• 통합자연과학논문집
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• 제9권2호
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• pp.113-120
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• 2016

Monopolar spindle 1 (Mps1) is an attractive cancer target due to its high expression levels in a wide range of cancer cells. Mps1 is a dual specificity kinase. It plays an essential role in mitosis. The high expression od Mps1 was observed in various grades of breast cancers. In the current study, we have developed a CoMFA model of pyridazine derivatives as Mps1 kinase inhibitors. The developed CoMFA model ($q^2=0.797$; ONC=6; $r^2=0.992$) exhibited a good predictive ability. The model was then validated by Leave out five, progressive sampling and bootstrapping and found to be robust. The analysis of the CoMFA contour maps depicted favorable and unfavorable regions to enhance the activity. Bulky positive substitution at $R^3$ position and Negative substitution in $R^1$ position is favored could increase the activity. In contrast, bulky substitution in $R^1$ position is not favored. Our results can be used in designing a potent Mps1 (TTK) inhibitor.

• 대한기계학회논문집B
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• 제20권7호
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• pp.2298-2314
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• 1996

Electric field effect on boiling of refrigerants R11, R113, and FC72 has been investigated experimentally. One purpose of the experimental investigation is to determine the effects of the electrode arrangements on electrohydrodynamic boiling of the above mentioned liquids. The test equipment employed in the experiment consists of a shell and tube heat exchanger with six or six and twelve rows of electrode wires around the tube. It has been found that the applied voltage promotes the boiling heat transfer coefficient except FC72. Boiling heat transfer enhancement obtained is about 230% for R11, 280% for R113. It has also been observed that bubbles detached from the tube aggregate at the place where the electrical gradient force balances with the buoyancy one. These aggregated bubbles force to decrease the boiling heat transfer coefficient as well as to reduce the voltage needed to the dielectric breakdown.

• The Korean Journal of Physiology and Pharmacology
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• 제23권2호
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• pp.113-120
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• 2019

Mannosylerythritol lipids (MELs) are glycolipids and have several pharmacological efficacies. MELs also show skin-moisturizing efficacy through a yet-unknown underlying mechanism. Aquaporin-3 (AQP3) is a membrane protein that contributes to the water homeostasis of the epidermis, and decreased AQP3 expression following ultraviolet (UV)-irradiation of the skin is associated with reduced skin moisture. No previous study has examined whether the skin-moisturizing effect of MELs might act through the modulation of AQP3 expression. Here, we report for the first time that MELs ameliorate the UVA-induced downregulation of AQP3 in cultured human epidermal keratinocytes (HaCaT keratinocytes). Our results revealed that UVA irradiation decreases AQP3 expression at the protein and messenger RNA (mRNA) levels, but that MEL treatment significantly ameliorated these effects. Our mitogen-activated protein kinase inhibitor analysis revealed that phosphorylation of c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase or p38, mediates UVA-induced AQP3 downregulation, and that MEL treatment significantly suppressed the UVA-induced phosphorylation of JNK. To explore a possible mechanism, we tested whether MELs could regulate the expression of peroxidase proliferator-activated receptor gamma ($PPAR-{\gamma}$), which acts as a potent transcription factor for AQP3 expression. Interestingly, UVA irradiation significantly inhibited the mRNA expression of $PPAR-{\gamma}$ in HaCaT keratinocytes, whereas a JNK inhibitor and MELs significantly rescued this effect. Taken together, these findings suggest that MELs ameliorate UVA-induced AQP3 downregulation in HaCaT keratinocytes by suppressing JNK activation to block the decrease of $PPAR-{\gamma}$. Collectively, our findings suggest that MELs can be used as a potential ingredient that modulates AQP3 expression to improve skin moisturization following UVA irradiation-induced damage.

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2002년도 Current Trends in Toxicological Sciences
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• pp.113-113
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• 2002

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.113.1-113.1
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• 2000

• 한국문헌정보학회지
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• 제49권1호
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• pp.113-128
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• 2015

주요 선진국은 공공정보 개방과 재활용의 중요성을 인식하고, 공공정보를 원활하게 제공하고 활용할 수 있도록 촉진하는 정책적 방안을 모색하고 있다. 우리나라의 경우, 국가 차원의 R&D 사업과 성과물의 양적 증가에도 불구하고 현재까지 성과활용 실적은 여전히 낮은 편으로, 연구 성과물에 대한 실질적인 활용분석 및 경제적 기여도 분석 노력이 시급한 상황이다. 본 연구의 목적은 국가 R&D 보고서 원문의 활용도와 경제적 기여도를 분석하는데 있다. 본 연구의 목적을 위해 문헌조사, 설문조사, 포커스 그룹 인터뷰, 전문가 자문 등 정량적인 방법과 정성적인 방법을 병행하였다.

• Journal of applied mathematics & informatics
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• 제32권1_2호
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• pp.113-128
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• 2014

Consider a class of p(x)-Kirchhoff type equations of the form $$\left\{-M\left({\int}_{\Omega}\;\frac{1}{p(x)}{\mid}{\nabla}u{\mid}^{p(x)}\;dx\right)\;div\;({\mid}{\nabla}u{\mid}^{p(x)-2}{\nabla}u)={\lambda}V(x){\mid}u{\mid}^{q(x)-2}u\;in\;{\Omega},\\u=0\;on\;{\partial}{\Omega},$$ where p(x), $q(x){\in}C({\bar{\Omega}})$ with 1 < $p^-\;:=inf_{\Omega}\;p(x){\leq}p^+\;:=sup_{\Omega}p(x)$ < N, $M:{\mathbb{R}}^+{\rightarrow}{\mathbb{R}}^+$ is a continuous function that may be degenerate at zero, ${\lambda}$ is a positive parameter. Using variational method, we obtain some existence and multiplicity results for such problem in two cases when the weight function V (x) may change sign or not.

• 충청수학회지
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• 제27권1호
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• pp.113-121
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• 2014

In this paper, we define an extension $f^*:[a,\;b]{\rightarrow}\mathbb{R}$ of a function $f:[a,\;b]_{\mathbb{T}}{\rightarrow}\mathbb{R}$ for a time scale $\mathbb{T}$ and show that f is McShane delta integrable on $[a,\;b]_{\mathbb{T}}$ if and only if $f^*$ is McShane integrable on [a, b].

• 대한수학회보
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• 제47권1호
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• pp.113-119
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• 2010

If f is M-harmonic and integrable with respect to a weighted radial measure $\upsilon_{\alpha}$ over the unit ball $B_n$ of $\mathbb{C}^n$, then $\int_{B_n}(f\circ\psi)d\upsilon_{\alpha}=f(\psi(0))$ for every $\psi{\in}Aut(B_n)$. Equivalently f is fixed by the weighted Berezin transform; $T_{\alpha}f = f$. In this paper, we show that if a function f defined on $B_n$ satisfies $R(f\circ\phi){\in}L^{\infty}(B_n)$ for every $\phi{\in}Aut(B_n)$ and Sf = rf for some |r|=1, where S is any convex combination of the iterations of $T_{\alpha}$'s, then f is M-harmonic.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2009년 추계학술발표대회
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• pp.113-113
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• 2009

세계적으로 환경문제에 대한 관심이 커짐에 따라 연료 효율 향상과 매연을 줄이기 위해 차량 경량화 요구가 증가하는 동시에 안전 규제가 강화되고 있어 높은 강도를 가지는 소재의 적용이 증가하고 있다. 충돌 시 차량 구조를 유지시켜주는 범퍼나 B-필러와 같은 부품에 1500MPa급의 초고강도강이 적용되고 있으며 레이저 용접이 가지는 장점이 많이 알려지면서 그 사용이 증가하는 추세이다. 따라서 레이저 용접에 의한 초고강도강의 용접 특성에 대한 연구가 필요하다. 본 연구에서는 1500MPa급 초고강도강의 레이저 맞대기 용접을 실시하여 단면, 경도 측정, 인장시험을 통해 용접부 특성을 파악하였다. 파이버 레이저와 디스크 레이저를 사용하여 각각의 레이저빔 직경 변화에 따른 입열량 변화에 따라 용접성에 미치는 영향에 대해 알아보았다.