• Molecules and Cells
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• v.38 no.1
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• pp.81-88
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• 2015

Flowering time (or heading date) is controlled by intrinsic genetic programs in response to environmental cues, such as photoperiod and temperature. Rice, a facultative short-day (SD) plant, flowers early in SD and late in long-day (LD) conditions. Casein kinases (CKs) generally act as positive regulators in many signaling pathways in plants. In rice, Heading date 6 (Hd6) and Hd16 encode $CK2{\alpha}$ and CKI, respectively, and mainly function to delay flowering time. Additionally, the major LD-dependent floral repressors Hd2/Oryza sativa Pseudo-Response Regulator 37 (OsPRR37;hereafter PRR37) and Ghd7 also confer strong photoperiod sensitivity. In floral induction, Hd16 acts upstream of Ghd7 and CKI interacts with and phosphorylates Ghd7. In addition, Hd6 and Hd16 also act upstream of Hd2. However, whether CKI and $CK2{\alpha}$ directly regulate the function of PRR37 remains unclear. Here, we use in vitro pull-down and in vivo bimolecular fluorescence complementation assays to show that CKI and $CK2{\alpha}$ interact with PRR37. We further use in vitro kinase assays to show that CKI and $CK2{\alpha}$ phosphorylate different regions of PRR37. Our results indicate that direct posttranslational modification of PRR37 mediates the genetic interactions between these two protein kinases and PRR37. The significance of CK-mediated phosphorylation for PRR37 and Ghd7 function is discussed.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.4
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• pp.201-210
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• 2021

Purpose : There is a lack of research on this field in the Republic of Korea, especially those that have seen the effect of interaction between transcranial direct current stimulation and computerized cognitive rehabilitation therapy. This study divided 30 dementia patients into a treatment group, which received transcranial direct current stimulation and computerized cognitive rehabilitation, and a control group, which received pseudo-transcranial direct current stimulation and pseudo-computerized cognitive rehabilitation. This study evaluated the effects of these treatments on the visual perception, cognition functions, and daily activities of dementia patients. Methods : Fifteen subjects were allocated to the treatment group and the other 15 subjects were allocated to the control group. Treatments were given at intervals of five sessions per week (30 minutes per session) for six weeks (30 times in total). This study used the Neurobehavioral Cognitive Status Examination (NCSE) to examine cognitive functions, MVPT to evaluate visual perception, and FIM to test daily living activities before and after applying the treatments. Results : The results of this study showed that cognitive functions, visual perception, and daily living activities significantly (p<.05) improved after the intervention in the treatment group and the control group. The changes in cognitive functions, visual perception, and daily living activities due to the treatments were significantly different between the groups (p<.05). Conclusion : The results indicated that transcranial direct current stimulation and computerized cognitive rehabilitation therapy improved visual perception and daily living activities by increasing cognitive functions. Consequently, it was found that the simultaneous application of transcranial direct current stimulation in conjunction with a computerized cognitive rehabilitation program was an intervention method that could positively affect the visual perception, cognitive function, and daily living activities of dementia patients. Based on the results of this study, the study of arbitration protocols for demential will have to be more active.

• Investigative Magnetic Resonance Imaging
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• v.18 no.4
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• pp.314-322
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• 2014

Purpose: Diastolic dysfunction is a common problem in patients with hypertrophic cardiomyopathy (HCM). The purpose of this study was to assess the role of MRI in the assessment of diastolic function using mitral valve and pulmonary vein flow velocities in HCM patients. Methods and Results: Phase-contrast MRI (mitral valve and pulmonary vein) and transthoracic echocardiography was successfully performed for 59 HCM patients (44 men and 15 women; mean age, 51 years). Forty-nine patients had a diastolic dysfunction; grade 1 (n = 20), grade 2 (n = 27), and grade 3 (n = 2) using echocardiography, and ten patients had normal diastolic function. The transmitral inflow parameters (E, A, and E/A ratios) obtained by MRI showed positive correlation with the same parameters measured by echocardiography (Pearson's r values were 0.47, 0.60, and 0.75 for E, A, E/A, respectively, all P < 0.001). With the flow information of the pulmonary vein from cardiac MRI, pseudo-normalized pattern (n = 8) could be distinguished from true normal filling pattern (n = 17), and the diastolic function grades by cardiac MRI showed moderate agreement with those of echocardiography (kappa value = 0.45, P < 0.001). Conclusions: Assessment of left ventricle diastolic function is feasible using phase-contrast MRI in HCM patients. Analysis of pulmonary vein flow velocity on MRI is useful for differentiating pseudo-normal from normal diastolic function in HCM patients.

• Korean Journal of Computational Design and Engineering
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• v.21 no.4
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• pp.443-452
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• 2016

This paper proposes a method for expensive black box optimization using radial basis functions (RBFs). The proposed algorithm is a computational strategy that uses a RBF model approximating the expensive black box function to predict an optimum. First, a RBF-based approximation technique is introduced and a sampling plan for estimation of the black box function is described. Then the proposed algorithm is explained, which presents the pseudo-codes for implementation and the detailed description of each step performed in the optimization process. In addition, numerical experiments will be given to analyze the performance of the proposed algorithm, by investigating computation accuracy, number of function evaluations, and convergence history. Finally, geometric distance problem as application example will be also presented for showing the algorithm applicability to different engineering problems.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 1987.04a
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• pp.191-195
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• 1987

When a 160QAM receiver in the band of spread spectrum system is interfered with a pseudo-random frequency-hopp-ing signal the interference signal has the form of the pulse amplitude probability density function. Each interfrering pulse amplitude probability density function Each interfering pulse amplitude is dependent upon theprobability density function of hopping frequency and the selectivity characteristic of 16QAM system in this paper the error rate equation of a system performance has been derived in the above condition which are interfrerence form and impulsive noise environmensts. The results of system analysis show us that the system performance is de-graded by impulsive noise and interference power, which improved as the frequency hopping bandsidth increases whit respect to receiver bandwidth

• Journal of Biomedical Engineering Research
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• v.9 no.2
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• pp.171-178
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• 1988

In this study, we proposed a test to explore the function of Vestibulo-ocular reflex (VOR) which subjected to an angular head acceleration using pseudo random binary stimulus. Resultant eye movements(horizontal vestibular nystagmus) were digitized, filtered and transformed into the frequency domain. At first we evaluated the transfer function of V.0.R(gain and phase) and the coherence function between stimulus and response by linear frequency methods in view of the quantitative analysis since the vestibulo-ocular reflex can be considered as a linear system. at least, in normals. Secondly. with the proposed test, we showed a direct possibility that we could interpret the pathological situation quantitatively as an illustration of clinical application.

• Communications for Statistical Applications and Methods
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• v.30 no.5
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• pp.467-483
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• 2023

In this research, a conversion function and a distortion associated with the conversion function are defined and used to derive a unit power Gompertz distortion. A new family of copulas is built using the global distorted function. Four base copulas, namely Clayton, Gumbel, Frank, and Gaussian, are distorted into the family. Some properties including tail dependence coefficients and tail order are examined. Kendall's tau formula is derived for new copulas when the base copula is Clayton, Gumbel, or Frank. The maximum pseudo-likelihood estimation method is employed, and a simulation study was performed. The log-likelihood and AIC are reported to compare the performance of the fitted copulas. According to the applied data, the results indicate that new distorted copulas with additional parameters improve the fit.

• Bulletin of the Korean Mathematical Society
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• v.47 no.3
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• pp.633-643
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• 2010

In this paper, the concept of maximal ideals relative to a filter on posets is introduced and examined. An intrinsic characterization of distributive lattices is obtained. In addition, we also give a characterization of pseudo primes in semicontinuous lattices and a characterization of semicontinuous lattices. Functions of semicontinuous lattices which are order preserving and semicontinuous are studied. A new concept of semiarithmetic lattices is introduced and examined.

• The Korean Journal of Applied Statistics
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• v.13 no.1
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• pp.81-96
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• 2000

본 논문은 의학분야에서 주로 사용되는 메타분석 중 그룹화 임의효과 모형(grouped random effects model)을 프라빗 연결함수(probit link function)를 이용하여 베이즈적 관점에서 연구하였다. 이때 프라빗 함수를 강요하기 위해 잠재변수를 정의하였고, 사전 분포를 달리한 세가지 모형을 고려하였다. 주어진 세가지 모형들에게서 적합한 모형 선택을 위하여 베이즈 인자(Bayes factor, BF)와 유사베이즈 인자(pseudo-Bayes factor, PsBF)를 이용하였다. 깁스샘플러와 메트로폴리스 알고리즘을 이용하여 베이지안 계산상의 어려움을 해결하였다. 예로써, 새로운 간질약에 대한 효과를 조사하기 위하여 앞에서 제시된 방법으로 해석하였다.

• Communications of the Korean Mathematical Society
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• v.23 no.3
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• pp.357-369
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• 2008

We obtain the superstability of a generalized exponential functional equation f(x+y)=E(x,y)g(x)f(y) and investigate the stability in the sense of R. Ger [4] of this equation in the following setting: $$|\frac{f(x+y)}{(E(x,y)g(x)f(y)}-1|{\leq}{\varphi}(x,y)$$ where E(x, y) is a pseudo exponential function. From these results, we have superstabilities of exponential functional equation and Cauchy's gamma-beta functional equation.