• Molecules and Cells
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• v.40 no.9
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• pp.613-620
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• 2017

The most common form of senile dementia is Alzheimer's disease (AD), which is characterized by the extracellular deposition of amyloid ${\beta}-peptide$ ($A{\beta}$) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson's disease, and Pick's disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than $A{\beta}$ plaque accumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD. A growing amount of evidence suggests that soluble $A{\beta}$ oligomers in concert with hyperphosphorylated tau (pTau) serve as the major pathogenic drivers of neurodegeneration in AD. Increased $A{\beta}$ oligomers trigger neuronal dysfunction and network alternations in learning and memory circuitry prior to clinical onset of AD, leading to cognitive decline. Furthermore, accumulated damage to mitochondria in the course of aging, which is the best-known nongenetic risk factor for AD, may collaborate with soluble $A{\beta}$ and pTau to induce synapse loss and cognitive impairment in AD. In this review, I summarize and discuss the current knowledge of the molecular and cellular biology of AD and also the mechanisms that underlie $A{\beta}-mediated$ neurodegeneration.

• The Journal of the Korea Contents Association
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• v.10 no.12
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• pp.342-351
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• 2010

This study aims to investigate the major causes of conflict between clients and vendors in the outsourced IS development. A research model is established based on the prior research of IS outsourcing, system development and conflict. An empirical study was executed using 214 survey questionnaire of project teams composed of client and vendor with PASW 18.0. Research results using multiple regressions show that contract specificity, requirements certainty, objective alignment and client knowledge have negative effects on conflict. This research results will provide various implications for outsourcing project success.

• Journal of Intelligence and Information Systems
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• v.17 no.3
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• pp.169-185
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• 2011

Data redundancy is problematic in that it not only induces heavy storage management cost but also could bring critical degradation of information systems. Unfortunately, to our knowledge, only few enterprises willingly afford time and efforts for the faithful conceptual design to prevent the degree of inappropriate data as much as they could, while most of enterprises pay rare attention to the notion of that sort of data quality. Wondering if there would be any other way to design the enterprise.wide data design without prior knowledge about business works is our major motivation for this study. In this paper, we present our data modeling methodology in which associations among objects in each sentences of a business job descriptions are treated as the focal point in database design. A proposed agent for automated design tool simply takes a business job description written in natural language as an input, and then designs an entity relationship diagram with some smart rules. We introduce the scope of the proposed agent and its detailed logics with several examples. And then, we verify the appropriateness of the resulted associations among objects. Lastly, we perform case studies to evaluate the devised agent's applicability to a business field.

• Science of Emotion and Sensibility
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• v.15 no.1
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• pp.47-56
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• 2012

The purpose of this study is to test the effect of pedagogical agent realism and expertise on persona effect. There were two perspectives of the pedagogical agents' social interaction. Self-identification hypothesis argues that complexity of agent image is better to increase social interaction. Subjective identification insists that simplified image is more helpful to facilitate social interaction. However, from the cognitive load theory perspective, learners' expertise can be a major factor to determine persona effect. Sixty-eight college students (male=19 and female=49) participated. The independent variables were the degree of realism of pedagogical agent (detailed vs. simplified image) and the expertise (high prior knowledge group vs. low prior knowledge group). The dependant variables were comprehension test and the agent persona instrument (API). There was no significant difference in comprehension test score; however, there were significant interaction effect on the most constructs of API: 1) facilitating of learning, 2) credible, and 3) human-like. The follow-up analysis of simple main effect revealed that high expertise group showed significantly higher perception of the three construct with high realism of pedagogical agent. The results of study show that learners' expertise plays a key role of perception of persona effect.

• Korea Trade Review
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• v.44 no.5
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• pp.1-16
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• 2019

As the activities of global enterprises have become more globalized and the labor movement among nations has increased, many studies have been carried out on the effective adjustment of expatriate managers. By examining the literature over the past 30 years on the adjustment of expatriate managers, this study identified major research trends and presented future research directions. While prior studies have often been cumbersome, time-consuming, and dependent on the researchers' subjective judgments, this study performs a bibliometric analysis using quantitative and visualized reference materials to provide a map showing the evolution process of existing research on the adjustment of expatriates. Using the CiteSpace program, this study conducted a bibliometric analysis of 517 papers focusing on major research trends, research countries, research institutions, authors, and journals. Study results found that the study of international adjustment was mainly focused on self-directed senders, attribution adaptations, and personal characteristics. The United States, Britain, and Australia were the most represented countries, while the most influential institutions included Aarhus University, the University of Wisconsin, and Hong Kong Baptist University. As one of the leading researchers, Selmer of Orhuss University published 19 papers, followed by Luring of Orhuss University. The Journal of International Business Studies (JIBs) most frequently featured studies of overseas expatriate adjustment.

• Journal of Information Technology Applications and Management
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• v.15 no.4
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• pp.159-188
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• 2008

This study suggests strategies which can enable to creation of new opportunities of competitive advantages while operating a long lasting and consistent business with major trading partners, based on interorganizational information systems (IOISs) specially established and installed for interorganizational transactions. Nowadays, IOISs based mechanism having been widely expanded as a conventional business infrastructure for the interorganizational transactions and/or exchanges, it is customary difficult to obtain any strongly sound advantage over the competitors who have adopted even the simplest deployment of the IOIS mechanisms. In this connection, this study intends to investigate the interorganizational collaborative activities conducted by under the auspicious of IOISs, focused on the prospect of the exploitation of IOISs rather than the implementation of the IOISs. In this study, we, firstly, suggest the concept of Electronic Collaboration which can be defined by the collaborative activities conducted by IOISs, compared to the ones conducted on off-line. In addition, we suggest the Electronic Collaboration as a multi-dimensional concept, constituted by three sub-constructs, the Electronic Information Sharing (EIS), the Electronic Joint Activity (EJA), and the construction of the Electronic Relational Knowledge Store (ERKS). Secondly, we empirically verify the effects of relational and environmental determinants on the Electronic Collaboration. In this study, the relational determinants relate to the variables created in interorganizational relationship like Trust, Influence, Relational Specific Asset-asset invested for the transaction-, and Continuity of the relationship. On the other hand, the environmental determinants relate to the variables surrounding the relationship which are difficult to control. We consider Product Complexity, Technological Uncertainty, and Market Variability as the domain of the environmental determinants. To test our hypotheses, we conducted both paper-based survey and online-based survey. After refining the data with missing responses, a total of 150 data was used for analysis. The results were as follows : Firstly, it is statistically significant that the Electronic Collaboration is composed of EIS, EJA, and ERKS. In particular, the results imply that the firms are able to accumulate relational knowledge base as well as to exchange information or knowledge, and to conduct joint activities through effort to further expand the Electronic Collaboration. Secondly, we have verified the individual effects of the relational and the environmental determinants on the Electronic Collaboration. Product Complexity has been revealed as the most influential variable affecting the Electronic Collaboration. Next, Interorganizational Trust and Technological Uncertainty, in that order, have been seen to have significant effects on the Electronic Collaboration. In other words, when products or services seem to be difficult to standardize, and the core technologies seem to rapidly change, the need for the Electronic Collaboration increase. In addition, the observation dictates that the interorganizational trust turns out to be a critical variable in building a relationship and in seeking further collaboration. The results, further, illustrate that the environmental determinants are relatively more effective than the relational determinants, which is not consistent with a few prior researches relational determinants emphasized. It is because this study doesn't consider the size of the firm. A few researchers have given an emphasis on the relational determinants like trust and influence, especially from the perspective of small firms in interorganizational relationship. However, in our study, where all the sizes of the firms are contained, electronic collaboration is considerably affected by the environmental determinants.

• Food Science and Preservation
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• v.13 no.1
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• pp.102-107
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• 2006

This study explores the effects of a television program on viewers' perception of vinegar. The 97 viewers were recruited from both students majoring in Food $(13.3\%)$ and those in non-Food subjects $(86.7\%)$. In this study the participants ($31.1\%$ males and $68.9\%$ females) were exposed to a 30 minute television program on vinegar. The students were surveyed to quantitatively test the effects of the television program on a viewer's perception. The results suggest that there is a correlation between viewing this television program and changes in perceptions of vinegar. The pre-test shows that $80.0\%$ of the participants had a minimum knowledge about vinegar and $16.7\%$ of the participants had no knowledge about vinegar. Only $3.3\%$ of the participants had a sufficient knowledge about vinegar before viewing the television program. After viewing the television program on vinegar, $80.0\%$ of the participants responded that the program 'highly influenced change' in their perception of vinegar and $20.0\%$ of the participants responded that the program gave them 'moderate effects on the perception change' while $0.0\%$ of the participants answered that there was 'no change' in their perception of vinegar. While there was no significant difference found among students' prior knowledge about vinegar in terms of gender and academic major, the study found the television program viewing experience made a great impact on their perception of vinegar. This research suggests that this television program about vinegar does not only influence the viewers' perception of vinegar but also creates an overall change in perception of purchase intention, practical uses of vinegar, and vinegar-drinking.

• Knowledge Management Research
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• v.24 no.3
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• pp.17-34
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• 2023

Recently, national concern for record breaking level of deficit operation of KEPCO grows bigger in Korea. With this regard, many stakeholders believe KEPCO should be responsible for this result although it is not clear whether KEPCO is only to blame who is in such position where full cost pricing is impossible and entrepreneurial efficiency is not guaranteed. Particularly, less concern is given to Performance Evaluation for Public Organization(PEPO) which did not give prior warning against major deficit of KEPCO or help to improve its capacity to deal with the problem, and thus prevented KEPCO from acknowledging its managerial weakness by crediting KEPCO with successive grade B during the period of previous government. Based on such viewpoint, this study analyzes reports of PEPO for 5 years in terms of evaluability assessment and suggests proper direction for better PEPO in the future. From this analysis, it was found that firstly, relevant suggestion was not made to prevent or improve defict problem; secondly, comments are increasing every year without consistency; thirdly, comments related to long-term investment are only recently found; fourthly, suggestions are based on political orientation rather than evidence or expertise. This study is expected to contribute to evidence-based evaluation and knowledge management since it tackles evaluation reports themselves for the first time.

• Journal of Distribution Science
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• v.12 no.6
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• pp.67-79
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• 2014

Purpose - This study aims to accomplish three major research goals. First, it strives to change consumers' focus from peripheral routes to a central route of public service advertising related to the good health policy, without problematic effects, by influencing consumers' knowledge or involvement. Second, this study examines the elaboration likelihood model (ELM) and construal level theory (CLT). Specifically, we consider that the central route of ELM might correspond with the focal goal of CLT. Third, this study analyzes ELM through CLT. That is, ELM predicted that low involvement would take the peripheral route, and high involvement would take the central route. Research design, data, and methodology - This study consisted of three experiments. The first experiment had a 2×2 between-subject design. The subjects were university students and the research period was approximately one year. The first independent variable was the involvement of the overweight issue; this variable was measured and split by the median. The second independent variable was the temporal distance (near vs. distant future); this variable was manipulated. The second experiment also had a 2×2 between-subject design. The first variable was the involvement of cervical adenocarcinoma prevention, and was considered already manipulated by sex. Specifically, males had a low involvement of the disease, but females had high involvement. The second independent variable was priming (power vs. submissive). Power priming would induce abstract thinking, but submissive priming would take concrete processing. The third experiment had a 2×2×2 between-subject design. The first variable was cognitive depletion, and was manipulated by memorizing 9-digit numbers. The second and third independent variables were involvement and abstract thinking induction, such as prior experiments. Data were collected through questionnaires, and were analyzed by an SPSS program. Major hypotheses were tested by examining the interaction effects through ANOVA. Results - Major findings are as follows. First, even for low-involved consumers in the overweight category, distant future manipulation induced them to focus not on the peripheral route but on the central route of the public service advertisement. This result does not correspond to the typical ELM prediction. Second, under power priming, low-involved males of the cervical adenocarcinoma category focused on the peripheral route because of the induction to abstract thinking. This result replicated the first experiment, and confirmed the theoretical robustness. Third, high-involved females focused not on the central but on the peripheral route under the mixed condition of cognitive depletion and near future manipulation. Depletion consumed cognitive resources, and the processing mode of consumers changed from systematic to heuristic. Conclusions - ELM needs to be complemented through CLT in context of public service good health advertising. Specifically, the involvement of ELM may impact consumers' thinking mode (abstract vs. concrete), and the interaction effects may influence consumers' focus on advertising (central vs. peripheral route). This study's limitations were bounded subjects, limited stimuli, and somewhat weak external validity.

• Spatial Information Research
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• v.23 no.1
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• pp.1-8
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• 2015

The purpose of this study is to develope BIM Template according to major building material for efficiently and quantitatively evaluating greenhouse gas emission at the design stage. Template users consider various environmental impacts without connecting simulation tools for analyzing environmental impact and Template users who have no prior knowledge can Life Cycle Assessment by using The green template. For this study, Database which was reflected in template was constructed considering environmental performance. and 6 kinds of environmental impact categories and PPS standard construction codes were analyzed by major building material derived from literature. Based on this analyzed data, The major Material Family according to the main building material was developed. When users conduct modeling by utilizing Family established, evaluating result can be confirmed in the Revit BIM Modeling program by using the schedule function of the Revit. Users through the modeling, the decision-making environment performance possible. In addition, we propose to create a guideline for the steps required to build an additional established family.