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http://dx.doi.org/10.7314/APJCP.2015.16.3.953

KRT13, FAIM2 and CYP2W1 mRNA Expression in Oral Squamous Cell Carcinoma Patients with Risk Habits  

Hartanto, Firstine Kelsi (Department of Oral-Maxillofacial Surgical and Medical Sciences, University of Malaya)
Karen-Ng, Lee Peng (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University of Malaya)
Vincent-Chong, Vui King (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University of Malaya)
Ismail, Siti Mazlipah (Department of Oral-Maxillofacial Surgical and Medical Sciences, University of Malaya)
Mustafa, Wan Mahadzir Wan (Oral Health Division, Ministry of Health Malaysia)
Abraham, Mannil Thomas (Oral Health Division, Ministry of Health Malaysia)
Tay, Keng Kiong (Oral Health Division, Ministry of Health Malaysia)
Zain, Rosnah Binti (Department of Oral-Maxillofacial Surgical and Medical Sciences, University of Malaya)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.3, 2015 , pp. 953-958 More about this Journal
Abstract
Background: Expression of KRT13, FAIM2 and CYP2W1 appears to be influenced by risk habits, thus exploring the associations of these genes in oral squamous cell cancer (OSCC) with risk habits, clinico-pathological parameters and patient survival may be beneficial in identifying relevant biomarkers with different oncogenic pathways. Materials and Methods: cDNAs from 41 OSCC samples with and without risk habits were included in this study. Quantitative real-time PCR was used to analyze KRT13, FAIM2 and CYP2W1 in OSCC. The housekeeping gene (GAPDH) was used as an endogenous control. Results: Of the 41 OSCC samples, KRT13 was down-regulated in 40 samples (97.6%), while FAIM2 and CYP2W1 were down-regulated in 61.0% and 48.8%, respectively. Overall, there were no associations between KRT13, FAIM2 and CYP2W1 expression with risk habits, selected socio-demographic and clinico-pathological parameters and patient survival. Conclusions: Although this study was unable to show significance, there were some tendencies in the associations of KRT13, FAIM2 and CYP2W1 expression in OSCC with selected clinic-pathological parameters and survival.
Keywords
CYPW1; FAIM2; KRT13; oral squamous cell carcinoma; risk habits;
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