• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.5
• /
• pp.2027-2033
• /
• 2014

Background: We aimed to assess RET proto-oncogene polymorphisms in three different Iranian families with medullary thyroid cancer (MTC), and performed molecular dynamics simulations and free energy stability analysis of these mutations. Materials and Methods: This study consisted of 48 patients and their first-degree relatives with MTC confirmed by pathologic diagnosis and surgery. We performed molecular dynamics simulations and free energy stability analysis of mutations, and docking evaluation of known RET proto-oncogene inhibitors, including ZD-6474 and ponatinib, with wild-type and mutant forms. Results: The first family consisted of 27 people from four generations, in which nine had the C.G2901A (P.C634Y) mutation; the second family consisted of six people, of whom three had the C.G2901T (P.C634F) mutation, and the third family, who included 12 individuals from three generations, three having the C.G2251A (P.G691S) mutation. The automated 3D structure of RET protein was predicted using I-TASSER, and validated by various protein model verification programs that showed more than 96.3% of the residues in favored and allowed regions. The predicted instability indices of the mutated structures were greater than 40, which reveals that mutated RET protein is less thermo-stable compared to the wild-type form (35.4). Conclusions: Simultaneous study of the cancer mutations using both in silico and medical genetic procedures, as well as onco-protein inhibitor binding considering mutation-induced drug resistance, may help in better overcoming chemotherapy resistance and designing innovative drugs.

• Proceedings of the KIEE Conference
• /
• 1998.07e
• /
• pp.1629-1631
• /
• 1998

Crosslinked polyethylene (XLPE) insulated cables are now widely used all over the world for extra-high voltage underground transmission systems. Prefabricated type (compression type) joint has developed in order to shorten the assembly time and lower the possibility of contamination at site by many companies in the world. For outdoor termination, to control the electric field distribution as uniform as possible, especially for the use of extra-high voltage system. much of products are adopting the oil-impregnated condensor cone type instead of electric field control element which uses the permitivity of it only (not capacitance). For Gas-immersed termination, dimension of outer insulation bushing was determined by IEC Publication 859. The highest voltage of underground power cable system is 345kV now, in Korea. We have much of experiences of the development of prefabricated type accessories for CV cable systems (154kV, 161kV, 230kV level). So it was possible to inspect the proto type of accessories for 345kV CV cable system and seems that the need time for the development of products is reduced.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.39 no.1
• /
• pp.33-43
• /
• 2003

The midwater pair trawl which is being used at present in Korea have several problems. Firstly, it is difficult to control the net height on high towing speed. Secondly, net breaking often occurs owing to floats and thirdly, the volume of net on the net drum is so large. This study is aiming for examining the possibility of application for the Korean midwater pair trawl through the model experiment of non-float midwater pair trawl. The model of non-float midwater pair trawl was manufactured as 1/100 of the full scale net which is being used in bottom pair trawl for 850ps class considering the Tauti's Similarity law. The model experiment was carried out to analyze the opening efficiency according to the variation of lower warp length and the opening efficiency was investigated between th proto type and non-float type. The results obtained can be summarized as follows ; 1. The hydrodynamic resistance of non-float type was about 10~20% smaller than that of the proto type and it increased about 1ton according to the increase of dL at the condition of the same flow speed. The resistance acting on the lower warp decreased about 5% but that of the upper warp increased according to the increase of lower warp length (dL) at the condition of the same flow speed. 2. The net height of the non-float type decreased almost linearly according as the increased of flow speed and it increased in a logarithmic functional form with the increase of the lower warp length at the condition of the same flow speed. On the decreasing rate of the net height, the non-float type was lower than the proto type and the difference of the decreasing rate was about 12% at 3.0 knot, 25% at 4.0 knot, 25% at 4.0 knot respectively when dL was 30m. 3. The net width of non-float type was not varied so much as only 2m range and was larger than that of proto type. 4. The mouth area of non-float type decreased in a exponential functional form. On the decreasing rate of the mouth area, the non-float type was lower than the proto type. The filtering volume increased in a logarithmic functional form with increasing flow speed and the filtering volume of proto type decreased steeply over 3.0knot, but that of non-float type increased until 4.0knot. 5. The optimal length of lower warp was when the value of dL was about 30m and the optimal position of front weight was at the connection point of four net pendants.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
• /
• 1998.10a
• /
• pp.139-143
• /
• 1998

Applying design methodology, new type friction tester has been developed. Functional analysis has been executed and functional structure were constructed during the conceptual design. Optimal solution has been selected and a proto model has been manufactured according to the conceptual design. Using the proto model, experiments have been carried out and the test results were proved to be satisfied and reliable.

• Proceedings of the KIEE Conference
• /
• 1999.11d
• /
• pp.1041-1043
• /
• 1999

In this work, a possible new PD detection technique, based on the electro-optic effect, has been proposed. A proto-type probe sensor for detection partial discharge is made by $LiNbO_3$ Pockels cell, diachroic sheet polarizer and right-angle prism. The Mach-Zehnder interferometer system is proposed by using this sensor and this system is applied to detecting high electric field. we show the characteristic of the proto-type probe sensor and the design of a proposed probe type sensor.

• KIEAE Journal
• /
• v.7 no.6
• /
• pp.3-8
• /
• 2007

Recently, because of the continuous rise of international oil price, energy saving is strongly demanding. So, Ecological technics of architecture such as use of natural energy have been actively explored in the field of building. In the method of utilizing natural energy, the key point is to saving energy effectively as not lowering the comfort of indoor environment, various systems investigated. Many papers about double skin facade system have been reported, it is announced broadly that the system is very effective in improvement of natural ventilation and indoor thermal environment, and also protecting outdoor sound. The shaft box facade is a special form of box window construction. It consists of a system of box windows with continuous vertical shafts that extend over a number of stories to create a stack effect. The facade layout consists of an alternation of box windows and vertical shaft segments. This research investigated the natural ventilation performance of shaft box type balcony which conform the shaft box type double skin to the exiting balcony construction. First, analyzed various types of exiting apartments, proto-type was decided. By using virtual environment Program, modeling the proto-type, compared the contribution of air temperature and the effect of outdoor air cooling. by this research, we confirmed that shaft box type balcony had many possibility for improvement of indoor environment.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.39 no.3
• /
• pp.189-196
• /
• 2003

In this study, the vertical opening of the non-float midwater pair trawl net was maintained by controlling the length of upper warp. This was because the head rope was able to be kept linearly and the working depth was not nearly as changed with the variation of flow speed as former experiments in this series of studies have demonstrated. We confirmed that the opening efficiency of the non-float midwater pair trawl net was able to be developed according to the increase in front weight and wing-end weight. In this study, we described the opening efficiency of the non-float midwater pair trawl net according to the variation of front weight and wing-end weight obtained by model experiment in circulation water channel. We compared the opening efficiency of the proto type with that of the non-float type. The results obtained can be summarized as follows：1. The hydrodynamic resistance was almost increased linearly in proportion to the flow speed and was increased in accordance with the increase in front weight and wing-end weight. The increasing rate of hydrodynamic resistance was displayed as an increasing tendency in accordance with the increase in flow speed. 2. The net height of the non-float type was almost decreased linearly in accordance with the increase in flow speed. As the reduced rate of the net height of the non-float type was smaller than that of the net height of the proto type against increase of flow speed, the net height of the non-float type was bigger than that of the proto type over 4.0 knot. The net width of the non-float type was about 10 m bigger than that of the proto type and the change rate of net width varied by no more than 2 m according to the variation of the front weight and wing-end weight. 3. The mouth area of the non-float type was maximized at 1.75 ton of the front weight and 1.11 ton of the wing-end weight, and was smaller than that of the proto type at 2.0∼3.0 knot, but was bigger than that of the proto type at 4.0∼5.0 knot. 4. The filtering volume was maximized at 3.0 knot in the proto type and at 4.0 knot in the non-float type. The optimal front weight was 1.40 ton.

• Proceedings of the KIEE Conference
• /
• 2001.07b
• /
• pp.675-677
• /
• 2001

The neutron controls a nuclear fission in the core of reactor. In-core neutron detector drive system is a equipment that drives detector and cable to survey neutron flux in the reactor. The program introduced by this paper governs proto-type drive system. The basic function of drive system is the insert and the withdraw of a cable, and the control of the movement speed. Also this program have a special function, test, auto operation, to increase the capacity of drive system.

• Proceedings of the KIEE Conference
• /
• 2002.11d
• /
• pp.300-303
• /
• 2002

Combined generation system of Photovoltaic and wind generation have shortcoming that is different output power according to change of weather. So, the combined generation system is required backup system that such as a storage battery to supply energy, when not enough photovoltaic and wind power source for power supply equally and continually because the energy source is changeable and stable through change of weather as irradiation. temperature, wind speed. wind direction. seasons, etc.

• 유체기계공업학회:학술대회논문집
• /
• 2005.12a
• /
• pp.393-400
• /
• 2005

As one of the useful and powerful methods for designing the optimum pump is using model pump, it is based on the similarity characteristics of turbomachinery. With this theory, we can predict the performance of various pumps. In fact we have performed huge pumps using this, the experimental results were to be sufficient to prove the similarity characteristics. In this study, we predicted the performance of the huge proto-type pump that cannot be installed and made a test. First of all, we had calculated the model ratio between proto-type and model. There were two ways to estimate the performance. One was the application of CFD code, and the other way was model field test. So We selected both of them to guarantee the dependable data and evaluated each other.