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http://dx.doi.org/10.7314/APJCP.2015.16.2.679

Expression of IER3 in Primary Hepatocarcinoma: Correlation with Clinicopathological Parameters  

Liu, Zhong (Medical College, Qingdao University)
Wang, Xin-Mei (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital)
Jia, Tong-Fu (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital)
Zhai, Yi (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital)
Sun, Ling-Yan (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital)
Cheng, Yu-Ping (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital)
Zhang, Yue-Min (Department of Chemotherapy, Department of Pathology, Zibo Center Hospital)
Liu, Shi-Hai (Department of Medical Research Center, Department of Oncology, the Affiliated Hospital of Qingdao University)
Liang, Jun (Department of Medical Research Center, Department of Oncology, the Affiliated Hospital of Qingdao University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.2, 2015 , pp. 679-682 More about this Journal
Abstract
Background: Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes. Recently, it was discovered that IER3 plays an important role in tumorigenesis and tumor progression. Thus it may be a valuable biomarker in tumor. This study was designed to investigate the expression status of IER3 in primary hepatocarcinoma (PHC) and correlation with clinicopathological parameters. Materials and Methods: Real-time PCR was performed to evaluate the expression levels of IER3 in 62 pathologically diagnosed human PHC specimens. Results: A statistically significant association was disclosed between the expression of IER3 and P53 mutant protein (short for P53), Ki-67, EGFR and the biggest diameter, differentiation grade of tumor. Conclusions: This work is the first to shed light on the potential clinical usefulness of IER3, as an efficient tumor biomarker in PHC.
Keywords
Immediate early response gene 3; primary hepatocarcinoma; expression; tumor progression;
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