• The Korean Journal of Physiology and Pharmacology
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• v.22 no.5
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• pp.555-566
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• 2018

Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of hUCB-MSCs treatment to determine whether hUCB-MSCs enhance the promotion of hair growth. Furthermore, we attempted to identify the factors responsible for hair growth. The effects of hUCB-MSCs on hair growth were investigated in vivo, and hUCB-MSCs advanced anagen onset and hair follicle neogeneration. We found that hUCB-MSCs co-culture increased the viability and up-regulated hair induction-related proteins of human dermal papilla cells (hDPCs) in vitro. A growth factor antibody array revealed that secretory factors from hUCB-MSCs are related to hair growth. Insulin-like growth factor binding protein-1 (IGFBP-1) and vascular endothelial growth factor (VEGF) were increased in co-culture medium. Finally, we found that IGFBP-1, through the co-localization of an IGF-1 and IGFBP-1, had positive effects on cell viability; VEGF secretion; expression of alkaline phosphatase (ALP), CD133, and ${\beta}-catenin$; and formation of hDPCs 3D spheroids. Taken together, these data suggest that hUCB-MSCs promote hair growth via a paracrine mechanism.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2475-2478
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• 2016

Background: Laparoscopic partial nephrectomy is one of the major surgical techniques for small renal masses. However, it is difficult to manage cutting and suturing procedures within acceptable time periods. To overcome this difficulty, we applied a three-dimensional (3D) video system with laparoscopic partial nephrectomy, and evaluated its utility. Materials and Methods: We retrospectively enrolled 31 patients who underwent laparoscopic partial nephrectomy between November 2009 and June 2014. A conventional two-dimensional (2D) video system was used in 20 patients, and a 3D video system in 11. Patient characteristics and video system type (2D or 3D) were recorded, and correlations with perioperative outcomes were analyzed. Results: Mean age of the patients was $55.8{\pm}12.4$, mean body mass index was $25.7{\pm}3.9kg/m^2$, mean tumor size was $2.0{\pm}0.8cm$, mean R.E.N.A.L nephrometry score was $6.9{\pm}1.9$, and clinical stage was T1a in all patients. There were no significant differences in operative time (p=0.348), pneumoperitoneum time (p=0.322), cutting time (p=0.493), estimated blood loss (p=0.335), and Clavien grade of >II complication rate (p=0.719) between the two groups. However, warm ischemic time was significantly shorter in the 3D group than the 2D group (16.1 min vs. 21.2min, p=0.021), which resulted from short suturing time (9.1 min vs. 15.2 min, p=0.008). No open conversion occurred in either group. Conclusions: A 3D video system allows the shortening of warm ischemic time in laparoscopic partial nephrectomy and thus may be useful in improving the procedure.

• Journal of The Korean Ophthalmological Society
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• v.59 no.12
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• pp.1129-1136
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• 2018

Purpose: To compare the postoperative clinical outcomes after cataract surgery and implantation using the BunnyLens $MF^{(R)}$ and $ReSTOR^{(R)}$ multifocal intraocular lenses. Methods: Sixty-five eyes implanted with multifocal intraocular lenses were divided into two groups involving either $ReSTOR^{(R)}$ (39 eyes) or BunnyLens $MF^{(R)}$ (26 eyes) lenses. In these two groups, the distant and near visual acuity, astigmatism, spherical equivalent, and contrast sensitivity test were examined at preoperative and postoperative 1 week, 8 weeks, and 24 weeks. We compared the clinical efficacy between the two groups before and after cataract surgery using statistical analysis. Results: The mean value of distant and near visual acuity, and spherical equivalent of both groups after intraocular lens implantation were significantly improved, compared with the preoperative values (p < 0.05), while there was no significant differences between the two groups (p > 0.05). The means of postoperative distant and near visual acuity, astigmatism, and contrast sensitivity test were not significantly different between $ReSTOR^{(R)}$ and BunnyLens $MF^{(R)}$ lenses (p > 0.05). The mean numeric error of spherical equivalent at the final postoperative 24 weeks was $-0.17{\pm}0.50$ diopters (D) for the $ReSTOR^{(R)}$ lenses and $-0.34{\pm}0.52D$ for the BunnyLens $MF^{(R)}$ lenses (p > 0.05). Conclusions: BunnyLens $MF^{(R)}$ and $ReSTOR^{(R)}$ lenses showed no significant difference in clinical efficacy, including distance and near vision, spherical equivalent error, and contrast sensitivity test after cataract surgery. However, it should be noted that BunnyLens $MF^{(R)}$ lenses had a tendency toward myopic shift compared with $ReSTOR^{(R)}$ lenses.

• Journal of Gastric Cancer
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• v.13 no.2
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• pp.73-78
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• 2013

Surgery is still considered to be the mainstay for the treatment of localized gastric cancer with negative margins (R0-resection) and an adequate lymph-node-dissection (D2-lymphadenectomy). Unfortunately, most cases of gastric cancer are only diagnosed at an advanced stage due to frequent recurrences after primary resection in curative intent. In order to improve prognosis after curative resection, in the recent past, patients with locally advanced tumors were subjected to a pre-, peri-, or postoperative treatment. Interestingly, postoperative chemotherapy has significantly improved survival after gastric resection in Asia, adjuvant radiochemotherapy is favored in North America and perioperative chemotherapy is considered as a treatment of choice in Europe indicating region specific approach towards the treatment. Recently there has also been growing evidence of positive outcomes of neoadjuvant radiochemotherapy on patient survival. In the present article, we discuss the concepts of neoadjuvant treatment approach and provide recommendations to surgeons based on current evidence.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2006.04a
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• pp.50-57
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• 2006

In recent years, a mm1ber of construction robots have been developed, but few practical examples can be found on construction sites today. Nevertheless, automation and robotics are proposed as apparent solutions to problems in productivity, quality, safety, and skilled-labor availability in future construction industry. Since the early 2000s, there has been growing interest in construction automation and robotics in Korea, and significant progresses have also been made. This paper mainly describes the needs of research and development program to introduce robots on construction sites, and primary outcomes which are developed in domestic construction industry. Essential technologies required for the development of construction robots, future prospects of the technology advances, and several suggestions are also presented in this paper.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.1566-1573
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• 2008

Generally, a system or service is verified by requirements if it has met them in transforming customer requirements into a system or service. But as the national research and development projects to develope safety systems or standards or process in railway system domain, it can be quite limiting that the product or systems verification process presented the international or industrial standards to be applied. This paper has analyzed and made up for the general verification process and presented the effective and efficient verification process about safety system, safety standard, process, and safety documents and the methods to manage the outcomes of verification process.

• East Asian Economic Review
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• v.16 no.2
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• pp.139-154
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• 2012

This paper provides a theoretical setup for an analysis of strategic relationships inherent to activities of an innovative multinational enterprise (MNE) and a local company in a host country. Additionally, we explore the incentives of the host country's government to provide subsidies to attract foreign direct investment (FDI) and to protect outcomes of R&D activities conducted by the MNE. We show that the MNE's commercial interests may collide with local companies' over protection of IPRs. Therefore, the extent of knowledge spillovers from the MNE to the local company and the magnitude of incentives to the MNE perform a crucial function in determining the optimal policy mix of IPR protection and FDI subsidies of the host country's government.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.23 no.3
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• pp.157-178
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• 2019

The present correspondence is conveyed on to consider the fascinating and novel characteristics of radiative hydromagnetic convective flow of a chemically reacting fluid over an exponentially accelerated inclined porous plate. Exact solutions for the fluid velocity, temperature and species concentration, under Boussinesq approximation, are obtained in closed form by the two term perturbation technique. The interesting parts of thermal dispersing outcomes are accounted in this correspondence. Graphical evaluation is appeared to depict the trademark direct of introduced parameters on non dimensional velocity, temperature and concentration profiles. Also, the numerical assortment for skin friction coefficient, Nusselt number and Sherwood number is examined through tables. The certification of current examination is confirmed by making an examination with past revelations available in composing, which sets a benchmark for utilization of computational approach.

• Nuclear Engineering and Technology
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• v.55 no.7
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• pp.2670-2677
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• 2023

In the nuclear safety studies, a new trend refers to the evaluation of uncertainties as a mandatory component of best-estimate safety analysis which is a modern and technically consistent approach being known as BEPU (Best Estimate Plus Uncertainty). The major objectives of this study consist in performing a study of uncertainties/sensitivities of the major analysis results for a generic CANDU 6 Nuclear Power Plant during Station Blackout (SBO) progression to understand and characterize the sources of uncertainties and their effects on the key figure-of-merits (FOMs) predictions in severe accidents (SA). The FOMs of interest are hydrogen mass generation and event timings such as the first fuel channel failure time, beginning of the core disassembly time, core collapse time and calandria vessel failure time. The outcomes of the study, will allow an improvement of capabilities and expertise to perform uncertainty and sensitivity analysis with severe accident codes for CANDU 6 Nuclear Power Plant.

• Journal of Acupuncture Research
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• v.31 no.4
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• pp.29-32
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• 2014

Objectives : Jakyakgamcho decoction is a traditional prescription known to be an effective pain control medication and muscle relaxant. For more localized treatment outcomes achieved in a shorter period of time, Jakyakgamcho decoction was reprocessed into a form of pharmacopuncture. An analysis of Jakyakgamcho decoction pharmacopuncture showed that there was a significant loss of paeoniflorin(Jakyak's index component). This study was designed to investigate ways to minimize this loss. Methods : After making changes to the processing methods of Jakyakgamcho decoction pharmacopuncture, we measured the quantity of paeoniflorin using high performance liquid chromatography(HPLC) for a before-and-after analysis Results : Paeoniflorin loss was observed 15 minutes after sterilization with $Na_2HPO_4$ at $121^{\circ}C$ Conclusions : It was found that paeoniflorin loss did not occur when pH was not controlled for during processing.