• Journal of Microbiology and Biotechnology
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• v.28 no.6
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• pp.849-859
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• 2018

Herpes simplex virus type 2 (HSV-2) infection has been a public health concern worldwide. It is the leading cause of genital herpes and a contributing factor to cervical cancer and human immunodeficiency virus (HIV) infection. No vaccine is available yet for the treatment of HSV-2 infection, and routinely used synthetic nucleoside analogs have led to the emergence of drug resistance. The small molecule $Retro-2^{cycl}$ has been reported to be active against several pathogens by acting on intracellular vesicle transport, which also participates in the HSV-2 lifecycle. Here, we showed that Retro-2.1, which is an optimized, more potent derivative of $Retro-2^{cycl}$, could inhibit HSV-2 infection, with 50% inhibitory concentrations of $5.58{\mu}M$ and $6.35{\mu}M$ in cytopathic effect inhibition and plaque reduction assays, respectively. The cytotoxicity of Retro-2.1 was relatively low, with a 50% cytotoxicity concentration of $116.5{\mu}M$. We also preliminarily identified that Retro-2.1 exerted the antiviral effect against HSV-2 by a dual mechanism of action on virus entry and late stages of infection. Therefore, our study for the first time demonstrated Retro-2.1 as an effective antiviral agent against HSV-2 in vitro with targets distinct from those of nucleoside analogs.

• Korean journal of communication and information
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• v.44
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• pp.223-247
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• 2008

The purpose of this study is to explore the anti-smoking message effects and smoking status on smoking belief attributes. Based on the health behavior theories such as theory of reasoned action, health belief model, and social cognitive theory, three factors are selected to investigate the effects of anti-smoking campaign messages. The balance of benefits and barriers, self-efficacy, and social pressure are selected as independent variables. Three two-way ANOVA were conducted. Results showed that the main effect of social pressure were found with the social smoking attributes. Interaction effects were found on the nonsmoker-social pressure group and the non-smoker-two sided message group. It is found that nonsmokers accepted these two anti-smoking messages easily as compared to smoker groups. No main smoking status was found in this study; it is believed that smoking is a habitual that is not changed easily because attitude formation takes time. Results revealed that the two-sided message video releases and the social pressure video releases were favored by both smokers and nonsmokers. This study contributes the theoretical framework that can be transferred to the practices of anti-smoking campaign. Also, the researcher produced the televised stimuli which is not common in health message studies. By using the televised message material, the research tried to solve the validity problem which is common in experimental design.

• Journal of the Korean Data and Information Science Society
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• v.24 no.4
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• pp.679-688
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• 2013

This study figured out the influential factors of region-based characteristic factors in our country upon asthmatic occurrence. Research subjects were 2,266,451 people who were confirmed the diagnosis of asthma (J45~J46) among patients in national health insurance for the year in 2010. The influence in each of factors upon the asthmatic occurrence was analyzed through hierarchical regression after comparing difference in asthmatic occurrence by basic local government. As a result of hierarchical regression, the whole asthmatic occurrence had significant difference in infants ratio, $SO_2$,Temperature, basin and dam area. The asthmatic occurrence had significant difference in subjective awareness of health level, $SO_2$, basin and dam area. A case of asthmatic occurrence had significant difference in infants ratio, temperature, $NO_2$ and coastal area. Diverse characteristic factors by region were indicated to have influence upon the asthmatic occurrence by causing or weakening asthma through mutually complex action. Accordingly, a region-based customized environmental health measure will need to be arranged that infants and elderly people, who are vulnerable classes, can be protected and prevented from harmful environment of asthma.

• Korea Journal of Hospital Management
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• v.14 no.1
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• pp.123-144
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• 2009

Recently, a long strike by hospital labor union emerged as a serious social issue. During the Worldcup Games in June, 2002, labor strikes broke up at 'C', 'K' and other hospitals, and in 2007, 'Y' hospital suffered much from a strike. Such series of extreme labor disputes have awakened people of importance of a more stable labor-management relationship for the medical institutions responsible for people's health than any other business organization. The purpose of this study was to examine the labor-management disputes at 'Y' hospital in 2007 and 'C' and 'K' hospitals in 2002. The results of this study can be summarized as follows; First, requests of the labor union such as pay raise, reemployment of the irregular workers as regular employees and participation of the labor union in personnel affairs are the long-held or core issues suffered by the medical institutions. Such issues are not independent from each other but complicated with each other surrounding the pay raise. Accordingly, it is not easy to determine the genuine bone of issue for labor-management disputes. Second, the model type of disputes between labor and management at medical institutions may be strike. However, it is conceived that the type of disputes would be subject to change as the essential medical service area system began to be operated since 2008. Third, the common characteristic of the labor strike among the 3 sample hospitals was occupation of the hospital lobby for a sit-in strike to maximize the negative effects of strike. Article 42 (Prohibition of Violence) of Labor Union and Labor Relation Coordination Act prohibits occupation of production or other important business facilities. In addition, since Ministry of Labor interprets that the hospital lobby belongs to the important business facilities enumerated by Article 42 of the above act, occupation of the hospital lobby for a sit-in strike may be too controversial to be admitted as a fair act of labor dispute when its legitimacy should be judged. Fourth, the counter-measures taken by the hospitals against the strike were observance of the principle 'no labor no pay,' closure, legal action, accusation, claim for recovery of damage, provisional seizure, disciplinary punishment, etc., but the principle of 'no labor, no pay' was not applied in a fair manner by 'C' and 'K' hospitals. However, 'Y' hospital applied this principle thoroughly to the strike; the hospital conduced to correction of the wrong labor-management relationship by refusing inclusion in the labor collective agreement of a provision about payment of wage during the period of strike or labor union's request to that effect during a strike. In addition, 'Y' hospital took an effective measure to end the strike earlier by notifying the labor union of cancellation of the collective agreement and banning the unionists from entering the hospital.

• Journal of the Korean Institute of Landscape Architecture
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• v.39 no.2
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• pp.65-72
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• 2011

Since walking and physical activity are critical for older adults to maintain their health, it is important to provide neighborhood environments which encourage their walking in daily life. The purposes of the present study were to investigate walking activity patterns of older people in an urban setting and to identify environmental correlates with walking of older adults. This study examined spatial and temporal patterns of physical activities, environmental barriers and motivations, satisfaction levels and demands on the physical environment. In-depth interviews with older adults over age sixty residing in Seoul metropolitan areas revealed that most respondents have a positive perception on walking in daily life, and many of them walk regularly for their health. A primary purpose of walking for older adults was exercise for health rather than transportation. The study result demonstrated that parks and trails were the most preferred places for walking by older adults, and there is an association between frequency of walking participation and access or convenience to parks, traffic safety, and street lights. Most respondents were concerned about traffic safety when they walk in their neighborhoods due to traffic speeds and unsafe streets. Lack of separate sidewalks or benches, stairs and slopes were barriers to older adults' walking habits. This data suggests that the promotion of walking behavior among older adults, some level of public health action, and community support are needed to ensure safe physical environments within communities.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.292-294
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• 2018

Recently, damage caused by natural disasters such as fire, earthquake, heavy rains and heavy snow is increasing. In addition, traffic accidents due to freezing, fog and fire in tunnels and bridges are frequently occurring. In such a disaster situation, it is very important to take prompt action by the person in charge of managing the facility and area.To this end, a disaster broadcasting system is used, but in the existing system, the broadcasting room and the speaker are connected by a wired connection. Also, the person in charge has to be in the broadcasting room to broadcast, which has a problem of delaying the time. In this paper, we design a disaster broadcasting system using LTE modem. The designed system enables a broadcasting person to make a call to a broadcasting system from anywhere using a cellular phone and a public telephone. Broadcasting via telephone is possible only with the telephone number pre-registered in the system and can be registered / deleted by the administrator. The registered telephone number, incoming voice file, and announcement voice for automatic broadcasting are stored in the system internal SD memory for convenient management. This disaster broadcasting system is expected to contribute to quick and convenient disaster broadcasting.

• International Commerce and Information Review
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• v.14 no.2
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• pp.121-145
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• 2012

This research was performed to review the marketing PR(MPR) strategy to build the brand image of Chungnam tourism for the inducement of foreign tourist. Because each local governments are looking for the industries of new growth power from the tourism industry recently, we applied the BI strategy of Chungnam tourism with expended BLC model and GRID model after we analyzed the variety of PR situation and tasks to build the Chungnam tourism's brand image in the competitive domestic and foreign tourism industry. In the result of the study, we set up the limited brand image of Chungnam tourism newly; also we derived a specific action plan. First of all, they need every possible means for Brand Awareness PR, Issue PR, Brand Loyalty PR, etc. depend on brand life cycle with the Chungnam's tourism service products. Secondly, for the each tourism service products, it is requiring to repositioning from present position (B, C, D area) to A area by MPR strategy. Finally, many additional MPR strategies should put in to support for building the brand image for the 'Tourism Chungnam'. The strategic SNS public relations are required with considerations of items that are necessarily need to have the reasons and circumstances for the new foreign tourists, so they can have experiences for the Chungnam Tourism. For the existing foreign tourists, we should keep to build relationship in order to give them trusts and to feel sympathy.

• Journal of dental hygiene science
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• v.6 no.2
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• pp.79-84
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• 2006

The purpose of this study was to collect base-data for evaluation of primary school oral health program. The data was Obtained from 648 children of four primary schools in Gwangiu city, Gyeonggi-Do Korea, during 2 month (March to May, 2006). The survey was performed by a face-to-face interview questionnaire consisting of OIDP. We analyzed knowledge, attitude, action and DMFT, oral health knowledge, the state satisfaction, no dental treatment need according to being or not being of the score using SPSS 12.0. ODIP score measure was based on scoring method for OIDP. The results were as follows. 1. In knowledge, attitude, behavior of oral hygiene with regard to OIDP score, he group with OIDP score is higher than the group without that and in case of knowledge and behavior, the group with OIDP score has a significant difference from the group without (p < 0.05). 2. In case of the oral hygiene cognition, a situation satisfaction, a no dental treatment need based on OIDP score, the group without OIDP score has a desirable andsignificant difference from the group with OIDP score (p < 0.05). 3. In case of DMFT based on OIDP score, the group with has a higher DMFT than the group without and has an significant difference from the group without (p < 0.05).

• Archives of design research
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• v.12 no.2
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• pp.75-86
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• 1999

Faced with various challenges given from internal or external, universities and colleges, about 300 in number, began to feel one another as their rival and recognized advertising marketing as a solution of unlimited competition and were in serious action for advertising. School advertising has suddenly increased in quantity, but falls in creative strategy of qualitative level behind corporate or product advertising. This study suggests effective creative strategy, based on comprehension of characteristics of school advertising and on analysis of creative as a strategy, of advertisements put by schools. School advertising demands the approach different from commercial dimension of corporate advertising, because schools are characteristic of public interests. Schools need to take positive creative strategy of image advertising instead of passive type of recruitment announcement. This effective and Positive creative strategy des not only Provide the chance to select schools for customers of school advertising which sets up applicants for admission as the first target audience, but also instills affirmative and positive image in potential customers of the future such as pupils of elementary or middle schools and ordinary people so that it may make effective communication possible

• Korean Security Journal
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• no.16
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• pp.321-338
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• 2008

Soongrae-Mun Fire shows safety problem in Korea intimately. People have pressed for the responsibility of persons in charge and have asked for improvement measure whenever Fire accident occur, but similar accidents occur again without any improvement. This research is to provide improvement. measure on the base of the analysis of the cause of Soongrae-Mun fire to prevent similar accident, also to help private security company do effective security job. This research is approached from a security point of view. A lot of accidents occur by direct cause such as people's unsafe action and unsafe condition. but it is very difficult to remove the facts of direct cause, so the facts of indirect cause should be analyzed together. Drew-up of security related legislation should be included when the establishment of fire fighting related legislation is examined, also technical improvement should be examined with legislation. security company should be concerned about securing of expertise and reinvestment for the improvement of expertise to overcome limitations of private security such as job boundary, capability and responsibility. Also private security company should try to service for public benefit and to examine practical compensation for loss occurred by mistake of security company.