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http://dx.doi.org/10.5230/jgc.2013.13.2.73

Neoadjuvant Treatment for Gastric Cancer  

Schuhmacher, Christoph (Department of Surgery, Klinikum rechts der Isar der Technischen Universitaet Muenchen)
Reim, Daniel (Department of Surgery, Klinikum rechts der Isar der Technischen Universitaet Muenchen)
Novotny, Alexander (Department of Surgery, Klinikum rechts der Isar der Technischen Universitaet Muenchen)
Publication Information
Journal of Gastric Cancer / v.13, no.2, 2013 , pp. 73-78 More about this Journal
Abstract
Surgery is still considered to be the mainstay for the treatment of localized gastric cancer with negative margins (R0-resection) and an adequate lymph-node-dissection (D2-lymphadenectomy). Unfortunately, most cases of gastric cancer are only diagnosed at an advanced stage due to frequent recurrences after primary resection in curative intent. In order to improve prognosis after curative resection, in the recent past, patients with locally advanced tumors were subjected to a pre-, peri-, or postoperative treatment. Interestingly, postoperative chemotherapy has significantly improved survival after gastric resection in Asia, adjuvant radiochemotherapy is favored in North America and perioperative chemotherapy is considered as a treatment of choice in Europe indicating region specific approach towards the treatment. Recently there has also been growing evidence of positive outcomes of neoadjuvant radiochemotherapy on patient survival. In the present article, we discuss the concepts of neoadjuvant treatment approach and provide recommendations to surgeons based on current evidence.
Keywords
Gastric cancer; Neoadjuvant therapy; Chemotherapy; Chemoradiotherapy; Surgery;
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