• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2002.11a
• /
• pp.14-40
• /
• 2002

15-Deoxy-${\Delta}^{12, 14}$-prostaglandin $J_2$ (15-deoxy-$PGJ_2$), a naturally occurring ligand activates the peroxisome proliferator-activated $receptor-{\gamma}(PPAR-{\gamma}$). Activation of $PPAR-{\gamma}$ has been found to induce cell differentiation such as adipose cell and macrophage. Here it was investigated whether 15-deoxy-$PGJ_2$ has neuronal cell differentiation and possible underlying molecular mechanisms. Dopaminergic differentiating PC 12 cells treated with 15-deoxy-$PGJ_2$ (0.2 to 1.6 ${\mu}M$) alone showed measurable neurite extension and expression of neurofilament, markers of cell differentiation. However much greater extent of neurite extension and expression of neurofilament was observed in the presence of NGF (50 ng/ml). In parallel with its increasing effect on the neurite extension and expression of neurofilament, 15-deoxy-$PGJ_2$ enhanced NGF-induced p38 MAP kinase expression and its phosphorylation in addition to the activation of transcription factor AP-1 in a dose dependent manner. Moreover, pretreatment of SD 203580, a specific inhibitor of p38 MAP kinase inhibited the promoting effect of 15-deoxy-$PGJ_2$(0.8 ${\mu}M$) on NGF-induced neurite extension. This inhibition correlated well with the ability of SB203580 to inhibit the enhancing effect of 15-deoxy-$PGJ_2$ on the expression of p38 MAP kinase and activation of AP-1, The promoting ability of 15-deoxy-$PGJ_2$ did not occur through $PPAR-{\gamma}$, as synthetic PPAR-${\gamma}$ agonist andantagonist did not change the neurite promoting effect of 15-deoxy-PGJ$_2$. In addition, contrast to other cells (embryonic midbrain and SK-N-MC cells), $PPAR-{\gamma}$ was not expressed in PC-12 cells. Other structure related prostaglandins, PGD$_2$ and $PGE_2$ acting via a cell surface G-protein-coupled receptor (GPCR) did not increase basal or NGF-induced neurite extension. Moreover, GPCR (EP and DP receptor) antagonists did not alter the promoting effect of f 5-deoxy-$PGJ_2$ on neurite extension and activation of p38 MAP kinase, suggesting that the promoting effect of 15-deoxy-$PGJ_2$ may not be mediated GPCR. These data demonstrate that activation of p38 MAP kinase in conjunction with AP-1 single pathway may be important in the promoting activity of 15-deoxy-$PGJ_2$ cells.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2002.11b
• /
• pp.14-40
• /
• 2002

15-Deoxy- Δ$\^$12,14/-prostaglandin J$_2$ (15-deoxy-PGJ$_2$), a naturally occurring ligand activates the peroxisome proliferator-activated receptor-${\gamma}$ (PPAR-${\gamma}$). Activation of PPAR-y has been found to induce cell differentiation such as adipose cell and macrophage. Here it was investigated whether 15-deoxy-PGJ$_2$ has neuronal cell differentiation and possible underlying molecular mechanisms. Dopaminergic differentiating PC 12 cells treated with 15-deoxy-PGJ$_2$ (0.2 to 1.6 ${\mu}$M) alone showed measurable neurite extension and expression of neurofilament, markers of cell differentiation. However much greater extent of neurite extension and expression of neurofilament was observed in the presence of NGF (50 ng/$m\ell$). In parallel with its increasing effect on the neurite extension and expression of neurofilament, 15-deoxy-PGJ$_2$ enhanced NGF-induced p38 MAP kinase expression and its phosphorylation in addition to the activation of transcription factor AP-1 in a dose dependent manner. Moreover, pretreatment of SD 203580, a specific inhibitor of p38 MAP kinase inhibited the promoting effect of 15-deoxy-PGJ$_2$ (0.8 ${\mu}$M) on NGF-induced neurite extension. This inhibition correlated well with the ability of SB203580 to inhibit the enhancing effect of 15-deoxy-PGJ$_2$ on the expression of p38 MAP kinase and activation of AP-1. The promoting ability of 15-deoxy-PGJ$_2$ did not occur through PPAR-${\gamma}$, as synthetic PPAR-${\gamma}$ agonist and antagonist did not change the neurite promoting effect of 15-deoxy-PGJ$_2$. In addition, contrast to other cells (embryonic midbrain and SK-N-MC cells), PPAR-${\gamma}$ was not expressed in PC-12 cells. Other structure related prostaglandins, PGD$_2$ and PGE$_2$ acting via a cell surface G-protein-coupled receptor (GPCR) did not increase basal or NGF-induced neurite extension. Moreover, GPCR (EP and DP receptor) antagonists did not alter the promoting effect of 15-deoxy-PGJ$_2$ on neurite extension and activation of p38 MAP kinase, suggesting that the promoting effect of 15-deoxy-PGJ$_2$ may not be mediated GPCR. These data demonstrate that activation of p38 MAP kinase in conjunction with AP-1 signal pathway may be important in the promoting activity of 15-deoxy-PGJ$_2$ on the differentiation of PC12 cells.

• Korean Journal of Soil Science and Fertilizer
• /
• v.36 no.2
• /
• pp.86-91
• /
• 2003

Carbon material such as graphite and activated charcoal can promote the growth of some formsog bacteria. We examined whether this bacterial growth promoting effect can have a positive influence on field crops. Refined graphite was mixed into the standard soil used in rice cultivation. Varying soil graphite mixtures of 0.1%, 0.5% and 1% were used to cultivate rice seedling for 3 weeks. After transplanting in the filed, rice plants were cultivated for 4 months. To observe the effect of graphite(carbon material) during the cultivation of rice, we examined various different growth components in this research. During the transplanting stage, growth promoting effect of carbon was observed in the 0.1% carbon added soil. However, there were not much difference between graphite added soil and standard soil in the other stages. Rice yield was highest in the soil with 0.1% graphite.

• Journal of the Korean Society of School Health
• /
• v.11 no.2
• /
• pp.189-201
• /
• 1998

The objectives of this study are first to develop the index of school health promoting behaviors, two, to measure those, third, to analysis the relative importance of factors that effect on school health promoting behaviors. School health promotion indexes were composed of 60 components of six areas which modify the element of health promoting schools are developed by world health organization. The survey data were collected by questionnaires from June to September in 1998. The number of subjects was 294 school nurses. The SAS-PC program was used for the statistical analysis. The major results were as follows: 1. The six areas of school health promoting behaviors are: school health politics (20 components), the school physical environment (17 component), the school social environment (7 component), community relationships (6 component), personal health skills (7 component) and health services (3 component). 2. The mean of total school health promotion indexes was highest at elementary school as 3.46. The order of area was health services, the school physical environment, school health politics, the school social environment, personal health skills, community relationships. 3. The regression model used in this analysis presented significant relationships between school health promoting behaviors and independent variables. The important variable affecting the area of school physical environment was education level of school nurses. The important variable affecting the area of the school social environment and personal health services were the location of school, credential education program. Age or career also were significant variables affect the community relationships and health services. In summary, The health promoting behavior of elementary school was higher than other school. It is mean that have to perform active promoting behavior at middle school and high school. Health service level was highest among areas of school health promoting behaviors. It is mean also that school nurse teachers is interested in activity for other areas to improve of school health. Furthermore, it is necessary to develop the specific program for school health promoting behavior.

• The Journal of the Korea Contents Association
• /
• v.20 no.10
• /
• pp.726-737
• /
• 2020

This study analyzed 4,284 elderly people aged 65 or older by SPSS 22.0 in the 7th data of 「2018 Korean Longitudinal Study of Ageing(KLoSA)」 to confirm the effect of the health-promoting behavior of the elderly on life satisfaction through cognitive function. The cognitive function level of the subjects was 13.8% doubtful about dementia, 23.8% cognitive decline, and 62.4% normal, and the satisfaction level of life was 59.304 points. The results of the study were as follows: First, the difference in cognitive function according to demographic characteristics was significant in gender, age, education, religion, and marriage factors. Second, the satisfaction of the elderly's life according to demographic characteristics was confirmed to have significant differences in gender, age, education, religion, and marriage factors. Third, the satisfaction of the elderly's life was significantly positive in drinking and regular exercise factors among independent variable the health-promoting behavior when cognitive function was mediated. On the other hand, The significant negative effect of the restriction of daily life activities was confirmed. In this way, the mediating effect of cognitive function was verified in the effect of the health-promoting behavior on the satisfaction of the elderly life.

• Journal of Korean Academy of Nursing
• /
• v.26 no.2
• /
• pp.359-371
• /
• 1996

This study has been done for the purpose of testing the effect of health education on the performance of health promoting behavior in college students, and identifying the factors affecting health promoting behaviors. A Nonequivalent control group posttest research design was used. Two hundred thirty college students at K College in T city were studied. Of them, 114 who attended a systematic health education session for three hours a week during one semester were the experimental group. And 116 college students who were chosen of matched sampling of grade, class and sex were the control group. This study was conducted from March 1 to July 2, 1995. The instruments used for this study included a survey of general characteristics, perceived health status, self-esteem, health promoting behavior and health locus of control. Analysis of data was done by use of mean, 1-test, Pearson correlation coefficient and multiple regression. The results of this study are summarized as follows : 1) The average item score for the health promoting behavior was low at 2.52. In the sub-categories, the highest degree of performance was ‘harmonious relationships’, following ‘sanitary life’, ‘self-esteem’, ‘rest and sleep’, and ‘emotional support’ and the lowest degree was ‘professional health management’. 2) Hypothesis 1 that the college students who get health education will have a higher degree of health promoting behavior than the college students who do not get health education was accepted. There was a statistically significant difference between the average of the experimentalgroup, 2.60, and the average of the control group, 2.45.（t＝11.30, p＝0.0009）. 3) Hypothesis 2 that the college students who get health education will have a higher score of perceived health status than college students who do not get the health education was rejected. （t＝1.13, p＝0.289） 4) Performance of health promoting behavior was positively correlated with self-esteem and grade and negatively correlated with perceived health status. 5) The most important factor affecting performance of health promoting behavior was self-esteem. The following suggestions are made based on the above results : 1) Replication of the research is needed to confirm effects of health education. 2) More effective health education programs need to be developed through by modification of teaching methods and content analysis of health education. 3) Other factors affecting health promoting behavior should be identified. 4) Nursing colleges or departments of nursing should make an effort to develop and carry out various health education programs for the health promotion of all college students.

• Research in Community and Public Health Nursing
• /
• v.31 no.3
• /
• pp.360-374
• /
• 2020

Purpose: This study aims to identify the mediating effect of health promoting behavior in the relationship between depression and health-related quality of life, and between social support and health-related quality of life among migrant workers. Methods: Data were collected from 152 migrant workers working at companies in K and B metropolitan cities. The study conducted a survey from August 1 to September 30, 2019, and used self-report structured questionnaires that were translated into English and Korean. The data were analyzed using descriptive statistics, Pearson correlation coefficient, simple and multiple regression, Baron and Kenny's method, and Sobel test. Results: Depression was significantly negatively correlated with social support (r=-.29, p<.001), health promoting behavior (r=-.30, p<.001) and health-related quality of life (r=-.44, p<.001). And social support was significantly positively correlated with health promoting behavior (r=.50, p<.001) and health-related quality of life (r=.44, p<.001). And health promoting behavior was significantly positively correlated with health-related quality of life (r=.51, p<.001). Furthermore health promoting behavior showed partial mediating effects in the relationship between depression and health-related quality of life (Z=3.26, p<.001), and showed partial mediating effects in the relationship between the social support and health-related quality of life (Z=3.98, p<.001). Conclusion: In this study, depression and social support were shown to mediate health promotion behavior to improve health-related quality of life. Therefore, in order to improve the health-related quality of life of migrant workers, it is necessary to focus on the health promotion behaviors, and effective strategies are needed to reduce depression, and support social support.

• The Journal of the Korea Contents Association
• /
• v.15 no.11
• /
• pp.165-176
• /
• 2015

The purpose of this study was to identify the relationships among school-aged children's perceived parenting style, children's self-esteem, health promoting behavior and to determine whether self-esteem was a the mediator of the relationship between parenting style and health promoting behavior. Participants were 425 school-aged children of 5th and 6th grade. Data were analyzed using t-tests, Pearson correlation, and hierarchical multiple regression. The child's health promoting behavior was positively associated with receptive parenting style and positively associated with self-esteem. Also, the results showed that the effect of receptive parenting style on health promoting behavior was significantly partially mediated by self-esteem. Therefore, parenting style and children's self-esteem need to be factored in when designing and applying health education program for school-aged children. Also, the program need to be designed to enhance receptive parenting style that can lead to children's increase self-esteem.

• The Journal of the Korea Contents Association
• /
• v.12 no.7
• /
• pp.203-214
• /
• 2012

This study investigates the effect of health-promoting behaviors of the elderly women on the life satisfaction level. The 375 questionnaires were collected from the elderly women who are over sixty living in Seoul area. The frequency analysis, factor analysis, reliability analysis, multiple regression analysis, t-test, and ANOVA were carried out for the study using SPSS. 18.0. The results are as follows; First, it has been confirmed that the health-promoting behaviors of the elderly women affect positive life satisfaction level. Second, a comparative analysis between health-promoting behaviors and life satisfaction level in the categories of demographic characteristics showed differences, on health-promoting behaviors educational background, average earnings per month, religion, health status, economic and on life satisfaction level status domains including educational background, average earnings per month, religion, live with children, health status, economic status, spouse.

• Journal of Microbiology and Biotechnology
• /
• v.31 no.3
• /
• pp.398-407
• /
• 2021

Using salt-tolerant bacteria to protect plants from salt stress is a promising microbiological treatment strategy for saline-alkali soil improvement. Here, we conducted research on the growth-promoting effect of Brevibacterium frigoritolerans on wheat under salt stress, which has rarely been addressed before. The synergistic effect of B. frigoritolerans combined with representative salt-tolerant bacteria Bacillus velezensis and Bacillus thuringiensis to promote the development of wheat under salt stress was also further studied. Our approach involved two steps: investigation of the plant growth-promoting traits of each strain at six salt stress levels (0, 2, 4, 6, 8, and 10%); examination of the effects of the strains (single or in combination) inoculated on wheat in different salt stress conditions (0, 50, 100, 200, 300, and 400 mM). The experiment of plant growth-promoting traits indicated that among three strains, B. frigoritolerans had the most potential for promoting wheat parameters. In single-strain inoculation, B. frigoritolerans showed the best performance of plant growth promotion. Moreover, a pot experiment proved that the plant growth-promoting potential of co-inoculation with three strains on wheat is better than single-strain inoculation under salt stress condition. Up to now, this is the first report suggesting that B. frigoritolerans has the potential to promote wheat growth under salt stress, especially combined with B. velezensis and B. thuringiensis.