• Journal of Technology Innovation
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• v.11 no.1
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• pp.79-97
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• 2003

R&D expenditure of Korean firms has been increasing drastically since 1980 and occupied 84% of total R&D expenditure in 1994. After 1994, however, the growth rate of industry R&D expenditure has dropped below single digit. R&D concentration rate of upper 20 companies declined from 61.9% in 1999 to 49.8% in 2001. The technology trade balance has diverged by 2.8 billion dollars in 2000 compared to around 0.3 billion dollars in 1985. We find several reasons on declining the industry R&D growth rate in Korea. First, we carefully say there might be an crowding out effect in increasing government R&D investment from Granger causality test between industry R&D and government R&D. Second, the decreasing benefit of tax credit since 1992 on industry R&D expenditure has caused the decrease of industry R&D growth rate. Third, the type of R&D cost becomes to similar to matured countries type of cost, which means the portion of capital expenditure has been decreased since late of 1980s. Therefore, industry R&D growth rate gets to saturation point. We draw several policy implications from the changing structure of business R&D of Korean company. Firstly, to stimulate industry R&D investment Korean government needs to strengthen tax credit policy. Secondly, to induce foreign direct investment Korean government needs to establish technology infrastructures and high quality of manpower. To utilize foreign technology resources Korean government need to introduce global R&D program executed by foreign scientist as an Project Leader.

• Journal of Embryo Transfer
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• v.20 no.3
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• pp.233-238
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• 2005

This study was carried out to investigate effects of claw trimming on reproductive efficiency in lactating cow. The results obtained were summarized as follows: 1. Days to 1st postpartum service were 180.9$\pm$47.2 days for control and 111.9$\pm$17.1 days for claw trimming. 2. Conception rate by 1st postpartum service was $25.0\%$ for control and $66.7\%$ for claw trimming. 3. Days to 1st postpartum conception were 258.1$\pm$43.3 days for control and 151.6$\pm$26.2 days for claw trimming(p<0.05). 4. Services per conception were 1.88$\pm$0.23 times for control and 1.44$\pm$0.18 times for claw trimming. 5. Calving interval was 489.3$\pm$47.2 days for control and 430.8$\pm$26.2 days for claw trimming.

• The Journal of Korean Institute for Practical Engineering Education
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• v.4 no.2
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• pp.53-59
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• 2012

This article reviews the current issues of engineering education: engineering creativity, R&D 3.0 and Education 3.0 and comfirms need of refining quality of engineering education through learner-centered hybrid project learning. this article suggests the Global engineering project(GEP) program as an ideal hybrid project learning model that develop student's creativity and convergence capability. GEP program is learnner-centered interdisciplinary program that whole processes are managed by interdisciplinary students team aiming to global engineers who are globally competent and locally relevant so that they can function effectively in any country by local activity in developing country. The program consist of four main parts: 1)pre activity, 2)local activity from abroad, 3)design and producing prototype and 4)participating in the design contest or academic conference with the products. As a result, students' global competence, teamwork skill and capability of creative problem solving are remarkably improved.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.38 no.2
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• pp.147-154
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• 2012

In this study, we prepared elastic liposome containing rutin, known as antioxidants, and evaluated the physical characterization and enhanced skin permeation effect. The elastic liposome was prepared using the different ratios of egg phospholipids and $Tego^{(R)}$ care 450. The mean diameter of rutin loaded elastic liposomes formulations ranged between 205.7 ~ 298.0 nm and deforability 20.9 ~ 42.5, The loading efficiency was observed to be 52.0 ~ 71.0 %. The highest loading efficiency (71.0 %) and deformability (42.5) were observed at the optimal ratio of 85 : 15 (egg phospholipids : $Tego^{(R)}$ care 450) in the 0.1 % rutin loaded elastic liposome formulations. The elastic liposome formulation was selected for further transdermal permeation study. The elastic liposome(129.9 ${\mu}g/cm^2$) exhibited a significantly higher skin permeation compared with general liposome (98.0 ${\mu}g/cm^2$) and 1,3-butylene glycol (76.3 ${\mu}g/cm^2$) solution. These results suggest that the elastic liposome formulation using $Tego^{(R)}$ care 450 as a major edge activator could be useful for the delivery of active ingredient through the skin barrier.

• Journal of Animal Science and Technology
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• v.46 no.6
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• pp.981-988
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• 2004

An Experiment was conducted to investigate the effects of Natufermen$^{(R)}$;(Aspergillus oryzae) supplementation on the performance, ammonia gas production, microbial population in manure and serum IgG in pigs. Forty eight cross bred(YLD) weanling pigs(35d old) were assigned to 4 treatments; Control(C), $C^+$ Natufermen 0.1%, $C^+$ Natufermen 0.2% $C^+$natufermen 0.3% for 6 week feeding trial. Each treatment had 4 replications of 3 pigs each. Natufermen$^{(R)}$ supplemented treatments tended to increase ADG and ADFI, but there were no significant differences among treatments. Supplementation of Natufermen$^{(R)}$ at the level of 0.2% improved ADFI/ADG(P<0.05). Ammonia gas production from manure was not significantly affected by treatments. All Natufermen$^{(R)}$ treatments increased in DM, crude ash and phosphorus digestibility(P<0.05). Serum IgG decreased as supplemention level of Natufermen$^{(R)}$ increased(P<0.05). Supplemtation of Natufermen$^{(R)}$ at 0.1% and 0.2% increased fecal Lactobacilli population at 3 wks after feeding treated diets(P<0.05). It is concluded that supplementation of Aspergillers oryzae product Natufermen$^{(R)}$ improved feed conversion ratio and digestibility of DM, crud ash and phosphours. Fecal ammonia gas production was not significantly affected but serum IgG level was decreased and CFU of fecal Lactobacilli was increased at 3 wks after feeding Natufermen$^{(R)}$ supplemented diets.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.324.1-324.1
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• 2002

Human 5-reductase type II(5AR2) is an important target for the treatment of benign prostatic hyperplasia. In this study we describe the establishment of cell line which stably expressed 3X FLAG tagged human 5AR2. We used this cell line as a cell based assay tool and source for 5AR2 enzyme. First a plasmid (3XFLAGpCMVl0-5AR2) for the expression of 5AR2 was constructed by the use of the vector 3XFLAGpCMV10 and transfected into the HEK 293. By selection with G418 sulfate. ten HEK 293 single cell clones were obtained of which three stably exhibited high 5AR2 activity. (omitted)

• Journal of Applied Biological Chemistry
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• v.49 no.1
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• pp.21-23
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• 2006

As part of a program to discover bioactive natural products from marine organisms, two new enantiomers, ent-3,6-Epidioxy-4,6,8,10-tetraethyltetradeca-7,11-dienoic acid and ent-[3,5-Diethyl-5-(2-ethyl-hex-3-enyl)-5H-furan-2-ylidene]-acetic acid methyl ether, were isolated from a sponge Plakortis sp. These compounds showed strong in vitro antiproliferative effects on promastigotes of Leishmania mexicania, flagellate protozoan that causes leishmaniasis. Structures were assumed by interpretation of NMR spectroscopic data and optical rotation. Both compounds exhibited significant antileishmanial activities in vitro with $IC_{50}$ of 1.0-23.0 ${\mu}g/ml$.

• Journal of electromagnetic engineering and science
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• v.8 no.3
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• pp.96-99
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• 2008

This paper describes a $0.13-{\mu}m$ CMOS RF switch for $3{\sim}5$ GHz UWB band(mode 1). It can improve isolation characteristics between ports by using deep n-well RF devices while their source and body terminals are separated. From the measurement results, the proposed T/R switch is comparative to the on-wafer probing measurement results of the series-shunt T/R switches. When the proposed T/R switch operates as Tx mode, measured insertion loss from Tx to output port is less than 1.5 dB and isolation between Tx and Rx is more than 27 dB for $3{\sim}5$ GHz. Return loss for the Tx port is more than -10 dB and input P1dB is +10 dBm.

• Communications of the Korean Mathematical Society
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• v.27 no.3
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• pp.441-448
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• 2012

Let R be a prime ring with center Z and characteristic different from two, U a nonzero Lie ideal of R such that $u^2{\in}U$ for all $u{\in}U$ and $d$ be a nonzero (${\sigma}$, ${\tau}$)-derivation of R. We prove the following results: (i) If $[d(u),u]_{{\sigma},{\tau}}$ = 0 or $[d(u),u]_{{\sigma},{\tau}}{\in}C_{{\sigma},{\tau}}$ for all $u{\in}U$, then $U{\subseteq}Z$. (ii) If $a{\in}R$ and $[d(u),a]_{{\sigma},{\tau}}$ = 0 for all $u{\in}U$, then $U{\subseteq}Z$ or $a{\in}Z$. (iii) If $d([u,v])={\pm}[u,v]_{{\sigma},{\tau}}$ for all $u{\in}U$, then $U{\subseteq}Z$.

• Transactions on Electrical and Electronic Materials
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• v.11 no.3
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• pp.126-129
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• 2010

(1-X) $(Na_{0.5}K_{0.5})NbO_3-X$ $K_4CuNb_8O_{23}$ (NKN-X KCN) ceramics were produced using the conventional solid state sintering method, and their sinterability and electric properties were investigated. The density, dielectric constant (${\varepsilon}_r$), piezoelectric constant $d_{33}$, electromechanical coupling factor $k_p$ and mechanical quality factor $Q_m$ value of the NKN ceramics depended upon the KCN content and the sintering temperature. In particular, the KCN addition to the NKN greatly improved the mechanical quality factor $Q_m$ value. The ceramic with X = 2.0 mol% sintered at $1,150^{\circ}C$ possesses the optimum properties (${\varepsilon}_r=241$, $d_{33}=78$, $k_p=0.34$ and $Q_m=1,121$). These results indicate that the ceramic is a promising candidate material for applications in lead free piezoelectric transformer and filter materials.