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http://dx.doi.org/10.20307/nps.2019.25.1.28

Estrogenic Activity of Sanguiin H-6 through Activation of Estrogen Receptor α Coactivator-binding Site  

Trinh, Tuy An (College of Korean Medicine, Gachon University)
Park, Eun-Ji (Department of Obstetrics and Gynaecology, College of Korean Medicine, Daejeon University)
Lee, Dahae (School of Pharmacy, Sungkyunkwan University)
Song, Ji Hoon (Department of Medicine, University of Ulsan College of Medicine)
Lee, Hye Lim (Department of Pediatrics, College of Korean Medicine, Daejeon University)
Kim, Ki Hyun (School of Pharmacy, Sungkyunkwan University)
Kim, Younghoon (Pharminogene Inc.)
Jung, Kiwon (Institute of Pharmaceutical Sciences, College of Pharmacy, CHA University)
Kang, Ki Sung (College of Korean Medicine, Gachon University)
Yoo, Jeong-Eun (Department of Obstetrics and Gynaecology, College of Korean Medicine, Daejeon University)
Publication Information
Natural Product Sciences / v.25, no.1, 2019 , pp. 28-33 More about this Journal
Abstract
A popular approach for the study of estrogen receptor ${\alpha}$ inhibition is to investigate the protein-protein interaction between the estrogen receptor (ER) and the coactivator surface. In our study, we investigated phytochemicals from Rubus coreanus that were able to disrupt $ER{\alpha}$ and coactivator interaction with an $ER{\alpha}$ antagonist. The E-screen assay and molecular docking analysis were performed to evaluate the effects of the estrogenic activity of R. coreanus extract and its constituents on the MCF-7 human breast cancer cell line. At $100{\mu}g/mL$, R. coreanus extract significantly stimulated cell proliferation ($574.57{\pm}8.56%$). Sanguiin H6, which was isolated from R. coreanus, demonstrated the strongest affinity for the $ER{\alpha}$ coactivator-binding site in molecular docking analysis, with a binding energy of -250.149. The initial results of the study indicated that sanguiin H6 contributed to the estrogenic activity of R. coreanus through the activation of the $ER{\alpha}$ coactivator-binding site.
Keywords
Rubus coreanus; Sanguiin H-6; Estrogen receptor ${\alpha}$; Coactivator-binding site; MCF-7 human breast cancer cells;
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1 Oh, C. M.; Won, Y. J.; Jung, K. W.; Kong, H. J.; Cho, H.; Lee, J. K.; Lee, D. H.; Lee, K. H. Cancer Res. Treat. 2016, 48, 436-450.   DOI
2 Jung, K. W.; Won, Y. J.; Oh, C. M.; Kong, H. J.; Lee, D. H.; Lee, K. H. Cancer Res. Treat. 2017, 49, 306-312.   DOI
3 Carmichael, A. R.; Mokbel, K. Arch. Plast. Surg. 2016, 43, 222-223.   DOI
4 Irelli, A.; Cocciolone, V.; Cannita, K.; Zugaro, L.; Di Staso, M.; Lanfiuti Baldi, P. L.; Paradisi, S.; Sidoni, T.; Ricevuto, E.; Ficorella, C. Bone 2016, 87, 169-175.   DOI
5 de Pedro, M.; Baeza, S.; Escudero, M. T.; Dierssen-Sotos, T.; Gomez-Acebo, I.; Pollan, M.; Llorca, J. Breast Cancer Res. Treat. 2015, 149, 525-536.   DOI
6 Esteva, F. J.; Hortobagyi, G. N. Sci. Am. 2008, 298, 58-65.   DOI
7 Heo, J. Donguibogam; Yeogang: Korea, 1994, pp 946-947.
8 Howell, S. J.; Johnston, S. R. D.; Howell, A. Best Pract. Res. Clin. Endocrinol. Metab. 2004, 18, 47-66.   DOI
9 Zheng, J.; Zhou, Y.; Li, Y.; Xu, D. P.; Li, S.; Li, H. B. Nutrients. 2016, 8, 495.   DOI
10 Lee, J.; Dossett, M.; Finn, C. E. Molecules. 2014, 19, 10524-10533.   DOI
11 Li, J.; Du, L. F.; He, Y.; Yang, L.; Li, Y. Y.; Wang, Y. F.; Chai, X.; Zhu, Y.; Gao, X. M. Chem. Biodivers. 2015, 12, 1809-1847.   DOI
12 Ju, H. K.; Cho, E. J.; Jang, M. H.; Lee, Y. Y.; Hong, S. S.; Park, J. H.; Kwon, S. W. J. Pharm. Biomed. Anal. 2009, 49, 820-827.   DOI
13 Choung, M. G.; Lim, J. D. Korean J. Med. Crop Sci. 2012, 20, 259-269.   DOI
14 Korner, W.; Hanf, V.; Schuller, W.; Kempter, C.; Metzqer, J.; Haqenmaier, H. Sci. Total Environ. 1999, 225, 33-48.   DOI
15 Soto, A. M.; Sonnenschein, C.; Chung, K. L.; Fernandez, M. F.; Olea, N.; Serrano, F. O. Environ. Health Perspect. 1995, 103, 113-122.
16 Lee, S.; Barron, M. G. PloS One 2017, 12, 1-14.
17 Jameera Begam, A.; Jubie, S.; Nanjan, M. J. Bioorg. Chem. 2017, 71, 257-274.   DOI
18 Ng, H. W.; Zhang, W.; Shu, M.; Luo, H., Ge, W.; Perkins, R.; Tong, W.; Hong, H. BMC Bioinformatics. 2014, 15, 1-15.   DOI
19 Jordan, V. C. J. Med. Chem. 2003, 46, 883-908.   DOI
20 Pang, X.; Fu, W.; Wang, J.; Kang, D.; Xu, L.; Zhao, Y.; Liu, A. L.; Du, G. H. Oxid. Med. Cell. Longev. 2018, 2018, 1-11.
21 McDonnell, D. P.; Chang, C. Y.; Norris, J. D. J. Steroid Biochem. Mol. Biol. 2000, 74, 327-335.   DOI
22 Choi, M. H.; Shim, S. M.; Kim, G. H. J. Food Sci. Technol. 2016, 53, 1214-1221.   DOI
23 Sun, A.; Moore, T. W.; Gunther, J. R.; Kim, M. S.; Rhoden, E.; Du, Y.; Fu, H.; Snyder, J. P.; Katzenellenbogen, J. A. Chem. Med. Chem. 2011, 6, 654-666.   DOI
24 Park, E. J.; Lee, D.; Baek, S. E.; Kim, K. H.; Kang, K. S.; Jang, T. S.; Lee, H. L.; Song, J. H.; Yoo, J. E. Bioorg. Med. Chem. Lett. 2017, 27, 4389-4392.   DOI
25 Park, E. H.; Park, J. Y.; Yoo, H. S.; Yoo, J. E.; Lee, H. L. Bioorg. Med. Chem. Lett. 2016, 26, 3291-3294.   DOI
26 Ko, H.; Jeon, H.; Lee, D.; Choi, H. K.; Kang, K. S.; Choi K. C. Bioorg. Med. Chem. Lett. 2015, 25, 5508-5513.   DOI
27 Helferich, W. G.; Andrade, J. E.; Hoagland, M. S. Inflammopharmacology 2008, 16, 219-226.   DOI
28 Hsieh, C. Y.; Santell, R. C.; Haslam, S. Z.; Helferich, W. G. Cancer Res. 1998, 58, 3833-3838.
29 Lee, J. Y.; Kim, H. S.; Song, Y. S. J. Tradit. Complement. Med. 2012, 2, 96-104.   DOI