• Journal of Applied Reliability
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• v.18 no.1
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• pp.80-86
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• 2018

Purpose: This article provides a mathematical model for the accelerated degradation test when the performance degradation characteristic follows the lognormal distribution. Method: For developing test plans, the total number of test units and the test time are determined based on the minimization of the asymptotic variance of the q-th quantile of the lifetime distribution at the use condition. Results: The mathematical model for the accelerated degradation test is provided. Conclusion: Accelerated degradation test method is widely used to evaluate the product lifetime within a resonable amount of cost and time. In this article. a mathematical model for the accelerated degradation test method is newly developed for this purposes.

• Journal of Korean Society for Quality Management
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• v.42 no.3
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• pp.279-290
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• 2014

Purpose: The purpose of this study is to propose adoption of QFD and Stage-gate in order to analyze the quality of korea defense system. Methods: Drawing change data of initial production phase in korea defense system were anlayzed and a practical method was proposed. Results: The results of this study are as follows; Off line Quality Control should be introduced in development phase. Specially, in case of defense system, the best method is QFD(Quality Function Deployment) and Stage-gate process. At first, QFD 1 step defines product planning from VOC(Voice Of Customer), QFD 2 step specifies part planning from product planning, QFD 3 step defines process planning from part planning, QFD 4 step defines production planning from previous process planning. Secondly, Stage-gate process is adopted. This study is proposed 5 stage-gate in case of korea defense development. Gate 1 is located after SFR(System Function Review), Gate 2 is located after PDR(Preliminary Design Review), Gate 3 is located after CDR(Critical Design Review), Gate 4 is located after TRR(Test Readiness Review) and Gate 5 is located before specification documentation submission. Conclusion: Off line QC(Quality Control) in development phase is necessary prior to on line QC(Quality Control) in p roduction phase. For the purpose of off line quality control, QFD(Quality Function Deployment) and Stage-gate process can be adopted.

• Bulletin of the Korean Chemical Society
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• v.23 no.8
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• pp.1139-1143
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• 2002

Analysis of lysophosphatidic acids (LPAs) is of clinical importance as they can serve a potential marker for ovarian and other gynecological cancers and obesity. It is critically important to develop a highly sensitive and specific method for the early detection of gynecological cancers to improve the overall outcome of this disease. We have established a novel quantification method of LPAs in human plasma by negative ionization tandem mass spectrometry (MS-MS) using multiple reaction monitoring (MRM) mode without the conventional TLC step. Protein-bound lipids, LPAs in plasma were extracted with methanol : chloroform (2:1) containing LPA C14:0 as an internal standard under acidic condition. Following back extraction with chloroform and water, the centrifuged lower phase was evaporated and reconstituted in methanol. The reconstituted solution was directly injected into electrospray source of MS/MS. For MRM mode, Q1 ions selected were m/z 409, 433, 435, 437 and 457 which corresponds to molecular mass [M-H]- of C16:0, C18:2, C18:1, C18:0 and C20:4 LPA, respectively. Q2 ions selected for MRM were m/z 79, phosphoryl product. Using MS/MS with MRM mode, all the species of LPAs were completely separated from plasma matrix without severe interferences. This method allowed simultaneous detection and quantification of different species of LPAs in a plasma over a linear dynamic range of 0.01-25 ㎛olL-1 . The detection limit of the method was 0.3 pmol/mL, with a correlation coefficient of 0.9983 in most LPAs analyzed. When applied to the plasmas of normal and gynecological cancer patients, this new method differentiated two different groups by way of total LPA level.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.2
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• pp.138-149
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• 2016

Quality function deployment (QFD) is a widely adopted customer-oriented product development methodology by translating customer requirements (CRs) into technical attributes (TAs), and subsequently into parts characteristics, process plans, and manufacturing operations. A main activity in QFD planning process is the determination of the target levels of TAs of a product so as to achieve a high level of customer satisfaction using the data or information included in the houses of quality (HoQ). Gathering the information or data for a HoQ may involve various inputs in the form of linguistic data which are inherently vague, or human perception, judgement and evaluation for the information and data. This research focuses on how to deal with this kind of impreciseness in QFD optimization. In this paper, it is assumed as more realistic situation that the values of TAs are taken as discrete, which means each TA has a few alternatives, as well as the customer satisfaction level acquired by each alternative of TAs and related cost are determined based on subjective or imprecise information and/or data. To handle these imprecise information and/or data, an approach using some basic definitions of fuzzy sets and the signed distance method for ranking fuzzy numbers is proposed. An example of a washing machine under two-segment market is provided for illustrating the proposed approach, and in this example, the difference between the optimal solution from the fuzzy model and that from the crisp model is compared as well as the advantage of using the fuzzy model is drawn.

• Journal of the Korean Chemical Society
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• v.12 no.4
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• pp.146-149
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• 1968

A new chelate compound, tris(8-bydroxyquinolino)molybdenum(III), [$Mo(C_9H_6ON)_3$], has been prepared by the method of electrolytic reduction of the acidic molybdate solution. Thermal decomposition products of the chelate has been studied by DTA and TGA method. It is concluded that the decomposition product is a yellowish green colored bis(8-hydroxyquinolino)dioxo molybdenum(VI), [$MoO_2(C_9H_6ON)_2$].

• Natural Product Sciences
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• v.23 no.3
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• pp.175-182
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• 2017

This study evaluated the anti-Helicobacter and anti-inflammatory effects of Sohamhyungtang (SHHT). The minimum inhibitory concentration (MIC) of SHHT against Helicobacter pylori (H. pylori) was determined by the agar dilution method. Expression of the H. pylori cagA gene in the presence of SHHT was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Inhibition of H. pylori urease by SHHT was determined by the phenol-hypochlorite assay. Antiadhesion activity of SHHT was measured by urea-phenol red reagent. Inhibition of nitric oxide (NO) production in AGS cells was measured with Griess reagent. Inducible nitric oxide synthase (iNOS) and IL-8 mRNA expression in AGS cells which were infected with H. pylori was determined by qRT-PCR. IL-8 level was measured by enzyme-linked immunosorbent assay (ELISA). The MIC of SHHT was $100{\mu}g/mL$ and the expression of cagA gene was decreased about 25 folds in the presence of SHHT. H. pylori urease was inhibited 90% by SHHT. SHHT inhibited H. pylori adhesion on AGS cell in a concentration dependent manner. mRNA expression of iNOS and IL-8 and the production of NO and IL-8 were significantly decreased in the presence of SHHT. In conclusion, SHHT showed anti-Helicobacter activity and has potent anti-inflammatory effect on H. pylori-induced inflammation in human gastric epithelial AGS cells.

• Nuclear Engineering and Technology
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• v.49 no.2
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• pp.395-403
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• 2017

An efficient evaluation method for the probability of a tornado missile strike without using the Monte Carlo method is proposed in this paper. A major part of the proposed probability evaluation is based on numerical results computed using an in-house code, Tornado-borne missile analysis code, which enables us to evaluate the liftoff and flight behaviors of unconstrained objects on the ground driven by a tornado. Using the Tornado-borne missile analysis code, we can obtain a stochastic correlation between local wind speed and flight distance of each object, and this stochastic correlation is used to evaluate the conditional strike probability, $Q_V(r)$, of a missile located at position r, where the local wind speed is V. In contrast, the annual exceedance probability of local wind speed, which can be computed using a tornado hazard analysis code, is used to derive the probability density function, p(V). Then, we finally obtain the annual probability of tornado missile strike on a structure with the convolutional integration of product of $Q_V(r)$ and p(V) over V. The evaluation method is applied to a simple problem to qualitatively confirm the validity, and to quantitatively verify the results for two extreme cases in which an object is located just in the vicinity of or far away from the structure.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.9
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• pp.1654-1665
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• 2008

This paper presents bit splitting methods to apply multilevel modulation to iterative codes such as turbo code, low density parity check code and turbo product code. Log-likelihood ratio method splits multilevel symbols to soft decision symbols using the received in-phase and quadrature component based on Gaussian approximation. However it is too complicate to calculate and to implement hardware due to exponential and logarithm calculation. Therefore this paper presents Euclidean, MAX, sector and center focusing method to reduce the high complexity of LLR method. Also, this paper proposes optimal soft symbol split method for three kind of iterative codes. Futhermore, 16-APSK modulator method with double ring structure for applying DVB-S2 system and 16-QAM modulator method with lattice structure for T-DMB system are also analyzed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.401-409
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• 2018

This paper presents means of reducing noise in NSD using path control methods for Light Tactical Vehicles (LTV). NSD is applied to the rear axle of LTVs for enhancing mobility. NSD can improve mobility of vehicles with a high locking ratio but causes noise under certain conditions due to its mechanical structure. This noise results from contact between gears due to the differential role of NSD. The noise affects users, so users have continually requested noise reductions. Though the noise doesn't affect product performance and durability, and satisfies the National Defense's noise condition standards, users request for noise reduction is the focus of this research. Eliminating the source of sound for LTVs is realistically limited, so this research applies a path control method to reduce noise by controlling the path which transmits the noise. This study improves the structural delivery system and examines methods of reducing noise in LTV systems.

• Journal of Multimedia Information System
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• v.2 no.3
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• pp.255-262
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• 2015

The modern manufacturing systems and technologies produce products that are more accurate day by day. This can be reached mainly by improvement the manufacturing process with at the same time restricting more and more the quality specifications and reducing the uncertainty in part. The main objective an industry becomes to lower the part's variability, since the less variability - the better is product. One of the part of this task is measuring the object's uncertainty. The main purpose of this study is to understand the application of bootstrap method for uncertainty evaluation. Bootstrap method is a collection of sample re-use techniques designed to estimate standard errors and confidence intervals. In the case study a surface of an automobile engine block - (Top view side) is measured by Coordinate Measuring Machine (CMM) and analyzed for uncertainty using Geometric Least Squares in complex with bootstrap method. The designed experiment is composed by three similar measurements (the same features in unique reference system), but with different points (5, 10, 20) concentration at each level. Then each cloud of points was independently analyzed by means of non-linear Least Squares, after estimated results have been reported. A MatLAB software tool used to generate new samples using bootstrap function. The results of the designed experiment are summarized and show that the bootstrap method provides the possibility to evaluate the uncertainty without repeating the Coordinate Measuring Machine (CMM) measurements many times, i.e. potentially can reduce the measuring time.