• Nuclear Engineering and Technology
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• 제52권6호
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• pp.1318-1326
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• 2020

Structural modification in the electrical cabinet is investigated by a proposed procedure that comprises of an experimental, analytical and numerical solution. This research emphasizes the linear dynamic analysis of the cabinet that is studied under the seismic excitation to demonstrate the real behavior of the cabinets in NPP. To this end, an actual electric cabinet is experimentally tested using an impact hammer test which reveals the fundamental parameters of the cabinet. The Frequency-domain decomposition (FDD) method is used to extract the dynamic properties of the cabinet from the experiment which is then used for numerical modeling. To validate the dynamic properties of the cabinet an analytical solution is suggested. The calibrated model is analyzed under the floor response obtained from the Connecticut nuclear power plant structure excited by Tabas 1978 (Mw 7.4) earthquake. Eventually, the grouping effect of the cabinets is proposed which represents the influence on the dynamic modification. This grouping of the cabinets is described more sophisticatedly by the theoretical understating, which results in a significant change in the seismic response. Considering the grouping effects will be helpful in the assessment of the real seismic behavior, design, and performance of cabinets.

• The Plant Pathology Journal
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• 제35권6호
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• pp.609-622
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• 2019

Sound vibration (SV) treatment can trigger various molecular and physiological changes in plants. Previously, we showed that pre-exposure of Arabidopsis plants to SV boosts its defense response against Botrytis cinerea fungus. The present study was aimed to investigate the changes in the proteome states in the SV-treated Arabidopsis during disease progression. Proteomics analysis identified several upregulated proteins in the SV-infected plants (i.e., SV-treated plants carrying Botrytis infection). These upregulated proteins are involved in a plethora of biological functions, e.g., primary metabolism (i.e., glycolysis, tricarboxylic acid cycle, ATP synthesis, cysteine metabolism, and photosynthesis), redox homeostasis, and defense response. Additionally, our enzyme assays confirmed the enhanced activity of antioxidant enzymes in the SV-infected plants compared to control plants. Broadly, our results suggest that SV pre-treatment evokes a more efficient defense response in the SV-infected plants by modulating the primary metabolism and reactive oxygen species scavenging activity.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5037-5041
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• 2015

Background: An hCG regression curve has been used to predict the natural history and response to chemotherapy in gestational trophoblastic disease. We constructed hCG regression curves in high-risk gestational trophoblastic neoplasia (GTN) treated with EMA/CO and identified an optimal hCG level to detect EMA/CO resistance in GTN. Materials and Methods: Eighty-one women with GTN treated with EMA/CO were classified as primary high-risk GTN (n = 65) and single agent-resistance GTN (n = 16). The hCG levels prior to each course of chemotherapy were plotted in the 10th, 50th, and 90th percentiles to construct the hCG regression curves. Diagnostic performance was evaluated for an optimal cut-off value. Results: The median hCG levels were 264,482 mIU/mL mIU/mL and 495.5 mIU/mL mIU/mL for primary high-risk GTN and single agent-resistance GTN, respectively. The 50th percentile of the hCG level in primary high-risk GTN and single agent-resistance turned to normal before the 4th and the 2nd course of chemotherapy, respectively. The 90th percentile of the hCG level in primary high-risk GTN and single agent-resistance turned to normal before the 9th and the 2nd course of chemotherapy, respectively. The hCG level of ${\geq}118.6mIU/mL$ mIU/mL at the 5thcourse of EMA/CO predicted the EMA/CO resistance in primary high-risk GTN patients with a sensitivity of 85.7% and a specificity of 100%. Conclusion: EMA/CO resistance in primary high-risk GTN can be predicted by using an hCG regression curve in combination with the cut-off value of 118.6 mIU/mL at the 5thcourse of chemotherapy.

• 대한영상의학회지
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• 제85권2호
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• pp.482-483
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• 2024

• 한국자동차공학회논문집
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• 제10권3호
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• pp.201-208
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• 2002

In this paper, the control strategy of ratio changing system for a metal belt CVT adopting primary pressure regulation is developed, and the shirting performance of pressure regulating type CVT with the suggested control strategy is investigated. The control strategy suggested in this study is composed of 2 feedback loop, one is speed ratio feedback and the other is primary pressure feedback. The pressure feedback is adopted to ensure prohibiting a belt slip during transient period in a fast downshift mode. Simulation results show that the system with suggested control strategy gives appropriate response time and tracking Performance for upshift and also gives a proper primary pressure which can prohibit the belt slip. In addition, it is fecund that the given system has an acceptable servo property in tracking the target speed ratio and robustness for the disturbance of line pressure.

• 한국자동차공학회논문집
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• 제9권5호
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• pp.179-187
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• 2001

In this paper, a primary pressure regulating type ratio control system is developed for a metal belt CVT, and the CVT ratio changing characteristics are investigated by simulation and experiment. The hydraulic part of the ratio control system has a simple structure with one 3-way spool valve as a main ratio control valve and one bleed type variable force solenoid as a pilot valve. The mathematical modelling of the CVT hydraulic system is derived by considering the CVT shift dynamics. Simulation results of CVT speed ratio and the primary pressure agree with the experimental results demonstrating the validity of the dynamic models. It is found from the simulation and experimental results that the response time of speed ratio and primary pressure can be shortened by increasing the ratio control valve port area, and the size of feedback orifice of ratio control valve gives a damping effect on the primary pressure oscillation.

• 생명과학회지
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• 제24권12호
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• pp.1364-1370
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• 2014

Ascorbic acid (AA)는 식물 발달과 생장에 필수적인 다기능성 대사산물이다. 본 연구에서는 항산화제인 AA가 옥수수 일차 뿌리에서 굴중성 반응에 미치는 효과를 조사하였다. $10^{-3}$ M AA를 신장대에 처리하면 뿌리 굴중성 반응은 영향을 받지 않고 뿌리 생장은 약간 억제되었다. 그러나 $10^{-5}$ M과 $10^{-3}$ M AA를 뿌리 끝에 처리하였을 때, 뿌리 굴중성 반응은 촉진된 반면, 뿌리 생장은 억제되었다. 수평으로 놓인 뿌리의 윗면과 아랫면에서 IAA함량의 차이는 차등 생장을 유발한다. 뿌리는 IAA에 대하여 매우 민감하여 아랫면에 증가된 IAA는 뿌리 생장을 억제한다. 그러므로 본 연구에서 AA가 존재할 때 IAA의 효과를 조사하였다. AA는 IAA와 함께 처리하면 굴중성 반응을 더욱 억제시켰다. 뿌리 생장과 굴중성 반응의 조절에 관여하는 AA의 작용을 알아보기 위하여, AA를 처리한 후 에틸렌 생성을 측정하였다. AA는 ACC가 에틸렌으로 전환되는 단계를 조절하는 ACC oxidase gene을 활성화시켜 에틸렌 생성을 촉진하였다. 이 결과는 AA가 에틸렌 작용의 조절을 통하여 옥수수 뿌리에서 굴중성 반응에 영향을 준다는 것을 제시한다.

• 소음진동
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• 제9권4호
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• pp.778-784
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• 1999

A method for obtaining the motion of an impact system whose primary and secondary system are composed of lumped masses, springs and dampers, and all the contacts are made through spring and damping elements is presented. The frequency response functions derived from the equations of motion and the impulse response functions obtained from the inverse Fourier transform of the derived frequency response functions are used for the calculation of the system responses. The procedure developed for the calculation of displacements and force time-histories was based on the convolution integrals of impulse response functions and forces applied to the systems. Time histories of displacements and contact forces are obtained for the case where a random excitation is applied to a point in the system. Impact statistics such as contact forces and the time between impacts calculated from those time histories is presented.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.679-682
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• 2015

Background: Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate the expression status of IER3 in primary hepatocarcinoma (PHC) and correlation with clinicopathological parameters. Materials and Methods: Real-time PCR was performed to evaluate the expression levels of IER3 in 62 pathologically diagnosed human PHC specimens. Results: A statistically significant association was disclosed between the expression of IER3 and P53 mutant protein (short for P53), Ki-67, EGFR and the biggest diameter, differentiation grade of tumor. Conclusions: This work is the first to shed light on the potential clinical usefulness of IER3, as an efficient tumor biomarker in PHC.

• Nuclear Engineering and Technology
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• 제52권8호
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• pp.1847-1861
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• 2020

A design study was performed to improve the limit aseismic performance (LSP) of a primary heat transport system (PHTS) pump. This pump is part of the primary equipment of a prototype generation IV sodium-cooled fast reactor (PGSFR). The LSP is the maximum allowable seismic load that still ensures structural integrity. To calculate the LSP of the PHTS pump, a structural analysis model of the pump was developed and its dynamic characteristics were obtained by modal analysis. The floor response spectrum (FRS) initiated from a safety shutdown earthquake (SSE), 0.3 g, was applied to the support points of the PHTS pump, and then the seismic induced stresses were calculated. The structural integrity was evaluated according to the ASME code, and the LSP of the PHTS pump was calculated from the evaluation results. Based on the results of the modal analysis and LSP of the PHTS pump, design parameters affecting the LSP were selected. Then, ways to improve the LSP were proposed from sensitivity analysis of the selected design variables.