• Development and Reproduction
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• v.23 no.1
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• pp.1-9
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• 2019

The ability of oocytes to undergo normal fertilization and embryo development is acquired during oocyte maturation which is transition from the germinal vesicle stage (GV), germinal vesicle breakdown (GVBD) to metaphase of meiosis II (MII). Part of this process includes redistribution of inositol 1, 4, 5-triphosphate receptor (IP3R), a predominant $Ca^{2+}$ channel on the endoplasmic reticulum membrane. Type 1 IP3R (IP3R1) is expressed in mouse oocytes dominantly. At GV stage, IP3R1 are arranged as a network throughout the cytoplasm with minute accumulation around the nucleus. At MII stage, IP3R1 diffuses to the entire cytoplasm in a more reticular manner, and obvious clusters of IP3R1 are observed at the cortex of the egg. This structural reorganization provides acquisition of $[Ca^{2+}]_i$ oscillatory activity during fertilization. In this review, general properties of IP3R1 in somatic cells and mammalian oocyte are introduced.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.16 no.2
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• pp.95-108
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• 2021

Technology innovation activities are very important for companies to secure technological competitiveness and continue to grow. Korea operates a certification system at the national level to promote corporate innovation activities, and strives to enhance SMEs' global technological competitiveness. Among these, the representative system related to technological innovation is the New Excellent Technology (NET) certification. NET is certified through a strict three-stage screening process, and is operated for the purpose of commercialization of new technology, technology trading, and promotion of early market entry by companies. Acquiring NET certification means that the company has a certain level of technological competitiveness. Therefore, this study attempted to conduct an empirical analysis on which technology innovation activities of companies affect the success of R&D projects and improvement of management performance, centering on NET certification system. To verify this, technology strategy, technology planning, systematic R&D process, internal cooperation, and external cooperation activities were set as major variables. As a result of the empirical analysis, it was confirmed that all variables set in this study individually contributed to the success of the R&D project and improvement of management performance. However, when looking at a comprehensive level that considers all variables, it was analyzed that systematic R&D process management and cooperation activities with external organizations have a statistically significant effect on R&D project success, and technology strategy establishment and technology planning activities, which are the initial stages of R&D, have a statistically significant effect on management performance. This study was conducted on innovation-oriented SMEs that have established and operated corporate R&D centers and are actively conducting R&D activities, and multiple regression analysis was used as an analysis method.

• Journal of Information Technology Services
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• v.11 no.2
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• pp.185-196
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• 2012

The rapid evolution of ICT industry brings not only new services or products but also changes from common individual life to whole human society. Coping with these situations and survival, companies cannot help regarding R&D as the most important thing. So, discovering R&D projects which are suitable for the alternation is a big issue for many companies. To resolve the issue, KT has adopted Innovative Management Methodology developed by Strategos, which is co-founded by Gary Harmel. This paper describes this Innovative Management Methodology tailored to KT R&D. The methodology consists of five phases : focusing discovery, discovery, ideas/domains, domain elaboration & aiming point and R&D project proposal. Also, it shows some interim findings that came from the Innovative Management Process. Finally, the future plan for elaborating the methodology itself and generating new R&D projects is suggested.

• Journal of Korean Society of Environmental Engineers
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• v.28 no.6
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• pp.613-619
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• 2006

The objectives of this research are to evaluate the effect of membrane materials, particulate matter and membrane pore size on permeate flux. It was shown that the removal efficiency of high MW organic matter more than 10 kDa was lower than that of low MW organic matter for $MIEX^{(R)}$ process. For the change of permeate flux by the pretreatment process, $MIEX^{(R)}+UF$ process showed high removal efficiency of organic matter as compared with coagulation+UF processes, but high reduction rate of permeate flux was presented through the reduction of removal efficiency of high MW organic matter. The pretreatment of the raw water significantly reduced the fouling of the hydrophilic membrane, but did not decrease the flux reduction of the hydrophobic membrane. Flux decline on MF process increased due to the pore clogging, while the permeate flux decline of UF process decreased due to the formation of cake layer. It was shown that particle matter was not effect on MIEX+membrane process. But, for coagulation+membrane process, particle matter was important factor on permeate flux.

• Journal of Korean Physical Therapy Science
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• v.18 no.2
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• pp.73-80
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• 2011

Purpose: The purpose of this study was to investigate the correlation between the visual perception ability and the static dynamic balance ability in health elderly. Method: The Motor Free Visual Perception Test-Row Score(MVPT-RS) and MVPT-Process Time(MVPT-PT) were used for evaluating the visual perception abilities. Assessment of the balance ability was taken by using Good Balance System. In the assessment using Good Balance System, X, Y coordinate speed, anterior-posterior direction, medial-lateral direction and Velocity Movement(VM) in standing posture when eye open were measured as static balance abilities. Thirty-seven healthy elderly who live in Gwangyang participated in the experiment for 2 months, from October to November 2010. Results: 1. There were statistically significant differences of MVPT-RS, MVPT-PT, NSB-X, NSB-Y, NSB-VM, OLB-X, and OLB-VM based on the gender(p<0.05). 2. The negative correlations of MVPT-RS:NSB-Y(r=-0.354), MVPT-RS:OLB-X(r=-0.4), MVPT-RS: OLB-Y(r=-0.371), but positive correlations of MVPT-PT:DTB-T showed a statistical significance(r=0.45, p<0.05). 3. The positive correlations of NSB-X:NSB-Y(r=0.54), NSB-X: NSB-VM(r=0.848), NSB-Y:NSB-VM(r=0.531), OLB-X:OLB-Y(r=0.876), OLB-X:OLB-VM(r=0.872), and OLB-Y:OLB-VM(r=0.787) showed statistical significances(p<0.05). Conclusion: These results showed that the visual perception ability was correlated with some balance ability in health elderly. Especially the perception test process time(MVPT-PT) has closely related with the DTB-T. The visual perception ability is considered as a factor on the balance ability in health elderly. Further study will focus on the development of improving program of visual perception ability as an improving method of balancing ability in health elderly.

• IMMUNE NETWORK
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• v.4 no.3
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• pp.184-189
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• 2004

Background: Hu syndrome, a neurological disorder, is characterized by the remote effect of small cell lung cancer on the neural degeneration. The suspicious effectors for this disease are anti-Hu autoantibodies or Hu-related CD8+ T lymphocytes. Interestingly, the same effectors have been suggested to act against tumor growth and this phenomenon may represent natural tumor immunity. For these diagnostic and therapeutic reasons, the demand for antibodies against Hu protein is rapidly growing. Methods: Polyclonal and monoclonal antibodies were generated using recombinant HuR protein. Western blot analyses were performed to check the specificity of generated antibodies using various recombinant proteins and cell lysates. Extracellular stimuli for HuR expression had been searched and HuR-associated proteins were isolated from polysome lysates and then separated in a 2-dimensional gel. Results: Polyclonal and monoclonal antibodies against HuR protein were generated and these antibodies showed HuR specificity. Antibodies were also useful to detect and immunoprecipitate endogenous HuR protein in Jurkat and BJAB. This report also revealed that TNF-${\alpha}$ treatment in BJAB up-regulated HuR expression. Lastly, protein profile in HuR-associated mRNAprotein complexes was mapped by 2-dimensional gel electrophoresis. Conclusion: This study reported that new antibodies against HuR protein were successfully generated. Currently, project to develop a diagnostic kit is in process. Also, this report showed that TNF-${\alpha}$ up-regulated HuR expression in BJAB and protein profile associated with HuR protein was mapped.

• Transactions of Materials Processing
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• v.20 no.1
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• pp.42-47
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• 2011

Recently, with the merits of simplicity, ease of mass production and cost effectiveness, a roll-to-roll (R2R) forming process is tried to be employed in the manufacturing of the circuit board, barrier ribs and other electronic device. In this study, the roll-to-roll process for the forming of micro-pattern in electronic device panel is designed and analyzed. In the preliminary experiments, two major defects, i.e., crack near the dimple wall and wrinkling on outside region of dimple, are found. The study on the crack prevention is carried out in previous works by authors. In this study, the cause of wrinkling and modification of tooling to prevent the wrinkling is studied. The main cause of wrinkling is considered to be the uneven material flow along the rolling direction. To reduce or to retard the wrinkling initiation, a dummy shape on outside the pattern is introduced. From the finite element analysis results, it is shown that the dummy shape can reduce the uneven material flow significantly. Finally the effect of dimensions of the dummy shape on material flow is investigated and the optimum dimensions are found.

• Industrial Engineering and Management Systems
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• v.9 no.3
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• pp.262-274
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• 2010

This article investigates how to adaptively predict the time-varying metrology delay that could realistically occur in the semiconductor manufacturing practice. Metrology delays pose a great challenge for the existing run-to-run (R2R) controllers, driving the process output significantly away from target if not adequately predicted. First, the expected asymptotic double exponentially weighted moving average (DEWMA) control output, by using the EWMA and recursive least squares (RLS) prediction methods, is derived. It has been found that the relationships between the expected control output and target in both estimation methods are parallel, and six cases are addressed. Within the context of time-varying metrology delay, this paper presents a modified recursive least squares-linear trend (RLS-LT) controller, in combination with runs test. Simulated single input-single output (SISO) R2R processes subject to various time-varying metrology delay scenarios are used as a testbed to evaluate the proposed algorithms. The simulation results indicate that the modified RLS-LT controller can yield the process output more accurately on target with smaller mean squared error (MSE) than the original RLSLT controller that only deals with constant metrology delays.

• Journal of Korean Society of Water and Wastewater
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• v.21 no.5
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• pp.641-647
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• 2007

This study aims to find out optimum condition for hydrogen production and organic removal when treating food and swine wastewater together. For this purpose, various batch tests were conducted by changing mixture ratio from 6:4 (food wastewater:swine wastewater) to 1:9 without pretreatment process. For hydrogen production through anaerobic fermentation, the mixture ratios of R-1 (6:4), R-2 (5:5) and R-6 (1:9) were out of pH range appropriate for hydrogen production and mixture ratios of R-3 (4:6), R-4 (3:7), and R-5(2:8) showed appropriate hydrogen production where their pH ranges were 5.1~5.5. Especially in case of R-3, it consistently maintained appropriate pH range for hydrogen production for 72hr and produced maximum hydrogen. The characteristics of hydrogen production and cumulative hydrogen production according to each mixture ratio showed that R-1, R-2 and R-6 did not produce any hydrogen, and maximum hydrogen productions of R-3, R-4 and R-5 were 593ml, 419ml and 90ml, respectively. Total cumulative hydrogen productions of R-3, R-4 and R-5 were 1690ml, 425ml and 96ml, respectively. Based on previous results, it was concluded that, the most appropriate mixture ratio of food wastewater and swine wastewate rwas 4:6 (R-3). The experiment for COD removal rate to evaluate organic removal efficiency revealed that R-3, R-4 and R-5 showed high removal efficiencies during the highest hydrogen production amount and the highest efficiency was 41% with R-3.

• 한국정보디스플레이학회:학술대회논문집
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• 2008.10a
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• pp.765-768
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• 2008

To make 3D camera system, we check the possibility of advanced range camera module based on measuring the time delay of modulated infrared light, using a single detector chip fabricated on standard CMOS process. To depth information, electronic shutter and interlaced scanning method of 2D sensor is needed. Especially, we design "lens system, illumination unit" and review simulation result.