• Korean Journal of Clinical Laboratory Science
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• v.37 no.2
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• pp.71-77
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• 2005

We experienced the specimen that contains a hemoglobin variant known as interference from HbAS in October 2003. It was the first case of Hb variants since Samsung Medical Center began conducting glycohemoglobin College of American Pathologists surveys in 1997. The purpose of this study is to share our experience with the specimen and promote the understanding of Hb variants & derivatives. We've performed cross checks to examine HbA1c by using two pieces of equipment; the TOSHOH G7 and BIO-RAD VARIANT-T(turbo), and Automatic High Performance Liquid Chromatography(HPLC) as an analytic measurement method. HPLC provides different fractional information of hemoglobin with a two-dimensional graph as well as numeric results. We have been performing a "Systematic Checking Process". Three specimen suspicious of Hb variants & derivatives were found through this process. College of American Pathologists notified that it is important for users to be aware of the limitation of their glycohemoglobin method to avoid reporting incorrect results due to interference from hemoglobin variants or hemoglobin adducts. Therefore, laboratory findings of Hb variants & derivatives are very important. The experience of qualified technicians with professional knowledge in Hb variants is the most important aspect in finding Hb variants. Korea is homogeneous in race and is not in an area with a higher finding rate of Hb variants. While 1,024 cases of Hb variants have been found in Japan, we do not have specific data on how many cases of Hb variants have been found in Korea. Considering Hb variant cases in Japan, which is geographically close to us, it is presumed that there must be various Hb variant cases in Korea. If domestic laboratories set a systemic protocol and build a network to share our experience in Hb variants, I expect the Korean Hb variants could also be listed on the world's Hb variant list.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.12 no.6
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• pp.37-44
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• 2013

Friction stir welding (FSW) is a solid state joining technique that has expanded rapidly since its development in 1991 and has numerous applications in a wide variety of industries. This paper introduces the basic principles of friction stir welding (FSW) and presents a survey of the latest technologies and applications in the field. The basic principles that are discussed include the terminology, tool/workpiece processes, FSW merits and process variants. In particular, the process variants including the rotation speed and traveling speed are discussed, which include the defect-free zone in an oxygen free copper and Al alloy, respectively. Multiple aspects of the FSW machine are developed, including a horizontal 2D FSW machine and a hybrid complex FSW machine. The latest applications are introduced, with an emphasis on the recent advances in the aerospace, automotive, and IT display industries. Finally, the direction for future research and potential applications are examined.

• The Korean Journal of Nuclear Medicine
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• v.38 no.1
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• pp.1-20
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• 2004

Bone scan is one of the most frequently peformed studios in nuclear medicine. In bone scan, the amount of radiolsotope taken up by lesion depends primarily on the local rate of bone turnover rather than on the bone mass. Bone scan is extremely sensitive for defecting bony abnormalities. However, abnormalities that appear on bone scan may not always represent disease. The normal scan appearances may be affected not only by skeletal physiology and anatomy but also by a variety of technical factors which can influence image quality. Many normal variants and artifacts may appear on bone scan. They could simulate a pathologic process and could mislead into the wrong diagnostic interpretation. Therefore, their recognition is necessary to avoid misdiagnosis. A nuclear medicine physician should be aware of variable appearance of the normal variants and artifacts on bone scan. In this article, a variety of normal variants and artifacts mimicking real pathologic lesion in bone scan interpretation are discussed and illustrated.

• Journal of the Korean Society of Radiology
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• v.85 no.3
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• pp.488-504
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• 2024

Normal variants refer to imaging findings that are generally asymptomatic and discovered incidentally, yet may exhibit findings similar to those observed in pathological conditions. Recognizing normal variants in pediatric bone requires comprehension of the developmental process of long tubular bones and secondary ossification centers. Familiarity with various radiological findings of normal variants can prevent unnecessary follow-up imaging tests, as well as incorrect diagnosis and treatment. In this review, we will discuss the characteristic imaging findings of normal variants seen in growing pediatric bones, along with strategies for distinguishing them from pathologic conditions.

• The Journal of the Acoustical Society of Korea
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• v.20 no.2
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• pp.35-43
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• 2001

Many speech recognition systems have used pronunciation lexicon with possible multiple phonetic transcriptions for each word. The pronunciation lexicon is of often manually created. This process requires a lot of time and efforts, and furthermore, it is very difficult to maintain consistency of lexicon. To handle these problems, we present a model based on morphophon-ological analysis for automatically generating Korean pronunciation variants. By analyzing phonological variations frequently found in spoken Korean, we have derived about 700 phonemic contexts that would trigger the multilevel application of the corresponding phonological process, which consists of phonemic and allophonic rules. In generating pronunciation variants, morphological analysis is preceded to handle variations of phonological words. According to the morphological category, a set of tables reflecting phonemic context is looked up to generate pronunciation variants. Our experiments show that the proposed model produces mostly correct pronunciation variants of phonological words. Then we estimated how useful the pronunciation lexicon and training phonetic transcription using this proposed systems.

• Genomics & Informatics
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• v.21 no.4
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• pp.48.1-48.8
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• 2023

Liver cancer is the fourth leading cause of death worldwide. Well-known risk factors include hepatitis B virus and hepatitis C virus, along with exposure to aflatoxins, excessive alcohol consumption, obesity, and type 2 diabetes. Genomic variants play a crucial role in mediating the associations between these risk factors and liver cancer. However, the specific variants involved in this process remain under-explored. This study utilized a bioinformatics approach to identify genetic variants associated with liver cancer from various continents. Single-nucleotide polymorphisms associated with liver cancer were retrieved from the genome-wide association studies catalog. Prioritization was then performed using functional annotation with HaploReg v4.1 and the Ensembl database. The prevalence and allele frequencies of each variant were evaluated using Pearson correlation coefficients. Two variants, rs2294915 and rs2896019, encoded by the PNPLA3 gene, were found to be highly expressed in the liver tissue, as well as in the skin, cell-cultured fibroblasts, and adipose-subcutaneous tissue, all of which contribute to the risk of liver cancer. We further found that these two SNPs (rs2294915 and rs2896019) were positively correlated with the prevalence rate. Positive associations with the prevalence rate were more frequent in East Asian and African populations. We highlight the utility of this population-specific PNPLA3 genetic variant for genetic association studies and for the early prognosis and treatment of liver cancer. This study highlights the potential of integrating genomic databases with bioinformatic analysis to identify genetic variations involved in the pathogenesis of liver cancer. The genetic variants investigated in this study are likely to predispose to liver cancer and could affect its progression and aggressiveness. We recommend future research prioritizing the validation of these variations in clinical settings.

• Journal of the Korea Institute of Military Science and Technology
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• v.25 no.3
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• pp.311-320
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• 2022

In this paper, we studied the optimal method of improving performance for aircraft having various variants within the same type. The study defined configuration of an entire fleet of aircraft being subject to a performance improvement program. And selected the most complicated aircraft configuration among them as a Standard Aircraft for modification by according to the proposed Aircraft Selection Process for developing an optimal Aircraft Performance Improvement Process. Based on the selected the Standard Aircraft, drew a system integration design result and carried out Evaluation Test and obtained Airworthiness Certification. Created the database with the design data of the Standard Aircraft, Evaluation Test, and Airworthiness Certification results, and applied it to variants of aircraft to complete the performance improvement program with optimized schedules and costs. By applying the proposed method to IFF performance improvement program, drew optimal system integration design and completed the program with minimized schedule.

• Journal of the Korean Society of Industry Convergence
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• v.10 no.1
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• pp.5-14
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• 2007

It is necessary for development of drawing product with press to have suitable material selection & all process design and the problem during press process has been cleared from judgement of experience & trial and error. Recently we can estimate press process result from computer aided design & FEM. But we can get more reliable result when we can put more precise process variants during FEM. In case of using a drawbead that is used for the material inflow, it is considered for us to put material property, other analysis condition & friction figure when material is passing through the drawbead for better FEM. From our study, we have drawn an analogy bead connection depth, friction figure & drawing and restraining load according to kinds of lubrication from experiment & FEM for the drawbead. We applied above result to the drawing experiment & FEM and confirmed the validity. We could notice the relation between friction figure & drawing load and the friction figure variation according to kinds of lubrication. It is expected to draw more precise analogy that can be used for real process due to more precise process variants application to FEM.

• Journal of Korean Society for Quality Management
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• v.33 no.4
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• pp.96-102
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• 2005

Cusum control chart is an efficient method to detect the change of process status. Many variants of cusum have considered, and the effects of design parameters have reviewed. To find the best cusum out of variants and to decide the best values of the design parameters, we need a criterion measuring the performance of the cusum control chart. People used and suggested several criterions which appear to be similar, but those have quite different properties. In this paper we review the properties of performance measure of cusum and its variants. Our goal is to provide fair and impartial criterion for comparison of cusums when the decision boundaries of the cusums are much different each other. We comparatively tested newly suggested measure and traditional measure with the examples of cumulative scored chart as a special case of cusum chart.

• Genomics & Informatics
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• v.11 no.4
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• pp.191-199
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• 2013

High-throughput next-generation sequencing (NGS) technology produces a tremendous amount of raw sequence data. The challenges for researchers are to process the raw data, to map the sequences to genome, to discover variants that are different from the reference genome, and to prioritize/rank the variants for the question of interest. The recent development of many computational algorithms and programs has vastly improved the ability to translate sequence data into valuable information for disease gene identification. However, the NGS data analysis is complex and could be overwhelming for researchers who are not familiar with the process. Here, we outline the analysis pipeline and describe some of the most commonly used principles and tools for analyzing NGS data for disease gene identification.