• KOREAN JOURNAL OF CROP SCIENCE
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• v.51 no.spc1
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• pp.304-309
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• 2006

Near infrared reflectance spectroscopy (NIRS) was used to develop a rapid and nondestructive method for the determination of fatty acid composition in sesame (Sesamum indicum L.) seed oil. A total of ninety-three samples of intact seeds were scanned in the reflectance mode of a scanning monochromator, and reference values for fatty acid composition were measured by gas-liquid chromatography. Calibration equations were developed using modified partial least square regression with internal cross validation (n=63). The equations obtained had low standard errors of cross-validation and moderate $R^2$ (coefficient of determination in calibration). Prediction of an external validation set (n=30) showed significant correlation between reference values and NIRS estimated values based on the SEP (standard error of prediction), $r^2$ (coefficient of determination in prediction) and the ratio of standard deviation (SD) of reference data to SEP. The models developed in this study had relatively higher values (more than 2.0) of SD/SEP(C) for oleic and linoleic acid, having good correlation between reference and NIRS estimate. The results indicated that NIRS, a nondestructive screening method could be used to rapidly determine fatty acid composition in sesame seeds in the breeding programs for high quality sesame oil.

• IE interfaces
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• v.17 no.1
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• pp.1-12
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• 2004

In a modern semiconductor device manufacturing industry, statistical bin limits on wafer level test bin data are used for minimizing value added to defective product as well as protecting end customers from potential quality and reliability excursion. Most wafer level test bin data show skewed distributions. By Monte Carlo simulation, this paper evaluates methods and sample size effect regarding determination of statistical bin limits. In the simulation, it is assumed that wafer level test bin data follow the Poisson distribution. Hence, typical shapes of the data distribution can be specified in terms of the distribution's parameter. This study examines three different methods; 1) percentile based methodology; 2) data transformation; and 3) Poisson model fitting. The mean square error is adopted as a performance measure for each simulation scenario. Then, a case study is presented. Results show that the percentile and transformation based methods give more stable statistical bin limits associated with the real dataset. However, with highly skewed distributions, the transformation based method should be used with caution in determining statistical bin limits. When the data are well fitted to a certain probability distribution, the model fitting approach can be used in the determination. As for the sample size effect, the mean square error seems to reduce exponentially according to the sample size.

• Herbal Formula Science
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• v.18 no.1
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• pp.95-103
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• 2010

Objectives : To develop and validate HPLC-PDA methods for simultaneous determination of seven constituents in Samsoeum(SSE). Methods : Reverse-phase chromatography using a Gemini C18 column operating at $40^{\circ}C$, and photodiode array(PDA) detection at 254 and 280 nm, were used for quantification of the seven marker components of SSE. The mobile phase using a gradient flow consisted of two solvent systems. Solvent A was 1.0% (v/v) aqueous acetic acid and solvent B was acetonitrile with 1.0% (v/v) acetic acid. Results : Calibration curves were acquired with $r^2$>0.9997, and the relative standard deviation (RSD) values (%) for intra- and inter-day precision were less than 3.0%. The recovery rate of each compound was in the range of 100.07-112.65%, with an RSD less than 4.0%. The contents of seven compounds in SSE were 1.24-10.53 mg/g. Conclusions : The established method will be helpful to improve quality control of SSE.

• Biomolecules & Therapeutics
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• v.14 no.1
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• pp.40-44
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• 2006

Mirtazapine is an antidepressant agent with dual action on both the noradrenergic and serotonergic neurotransmitter systems. A simple high performance liquid chromatographic method has been developed and validated for the quantitative determination of mirtazapine in human plasma. A reversed-phase Cl8 column was used for the determination of mirtazapine with a mobile phase composed of 0.01M ammonium acetate solution (pH 4.2) and acetonitrile (75:25, v/v%) at a flow rate of 1.2 mL/min. Terazosin hydrochloride was used as an internal standard. The fluorescence detector was set at excitation and emission wavelengths of 290 and 350 nm, respectively. Intra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification of 3 ng/mL. Mirtazapine was stable in human plasma under various storage conditions. This method was used successfully for a pharmacokinetic study using plasma samples after oral administration of a single 30 mg dose as mirtazapine base to 8 healthy volunteers. The maximum plasma concentration of mirtazapine was $64.1{\pm}28.0ng/mL$ at 1.8 h, and the area under the curve and elimination half-life were calculated to be $674.1{\pm}218.5ng\;h/mL\;and\;23.4{\pm}3.8h$, respectively.

• Analytical Science and Technology
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• v.23 no.4
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• pp.389-394
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• 2010

An ICP-AES method for determination of calcium content and dissolution characteristics of oyster shell (Ostrea gigas) has been developed and validated. Total calcium content in oyster shell was determined using ICPAES. The dissolution characteristics, which would reflect the composition of $CaCO_3$ polymorphs and calcium salts in oyster shell, were also evaluated by dissolution test. The total calcium contents ranged from 31.8 to 39.9% and the dissolution ratios varied from 62.7 to 83.6% (n=15). The determination of calcium content and dissolution characteristics by ICP-AES would provide useful information for the quality control of oyster shell.

• YAKHAK HOEJI
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• v.51 no.3
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• pp.174-178
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• 2007

A reverse-phase high performance liquid chromatography method with electrospray ionization and detection by mass spectrometry is described for the simultaneous determination of doxifluridine and its active metabolite 5-flu-orouracil (5-FU) in monkey serum. The method has greater sensitivity and simpler process than previous published methods with good accuracy and precision. A proper liquid/liquid extraction was used to extract simultaneously doxifluridine and 5-FU which has considerable difference in the polarity. Extracts were analyzed using LC/MS/MS providing a short analysis time within 5 min. The lower limit of quantification was validated at 10.0 ng/ml of serum for both doxifluridine and 5-FU. Accuracy and precision of quality control (QC) samples for both analytes met FDA Guidance criteria of ±15% for average QC accuracy with coefficients of variation less than 15%. The method will be applicable for preclinical studies and bioequivalence studies.

• Safety and Health at Work
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• v.12 no.2
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• pp.209-216
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• 2021

Background: The article presents the results of studies performed in order to develop a new method of airborne potassium bromate(V) determination at workplaces. Methods: The method is based on a collection of the inhalable fraction of potassium bromate(V) using the IOM Sampler, then extraction of bromates with deionized water and chromatographic analysis of the obtained solution. The analysis was performed using ion chromatography with conductometric detection. The tests were performed on a Dionex IonPac®AS22 analytic column (250 × 4 mm, 6 ㎛) with AG22 precolumn (50 × 4 mm 11 ㎛). Results: The method provides for potassium bromate(V) determination within the concentration range of 0.043 ÷ 0.88 mg/m³ for an air sample of 0.72 m³ in volume, i.e., 0.1-2 times the exposure limit value as proposed in Poland. The method was validated in accordance with PN-EN 482. The obtained validation data are as follows: measuring range: 3.1-63.4 ㎍/mL, limit of detection (LOD) = 0.018 ㎍/mL and limit of quantification (LOQ) = 0.053 ㎍/mL. The developed method has been tested in the work environment, on laboratory employees having contact with potassium bromate(V). Conclusion: The analytical method allowed the determination of the inhalable fraction of airborne potassium bromate(V) at workplaces and can be used to assess occupational exposure.

• Korean Journal of Plant Resources
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• v.13 no.2
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• pp.111-117
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• 2000

In an attempt to select grape bag, which elevates grape quality and make easy maturation period determination, the following research was carried out at Chungbuk Institute of Agricultural Technology, Grape Experiment Station. Light transmittance rate of bag reached to 11-65% with non-woven fabric and non-dripped vinyl bags. Non-dripped vinyl perforation and white painting bag resulted in 50 and 75%, respectively. Berry weights in non-woven fabric and non-dripped vinyl bag were high than that in paper bag. Non-dripped vinyl perforation 50%, white painting bag brought into fruit cracking, shattering, and rotten fruit, making the investigation difficult. Maturation period preceded about 1-4 day with non-woven fabric and non-dripped vinyl compared with that in paper bag. Soluble solids content with non-woven fabric and non-dripped vinyl bags was high and acidity showed a reverse result. Coloring extent was developed rapidly with non-woven fabric and non-dripped vinyl than paper bag. During initial state of coloring, coloring was rapid with Maekban-Stone mixed non-woven fabric and non-dripped vinyl + non-woven fabric bag. This was rapid with non-woven fabric bag as long appropriate maturation period. Abnormal berry rate was 5.4-7.0% with paper and non-woven fabric bags but brought about as much as 16.6-100% with non-dripped vinyl and it's mixed bags. Appearance quality was the best with index 9.0 for non-woven fabric bag. Maekban-Stone mixed non-woven fabric but non-dripped vinyl performance 50% white painting bag was the least, showing index 1.0. The time consumed for maturation determination was reduced to 74-93% with non-woven fabric and non-dripped vinyl bag compared with 17.4h/10a with paper bag.

• Journal of the Korean Operations Research and Management Science Society
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• v.25 no.3
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• pp.109-124
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• 2000

For rational human value judgement and evaluation, provision of clear evaluation data, objective value judgement criteria, and properly generalized methods are required. For instance, this is true for software quality evaluation, and the measure of software quality and the weighting method of evaluation target directly affect final decisions. However it is not easy to find a generalized method for the software quality evaluation or product selection, because of its complex characteristics. In this paper, we apply the qualitative preference method based on quantitative belief functions to find a general weighing method for the software quality evaluation. In particular, the qualitative preference method, in which the differentiated preference expression is possible, is conceptually expanded for general applications in future. For this purpose, we hierarchically differentiate the strong preference relation from the weak preference relation, and show an example of quantification of software quality evaluation on different applications, by comparing the qualitative preference method with AHP. We believe that the application domain of this method is not limited to the software quality evaluation and it is very useful to apply this results to other SE areas, e.g., metric selection with different views and riority determination of practices to be assessed in the SPICE.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.16 no.5 s.110
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• pp.485-494
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• 2006

The state-of-the-art of low-noise fan design usually includes the consideration of optimal sound level and sound quality. The influential design parameters of the noise level by the centrifugal fan were selected based on the preliminary test. The centrifugal fans were designed according to the experiment plan method by specifying the selected design parameters. The experiment with these machined mock-up's of centrifugal impellers suggested the major design parameters among many, having impacts upon the indices of sound quality (e.g. loudness, sharpness, roughness and fluctuation strength) at the same operation point. With the response surface method, the major design parameters selected thereafter were analyzed to estimate each contribution upon the sound quality of the centrifugal fan, and the optimal values were drawn by the consideration of the sound quality levels and their regression equations. In addition, the validity of the regression equations was numerically verified by means of the coefficient of determination. Furthermore, the mechanism by which the centrifugal fan impeller influences the determinants of its sound quality was suggested.