• Diabetes and Metabolism Journal
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• v.42 no.6
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• pp.513-518
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• 2018

Background: Recent studies have correlated serum cystatin C (CysC) with vascular complications, but few studies have investigated this correlation in diabetes patients without nephropathy. This study aimed to evaluate if higher serum CysC levels increase the risk for vascular complications in type 2 diabetes mellitus patients with normal renal function or mild renal impairment. Methods: A total of 806 consecutive patients with type 2 diabetes mellitus who were admitted to the diabetes center of Soonchunhyang University Hospital for blood glucose control were retrospectively reviewed. Patients with nephropathy were excluded. Subjects were categorized into quartiles of serum CysC levels (Q1, ${\leq}0.65mg/L$; Q2, 0.66 to 0.79 mg/L; Q3, 0.80 to 0.94 mg/L; and Q4, ${\geq}0.95mg/L$). Results: The proportion of patients with diabetic retinopathy (DR) (P for trend <0.001), coronary heart disease (CHD) (P for trend <0.001), and stroke (P for trend <0.001) increased across the serum CysC quartiles. After adjustment for confounding factors, the highest serum CysC level remained a significant risk factor for DR (odds ratio [OR], 1.929; 95% confidence interval [CI], 1.007 to 4.144; P=0.040). Compared with Q1, a significant positive association was observed between serum CysC and CHD in Q2 (OR, 7.321; 95% CI, 1.114 to 48.114; P=0.012), Q3 (OR, 6.027; 95% CI, 0.952 to 38.161; P=0.020), and Q4 (OR, 8.122; 95% CI, 1.258 to 52.453; P=0.007). No associations were observed between CysC and stroke after additional adjustment for confounding variables. Conclusion: Serum CysC levels are independently associated with DR and CHD, suggesting that CysC may be useful for identifying type 2 diabetes mellitus patients without nephropathy who are at high risk for vascular complications.

• Annual Conference on Human and Language Technology
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• 2018.10a
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• pp.147-150
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• 2018

목적 지향 대화 시스템은 자연어 이해, 대화 관리자, 자연어 생성과 같은 세분화 모델들의 결합으로 이루어져있어 하위 모델에 대한 오류 전파에 취약하다. 이러한 문제점을 해결하기 위해 자연어 이해 모델과 대화 관리자를 하나의 네트워크로 구성하고 오류에 강건한 심층 Q 네트워크를 제안한다. 본 논문에서는 대화의 전체 흐름을 파악 할 수 있는 순환 신경망인 LSTM에 심층 Q 네트워크 적용한 심층 순환 Q 네트워크 기반 목적 지향 대화 시스템을 제안한다. 실험 결과, 제안한 심층 순환 Q 네트워크는 LSTM, 심층 Q 네트워크보다 각각 정밀도 1.0%p, 6.7%p 높은 성능을 보였다.

• Proceedings of the Korean Information Science Society Conference
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• 2011.06b
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• pp.474-477
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• 2011

본 논문은 평면상에 주어진 자료점의 집합 P로부터 질의 집합 Q에 대해 skyline을 성질을 만족하는 P의 부분집합을 찾는 알고리즘을 제시한다. 이 때 P의 점들 간의 우위는 Q의 점에서의 거리를 이용하여 판단하는데 이 논문에서는 두 점간의 거리를 $L_1$거리로 정의한다. 이와 같은 환경 하에서 |P|$\geq$|Q|라고 가정할 때 우리는 O(|P|log|P|) 시간에 모든 skyline을 찾는 알고리즘을 제시하였다.

• Korean Journal of Poultry Science
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• v.37 no.3
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• pp.247-253
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• 2010

Telomeres are nucleoprotein structures at the ends of chromosomes consisting of DNA sequences arranged in tandemly repeated units $(TTAGGG)_n$. However, this hexamers can also occur at non-telomeric sites in some avians and vertbrate. This study was carried out to present the distribution of telomeric DNA sequences in Korean Native Chicken chromosomes. The fluorescence in situ hybridization technique using a telomeric DNA probe was performed to the metaphase spreads of chicken early embryonic cells. Telomeric DNA signals were detected at the ends of chromosomes including macrochromosomes and microchromosomes. In chicken, surprisingly, chromosome 1 showed very distinct interstitial telomeric DNA hybridization patterns which located two interstitial sites in the p-arm at 1p11 and 1p23, and one in the q-arm at 1q32. In chromosome number 2 and 3 also displayed interstitial telomeric signals (ITS) in the long arms at 2q24 and 3q32, respectively. The pattern of telomeric DNA distribution in Korean Native Chicken chromosomes was in agreement with a previously reported in Gallus domesticus. The relative amount of telomeric DNA sequences in each macrochromosomes ranged from 4.6% to 16.3%. Distribution of telomeric DNAs at the end of p-arm was much more than that of q-arm in almost chicken chromosomes. The distribution of ITS in chicken chromsomes implicate to tandem chromosome fusions that might have occurred during the process of karyotype evolution.

• Tuberculosis and Respiratory Diseases
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• v.48 no.2
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• pp.180-190
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• 2000

Background: Genomic instability, which is manifested by the replication error(RER) phenotype, has been proposed for the promotion of genetic alterations necessary for carcinogenesis. Merlo et al. reported frequent microsatellite instability in primary small cell lung cancers. However, Kim et al. found that instability occurred in only 1% of the loci tested and did not resemble the replication error-positive phenotype. The significance of microsatellite instability in the tumorigenesis of small cell lung cancer as well as the relationship between microsatellite instability and its clinical prognosis was investigated in our study. Methods: Fifteen primary small cell lung cancers were chosen for this study. The DNAs extracted from paraffin-embedded tissue blocks with primary tumor and corresponding control tissue were investigated. Forty microsatellite markers on chromosome 1p, 2p, 3p, 5q, 6p, 6q, 9p, 9q, 13q, and 17p were used in the microsatellite analysis. Results: Thirteen(86.7%) of 15 tumors exhibited LOH in at least one of the tested microsatellite markers. Three of 13 tumors exhibiting LOH lost a larger area in chromosome 9p. LOH was shown in 72.7% on chromosome 2p, 40% on 3p, 50% on 5q, 46.7% on 9p, 69.2% on 13q, and 66.7% on 17p(Table 1). Nine(60%) of 15 tumors exhibited shifted bands in at least one of the tested microsatellite markers. Nine cases exhibiting shifted bands showed altered loci ranging 2.5~52.5%(mean $9.4%\pm16.19$)(Table 2). Shifted bands occurred in 5.7% (34 of 600) of the loci tested(Table 2). Nine cases with shifted bands exhibited LOH ranging between 0~83.3%, and the median survival duration of those cases was 35 weeks. Six cases without shifted bands exhibited LOH ranging between 0~83.3%, and the median survival duration of those cases was 73 weeks. There was no significant difference between median survival durations of the two groups(p=0.4712). Conclusion: Microsatellite instability as well as the inactivation of several tumor suppressor genes may play important roles in the development and progression process of tumors. However, the relationship between microsatellite instability and its clinical prognosis in primary small cell lung cancer could not be established.

• Communications of the Korean Mathematical Society
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• v.34 no.1
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• pp.287-301
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• 2019

In this paper we study monotonicity the first eigenvalue for a class of (p, q)-Laplace operator acting on the space of functions on a closed Riemannian manifold. We find the first variation formula for the first eigenvalue of a class of (p, q)-Laplacians on a closed Riemannian manifold evolving by the Ricci-Bourguignon flow and show that the first eigenvalue on a closed Riemannian manifold along the Ricci-Bourguignon flow is increasing provided some conditions. At the end of paper, we find some applications in 2-dimensional and 3-dimensional manifolds.

• Journal of the Chungcheong Mathematical Society
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• v.23 no.1
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• pp.169-176
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• 2010

Let $k={\mathbb{F}}_q(T)$ and ${\mathbb{A}}={\mathbb{F}}_q[T]$. In this paper, we obtain the the criterion for the parity of the ideal class number h(${\mathcal{O}}_K$) of the real biquadratic function field $K=k(\sqrt{P_1},\;\sqrt{P_2})$, where $P_1$, $P_2{\in}{\mathbb{A}}$ be two distinct monic primes of even degree.

• Journal of Korean Society of Forest Science
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• v.109 no.3
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• pp.271-280
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• 2020

This study compared soil CO₂ efflux rates after fertilization, in Pinus densiflora and Quercus variabilis stands. Compound fertilizers were applied to the forest floor in March 2016, following a one-year calibration period (from March 2015 to February 2016). In situ soil CO₂ efflux rates were measured every month during the two-year study periods, using an infrared gas analyzer with a closed chamber system. Mean annual soil CO₂ efflux rates were higher following fertilizer application in the P. densiflora and Q. variabilis stands (P. densiflora: 2.180 μmol m^-2 s^-1; Q. variabilis: 1.977 μmol m^-2 s^-1) as compared with the rates measured during the calibration period (P. densiflora: 1.620 μmol m^-2 s^-1; Q. variabilis: 1.557 μmol m^-2 s^-1). The mean annual soil CO₂ efflux rates in the unfertilized treatments of both stands were not significantly different between the two-year study periods. The Q₁₀ values of fertilized treatments in Q. variabilis stands were higher in the fertilization period (3.41) than in the calibration period (3.14), whereas the Q₁₀ values in P. densiflora stands did not change between the fertilization and calibration periods. The Q₁₀ values of unfertilized treatments in the Q. variabilis stands were lower during the 2016-2017 period (3.69), than in the 2015-2016 period (3.85), whereas the Q₁₀ values in P. densiflora stands were higher during the 2016-2017 period (3.65), than in the 2015-2016 period (3.15). These results indicate that the increase in soil CO₂ efflux rates in P. densiflora stands could be more sensitive to fertilization compared with the rates in Q. variabilis stands.

• Bulletin of the Korean Mathematical Society
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• v.57 no.3
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• pp.535-545
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• 2020

Let A be an m × n matrix over nonnegative integers. The isolation number of A is the maximum number of isolated entries in A. We investigate linear operators that preserve the isolation number of matrices over nonnegative integers. We obtain that T is a linear operator that strongly preserve isolation number k for 1 ≤ k ≤ min{m, n} if and only if T is a (P, Q)-operator, that is, for fixed permutation matrices P and Q, T(A) = P AQ or, m = n and T(A) = P A^tQ for any m × n matrix A, where A^t is the transpose of A.

• Journal of the Korean Statistical Society
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• v.27 no.2
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• pp.165-187
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• 1998

Shin and Sarkar (1993, 1994) studied the problem of testing for a unit root in an AR(p) signal observed with MA(q) noise when the MA parameters are known. In this paper we consider the case when the MA parameters are unknown and to be estimated. Test statistics are defined using unit root parameter estimates based on three different estimation methods of Hannan and Rissanen (1982), Kohn (1979) and Shin and Sarkar (1995). An AR(p) process contaminated by MA(q) noise is a .estricted ARMA model, for which Shin and Sarkar (1995) derived an easy-to-compute Newton- Raphson estimator The two-stage estimation p.ocedu.e of Hannan and Rissanen (1982) is used to compute initial parameter estimates in implementing the iterative estimation methods of both Shin and Sarkar (1995) and Kohn (1979). In a simulation study we compare the relative performance of these unit root tests with respect to both size and power for p=q=1.