• Journal of Korea Technology Innovation Society
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• v.20 no.4
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• pp.989-1014
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• 2017

Major advanced countries pursuing accountability for research and development are carrying out gendered innovations by recognizing the importance of sex and gender analysis in science research and technology development. Korea needs to actively promote gendered innovations as a strategy moving from Fast Follower to First Mover. In order to promote gendered innovations in the science, technology and ICT fields, policies of integrating the gender dimension in the process of research from research design to the analysis of research outcomes should be declared and research support measures should be introduced from the proposal evaluation for the gendered innovations. In particular, in order to support the new gendered innovations research systematically in Korea's R & D system, a legal basis must precede. In this study, we propose an amendment to the law related to gender innovation by analyzing the cases in foreign countries.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.14 no.3
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• pp.39-46
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• 2019

Research has shown that alliances with external partners are valuable to foster internal R & D efforts. However, it is not well known how to take advantage of the potential benefits of strategic alliances to create innovative outcomes. This study examines the value of strategic alliances and analyzes the role of human capital in the impact of strategic alliances on innovation performance. This study focuses on whether the absorptive capacity of human capital affects firm innovation through interaction with strategic alliances. In the analysis using 2,205 Korean venture firm data, strategic alliances have a positive effect on innovation performance. However, the moderating role of human capital in the relationship between strategic alliances and innovation performance shows a significant negative impact. This implies that the ability to internalize knowledge and information acquired from external partners into the firm is important. This study provides valuable insights for managers who want to enhance the effectiveness of strategic alliances by considering the interaction of strategic alliances and human capital.

• Journal of Gastric Cancer
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• v.8 no.2
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• pp.57-64
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• 2008

In gastric cancer, the only potentially curative treatment is surgery that attempts to achieve curative (R0) resection. However, despite the use of curative resection, a recurrence develops in a high percentage of patients, especially in cases of serosa and/or lymph node involvement. As a strategy to improve the survival of the patients with resectable advanced gastric cancer, neoadjuvant chemotherapy has been evaluated in several phase II trials and a few phase III trials. The results of these trials have confirmed the feasibility and safety of this approach with no apparent increase in surgical complications. Recently, the findings of a large phase III randomized trial (MAGIC trial) have indicated that compared to the use of surgery alone, perioperative chemotherapy, using both a neoadjuvant and adjuvant strategy, decreased the number of T and N stage cancers and improved survival. The results of another recent phase III trial (FNLCC 94012/FFCD 9703) also showed that compared to the use of surgery alone, perioperative chemotherapy improved the R0 resection rate and survival. In both trials, the improved outcomes may be attributed to the use of neoadjuvant chemotherapy because of poor compliance with adjuvant chemotherapy. These results cannot be directly translated to clinical practice in Korea due to differences in surgical techniques and outcomes. However, the findings of a few small phase II and III trials performed in patients with locally advanced gastric cancer in Korea have also suggested that neoadjuvant chemotherapy would result in the improvement of the R0 resection rate and down-staging of the disease. More effective chemotherapy regimens are needed in future large randomized trials to determine the subset of patients that will benefit from neoadjuvant chemotherapy and to determine the extent of benefit.

• Journal of Chest Surgery
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• v.53 no.5
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• pp.301-305
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• 2020

Background: Radiographic modalities have been commonly used to evaluate pectus carinatum (PC), and compressive orthotic bracing is the most widely accepted treatment method. The aim of this study was to determine the efficacy of 3-dimensional (3D) body surface scanning as an alternative modality for the evaluation of PC. Methods: The medical records of 63 patients with PC who were treated with compressive orthotic bracing therapy between July 2017 and February 2019 were retrospectively analyzed. Using both 2-view chest radiography (posteroanterior and lateral view) and 3D body scanning, the height of maximal protrusion of the chest wall was measured both before and after 2 weeks of bracing therapy. The difference between the pre- and post-treatment measurements was calculated for both modalities, and these differences were compared and analyzed. Results: Based on the comparison between the pre- and post-treatment radiographs, bracing therapy produced favorable outcomes in all patients (p<0.001). The measurements obtained via 3D scanning were strongly correlated with those obtained via chest radiography (r=0.60). Conclusion: Based on the findings of this study, 3D body surface scanning appears to be an effective, radiation-free, and simple method for the post-treatment follow-up evaluation of PC, and thus can be considered an alternative to radiography.

• Food Science of Animal Resources
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• v.41 no.2
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• pp.312-323
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• 2021

The purpose of this study was to use 1H nuclear magnetic resonance (1H NMR) to quantify taste-active and bioactive compounds in chicken breasts and thighs from Korean native chicken (KNC) [newly developed KNCs (KNC-A, -C, and -D) and commercial KNC-H] and white-semi broiler (WSB) used in Samgye. Further, each breed was differentiated using multivariate analyses, including a machine learning algorithm designed to use metabolic information from each type of chicken obtained using 1H-13C heteronuclear single quantum coherence (2D NMR). Breast meat from KNC-D chickens were superior to those of conventional KNC-H and WSB chickens in terms of both taste-active and bioactive compounds. In the multivariate analysis, meat portions (breast and thigh) and chicken breeds (KNCs and WSB) could be clearly distinguished based on the outcomes of the principal component analysis and partial least square-discriminant analysis (R2=0.945; Q2=0.901). Based on this, we determined the receiver operating characteristic (ROC) curve for each of these components. AUC analysis identified 10 features which could be consistently applied to distinguish between all KNCs and WSB chickens in both breast (0.988) and thigh (1.000) meat without error. Here, both 1H NMR and 2D NMR could successfully quantify various target metabolites which could be used to distinguish between different chicken breeds based on their metabolic profile.

• Quality Improvement in Health Care
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• v.12 no.2
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• pp.75-83
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• 2006

Background : Utilization review has been adopted as a vehicle for cost and utilization control of health care services. Its role was further stressed and expanded through the establishment of Health Insurance Review Agency in 2001. This article is to introduce concept, activities, and effect of utilization review based on the experiences of U.S. and to suggest important characteristics for ideal utilization review activities at the national level in Korea. Method : Twenty-five articles related with utilization review were reviewed after being selected through web site search through Med Line and Richis. Result : Utilization review was introduced mainly for health care expenditure control either by insurer, provider or the third parties under the pressure of increasing health care cost. It's activities can be categorized to prospective, concurrent and retrospective review according to the time of service provision. Based on most of studies, utilization review has been effective in controling rising health care cost and utilization. However it's effectiveness assumes a reimbursement structure of managed care like capitation payment. More worse, it is still unknown it's effectiveness on quality of care. Conclusion : Utilization review should be employed to increase the cost effectiveness of medical care by optimizing quality and patient's outcomes while also attempting to reduce the use of resources. So, it should consider outcomes before expenditures, check for both under and over-use, and construct an structure in which consumption is reduced equitably. Aggressive adoption of utilization review in Korean health care setting with fee-for-service reimbursement structure might not be a cost-effective approach before adoption of prospective payment system such as D.R.G. and capitation.

• Journal of Korea Spatial Information System Society
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• v.11 no.4
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• pp.1-8
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• 2009

The Korean Government recognized that the importance of spatial information market is promoting Korean Land Spatialization Program(KLSP) to commercialize and practice of the technology. For achieve this purpose, KLSP is planning to build test-bed for field test, integration, display of outcomes. The most important problem in this process is reasonable decision of location. In this paper, the subject is to find how to decide efficiently in locating facilities to test Geospatial information technology like KLSP Test-bed. Consequently, we look over some cases of the inside and outside of the country, and analyze property of outcomes to apply the test-bed. And then we find assessment items for locating.

• Archives of Plastic Surgery
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• v.48 no.6
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• pp.599-606
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• 2021

Background Postoperative dehiscence and surgical site infection after spinal surgery can carry serious morbidity. Multidisciplinary involvement of plastic surgery is essential to minimizing morbidity and achieving definitive closure. However, a standardized approach is lacking. The aim of this study was to identify effective reconstructive interventions for the basis of an evidence-based management protocol. Methods A retrospective review was performed at a single tertiary institution for 45 patients who required 53 reconstruction procedures with plastic surgery for wounds secondary to spinal surgery from 2010 to 2019. Statistical analysis was performed for demographics, comorbidities, and treatment methods. Primary outcomes were postoperative complications, including dehiscence, seroma, and infection. The secondary outcome was time to healing. Results The overall complication rate was 32%, with dehiscence occurring in 17%, seroma in 15% and infection in 11% of cases. Median follow-up was 10 months (interquartile range, 4-23). Use of antibiotic beads did not affect rate of infection occurrence after wound closure (P=0.146). Use of incisional negative pressure wound therapy (iNPWT) was significant for reduced time to healing (P=0.001). Patients treated without iNPWT healed at median of 67.5 days while the patients who received iNPWT healed in 33 days. Demographics and comorbidities between these two groups were similar. Conclusions This data provides groundwork for an evidence-based approach to soft tissue reconstruction and management of dehiscence after spinal surgery. Timely involvement of plastic surgery in high-risk patients and utilization of evidence-based interventions such as iNPWT are essential for improving outcomes in this population.

• Nuclear Engineering and Technology
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• v.54 no.6
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• pp.2311-2320
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• 2022

The main outcomes of the experiments H2P6 performed in the thermal-hydraulics large-scale PANDA facility at PSI in the frame of the OECD/NEA HYMERES-2 project are presented in this article. The experiments of the H2P6 series consists of two PANDA tests characterized by the activation of three (H2P6_1) or one (H2P6_2) cooler(s) in an initially stratified and pressurized containment atmosphere. The initial stratification is defined by a helium-rich region located in the upper part of the vessel and a steam/air atmosphere in the lower part. The activation of the cooler(s) results i) in the condensation of the steam in the vicinity of the cooler(s), ii) the corresponding activation of large scale natural circulation currents in the vessel atmosphere, with the result of iii) the re-distribution and mixing of the Helium stratification initially located in the upper half of the vessel and iv) the continuous pressure decay. The initial helium layer represents hydrogen generated in a postulated severe accident. The main question to be answered by the experiments is whether or not the interaction of the different, localized cooler units would be important for the application of numerical methods. The paper describes the initial and boundary conditions and the experimental results of the H2P6 series with the suggestion of simple scaling laws for both experiments in terms of i) the temperature difference(s) across the cooler(s), ii) the transient steam and helium content and iii) the pressure decay in the vessel. The outcomes of this scaling indicate that the interaction between separate, closely localized units does not play a prominent role for the present experiments. It is therefore reasonable to model several units as one large component with equivalent heat transfer area and total water flow rate.

• Archives of Plastic Surgery
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• v.49 no.3
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• pp.378-396
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• 2022

Several reconstructive methods have been reported to restore the continuity of the aerodigestive tract following resection of pharyngeal and hypopharyngeal cancers. However, high complication rates have been reported after voice prosthesis insertion. In this setting, the ileocolon free flap (ICFF) offers a tubularized flap for reconstruction of the hypopharynx while providing a natural phonation tube. Herein, we systematically reviewed the current evidence on the use of the ICFF for reconstruction of the aerodigestive tract. A systematic literature search was conducted across PubMed MEDLINE, Web of Science, ScienceDirect, Scopus, and Ovid MEDLINE(R). Data on the technical considerations and surgical and functional outcomes were extracted. Twenty-one studies were included. The mean age and follow-up were 54.65 years and 24.72 months, respectively. An isoperistaltic or antiperistaltic standard ICFF, patch flap, or chimeric seromuscular-ICFF can be used depending on the patients' needs. The seromuscular chimeric flap is useful to augment the closure of the distal anastomotic site. The maximum phonation time, frequency, and sound pressure level (dB) were higher with ileal segments of 7 to 15 cm. The incidence of postoperative leakage ranged from 0 to 13.3%, and the majority was occurring at the coloesophageal junction. The revision rate of the microanastomosis ranged from 0 to 16.6%. The ICFF provides a reliable and versatile alternative for reconstruction of middle-size defects of the aerodigestive tract. Its three-dimensional configuration and functional anatomy encourage early speech and deglutition without a prosthetic valve and minimal donor-site morbidity.