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Scintigraphy with Indium-111-oxine Labeled Leukocytes for Localization of Abscesses (복부농양진단을 위한 Indium-111 표지백혈구스캔)

  • Kim, Byung-Tae;Lee, Dong-Soo;Lee, Kyung-Soo;Choi, Hyung-Shik;Kim, Myung-Joon;Yang, Seung-O;Lee, Jae-Hoon;Choi, Chang-Soon;Kim, Taek-Kyu;Chung, June-Key;Lee, Myung-Chul;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.24 no.1
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    • pp.37-48
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    • 1990
  • Detection of deep-seated abscesses is sometimes difficult with ultrasonogrpahy or computed tome graphy alone. Indium-111-labeled leukocyte has widely used in the localization of abscesses after introduction by Segal and Thakur in 1976. But there are some difficulties in using indium-111-oxine in our country because of hardness to get the radiopharmaceutical timely and long time for labeling leukocytes. So we peformed the indium-111-labeled leukocyte scan for establishment of the labeling procedure and clinical application. We labeled the mixed leukocytes from 36 ml of patient's blood using 4 ml of ACD solution, 7 ml of 6% hydroxyethyl starch solution $(HESPAN^{(R)})$, 1 mCi of indium-111 oxine, 5 ml of normal saline and centrifuge. It took about 2 hours for the preparation of radiolabeled leukocytes and attention for contamination was needed. The average injected dose of labeled mixed leukocytes was 465 uCi. The average number of injected leukocytes was $2.5\times10^8$ and the labeling ratio was $57{\pm}13%$ (Table 2, Fig. 5). These number and ratio were sufficient for the localization of abscess. About twenty per cent of indium was labeled to red blood cells and platelets (Fig. 6) and the half-life of injected radiolabeled leukocytes was 8.3 hours. Scan was performed in 9 patients who were suspected to have abscesses clinically or radiologically. Three patients were positive, in one patient who had abscess close to lower lumbar vertebrae was surgically drained and another 2 positive cases did not show abscess clearly on computed tomography, so only antibiotics were administrated and treated successfully. The negative 6 patients were improved without specific treatment. In conclusion, the use of indium-111 oxine labeled leukocytes for localization of abscesses were very specific and helpful in the decision of treatment considering its relatively simple labeling method, and could be easily performed providing timely supply of the radiopharmaceutical.

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Development and Validation of Analytical Methods for Picoxystrobin Determination in Agricultural Products by GC-ECD and GC-MS

  • Do, Jung-Ah;Lee, Min-Hye;Park, Hyejin;Kang, Il-Hyun;Kwon, Kisung;Oh, Jae-Ho
    • Journal of Food Hygiene and Safety
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    • v.27 no.4
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    • pp.332-338
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    • 2012
  • A simple and sensitive analytical method was developed using gas chromatography with electron capture detector (GC-ECD) and gas chromatography-mass spectrometry (GC-MS) for determination of Picoxystrobin in agricultural products (apple, hulled rice, mushroom, pepper, soybean, and mandarin). Picoxystrobin residues were extracted with acetonitrile, partitioned with saline water, and then they were cleaned up on a florisil solid-phase extraction (SPE) cartridge to obtain an extract suitable for analysis by GC-ECD and GC-MS. The method was validated using 6 agricultural product samples spiked with Picoxystrobin at different concentration levels (0.02, 0.05 and 0.5 mg/L). Average recoveries of Picoxystrobin (using each concentration three replicates) ranged 64.0~98.3% with relative standard deviations less than 10%, calibration solutions concentration in the range 0.1~5 mg/L, and limit of detection (LOD) and limit of quantification (LOQ) were 0.005 and 0.02 mg/L, respectively. The result showed that the developed analytical method is suitable for Picoxystrobin determination in agricultural products.

Characteristic of Precipitated Metal Carbonate for Carbon Dioxide Conversion Using Various Concentrations of Simulated Seawater Solution (해수 농축수 내 금속 이온 농도에 따른 이산화탄소 전환 생성물의 특성연구)

  • Choi, Eunji;Kang, Dongwoo;Yoo, Yunsung;Park, Jinwon;Huh, Il-sang
    • Korean Chemical Engineering Research
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    • v.57 no.4
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    • pp.539-546
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    • 2019
  • Global warming has mentioned as one of the international problems and these researches have conducted. Carbon Capture, Utilization and Storage (CCUS) technology has improved due to increasing importance of reducing emission of carbon dioxide. Among of various CCUS technologies, mineral carbonation can converted $CO_2$ into high-cost materials with low energy. Existing researches has been used ions extracted solid wastes for mineral carbonation but the procedure is complicated. However, the procedure using seawater is simple because it contained high concentration of metal cation. This research is a basic study using seawater-based wastewater for mineral carbonation. 3 M Monoethanolamine (MEA) was used as $CO_2$ absorbent. Making various concentrations of seawater solution, simulated seawater powder was used. Precipitated metal carbonate salts were produced by mixing seawater solutions and $rich-CO_2$ absorbent solution. They were analyzed by X-ray Diffraction (XRD), Scanning Electron Microscope (SEM), and Thermogravimetric Analysis (TGA) and studied characteristic of producing precipitated metal carbonate and possibility of reusing absorbent.

Framework for Car Safety Education Virtual Reality Simulation (자동차 안전교육 VR 시뮬레이션 제작을 위한 프레임워크)

  • Xie, Qiao;Ding, Xiu Hui;Jang, Young-Jick;Yun, Tae-Soo
    • Journal of the Korea Convergence Society
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    • v.10 no.9
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    • pp.37-45
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    • 2019
  • In recent years, the emergence of virtual reality (VR Virtual Reality) technology has provided a new model of safety education, enabling users to learn and respond to disasters in a virtual safety education environment. However, the related VR products related to domestic and foreign R & D are relatively simple, there is no practical training on specific accident, and it is not practical enough to play a sufficient role in safety education. In this paper, the problems and disadvantages of VR technology applied in the field of automobile safety education as an example of automobile accident among the types of disasters are examined, and a system framework of automotive safety education based on VR technology is proposed. The vehicle safety education system proposed in this paper will help users to improve driving safety consciousness, to acquire safety knowledge in driving, and to acquire driving safety skill which is very important for automobile safety education. In addition, the design and production methods of safety education based on VR technology are considered to have important reference implications for the application of modern teaching and teaching theory by integrating with VR technology and developing related teaching materials products and finally introducing education.

Effective material properties of radially poled piezoelectric ring transducer for analysis of tangentially poled piezoelectric ring (원주 분극 압전 링 트랜스듀서 해석을 위한 방사 분극 링 유효 물성 도출)

  • Lee, Haksue;Cho, Cheeyoung;Park, Seongcheol;Cho, Yo-Han;Lee, Jeong-min
    • The Journal of the Acoustical Society of Korea
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    • v.38 no.2
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    • pp.184-192
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    • 2019
  • Compared to 31-mode rings, 33-mode rings are highly utilized as wide bandwidth underwater acoustic transducers because the electro-mechanical coupling and piezoelectric constant d are high. On the other hand, the 31-mode ring is an axial symmetry structure, so it is possible to model it as a simple two-dimensional asymmetrical model for numerical analysis, but the 33-mode ring requires a three-dimensional numerical analysis. That is, a lot of computing resources and computation time are required. In this study, the effective material properties of an equivalent 31-mode ring were derived to simulate the electro-mechano-acoustical responses of the 33-mode ring transducer. Using the effective material properties derived from this study, a numerical analysis of rings in vacuum, air backed rings in water, and FFR (Free Flooded Ring) transducers were performed to compare the responses of 33-mode rings.

Development and application of the estimation method of flood damage in the ungauged basin using satellite data (위성자료를 활용한 미계측유역의 홍수피해액 추산기법 개발 및 적용)

  • Yeom, Woong-Sun;Park, Dong-Hyeok;Ahn, Jaehyun
    • Journal of Korea Water Resources Association
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    • v.53 no.12
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    • pp.1183-1192
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    • 2020
  • Economic analysis is a basic step in establishing disaster mitigation measures, but it is difficult to verify the results due to uncertainty. Therefore, the scope of investigation and analysis is wide. However, it is difficult to predict the amount of damage caused by flooding because the collection of relevant data is limited in the ungauged basin. In this study, distributed runoff analysis and flooding analysis were performed, and a method of estimating the amount of flood damage in the ungauged basin was proposed using collectible social and economic indicators and flood analysis results. For distributed runoff analysis and flooding analysis, GRM (Grid based Rainfall-runoff Model) and G2D (Grid based 2-Dimensional land surface flood model) developed by Korea Institute of Civil engineering and Building Technology were used. The method of substituting collectible social and economic indicators into the simple method and improvement method was used to estimate the amount of flood damage. As a result of the study, it was possible to estimate the amount of flood damage using satellite data and social and economic indicators in the ungauged basin.

A Methodology for Making Military Surveillance System to be Intelligent Applied by AI Model (AI모델을 적용한 군 경계체계 지능화 방안)

  • Changhee Han;Halim Ku;Pokki Park
    • Journal of Internet Computing and Services
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    • v.24 no.4
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    • pp.57-64
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    • 2023
  • The ROK military faces a significant challenge in its vigilance mission due to demographic problems, particularly the current aging population and population cliff. This study demonstrates the crucial role of the 4th industrial revolution and its core artificial intelligence algorithm in maximizing work efficiency within the Command&Control room by mechanizing simple tasks. To achieve a fully developed military surveillance system, we have chosen multi-object tracking (MOT) technology as an essential artificial intelligence component, aligning with our goal of an intelligent and automated surveillance system. Additionally, we have prioritized data visualization and user interface to ensure system accessibility and efficiency. These complementary elements come together to form a cohesive software application. The CCTV video data for this study was collected from the CCTV cameras installed at the 1st and 2nd main gates of the 00 unit, with the cooperation by Command&Control room. Experimental results indicate that an intelligent and automated surveillance system enables the delivery of more information to the operators in the room. However, it is important to acknowledge the limitations of the developed software system in this study. By highlighting these limitations, we can present the future direction for the development of military surveillance systems.

Spirituality and Social Work Scholarship in Korea - A Content Analysis - (한국에서의 Spirituality와 사회사업에 대한 연구 동향과 전망)

  • Kim, Kyung-Mee;Canda, Edward R.
    • Korean Journal of Social Welfare Studies
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    • v.40 no.2
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    • pp.203-225
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    • 2009
  • There are emerging international trends in social work scholarship toward increasing attention to spirituality in research and publications. However, little has been published about this beyond the North American and European contexts. Therefore, this article explores the state of the art scholarly social work publications in an East Asian country, the Republic of Korea. First, a brief overview is given of the history and current situation of connections between spirituality and religions with social work in Korea. Then, results of a content analysis of Korean academic journal articles are presented to indicate the state of the art and implications for further work, including international collaborations. The content analysis revealed that there is relatively little empirical work in this area, although it has grown in recent years. Most of the empirical research is based on simple statistical methods while systematic qualitative studies are lacking. Conceptual work provides guidelines for various religious specific approaches to social work; development of approaches that are inclusive of diverse religious and nonreligious spiritual perspectives is just beginning. However, there are indications of the potential for a significant increase of scholarly work on spirituality and social work. International collaborations could facilitate this.

Simultaneous GC/MS Analyses of Organic acids and Amino acids in Urine using TMS-TFA derivative (TMS-TFA 유도체화를 이용한 소변여지 중 유기산과 아미노산의 GC/MS 동시분석)

  • Yoon, Hye-Ran
    • Analytical Science and Technology
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    • v.19 no.1
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    • pp.107-114
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    • 2006
  • Early diagnosis and medical intervention are critical for the treatment of patients with metabolic disorders. A rapid analytical method was developed for simultaneous quantification of organic acids and amino acids in urine without labor-intensive pre-extraction procedure showing high sensitivity and specificity. A new method consisted of simple two-step trimethylsilyl (TMS)-trifluoroacetyl (TFA) derivatization using GC/MS-selective ion monitoring (SIM). Filter paper urine specimens were dried under nitrogen after being fortified with internal standard (tropate) in a mixture of distilled water and methanol. Methyl orange was added to the residue as indicator reagent. Silyl derivative of carboxylic functional group was followed by trifluoroacetyl derivative for amino functional group. N-methyl-N-(trimethylsilyl-trifluoroacetamide) and N-methyl-bistrifluoroacetamide were consecutively added and heated for 15-20 min at $65^{\circ}C-70^{\circ}C$, for TMS-TFA derivative, respectively. This reactant was analyzed by GC/MS-SIM. Linear dynamic range showed 0.001-50 mg with the detection limit of (S/N=3) 10-200 ng, and the quantification limit of 80-900 ng in urine. Correlation coefficient of regression line was 0.994-0.998. When the method was applied to the patients 'urine, it clearly differentiated the normal from the patient with metabolic disorder. The study showed that the developed method could be the method of choices in rapid and sensitive screening for organic aciduria and amino acidopathy.

Development of a rapid HPLC method for the determination of penciclovir in human plasma using a monolithic column and its application to a bioequivalence study (모노리틱 칼럼을 이용한 혈장 중 펜시를로버의 HPLC 신속분석법 개발 및 이를 이용한 생물학적동등성시험)

  • Kim, Jin Hee;Park, Ah Yeon;Jung, Eun Ha;Lee, Cheol Woo;Lee, Tae Ho;Youm, Jeong-Rok
    • Analytical Science and Technology
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    • v.20 no.4
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    • pp.323-330
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    • 2007
  • A simple and rapid HPLC method with fluorescence detection(FLD) for quantitation of penciclovir in human plasma using a monolithic column was developed and validated. Penciclovir and ganciclovir(internal standard, I.S.) were separated on a Chromolith column RP-18e ($4.6{\times}100mm$) with a mobile phase consisting of a mixture of (A) methanol/50 mM sodium phosphate buffer containing 200 mg/L sodium dodecyl sulfate (3/97, pH 2.5) and (B) methanol/50 mM sodium phosphate buffer containing 200 mg/L sodium dodecyl sulfate (50/50, pH 2.5) at a flow gradient of $1.6{\sim}4.0mL/min$. The retention times of penciclovir and internal standard were less than 4.0 min. Calibration curve was linear ($R^2=0.9994$) over a concentration range of $0.1{\sim}5{\mu}g/mL$. Intra-day precision, accuracy and inter-day precision were 1.36~8.55 %, 92.8~100.0 % and 0.93~5.62 %, respectively with a limit of quantitation at $0.1{\mu}g/mL$. The present HPLC-FLD method is sensitive, precise and accurate. The method described herein has been successfully used for the bioequivalence study of a famciclovir formulation product after oral administration to healthy Korean volunteers.