• 농촌지도와개발
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• 제4권1호
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• pp.165-173
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• 1997

This paper reviewed the legal bases and characteristics of agricultural extension services and organizational changes during the last fifty years in Korea. It was found that the legal bases extension services were rather weak are very important factors affecting agricultural extension services and organizational structures of agricultural extension institutions. It would be necessary to take legal steps to strengthen agricultural extension services by institute legal proceedings the characteristics of extension organization including the relationships among central, provincial and county level extension services, missions and objectives, personnel and facility management.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4493-4497
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• 2014

Background: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) can predict the clinical response to tyrosine kinase inhibitor (TKI) therapy. However, EGFR mutations may be different in primary tumors (PT) and metastatic lymph nodes (MLN). The aim of this study was to compare EGFR mutations between PT and the corresponding MLN in NSCLC patients, and provide some guidelines for clinical treatment using TKI therapy. Materials and Methods: A systematic review and meta-analysis was performed with several research databases. Relative risk (RR) with the 95% confidence interval (CI) were used to investigate the EGFR mutation status between PT and the corresponding MLN. A random-effects model was used. Results: 9 publications involving 707 patients were included in the analysis. It was found that activation of EGFR mutations identified in PT and the corresponding MLN was 26.4% (187/707) and 19.9% (141/707), respectively. The overall discordance rate in our meta-analysis was 12.2% (86/707). The relative risk (RR) for EGFR mutation in PT relative to MLN was 1.33 (95%CI: 1.10-1.60; random-effects model). There was no significant heterogeneity between the studies ($I^2$=5%, p=0.003). Conclusions: There exists a considerable degree of EGFR mutation discrepancy in NSCLC between PT and corresponding MLN, suggesting that tumor heterogeneity might arise at the molecular level during the process of metastasis.

• 생물환경조절학회지
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• 제18권4호
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• pp.425-430
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• 2009

본 시험은 고랭지 여름재배에 적합한 착색단고추의 품종을 선발하기 위하여 강원도 평창군 진부면 소재의 농가에서 암면배지의 수경재배로 수행되었다. 파종과 이식은 각각 2월과 4월에 하였고 7월부터 11월까지 매주 수확하였다. 총 12품종을 공시하여 7품종을 선발하였는데, 품종 선발 조건으로는 수출 규격품과의 비율이 높고 장마 및 고온기에 착과가 안정적이어서 8~10월의 수량이 높은 품종이었다. 따라서 고랭지 여름재배용 적품종으로는 적색계는 'Special'과 'Cupra', 주황 색계는 'Boogie', 'President'와 'Fellini' 그리고 황색계는 'Fiesta'와 'Derby'인 것으로 판단되었다. 결론적으로 본 시험은 품종 간의 다양한 특성을 제공하여 금후 여름재배에 적합한 품종을 선택하기 위한 기본자료로 쓰일 수 있을 것이며, 고랭지 여름재배 농가들의 영양생장 및 생식생장을 조절하는 정보에 활용될 수 있을 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2727-2732
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• 2014

Objectives: The aim of this study was to describe and analyze the incidence and mortality of female breast cancer in Jiangsu Province of China. Methods: Incidence and mortality data for female breast cancer and corresponding population statistics from eligible cancer registries in Jiangsu from 2006 to 2010 were collected and analyzed. Crude rates, age-specific rates and age-standardized rates of incidence and mortality were calculated, and annual present changes (APCs) were estimated to describe the time trends. Results: From 2006 to 2010, 11,013 new cases and 3,068 deaths of female breast cancer were identified in selected cancer registry areas of Jiangsu. The annual average crude incidence and age-standardized incidence by world population (ASW) were 25.2/ and 17.9/100,000 respectively. The annual average crude and ASW for mortality rates were 7.03/ and 4.81/100,000. The incidence was higher in urban areas than that in rural areas, and this was consistent in all age groups. No significant difference was observed in mortality between urban and rural areas. Two peaks were observed when looking at age-specific rates, one at 50-59 years and another at over 85 years. During the 5 years, incidence and mortality increased with APCs of 4.47% and 6.89%, respectively. Compared to the national level, Jiangsu is an area with relatively low risk of female breast cancer. Conclusion: Breast cancer has become a main public health problem among Chinese females. More prevention and control activities should be conducted to reduce the burden of this disease, even in relatively low risk areas like Jiangsu.

• Molecules and Cells
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• 제40권10호
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• pp.761-772
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• 2017

Glioblastoma is the most frequent and most aggressive brain tumor in adults. Solute carrier family 8 member 2 (SLC8A2) is only expressed in normal brain, but not present in other human normal tissues or in gliomas. Therefore, we hypothesized that SLC8A2 might be a glioma tumor suppressor gene and detected the role of SLC8A2 in glioblastoma and explored the underlying molecular mechanism. The glioblastoma U87MG cells stably transfected with the lentivirus plasmid containg SLC8A2 (U87MG-SLC8A2) and negative control (U87MG-NC) were constructed. In the present study, we found that the tumorigenicity of U87MG in nude mice was totally inhibited by SLC8A2. Overexpression of SLC8A2 had no effect on cell proliferation or cell cycle, but impaired the invasion and migration of U87MG cells, most likely through inactivating the extracellular signal-related kinases (ERK)1/2 signaling pathway, inhibiting the nuclear translocation and DNA binding activity of nuclear factor kappa B ($NF-{\kappa}B$), reducing the level of matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator (uPA)-its receptor (uPAR) system (ERK1/2-$NF-{\kappa}B$-MMPs/uPA-uPAR), and altering the protein levels of epithelial to mesenchymal transitions (EMT)-associated proteins E-cardherin, vimentin and Snail. In addition, SLC8A2 inhibited the angiogenesis of U87MG cells, probably through combined inhibition of endothelium-dependent and endothelium-nondependent angiogenesis (vascular mimicry pattern). Totally, SLC8A2 serves as a tumor suppressor gene and inhibits invasion, angiogenesis and growth of glioblastoma.

• Steel and Composite Structures
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• 제37권2호
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• pp.211-227
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• 2020

To explore the feasibility of eliminating the longitudinal rebars and stirrups by using ultra-high-performance fiber reinforcement concrete (UHPFRC) in concrete encased steel composite stub column, compressive behavior of UHPFRC encased steel stub column has been experimentally investigated. Effect of concrete types (normal strength concrete, high strength concrete and UHPFRC), fiber fractions, and transverse reinforcement ratio on failure mode, ductility behavior and axial compressive resistance of composite columns have been quantified through axial compression tests. The experimental results show that concrete encased composite columns with NSC and HSC exhibit concrete crushing and spalling failure, respectively, while composite columns using UHPFRC exhibit concrete spitting and no concrete spalling is observed after failure. The incorporation of steel fiber as micro reinforcement significantly improves the concrete toughness, restrains the crack propagation and thus avoids the concrete spalling. No evidence of local buckling of rebars or yielding of stirrups has been detected in composite columns using UHPFRC. Steel fibers improve the bond strength between the concrete and, rebars and core shaped steel which contribute to the improvement of confining pressure on concrete. Three prediction models in Eurocode 4, AISC 360 and JGJ 138 and a proposed toughness index (T.I.) are employed to evaluate the compressive resistance and post peak ductility of the composite columns. It is found that all these three models predict close the compressive resistance of UHPFRC encased composite columns with/without the transverse reinforcement. UHPFRC encased composite columns can achieve a comparable level of ductility with the reinforced concrete (RC) columns using normal strength concrete. In terms of compressive resistance behavior, the feasibility of UHPFRC encased steel composite stub columns with lesser longitudinal reinforcement and stirrups has been verified in this study.

• 한국조경학회지
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• 제23권3호
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• pp.167-176
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• 1995

The purpose of this study is to suggest objective basic data for park management proposal through the quantitative analysis of users' behaviors and satisfaction for the actual conditions of management in Moaksan provincial park. For this, users' behaviors and socio-ecnomic characteristics have been analyzed. Specifically, it attempts to investigate users' anticipation and degree of satisfaction applied Expectancy Theory by Likert scale. And users' satisfaction for the actual conditions of management had been analyzed by using the multiple regression. Results of this study can be summarized as follows ; From the aspect of utilization reality, the male usage was silighty higher than female usage, and the usage rate reality, the male usage was slighty higher than female usage, and the usage rate among the young and students such as university students also appeared slightly higher than the norm. Due to the fact, subject park had been provincial park, bus usage was predominant, and users' visit park 1 or 2 times a year. Generally, the value of users' post occupancy evaluation were higher than those of anticipated, and Use in night and facilities were lower. A sense of the season, dense of forest, beauty of skyline and a perspective view appeared as main explicatory variables having positive effects on the satisfaction level for the landscape. Amount of plant and shade were positive variables on the satisfaction and users' had dissatisfaction with trial damage. According to the multiple regression analysis, the major variables to the satisfaction for the actual condition of vegetation management were diversity, recovery of artificial injury.

• 정보관리연구
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• 제42권1호
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• pp.199-219
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• 2011

국내 외의 지식관리와 관련한 연구 대부분은 민간기업을 대상으로 이루어졌고, 공공부문 중에서 지방자치단체의 지식관리시스템 효과나 핵심요인에 대한 구체적인 사례연구는 부족한 상황이고, 그 기존 연구도 대부분 지식관리시스템 만족 요인 탐색인데 반해서 본 연구에서는 지식관리시스템의 이용 정도를 높이기 위해서는 어떤 영향 요인이 중요한지를 탐색하는 데 있다. 본 연구에서는 지식관리시스템이 갖고 있는 어떤 요인이 지식관리시스템 이용 유무에 원인이 되는지 고찰하기 위하여 분석모형에 포함된 지식관리시스템 케퍼빌리티의 구성요소와 개인 및 조직 케퍼빌리티의 구성요소 및 인구 통계학적 요인들을 독립변수로 하여 로짓회귀모형으로 분석 검증한다. '지식관리시스템 이용 유무'에 가장 영향을 미치는 변수는 '지식창조', 다음으로 유의한 변수인 '지식인프라', '부서장의 추진 의지' 요인도 유의하게 산출되었다.

• 국제지역연구
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• 제13권3호
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• pp.73-91
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• 2009

본 연구는 중국의 성(省)별 소득불균형의 추이를 살펴보고 패널 데이터 분석방법을 이용하여 지역별 소득불균형에 대한 세계화의 영향을 추정하였다. 실증분석을 위한 패널 자료는 중국의 지역별 소득불균형이 크게 확대되기 시작한 1990년부터 자료가 이용 가능한 2007년까지 중국의 29개 성별 자료를 이용하였다. 1990년대 중국의 성간 불균형은 크게 확대되는 추세를 보였으며, 2000년 이후 불균형 정도는 서서히 약화되는 것으로 나타났다. 중국을 대상으로 한 실증분석 결과는 성의 국제무역 규모 수준뿐만 아니라 전체 성들의 평균에 대한 비율 모두 중국의 성별 소득 불균형에 중요한 영향을 미치는 변수임을 확인하였다. 이러한 결과는 국제무역의 성장은 성간 소득불균형을 확대시킬 수 있음을 의미한다. 한편 중국의 각 성들은 넒은 영역을 포함하므로 각각의 성들 내에서도 도시와 농촌지역간 불균형이 지역간 소득불균형의 중요한 원인이 될 수 있다. 그러므로 지역간 균형발전을 위한 중앙정부의 서부대개발정책과 병행하여 소도시들에 대한 다양한 개발정책들이 필요함을 시사한다.

• 한국작물학회지
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• 제21권2호
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• pp.258-268
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• 1976

수도작에 피해를 가장 많이 주고 우리나라의 많은 면적에 분포되어 있는 답숙근초 가래의 생태조사와 제초제에 의한 방제법을 확립하기 위하여 1975년본 시험을 하였던 바 다음과 같은 결론을 얻었다. 1. 총 인경의 87%가 토양심도 10∼20cm 사이에 분포되어 있으며 지표로 부터 20cm길이에 강세인경이 형성되어 있다. 2. 인경의 이식심도별 발아율 및 인경형성수는 20cm 깊이에서부터 현저히 낮았다. 3. 가래 피해구는 수량이 16% 감소되었으며 그 최대요인 수수의 격감이었다. 4. 증식기에 적엽의 효과가 가장 높았고 증식기(17 DAT)와 개화기(8일하순경)의 2회 손제초로 인경형성의 방제가 가능하다. 5. 인경이 절단되면 가래발생량 및 인경형성량이 많아진다. 6. 가래는 이에서 약액을 흡수하여 살초된다. 7. 가래의 3∼5엽기 Avirosan처리에서 가래방제 효과가 가장 높았으며 약제살포로 인하여 인경은 표토부근에 이동형성되었다. 8. Avirosan은 수도묘의 발근에 저해하였다. 9. Avirosan처리후에는 수심 3cm로 일주일 정도의 심수가 적합하다. 10. 수수대, 메밀대는 가래 방제에 큰효과가 없었고 소석회는 손제초 정도의 효과가 있었다.