• Korean Journal of Radiology
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• 제22권10호
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• pp.1719-1729
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• 2021

Objective: Emphysema and small-airway disease are the two major components of chronic obstructive pulmonary disease (COPD). We propose a novel method of quantitative computed tomography (CT) emphysema air-trapping composite (EAtC) mapping to assess each COPD component. We analyzed the potential use of this method for assessing lung function in patients with COPD. Materials and Methods: A total of 584 patients with COPD underwent inspiration and expiration CTs. Using pairwise analysis of inspiration and expiration CTs with non-rigid registration, EAtC mapping classified lung parenchyma into three areas: Normal, functional air trapping (fAT), and emphysema (Emph). We defined fAT as the area with a density change of less than 60 Hounsfield units (HU) between inspiration and expiration CTs among areas with a density less than -856 HU on inspiration CT. The volume fraction of each area was compared with clinical parameters and pulmonary function tests (PFTs). The results were compared with those of parametric response mapping (PRM) analysis. Results: The relative volumes of the EAtC classes differed according to the Global Initiative for Chronic Obstructive Lung Disease stages (p < 0.001). Each class showed moderate correlations with forced expiratory volume in 1 second (FEV₁) and FEV₁/forced vital capacity (FVC) (r = -0.659-0.674, p < 0.001). Both fAT and Emph were significant predictors of FEV₁ and FEV₁/FVC (R² = 0.352 and 0.488, respectively; p < 0.001). fAT was a significant predictor of mean forced expiratory flow between 25% and 75% and residual volume/total vital capacity (R² = 0.264 and 0.233, respectively; p < 0.001), while Emph and age were significant predictors of carbon monoxide diffusing capacity (R² = 0.303; p < 0.001). fAT showed better correlations with PFTs than with small-airway disease on PRM. Conclusion: The proposed quantitative CT EAtC mapping provides comprehensive lung functional information on each disease component of COPD, which may serve as an imaging biomarker of lung function.

• 한국수소및신에너지학회논문집
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• 제22권3호
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• pp.386-401
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• 2011

Mathematical models for various steps in coal gasification reactions were developed and applied to investigate the effects of operation parameters on dynamic behavior of gasification process. Chemical reactions considered in these models were pyrolysis, volatile combustion, water shift reaction, steam-methane reformation, and char gasification. Kinetics of heterogeneous reactions between char and gaseous agents was based on Random pore model. Momentum balance and Stokes' law were used to estimate the residence time of solid particles (char) in an up-flow reactor. The effects of operation parameters on syngas composition, reaction temperature, carbon conversion were verified. Parameters considered here for this purpose were $O_2$-to-coal mass ratio, pressure of reactor, composition of coal, diameter of char particle. On the basis of these parametric studies some quantitative parameter-response relationships were established from both dynamic and steady-state point of view. Without depending on steady state approximation, the present model can describe both transient and long-time limit behavior of the gasification system and accordingly serve as a proto-type dynamic simulator of coal gasification process. Incorporation of heat transfer through heterogenous boundaries, slag formation and steam generation is under progress and additional refinement of mathematical models to reflect the actual design of commercial gasifiers will be made in the near futureK.

• 천문학회보
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• 제38권2호
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• pp.76-76
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• 2013

The current hierarchical model of galaxy formation predicts that galaxy halos contain merger relics in the form of long stellar streams. In order to find stellar substructures in galaxy, we focused our investigation on the stellar spatial density around globular clusters and on the quantitative properties of the evolved sequences in the color-magnitude diagrams (CMDs). First, we investigated the spatial configuration of stars around five metal-poor globular clusters in halo region (M15, M30, M53, NGC 5053, and NGC 5466) and one metal-poor globular cluster in bulge region (NGC 6626). Our findings indicate that all of these globular clusters show strong evidence of extratidal features in the form of extended tidal tails around the clusters. The orientations of the extratidal features show the signatures of tidal tails tracing the clusters' orbits and the effects of dynamical interactions with the galaxy. These features were also confirmed by the radial surface density profiles and azimuthal number density profiles. Our results suggest that these six globular clusters are potentially associated with the satellite galaxies merged into the Milky Way. Second, we derived the morphological parameters of the red giant branch (RGB) from the near-infrared CMDs of 12 metal-poor globular clusters in the Galactic bulge. The photometric RGB shape indices such as colors at fixed magnitudes, magnitudes at fixed colors, and the RGB slope were measured for each cluster. The magnitudes of the RGB bump and tip were also estimated. The derived RGB parameters were used to examine the overall behavior of the RGB morphology as a function of cluster metallicity. The behavior of the RGB shape parameters was also compared with the previous observational calibration relation and theoretical predictions of the Yonsei-Yale isochrones. Our results of studies for stellar spatial distribution around globular clusters and the morphological properties of RGB stars in globular clusters could add further observational evidence of merging scenario of galaxy formation.

• 한국측량학회지
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• 제19권3호
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• pp.229-236
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• 2001

수문학적 분석에서 기본연구과제 중의 하나는 유역설정과 하도망을 추출하는 것이다. 유역면적과 하도망 변수특성은 수문계산과 모델링에 많이 이용되고 있으며, 하도망의 자동추출과 유역설정방식은 일반적으로 수치표고모델이 많이 이용된다. 본 연구는 수치표고모델의 격자크기에 따른 유역특성인자의 분석에 관한 연구이다. 수문지형학에서의 정량적인 하도망 해석은 하천을 차수에 의해 분류하는 Horton의 방법을 이용한다. 위성영상에서 추출된 수치표고모델을 이용하여 수문지형정보추출이 가능하지만 일반 수문학자와 측량 및 지형공간정보공학자들이 쉽게 접근할 수 있는 방법은 아니며 실제로는 수치지도의 등고선으로부터 수치표고모델을 만들어 지형공간정보를 이용하여 수문지형정보를 추출하는 방식을 많이 사용한다. 본 논문에서는 1:25,000수치지도를 이용하여 수치표고모델의 격자크기에 따른 Horton 차수, 폭함수, 유역면적, 하도길이, 총하도길이, 유역폭함수, 유역고도값, 유역평균경사값 등을 분석하여 가장 적절한 해상도를 가지는 수치표고모델의 격자값을 제시하였다.

• 터널과지하공간
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• 제18권6호
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• pp.480-490
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• 2008

천공탐사는 암반 굴착시 점보드릴의 유압착암기로부터 계측되는 기계량들인 천공데이터를 분석하여 암반의 특성을 평가하는 기법이다. 천공탐사는 발파공 또는 록볼트공 천공시 실시간으로 계측할 수 있기 때문에 암반을 신속하고 정량적으로 예측 및 평가할 수 있는 장점이 있다. 현재까지도 천공데이터에 관한 다양한 연구가 수행되어져오고 있지만, 암반 특성을 평가하기 위한 천공파라미터들의 항목 선정과 기 계량들의 수치적인 정량화가 정립되어 있지 않은 실정이다. 따라서 본 연구에서는 암석 및 지반 특성을 평가할 수 있는 천공파라미터의 항목 선정 및 천공시 천공데이터들 간의 관계를 파악하기 위해 균질 모형 암석 시험편을 제작하여 천공데이터를 획득하였고, 획득된 천공데이터를 이용하여 천공파라미터들의 상관관계 분석을 수행하였다. 분석 결과를 통해 유압착암기의 굴착능력은 타격에 의해 가장 큰 영향을 받음을 확인하였다.

• Advances in environmental research
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• 제9권1호
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• pp.65-84
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• 2020

The potential use of Sargassum boveanum algae for the removal of uranium from aqueous solution has been studied by varying three independent parameters (pH, initial uranium ion concentration, S. boveanum dosage) using a central composite design (CCD) under response surface methodology (RSM). Batch mode experiments were performed in 20 experimental runs to determine the maximum metal adsorption capacity. In CCD design, the quantitative relationship between different levels of these parameters and heavy metal uptake (q) were used to work out the optimized levels of these parameters. The analysis of variance (ANOVA) of the proposed quadratic model revealed that this model was highly significant (R² = 0.9940). The best set required 2.81 as initial pH(on the base of design of experiments method), 1.01 g/L S. boveanum and 418.92 mg/L uranium ion concentration within 180 min of contact time to show an optimum uranium uptake of 255 mg/g biomass. The biosorption process was also evaluated by Langmuir, Freundlich, Temkin and Dubinin-Radushkevich isotherm models represented that the experimental data fitted to the Langmuir isotherm model of a suitable degree and showed the maximum uptake capacity of 500 mg/g. FTIR and scanning electron microscopy were used to characterize the biosorbent and implied that the functional groups (carboxyl, sulfate, carbonyl and amine) were responsible for the biosorption of uranium from aqueous solution. In conclusion, the present study showed that S. boveanum could be a promising biosorbent for the removal of uranium pollutants from aqueous solutions.

• 한국컴퓨터정보학회논문지
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• 제25권7호
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• pp.47-55
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• 2020

본 논문에서는 앵커 프리 방법을 이용한 FCN(Fully Convolutional Network)기반의 1단계 다중 크기 얼굴 검출기를 제안한다. 최근 대부분의 연구들은 사전 정의된 앵커를 사용하여 얼굴이 있을 만한 위치를 예측한다. 그러나 사전 정의 앵커를 이용함으로써 학습 시 하이퍼 파라미터의 설정과 추가적인 계산이 필요하다. 제안하는 방법의 핵심 아이디어는 앵커 프리 방법을 사용하여 하이퍼 파라미터를 없애고 여러 개의 특징 맵을 사용함으로써 클래스 내 불균형 문제를 완화하는 것이다. 이 방법들은 다음과 같은 효과가 있다. 첫째로 사전정의 앵커를 없앰으로써 앵커와 관련된 하이퍼 파라미터와 추가적인 계산을 피한다. 둘째로 클래스 내 불균형을 완화하기 위해 여러개의 특징 맵으로부터 얼굴을 예측한다. 정량적 평가를 통해 제안하는 방법에 따른 검출 성능을 평가 및 분석한다. FDDB(Face Detection Dataset & Benchmark) 데이터 셋의 실험 결과에서 제안하는 방법이 효과가 있음을 증명했다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.953-958
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• 2015

Background: Expression of KRT13, FAIM2 and CYP2W1 appears to be influenced by risk habits, thus exploring the associations of these genes in oral squamous cell cancer (OSCC) with risk habits, clinico-pathological parameters and patient survival may be beneficial in identifying relevant biomarkers with different oncogenic pathways. Materials and Methods: cDNAs from 41 OSCC samples with and without risk habits were included in this study. Quantitative real-time PCR was used to analyze KRT13, FAIM2 and CYP2W1 in OSCC. The housekeeping gene (GAPDH) was used as an endogenous control. Results: Of the 41 OSCC samples, KRT13 was down-regulated in 40 samples (97.6%), while FAIM2 and CYP2W1 were down-regulated in 61.0% and 48.8%, respectively. Overall, there were no associations between KRT13, FAIM2 and CYP2W1 expression with risk habits, selected socio-demographic and clinico-pathological parameters and patient survival. Conclusions: Although this study was unable to show significance, there were some tendencies in the associations of KRT13, FAIM2 and CYP2W1 expression in OSCC with selected clinic-pathological parameters and survival.

• Journal of Korean Neurosurgical Society
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• 제44권1호
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• pp.15-18
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• 2008

Objective : C2 laminar screw fixation is considered as an excellent alternative to Magerl's transfacetal approach or Harms construct for the atlantoaxial stabilization. However, to our knowledge, there is no report on the feasibility of the new approach to Korean population. We investigated morphometric parameters of the dorsal arch of the C2 to provide the quantitative data for the feasibility of laminar screw fixation. Methods : One-hundred-and-two patients' cervical computed tomography had been reconstructed and investigated on the anatomical parameters related with C2 laminar screw placement. Sixty patients were male and forty-two patients were female. Measurements included the laminar thickness and slope, spino-laminar angle, and maximal screw length. Results : Ages ranged from 20 to 81 and the mean age was 48.4. Mean laminar thickness was 5.7 mm (${\pm}1.0$) (5.8 mm in male and 5.4 mm in female). Fifty-one patients (50%) had a laminar thickness smaller than 5.5 mm at least unilaterally, therefore the patients were considered as inappropriate candidates for the laminar screw fixation in the smaller side of the laminae. Mean value of maximal length of screw was 33.3 mm (34.3 mm in male and 31.9 mm in female). Mean spino-laminar angle was $43.2^{\circ}$ and mean slope angle was $32.9^{\circ}$. Conclusion : Half of patients had inappropriate laminar profiles to accommodate a 3.5 mm screw in at least one side of the axis. The three-dimensional computed tomography reconstruction is mandatory for the preoperative assessment for the feasibility of the C2 lamina.

• KSBB Journal
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• 제5권3호
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• pp.235-240
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• 1990

Pseudomonas elodea 에 의한 Gellan gum생산시 이에 관련된 기초자료를 얻기 위하여 회분식 및 연속식 발효를 하였다. 회분식 배양의 결과로부터 비성장 속도는 $0.16hr^-^1$이었으며 72시간 배양후의 점도는 4500cp, 생성물 농도 0.7g dry weught/100g broth, 및 생산성은 0.08g dry weight/1/hr이었다. 연속식 배양을 통하여 최적 탄소원과 질소원의 농도비(3.0mg-carbon/mg-nitrogen)를 결정하였으며 Gellan gum의 최대 생성속도는 희석율 $0.14hr^-^1$에서 0.6g dry weight/l/hr이었다. 이러한 조건에서 각종 metabolic paeameter값을 계산하였다. 또한 배양액의 유변학적 특성은 Casson equation에 잘 부합됨을 확인하였고, 배양액의 점도와 산소전달계수를 측정하여 고점도 배양시 산소전달의 장애현상을 조사하였다.