to design the utility function and to determine the weights among criteria. The aggregation model is additive on the assumption the criteria are independent. AHP executes pairwise comparisons for criteria and alternatives. From the results of the case study, the results and theoretical characteristics are compared.

• Archives of Pharmacal Research
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• 제14권1호
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• pp.35-40
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• 1991

(R) (+) and (S) (-) $4-^2H$-phenytoin have been used as substrates for the determination of the percentage of deuterium retention (NIH shift) after para-hydroxylation of the substrates in rat. By using GC-MS analyses, the percentages of deuterium retention were found to be 69% and 70% for the (R) and (S) phenyl rings, respectively. The results add additional evidence for the involvement of arene oxide in the oxidation of the pro (R) and pro (S) phenyls of phenytoin. The oxidation process of each ring could be mediated by independent enzyme systems, a rapid oxidative enzyme for the pro (S) phenyl and a slow oxidative enzyme for the pro (R) phenyl.

• Progress in Superconductivity
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• 제6권1호
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• pp.74-78
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• 2004

YBCO coated conductor is one of the most promising materials as a new generations wire especially for practical power applications. In this work, $YBa_2$$Cu_3$$O_{7}$ -$\delta$/(YBCO) coated conductors (CC) were deposited by pulsed laser deposition (PLD) from buffer layers to superconducting layer on hi-axially textured metal tape. The oxide multilayer buffered substrate of architectures of $CeO_2$/$YSZ/Y_2$$O_3$ was fabricated by PLD at steady status. Then YBCO layer was deposited on RABiTS substrate by stationary and reel-to-reel (R2R) continuous process and we compared with deposition conditions of both processes. The degree of texture of each layer was investigated using X-ray diffraction including $\theta$-2$\theta$ scans, $\omega$-scans and $\Phi$-scans analysis. Their surface morphology was observed by scanning electron microscopy (SEM). The FWHM of the X-ray $\Phi$-scans and $\Phi$-scans indicated that YBCO and buffer layers closely replicate the in-plane and out-of-plane texture of metal tape. Critical current (Ic) at 77 K, self-field of 75.8 A/cm-width, critical temperature (Tc) of 85 K, and critical current density (Ic) of 3.7 MA/$\textrm{cm}^2$ were measured from coated conductor deposited by stationary process. And coated conductor deposited by R2R continuous process had Ic of 57.5 A/cm-width, Tc of 86.5 K and Jc of 2.0 MA/$\textrm{cm}^2$. The film also exhibits a homogeneous and dense surface morphology.

• 한국시스템다이내믹스연구
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• 제8권2호
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• pp.191-207
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• 2007

Nowadays almost nations try to promote the competition of nation through the development of national science technology. Also Korea has been engaging in this race of through public research&development institute. But recently the commercialization of R&D products appears a poor result in the royalty of technology according weak technology transfer toward IT small and medium-sized enterprises. Even If we have been trying to find the problems and causes, as yet it is true that we don't solve clearly the problem, make a diagnosis about it. This paper analyzes the process of commercialization in public R&D research institute(ETRI: Electronics and Telecommunications Research Institute) through system thinking and researches an interrelationship among government agency, public R&D research institute, and enterprise. This one can find the fact that between research fund and R&D products, transfer technology and royalty, and enterprise's operating profit and active technology transfer like adding technology development is a positive feedback loop. This positive feedback loop in the commercialization of public R&D research institute carries out very important role in examining problems in R&D product's commercialization. Also this paper looks forward to being a guide in the commercialization of public R&D research institute.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2005년도 International Meeting on Information Displayvol.II
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• pp.944-947
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• 2005

Highly stable gate driver circuit using a-Si TFT has been developed. The circuit has dual-pull down structure, in which bias stress to the TFTs is relieved by alternating applied voltage. The circuit has been successfully integrated in 4-in. QVGA and 14-in. XGA TFT-LCD with a normal a-Si process, which are stable for over 2,000 hours at $60^{\circ}C$. The enhancement of stability of the circuit is attributed to retarded degradation of pull-down TFTs by AC driving.

• 기술혁신연구
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• 제14권2호
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• pp.93-116
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• 2006

The purpose of this study is to contribute reference material that provides insight into innovative process management that increases R&D output in commercializing new products. A model of a process from research to commercialization with the cumulative profit and loss curve is put forward and hypotheses related to success and failure are developed at the stages up to product launch. Seventeen large projects that have resulted in successful product launches have been examined from the initial research stage to commercialization. Prefect duration, standardized cumulative R&D expenditures and research resource concentration are analyzed in terms of statistical method and patterns in cumulative profit and loss curves after product sales, as well as the reasons for and other aspects of success/failure are investigated and analyzed. Consequently, valuable information on future management tasks has been obtained such as: (1) project duration differs depending on market sectors, product types and presence/absence of materials research (2) cumulative profit and loss curves can be categorized into four patterns (3) reasons for failure can be divided into technological and market problem categories and (4) these factors have an impact on product sales.

• 산업경영시스템학회지
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• 제38권2호
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• pp.17-30
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• 2015

Technology-oriented national R&D programs produce intellectual property as their final result. Patents, as typical industrial intellectual property, are therefore considered an important factor when evaluating the outcome of R&D programs. Among the main components of patent evaluation, in particular, the patent right quality is a key component constituting patent value, together with marketability and usability. Current approaches for patent right quality evaluation rely mostly on intrinsic knowledge of patent attorneys, and the recent rapid increase of national R&D patents is making expert-based evaluation costly and time-consuming. Therefore, this study defines a hierarchy of patent right quality and then proposes how to quantify the evaluation process of patent right quality by combining text mining and regression analysis. This study will contribute to understanding of the systemic view of the patent right quality evaluation, as well as be an efficient aid for evaluating patents in R&D program assessment processes.

• 대한기계학회논문집
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• 제8권6호
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• pp.536-543
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• 1984

본 연구에서는 유동 조건을 표시하는 무차원 수로 널리 이용되고 있는 Richa- rdson수(R$_{i}$)를 변수로 하여 R$_{i}$의 변화에 따른 온도 분포, 표면 유동 속도와 확산율 등을 연구하였다. 아울러 이러한 열 구배에 의한 성층화 유동(stratifield flow)에서 R$_{i}$가 유동 특성과 어떤 상관 관계를 가지는 가를 알아보기 위하여 같 은 R$_{i}$값을 갖는 다른 조건들의 실험을 수행하였다. 비슷한 R$_{i}$값에서의 온 도 분포를 비교 분석함으로써 아직까지 정립되고 있지 않는 열오염 현상 해석에서의 지배 변수로서의 R$_{i}$의 위치를 확인하고, 부력 효과에 의한 흐름의 난류 구조가 어떻게 영향 받는가 하는 문제에도 관심을 두었다.제에도 관심을 두었다.