• 한국콘텐츠학회논문지
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• 제19권2호
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• pp.296-304
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• 2019

아마존고의 출시와 함께 온라인 기업들이 온라인 디지털 사업에서 축적한 자산과 역량에 기반하여 오프라인으로 진출하는 O4O의 시대가 열렸다. 디지털 콘텐츠 업계에서도 O4O 전략을 시행하는 회사들이 늘고 있다. 본 논문은 디지털 콘텐츠 업계 O4O의 대표적인 사례인 카카오프렌즈를 대상으로 온-오프라인 연계 마케팅을 연구한 결과물이다. 온라인에서 캐릭터 체험이 어떤 경로를 통해 오프라인 연관 상품의 구매 의향으로 연결되는지를 브랜드 경험과 브랜드 태도에 대한 선행연구 모형을 준용하여 탐구하였다. 연구 결과, 온라인 디지털 콘텐츠를 경험한 것은 경험만족도와 브랜드 선호도 및 브랜드 신뢰도를 매개로 하여 구매의도에 영향을 미친다는 것을 확인하였다. 그러나 체험만족도가 구매의도에 영향을 미친다는 가설은 기각되었다. 디지털 콘텐츠 기업을 포함하여 온-오프라인 트랜스미디어 마케팅을 수행하는 기업은 소비자의 구매의도를 높이고자 할 때, 체험만족도를 끌어올리는 것보다는 브랜드 선호도와 브랜드 만족도를 제고하는 데 집중할 필요가 있다.

• Natural Product Sciences
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• 제24권4호
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• pp.235-240
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• 2018

Betula platyphylla var. japonica (Betulaceae), also known as Asian white birch, is an endemic medicinal tree, the bark of which has been used in Chinese traditional medicine for the treatment of various inflammatory diseases. In our continuing search for bioactive compounds from Korean natural resources, a phytochemical investigation of the bark of B. platyphylla var. japonica led to the isolation of 7-oxo-${\beta}$-sitosterol (1) and soyacerebroside I (2) from its ethanol extract as main components by liquid chromatography (LC)/mass spectrometry (MS)-based analysis. The structures of isolates were identified by comparison of $^1H$ and $^{13}C$ nuclear magnetic resonance spectroscopic data and physical data with the previously reported values and LC/MS analyses. To the best of our knowledge, this is the first study to demonstrate that the isolated compounds, 7-oxo-${\beta}$-sitosterol and soyacerebroside I, were isolated in B. platyphylla var. japonica. We examined the effects of the isolates on the regulation of adipocytes and osteoblast differentiation. These isolates (1 and 2) produced fewer lipid droplets compared to the untreated negative control in Oil Red O staining of the mouse mesenchymal stem cell line without altering the amount of alkaline phosphatase staining. The results demonstrated that both compounds showed marginal inhibitory effects on adipocyte differentiation but did not affect osteoblast differentiation.

• 패션비즈니스
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• 제23권1호
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• pp.37-48
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• 2019

WKSF (Warp-knitted spacer fabrics) knitted using a double Raschel machine is the three-dimensional knit that has vertically connected separate layers in loop structures. Because of its unique structure, the fabric is light, compressible and breathable. Owing to the high production speed, the use of the fabric is increasing in various areas. The purpose of this study is to establish the design process in the utilization of WKSF program and analyze the difference between WKSF and Neoprene as garment materials.. The study on the design related to WKSF has rarely been carried out because of the complexity of WKSF structure and the difficulties encountered in analyzing the structure and thread. Therefore, checking beforehand the simulation results similar to a final knit using the CAD program for WKSF can only enhance the efficiency of the design for the light knits. The conclusion drawn after designing the light knits using the CAD program and analyzing the pros and cons of WKSF through the various property evaluation techniques is as follows. The tension characteristic analysis results indicated that Neoprene specimen has the elastic transformation and resilience, thus behaving like an elastic product such as rubber. By contrast, in the event that clothing and fashion accessories are designed with WKSF, these products are kept in a boxy style fit so that the fabric can be applied flexibly to a curvy body line. In addition, WKSF is good in forming noticeably around a curvy body, because its resistance shear deformation is lower than that of Neoprene.

• 한국융합학회논문지
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• 제10권10호
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• pp.91-97
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• 2019

최근 페미니즘이 주요 가치로 부상함에 따라 관련 디자인 연구도 증가하고 있다. 본 연구는 페미니스트 디자인 연구자들에게 연구의 계보를 제공하고자, 국내 페미니스트 디자인 연구의 특징을 분석한다. 먼저 '페미니스트 디자인'을 정의하고, 용어의 기원이자 국내 연구의 특수성 분석을 위한 비교군으로서 영미권 페미니스트 디자인 연구 역사를 살펴본다. 국내 페미니스트 디자인 연구 수는 1999년 급증한 후 2000년대 들어 지금까지 연평균 5.1건의 연구가 꾸준히 발표되었다. 전체 연구 중 패션, 시각, 건축, 디자인학, 제품 순으로 연구 수가 많았다. 연구 주제의 경우 2000년대 이전 연구가 남성중심사회에서 여성의 고정된 역할 탈피를 다루던 것에서 2000년대 이후 다양성과 탈 중심성의 포용으로 이행하는 양상을 볼 수 있다. 이후 장애인, 생태, 퀴어 등 더욱 세분화, 다양화된 주체들의 다양성을 수용하는 연구의 분야로서 지속 가능한 발전이 예상된다.

• Natural Product Sciences
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• 제25권2호
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• pp.103-110
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• 2019

We investigated the anti-inflammatory effect of Pyunkang-tang extract (PGT), a complex herbal extract based on traditional Chinese medicine that is used in Korea for controlling diverse pulmonary diseases, on cigarette smoke-induced pulmonary pathology in a rat model of chronic obstructive pulmonary disease (COPD). The constituents of PGT were Lonicerae japonica, Liriope platyphylla, Adenophora triphilla, Xantium strumarinum, Selaginella tamariscina and Rehmannia glutinosa. Rats were exposed by inhalation to a mixture of cigarette smoke extract (CSE) and sulfur dioxide for three weeks to induce COPD-like pulmonary inflammation. PGT was administered orally to rats and pathological changes to the pulmonary system were examined in each group of animals through measurement of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-6 (IL-6) levels in bronchoalveolar lavage fluid (BALF) at 21 days post-CSE treatment. The effect of PGT on the hypersecretion of pulmonary mucin in rats was assessed by quantification of the amount of mucus secreted and by examining histopathologic changes in tracheal epithelium. Confluent NCI-H292 cells were pretreated with PGT for 30 min and then stimulated with CSE plus PMA (phorbol 12-myristate 13-acetate), for 24 h. The MUC5AC mucin gene expression was measured by RT-PCR. Production of MUC5AC mucin protein was measured by ELISA. The results were as follows: (1) PGT inhibited CSE-induced pulmonary inflammation as shown by decreased TNF-${\alpha}$ and IL-6 levels in BALF; (2) PGT inhibited the hypersecretion of pulmonary mucin and normalized the increased amount of mucosubstances in goblet cells of the CSE-induced COPD rat model; (3) PGT inhibited CSE-induced MUC5AC mucin production and gene expression in vitro in NCI-H292 cells, a human airway epithelial cell line. These results suggest that PGT might regulate the inflammatory aspects of COPD in a rat model.

• Natural Product Sciences
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• 제25권1호
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• pp.28-33
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• 2019

A popular approach for the study of estrogen receptor ${\alpha}$ inhibition is to investigate the protein-protein interaction between the estrogen receptor (ER) and the coactivator surface. In our study, we investigated phytochemicals from Rubus coreanus that were able to disrupt $ER{\alpha}$ and coactivator interaction with an $ER{\alpha}$ antagonist. The E-screen assay and molecular docking analysis were performed to evaluate the effects of the estrogenic activity of R. coreanus extract and its constituents on the MCF-7 human breast cancer cell line. At $100{\mu}g/mL$, R. coreanus extract significantly stimulated cell proliferation ($574.57{\pm}8.56%$). Sanguiin H6, which was isolated from R. coreanus, demonstrated the strongest affinity for the $ER{\alpha}$ coactivator-binding site in molecular docking analysis, with a binding energy of -250.149. The initial results of the study indicated that sanguiin H6 contributed to the estrogenic activity of R. coreanus through the activation of the $ER{\alpha}$ coactivator-binding site.

• Biomolecules & Therapeutics
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• 제27권2호
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• pp.193-200
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• 2019

Ceramide metabolism is known to be an essential etiology for various diseases, such as atopic dermatitis and Gaucher disease. Glucosylceramide synthase (GCS) is a key enzyme for the synthesis of glucosylceramide (GlcCer), which is a main ceramide metabolism pathway in mammalian cells. In this article, we developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to determine GCS activity using synthetic non-natural sphingolipid C8-ceramide as a substrate. The reaction products, C8-GlcCer for GCS, could be separated on a C18 column by reverse-phase high-performance liquid chromatography (HPLC). Quantification was conducted using the multiple reaction monitoring (MRM) mode to monitor the precursor-to-product ion transitions of m/z $588.6{\rightarrow}264.4$ for C8-GlcCer at positive ionization mode. The calibration curve was established over the range of 0.625-160 ng/mL, and the correlation coefficient was larger than 0.999. This method was successfully applied to detect GCS in the human hepatocellular carcinoma cell line (HepG2 cells) and mouse peripheral blood mononuclear cells. We also evaluated the inhibition degree of a known GCS inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) on GCS enzymatic activity and proved that this method could be successfully applied to GCS inhibitor screening of preventive and therapeutic drugs for ceramide metabolism diseases, such as atopic dermatitis and Gaucher disease.

• International Journal of Computer Science & Network Security
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• 제21권3호
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• pp.295-303
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• 2021

The relevance of the research is due to the fact that the issue of poverty is one of the most acute social problems of the beginning of the third millennium. The phenomenon of poverty is widespread in third world countries as well as it is observed in relatively developed countries. Poverty rates in Latin America are threatening. Consequently, the issue of social and economic inequality in these countries has become extremely acute. The purpose of the research: to identify the causes of poverty and social inequality and substantiate the main directions of poverty reduction in third world countries. The research methods: comparative analysis; index method; systematization; grouping; generalization. Results. The classification of the causes of poverty has been carried out and the directions of its overcoming in the countries of Latin America on groups of indicators have been defined, namely: 1) political; 2) economic; 3) demographic; 4) regional-geographical; 5) social; 6) qualification; 7) personal. Based on the Net Domestic Product indicator, a comparison of economic indicators of the studied countries has been carried out. It has been revealed that from 1990 to 2018 income inequality increased in 52 of 119 countries studied, and decreased in 57 states. Inequality has increased in the world's most populous countries, particularly China and India. In general, countries with growing inequality are home to more than two-thirds (71%) of the world's population. Trends in the distribution of income in the world have been investigated by applying the Gini index, the high level of which is observed in Latin America (Colombia 48,9%, Panama 46,1%, Chile and Mexico 45,9%). The forecast of the impact of the Covid-19 pandemic on this issue has been outlined; the ways of its impact on the economies of the countries have been studied. As a result of the study, the main directions and mechanisms of the strategy for poverty reduction and social inequality in the third world countries have been identified. The implementation of the poverty reduction strategy presented in this academic paper may have a positive impact on the economic situation of the population of Latin American countries.

• 접착 및 계면
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• 제21권4호
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• pp.135-142
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• 2020

최근 미세플라스틱과 같은 환경 문제로 석유계 플라스틱을 대체할 자연 유래 친환경 플라스틱에 대한 사람들의 관심이 증가하고 있다. 점·접착제 분야에서도 이런 추세에 맞추어 천연 유래 소재를 이용한 친환경 점·접착제들이 개발되고 있다. 그 중에서 엿당은 전분에서 유래한 천연 물질이며 식품 첨가제로 쓰이는 물엿의 주성분이다. 전분보다 낮은 분자량 때문에 물에 쉽게 녹고 무엇보다 이를 이용해 용액중합으로 다른 단량체와 공중합 될 수 있다는 가능성이 있다. 그러나 아직 엿당을 이용하여 점·접착제에 응용한 연구는 미비한 실정이다. 본 연구에서는 엿당을 아크릴 무수물로 개질한 후 FT-IR과 H-NMR을 통해 개질여부를 확인하였다. 그리고 개질한 엿당을 2종의 아크릴 단량체와 공중합 하였다. 합성한 수지의 접착 성능은 목재접착을 통해 조사하였다.

• 한국축산식품학회지
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• 제41권1호
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• pp.95-109
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• 2021

Consumer's interest in sustainable livestock farming methods has grown in response to concerns for the environment and animal welfare. The purpose of this study is to examine the different influences of sustainability product information on sensory characteristics and purchase behaviors. To accomplish this aim, the study used salami, which is an Italian-style sausage processed by fermentation and drying. Three different types of information were provided: salami made from the pork of an antibiotic-free pig (SMAFP), of an animal welfare pig (SMAWP), and of a grazing pig (SMGP). This study was conducted as an off-line experiment with Korean participants (n=140). As a result, there were sensory differences according to the sustainability information. For the SMAFP, it had a significant difference in, sourness (p<0.05). With the SMAWP, there was a difference in gumminess (p<0.10), and the SMGP had significant differences in sourness (p<0.01), sweetness (p<0.01), andmoisture (p<0.05). Moreover, the purchase intention and willingness to pay were significantly higher when the sustainability information was given. Especially, among the three types of salamis, participants were willing to pay the most for the SMAWP. This is one of the first consumer studies to investigate sensory evaluation and purchase behavior for various types of sustainable livestock production. These results contribute by helping sustainable meat producers and marketers become aware of the kind of sustainable information to which consumers are sensitive.